Dr. John Poe is currently a research methodologist working as a postdoctoral scholar for the Cent... more Dr. John Poe is currently a research methodologist working as a postdoctoral scholar for the Center for Public Health Services and Systems Research at the University of Kentucky. He received his PhD in the Department of Political Science at UK in 2017. Dr. Poe teaches the advanced course on multilevel modeling for the ICPSR summer program at the University of Michigan and the GSERM program in Europe. His methodological training comes mostly from econometrics, psychometrics, statistics, and biostatistics. His current substantive work is focused on understanding community health systems using network science. In particular, he is focused on understanding how health system structures and interactions affect health disparities in different segments of the population. Dr. Poe’s past (and future) work was split between research about the determinants of the policy process and understanding how different mechanisms in policy making operate and how people react to the their political and so...
Replication Files for The Importance of Salience: Public Opinion and State Policy Action on Clima... more Replication Files for The Importance of Salience: Public Opinion and State Policy Action on Climate Chang
We present a comprehensive analysis of antibody and cellular responses in children aged 12-16 yea... more We present a comprehensive analysis of antibody and cellular responses in children aged 12-16 years who received COVID-19 vaccination with ChAdOx1 (n=6) or mRNA vaccine (mRNA-1273 or BNT162b2, n=9) using a 12-week extended-interval schedule. mRNA vaccination of seropositive children induces high antibody levels, with one dose, but a second dose is required in infection-naïve children. Following a second ChAdOx1 dose, antibody titres were higher than natural infection, but lower than mRNA vaccination. Vaccination induced live virus neutralising antibodies against Alpha, Beta and Delta variants, however, a second dose is required in infection-naïve children. We found higher T-cell responses following mRNA vaccination than ChAdOx1. Phenotyping of responses showed predominantly early effector-memory CD4 T cell populations, with a type-1 cytotoxic cytokine signature, with IL-10. These data demonstrate mRNA vaccination induces a co-ordinated superior antibody and robust cellular responses...
OF DISSERTATION HOW THE CLIMATE OF OPINION IN STATES AND COUNTRIES INFLUENCES GAY RIGHTS This dis... more OF DISSERTATION HOW THE CLIMATE OF OPINION IN STATES AND COUNTRIES INFLUENCES GAY RIGHTS This dissertation examines attitudes on same-sex marriage and how personal predispositions toward support and the climate of opinion interact to help create attitudes. Over the past few decades, support for gay rights has increased dramatically in the United States and many other countries around the world. I argue that, while the set of basic personal determinants of attitudes toward homosexuality and gay rights stays roughly the same, the impact of such determinants changes over time and space. The framework used in this dissertation draws on attitudinal and political psychology, political sociology and theories of contextual effects. I argue that over the course of their lives, people develop an overall propensity to tolerate or approve of homosexuality and support gay rights based on their political and social characteristics, such as religiosity, partisan or ideological identities, personal...
STUDY DESIGN Retrospective analysis of administrative billing data. OBJECTIVE To evaluate the ext... more STUDY DESIGN Retrospective analysis of administrative billing data. OBJECTIVE To evaluate the extent to which a metric of serious complications determined from administrative data can reliably profile hospital performance in spine fusion surgery. SUMMARY OF BACKGROUND DATA While payers are increasingly focused on implementing pay-for-performance measures, quality metrics must reliably reflect true differences in performance among the hospitals profiled. METHODS We used State Inpatient Databases from nine states to characterize serious complications after elective cervical and thoracolumbar fusion. Hierarchical logistic regression was used to risk-adjust differences in case mix, along with variability from low case volumes. The reliability of this risk-stratified complication rate (RSCR) was assessed as the variation between hospitals that was not due to chance alone, calculated separately by fusion type and year. Finally, we estimated the proportion of hospitals that had sufficient case volumes to obtain reliable (> 0.7) complication estimates. RESULTS From 2010-2017 we identified 154,078 cervical and 213,133 thoracolumbar fusion surgeries. 4.2% of cervical fusion patients had a serious complication, and the median RSCR increased from 4.2% in 2010 to 5.5% in 2017. The reliability of the RSCR for cervical fusion was poor and varied substantially by year (range 0.04-0.28). Overall, 7.7% of thoracolumbar fusion patients experienced a serious complication, and the RSCR varied from 6.8%-8.0% during the study period. Although still modest, the RSCR reliability was higher for thoracolumbar fusion (range 0.16-0.43). Depending on the study year, 0-4.5% of hospitals had sufficient cervical fusion case volume to report reliable (> 0.7) estimates, whereas 15-36% of hospitals reached this threshold for thoracolumbar fusion. CONCLUSION A metric of serious complications was unreliable for benchmarking cervical fusion outcomes and only modestly reliable for thoracolumbar fusion. When assessed using administrative datasets, these measures appear inappropriate for high-stakes applications, such as public reporting or pay-for-performance.Level of Evidence: 3.
In March 2020, our institution developed an interdisciplinary predictive analytics task force to ... more In March 2020, our institution developed an interdisciplinary predictive analytics task force to provide COVID-19 hospital census forecasting to help clinical leaders understand the potential impacts on hospital operations. As the situation unfolded into a pandemic, our task force provided predictive insights through a structured set of visualizations and key messages that have helped the practice to anticipate and react to changing operational needs and opportunities. The framework shared here for the deployment of a COVID-19 predictive analytics taskforce could be adapted for effective implementation at other institutions to provide evidence-based messaging for operational decision-making. For hospitals without such a structure, immediate consideration may be warranted in light of the devastating COVID-19 ‘third-wave’ which has arrived for winter 2020-2021.
ASAIO journal (American Society for Artificial Internal Organs : 1992), Jan 23, 2017
Extracorporeal membrane oxygenation (ECMO) has been reported as an alternative to cardiopulmonary... more Extracorporeal membrane oxygenation (ECMO) has been reported as an alternative to cardiopulmonary bypass during lung transplantation. The reports in the literature have been limited to adult practice and associated with decreased pulmonary and renal complications, lower mortality, and lower in-hospital mortality. We present four pediatric lung transplantations performed on ECMO and discuss relevant perfusion management.
In this chapter the authors explore two decades of research on the policies that have evolved fro... more In this chapter the authors explore two decades of research on the policies that have evolved from struggles for minority group inclusion. They focus on minority-targeted policies that are most relevant to state or local governments. As part of this effort the authors report the results of a content analysis of nine major political science and public policy journals. They find that the volume of research on minority-targeted policies has remained steady over time, but there have been significant changes in the content of these studies. In addition the authors dissect the research to examine the major questions that have been studied in the literature, as well as what we have learned about the politics and the impact of minority-targeted policies. They conclude by highlighting some recent trends in this literature that seem promising, as well as suggesting avenues for future research.
MMWR. Morbidity and mortality weekly report, Jan 9, 2010
On October 19, 2009, clinicians from Kentucky contacted CDC regarding a suspected case of rabies ... more On October 19, 2009, clinicians from Kentucky contacted CDC regarding a suspected case of rabies in a man from Indiana aged 43 years. This report summarizes the patient's clinical presentation and course, the subsequent epidemiologic investigation, and, for the first time, provides infection control recommendations for personnel performing autopsies on decedents with confirmed or suspected rabies infection. Before the patient's death on October 20, a diagnosis of rabies was suspected based on the history of acute, progressive encephalitis with unknown etiology. Preliminary serology results on antemortem serum samples detected rabies virus-specific antibodies. Because local pathologists were concerned about the biosafety risk posed by infectious aerosols at autopsy and potential contamination of autopsy facilities, the Kentucky Department for Public Health (KDPH) asked CDC staff members to travel to Kentucky and perform an autopsy to confirm the diagnosis and assist with the ...
Dr. John Poe is currently a research methodologist working as a postdoctoral scholar for the Cent... more Dr. John Poe is currently a research methodologist working as a postdoctoral scholar for the Center for Public Health Services and Systems Research at the University of Kentucky. He received his PhD in the Department of Political Science at UK in 2017. Dr. Poe teaches the advanced course on multilevel modeling for the ICPSR summer program at the University of Michigan and the GSERM program in Europe. His methodological training comes mostly from econometrics, psychometrics, statistics, and biostatistics. His current substantive work is focused on understanding community health systems using network science. In particular, he is focused on understanding how health system structures and interactions affect health disparities in different segments of the population. Dr. Poe’s past (and future) work was split between research about the determinants of the policy process and understanding how different mechanisms in policy making operate and how people react to the their political and so...
Replication Files for The Importance of Salience: Public Opinion and State Policy Action on Clima... more Replication Files for The Importance of Salience: Public Opinion and State Policy Action on Climate Chang
We present a comprehensive analysis of antibody and cellular responses in children aged 12-16 yea... more We present a comprehensive analysis of antibody and cellular responses in children aged 12-16 years who received COVID-19 vaccination with ChAdOx1 (n=6) or mRNA vaccine (mRNA-1273 or BNT162b2, n=9) using a 12-week extended-interval schedule. mRNA vaccination of seropositive children induces high antibody levels, with one dose, but a second dose is required in infection-naïve children. Following a second ChAdOx1 dose, antibody titres were higher than natural infection, but lower than mRNA vaccination. Vaccination induced live virus neutralising antibodies against Alpha, Beta and Delta variants, however, a second dose is required in infection-naïve children. We found higher T-cell responses following mRNA vaccination than ChAdOx1. Phenotyping of responses showed predominantly early effector-memory CD4 T cell populations, with a type-1 cytotoxic cytokine signature, with IL-10. These data demonstrate mRNA vaccination induces a co-ordinated superior antibody and robust cellular responses...
OF DISSERTATION HOW THE CLIMATE OF OPINION IN STATES AND COUNTRIES INFLUENCES GAY RIGHTS This dis... more OF DISSERTATION HOW THE CLIMATE OF OPINION IN STATES AND COUNTRIES INFLUENCES GAY RIGHTS This dissertation examines attitudes on same-sex marriage and how personal predispositions toward support and the climate of opinion interact to help create attitudes. Over the past few decades, support for gay rights has increased dramatically in the United States and many other countries around the world. I argue that, while the set of basic personal determinants of attitudes toward homosexuality and gay rights stays roughly the same, the impact of such determinants changes over time and space. The framework used in this dissertation draws on attitudinal and political psychology, political sociology and theories of contextual effects. I argue that over the course of their lives, people develop an overall propensity to tolerate or approve of homosexuality and support gay rights based on their political and social characteristics, such as religiosity, partisan or ideological identities, personal...
STUDY DESIGN Retrospective analysis of administrative billing data. OBJECTIVE To evaluate the ext... more STUDY DESIGN Retrospective analysis of administrative billing data. OBJECTIVE To evaluate the extent to which a metric of serious complications determined from administrative data can reliably profile hospital performance in spine fusion surgery. SUMMARY OF BACKGROUND DATA While payers are increasingly focused on implementing pay-for-performance measures, quality metrics must reliably reflect true differences in performance among the hospitals profiled. METHODS We used State Inpatient Databases from nine states to characterize serious complications after elective cervical and thoracolumbar fusion. Hierarchical logistic regression was used to risk-adjust differences in case mix, along with variability from low case volumes. The reliability of this risk-stratified complication rate (RSCR) was assessed as the variation between hospitals that was not due to chance alone, calculated separately by fusion type and year. Finally, we estimated the proportion of hospitals that had sufficient case volumes to obtain reliable (> 0.7) complication estimates. RESULTS From 2010-2017 we identified 154,078 cervical and 213,133 thoracolumbar fusion surgeries. 4.2% of cervical fusion patients had a serious complication, and the median RSCR increased from 4.2% in 2010 to 5.5% in 2017. The reliability of the RSCR for cervical fusion was poor and varied substantially by year (range 0.04-0.28). Overall, 7.7% of thoracolumbar fusion patients experienced a serious complication, and the RSCR varied from 6.8%-8.0% during the study period. Although still modest, the RSCR reliability was higher for thoracolumbar fusion (range 0.16-0.43). Depending on the study year, 0-4.5% of hospitals had sufficient cervical fusion case volume to report reliable (> 0.7) estimates, whereas 15-36% of hospitals reached this threshold for thoracolumbar fusion. CONCLUSION A metric of serious complications was unreliable for benchmarking cervical fusion outcomes and only modestly reliable for thoracolumbar fusion. When assessed using administrative datasets, these measures appear inappropriate for high-stakes applications, such as public reporting or pay-for-performance.Level of Evidence: 3.
In March 2020, our institution developed an interdisciplinary predictive analytics task force to ... more In March 2020, our institution developed an interdisciplinary predictive analytics task force to provide COVID-19 hospital census forecasting to help clinical leaders understand the potential impacts on hospital operations. As the situation unfolded into a pandemic, our task force provided predictive insights through a structured set of visualizations and key messages that have helped the practice to anticipate and react to changing operational needs and opportunities. The framework shared here for the deployment of a COVID-19 predictive analytics taskforce could be adapted for effective implementation at other institutions to provide evidence-based messaging for operational decision-making. For hospitals without such a structure, immediate consideration may be warranted in light of the devastating COVID-19 ‘third-wave’ which has arrived for winter 2020-2021.
ASAIO journal (American Society for Artificial Internal Organs : 1992), Jan 23, 2017
Extracorporeal membrane oxygenation (ECMO) has been reported as an alternative to cardiopulmonary... more Extracorporeal membrane oxygenation (ECMO) has been reported as an alternative to cardiopulmonary bypass during lung transplantation. The reports in the literature have been limited to adult practice and associated with decreased pulmonary and renal complications, lower mortality, and lower in-hospital mortality. We present four pediatric lung transplantations performed on ECMO and discuss relevant perfusion management.
In this chapter the authors explore two decades of research on the policies that have evolved fro... more In this chapter the authors explore two decades of research on the policies that have evolved from struggles for minority group inclusion. They focus on minority-targeted policies that are most relevant to state or local governments. As part of this effort the authors report the results of a content analysis of nine major political science and public policy journals. They find that the volume of research on minority-targeted policies has remained steady over time, but there have been significant changes in the content of these studies. In addition the authors dissect the research to examine the major questions that have been studied in the literature, as well as what we have learned about the politics and the impact of minority-targeted policies. They conclude by highlighting some recent trends in this literature that seem promising, as well as suggesting avenues for future research.
MMWR. Morbidity and mortality weekly report, Jan 9, 2010
On October 19, 2009, clinicians from Kentucky contacted CDC regarding a suspected case of rabies ... more On October 19, 2009, clinicians from Kentucky contacted CDC regarding a suspected case of rabies in a man from Indiana aged 43 years. This report summarizes the patient's clinical presentation and course, the subsequent epidemiologic investigation, and, for the first time, provides infection control recommendations for personnel performing autopsies on decedents with confirmed or suspected rabies infection. Before the patient's death on October 20, a diagnosis of rabies was suspected based on the history of acute, progressive encephalitis with unknown etiology. Preliminary serology results on antemortem serum samples detected rabies virus-specific antibodies. Because local pathologists were concerned about the biosafety risk posed by infectious aerosols at autopsy and potential contamination of autopsy facilities, the Kentucky Department for Public Health (KDPH) asked CDC staff members to travel to Kentucky and perform an autopsy to confirm the diagnosis and assist with the ...
Uploads
Papers by John Poe