Photovoltaic (PV) fault detection is crucial because undetected PV faults can lead to significant... more Photovoltaic (PV) fault detection is crucial because undetected PV faults can lead to significant energy losses, with some cases experiencing losses of up to 10%. The efficiency of PV systems depends upon the reliable detection and diagnosis of faults. The integration of Artificial Intelligence (AI) techniques has been a growing trend in addressing these issues. The goal of this systematic review is to offer a comprehensive overview of the recent advancements in AI-based methodologies for PV fault detection, consolidating the key findings from 31 research papers. An initial pool of 142 papers were identified, from which 31 were selected for in-depth review following the PRISMA guidelines. The title, objective, methods, and findings of each paper were analyzed, with a focus on machine learning (ML) and deep learning (DL) approaches. ML and DL are particularly suitable for PV fault detection because of their capacity to process and analyze large amounts of data to identify complex pat...
OnkoNetwork is a patient navigation program established in the Moritz Kaposi General Hospital to ... more OnkoNetwork is a patient navigation program established in the Moritz Kaposi General Hospital to improve the timeliness and completeness of cancer investigations and treatment. The H2020 SELFIE consortium selected OnkoNetwork as a promising integrated care initiative in Hungary and conducted a multicriteria decision analysis based on health, patient experience, and cost outcomes. In this paper, a more detailed analysis of clinical impacts is provided in the largest subgroup, non-small cell lung cancer (NSCLC) patients. A retrospective cohort study was conducted, enrolling new cancer suspect patients with subsequently confirmed NSCLC in two annual periods, before and after OnkoNetwork implementation (control and intervention cohorts, respectively). To control for selection bias and confounding, baseline balance was improved via propensity score weighting. Overall survival was analyzed in univariate and multivariate weighted Cox regression models and the effect was further characteriz...
Background: The Norwegian Coordination Reform (CR) in 2012 introduced new economic incentives aim... more Background: The Norwegian Coordination Reform (CR) in 2012 introduced new economic incentives aimed at weaknesses in interaction between primary care, social care and specialist care. This paper studies the association of a new co-payment scheme on the 30-day and 90-day survival probabilities for chronic and multimorbidity patients. We also analyse whether admission types ⸺ planned or emergency ⸺ matters for survival rates, and the importance of patient pathways. Several different pathways are possible, depending on where patients came from before being admitted to hospital and their destination after discharge from hospital. Methods: The study uses data from three different registers for the period 2010 to 2013. We consider 30 common chronic conditions for which administrative data are available (n=563,096 in-patient episodes). We look at three mutually exclusive pathways. They are relevant and important in terms of the number of patients depending on co-operation and co-ordination...
Background: The effect of zinc supplementation on birth weight, litter size, total erythrocyte co... more Background: The effect of zinc supplementation on birth weight, litter size, total erythrocyte count (TEC), hemoglobin estimation, total leukocyte count (TLC), blood glucose level, abnormal sperm count and histopathology of testis in mice was evaluated. Methods: 45 albino mice were randomly divided into 3 equal groups viz. control group, A; 10 mg zinc/kg feed treated group, B; 20 mg zinc/kg feed treated group, C. Each group was comprised of 10 male mice and 5 female mice. Then they are allowed to breed for about 25 days. After breeding males were withdrawn from each group and treated with zinc for 30 days. Then male mice were transferred back to female cage and were allowed to breed for 25 days. Results: Mice of group B and C showed a significant increase (p<0.01) in total erythrocyte count (TEC), total leukocyte count (TLC), hemoglobin content, litter size and decreased abnormal sperm count. No significant increase in body weight, even a decrease in glucose content was recorded ...
ABSTRACTThe mechanism of protection against cholera afforded by previous illness or vaccination i... more ABSTRACTThe mechanism of protection against cholera afforded by previous illness or vaccination is currently unknown. We have recently shown that antibodies targeting O-specific polysaccharide (OSP) of Vibrio cholerae correlate highly with protection against cholera. V. cholerae is highly motile and possesses a flagellum sheathed in O-specific polysaccharide (OSP), and motility of V. cholerae correlates with virulence. Using high speed video microscopy, and building upon previous animal-related work, we demonstrate that sera, polyclonal antibody fractions, and OSP-specific monoclonal antibodies recovered from humans surviving cholera block V. cholerae motility at both subagglutinating and agglutinating concentrations. This anti-motility effect is reversed by pre-adsorbing sera and polyclonal antibody fractions with purified OSP; and is associated with OSP-specific but not flagellin-specific monoclonal antibodies. F[ab] fragments of OSP-specific polyclonal antibodies do not inhibit m...
Background: Bisphenol-A [BPA, 2, 2-bis (hydroxyphenyl) propane] is widely used in the manufacture... more Background: Bisphenol-A [BPA, 2, 2-bis (hydroxyphenyl) propane] is widely used in the manufacture of polycarbonate plastic, water bottles, feeders , baby bottles, epoxy resins and inside coating in metallic food cans. Black seed oil (BSO) (Nigella sativa) commonly known as black cumin, reported to be beneficial in function of various systems in the body. The study was carried out to investigate the effect of BPA and BSO on body weight, lipid profile and serum glucose in male and female mice. Methods : A total of thirty (15 male and 15 female) Swiss Albino mice (Mus musculus), aged 25-28 days with an average body weight of 27.4±1g were randomly divided into 3 groups consisting 5 mice in each for each sex. Group A served as vehicle control. Group B was administered BPA @ 50 mg/kg bw daily, while group C received both BPA @ 50 mg/kg/day and BSO @ 1ml/kg/day respectively. Results: Data revealed that BPA treated mice showed slight increase in body weight gain while BSO controlled the wei...
Evaluation of integrated care programmes for individuals with multi-morbidity requires a broader ... more Evaluation of integrated care programmes for individuals with multi-morbidity requires a broader evaluation framework and a broader definition of added value than is common in cost-utility analysis. This is possible through the use of Multi-Criteria Decision Analysis (MCDA). This paper presents the seven steps of an MCDA to evaluate 17 different integrated care programmes for individuals with multi-morbidity in 8 European countries participating in the 4-year, EU-funded SELFIE project. In step one, qualitative research was undertaken to better understand the decision-context of these programmes. The programmes faced decisions related to their sustainability in terms of reimbursement, continuation, extension, and/or wider implementation. In step two, a uniform set of decision criteria was defined in terms of outcomes measured across the 17 programmes: physical functioning, psychological well-being, social relationships and participation, enjoyment of life, resilience, person-centered...
Clusterin (CLU) has been associated with the clinical progression of Alzheimer's disease (AD)... more Clusterin (CLU) has been associated with the clinical progression of Alzheimer's disease (AD) and described as a potential AD biomarker in blood plasma. Due to the enormous attention given to cerebrospinal fluid (CSF) biomarkers for the past couple of decades, recently found blood-based AD biomarkers like CLU have not yet been reported for biosensors. Herein, we report the electrochemical detection of CLU for the first time using a screen-printed carbon electrode (SPCE) modified with 1-pyrenebutyric acid-hydroxysuccinimide ester (Pyr-NHS) and decorated with specific anti-CLU antibody fragments. This bifunctional linker molecule contains succinylimide ester to bind protein at one end while its pyrene moiety attaches to the carbon surface by means of π-π stacking. Cyclic voltammetric and square wave voltammetric studies showed the limit of detection down to 1 pg/mL and a linear concentration range of 1-100 pg/mL with good sensitivity. Detection of CLU in spiked human plasma was de...
We report on a label-free immunosensor based on graphene field effect transistors (G-FETs) for th... more We report on a label-free immunosensor based on graphene field effect transistors (G-FETs) for the ultrasensitive detection of Human Chorionic Gonadotrophin (hCG), as an indicator of pregnancy and related disorders, such as actopic pregnancy, choriocarcinoma and orchic teratoma. Pyrene based bioactive ester was non-covalently anchored onto the graphene channel in order to retain the sp² lattice. The G-FET transfer characteristics showed repeatable and reliable responses in all surface modifying steps using a direct current (DC) readout system. The hCG concentration gradient showed a detection limit of ~1 pg·mL(-1). The proposed method facilitates the cost-effective and viable production of graphene point-of-care devices for clinical diagnosis.
ABSTRACTVibrio choleraeand enterotoxigenicEscherichia coli(ETEC) are noninvasive mucosal pathogen... more ABSTRACTVibrio choleraeand enterotoxigenicEscherichia coli(ETEC) are noninvasive mucosal pathogens that cause acute watery diarrhea in people in developing countries. Direct assessment of the mucosal immune responses to these pathogens is problematic. Surrogate markers of local mucosal responses in blood are increasingly being studied to determine the mucosal immune responses after infection. However, the volume of blood available in children and infants has limited this approach. We assessed whether an approach that first isolates β7-positive cells from a small volume of blood would allow measurement of the antigen-specific immune responses in patients with cholera and ETEC infection. β7 is a cell surface marker associated with mucosal homing. We isolated β7-expressing cells from blood on days 2, 7, and 30 and used an enzyme-linked immunosorbent spot (ELISPOT) assay to assess the gut-homing antibody-secreting cells (ASCs) specific to pathogen antigens. Patients with ETEC diarrhea s...
Arsenic (As) and Chromium (Cr) toxicity often occurs concurrently in agricultural soils, which le... more Arsenic (As) and Chromium (Cr) toxicity often occurs concurrently in agricultural soils, which lead to a significant decline in crop growth and yield. A pot experiment was conducted to investigate the effects of As and Cr in the soil on the uptake of mineral elements as well as As and Cr in the two jute varieties differing in Cr tolerance during May to October, 2013. Here we report the effects of combined As and Cr stresses on plant biomass, photosynthesis, metal and nutrient uptake compared to As or Cr stress alone. Chromium tolerant variety, O-795, had significantly (p≤0.05) higher Cr and As levels in roots, stems and leaf tissues than Cr sensitive variety, O-9897. Roots had much higher As and Cr contents than above-ground parts. Arsenic stress reduced potassium (K +), magnesium (Mg 2+), iron (Fe 3+), copper (Cu 2+), manganese (Mn 2+) and zinc (Zn 2+) contents in the roots and inhibited calcium (Ca 2+), and from being translocated into shoots and leaves. Chromium stress resulted i...
Epilachna vigintioctopunctata is an important pest that causes considerable economic losses to ma... more Epilachna vigintioctopunctata is an important pest that causes considerable economic losses to many crops including egg-plants. The crude aqueous extracts of leaves from three indigenous plants namely Ricinus communis, Calotropis procera and Datura metel were used against this beetle aiming at its control under laboratory conditions. Larvicidal bioassays of the extracts showed the following order of toxicity: R. communis (LC50=18.40%)…
Photovoltaic (PV) fault detection is crucial because undetected PV faults can lead to significant... more Photovoltaic (PV) fault detection is crucial because undetected PV faults can lead to significant energy losses, with some cases experiencing losses of up to 10%. The efficiency of PV systems depends upon the reliable detection and diagnosis of faults. The integration of Artificial Intelligence (AI) techniques has been a growing trend in addressing these issues. The goal of this systematic review is to offer a comprehensive overview of the recent advancements in AI-based methodologies for PV fault detection, consolidating the key findings from 31 research papers. An initial pool of 142 papers were identified, from which 31 were selected for in-depth review following the PRISMA guidelines. The title, objective, methods, and findings of each paper were analyzed, with a focus on machine learning (ML) and deep learning (DL) approaches. ML and DL are particularly suitable for PV fault detection because of their capacity to process and analyze large amounts of data to identify complex pat...
OnkoNetwork is a patient navigation program established in the Moritz Kaposi General Hospital to ... more OnkoNetwork is a patient navigation program established in the Moritz Kaposi General Hospital to improve the timeliness and completeness of cancer investigations and treatment. The H2020 SELFIE consortium selected OnkoNetwork as a promising integrated care initiative in Hungary and conducted a multicriteria decision analysis based on health, patient experience, and cost outcomes. In this paper, a more detailed analysis of clinical impacts is provided in the largest subgroup, non-small cell lung cancer (NSCLC) patients. A retrospective cohort study was conducted, enrolling new cancer suspect patients with subsequently confirmed NSCLC in two annual periods, before and after OnkoNetwork implementation (control and intervention cohorts, respectively). To control for selection bias and confounding, baseline balance was improved via propensity score weighting. Overall survival was analyzed in univariate and multivariate weighted Cox regression models and the effect was further characteriz...
Background: The Norwegian Coordination Reform (CR) in 2012 introduced new economic incentives aim... more Background: The Norwegian Coordination Reform (CR) in 2012 introduced new economic incentives aimed at weaknesses in interaction between primary care, social care and specialist care. This paper studies the association of a new co-payment scheme on the 30-day and 90-day survival probabilities for chronic and multimorbidity patients. We also analyse whether admission types ⸺ planned or emergency ⸺ matters for survival rates, and the importance of patient pathways. Several different pathways are possible, depending on where patients came from before being admitted to hospital and their destination after discharge from hospital. Methods: The study uses data from three different registers for the period 2010 to 2013. We consider 30 common chronic conditions for which administrative data are available (n=563,096 in-patient episodes). We look at three mutually exclusive pathways. They are relevant and important in terms of the number of patients depending on co-operation and co-ordination...
Background: The effect of zinc supplementation on birth weight, litter size, total erythrocyte co... more Background: The effect of zinc supplementation on birth weight, litter size, total erythrocyte count (TEC), hemoglobin estimation, total leukocyte count (TLC), blood glucose level, abnormal sperm count and histopathology of testis in mice was evaluated. Methods: 45 albino mice were randomly divided into 3 equal groups viz. control group, A; 10 mg zinc/kg feed treated group, B; 20 mg zinc/kg feed treated group, C. Each group was comprised of 10 male mice and 5 female mice. Then they are allowed to breed for about 25 days. After breeding males were withdrawn from each group and treated with zinc for 30 days. Then male mice were transferred back to female cage and were allowed to breed for 25 days. Results: Mice of group B and C showed a significant increase (p<0.01) in total erythrocyte count (TEC), total leukocyte count (TLC), hemoglobin content, litter size and decreased abnormal sperm count. No significant increase in body weight, even a decrease in glucose content was recorded ...
ABSTRACTThe mechanism of protection against cholera afforded by previous illness or vaccination i... more ABSTRACTThe mechanism of protection against cholera afforded by previous illness or vaccination is currently unknown. We have recently shown that antibodies targeting O-specific polysaccharide (OSP) of Vibrio cholerae correlate highly with protection against cholera. V. cholerae is highly motile and possesses a flagellum sheathed in O-specific polysaccharide (OSP), and motility of V. cholerae correlates with virulence. Using high speed video microscopy, and building upon previous animal-related work, we demonstrate that sera, polyclonal antibody fractions, and OSP-specific monoclonal antibodies recovered from humans surviving cholera block V. cholerae motility at both subagglutinating and agglutinating concentrations. This anti-motility effect is reversed by pre-adsorbing sera and polyclonal antibody fractions with purified OSP; and is associated with OSP-specific but not flagellin-specific monoclonal antibodies. F[ab] fragments of OSP-specific polyclonal antibodies do not inhibit m...
Background: Bisphenol-A [BPA, 2, 2-bis (hydroxyphenyl) propane] is widely used in the manufacture... more Background: Bisphenol-A [BPA, 2, 2-bis (hydroxyphenyl) propane] is widely used in the manufacture of polycarbonate plastic, water bottles, feeders , baby bottles, epoxy resins and inside coating in metallic food cans. Black seed oil (BSO) (Nigella sativa) commonly known as black cumin, reported to be beneficial in function of various systems in the body. The study was carried out to investigate the effect of BPA and BSO on body weight, lipid profile and serum glucose in male and female mice. Methods : A total of thirty (15 male and 15 female) Swiss Albino mice (Mus musculus), aged 25-28 days with an average body weight of 27.4±1g were randomly divided into 3 groups consisting 5 mice in each for each sex. Group A served as vehicle control. Group B was administered BPA @ 50 mg/kg bw daily, while group C received both BPA @ 50 mg/kg/day and BSO @ 1ml/kg/day respectively. Results: Data revealed that BPA treated mice showed slight increase in body weight gain while BSO controlled the wei...
Evaluation of integrated care programmes for individuals with multi-morbidity requires a broader ... more Evaluation of integrated care programmes for individuals with multi-morbidity requires a broader evaluation framework and a broader definition of added value than is common in cost-utility analysis. This is possible through the use of Multi-Criteria Decision Analysis (MCDA). This paper presents the seven steps of an MCDA to evaluate 17 different integrated care programmes for individuals with multi-morbidity in 8 European countries participating in the 4-year, EU-funded SELFIE project. In step one, qualitative research was undertaken to better understand the decision-context of these programmes. The programmes faced decisions related to their sustainability in terms of reimbursement, continuation, extension, and/or wider implementation. In step two, a uniform set of decision criteria was defined in terms of outcomes measured across the 17 programmes: physical functioning, psychological well-being, social relationships and participation, enjoyment of life, resilience, person-centered...
Clusterin (CLU) has been associated with the clinical progression of Alzheimer's disease (AD)... more Clusterin (CLU) has been associated with the clinical progression of Alzheimer's disease (AD) and described as a potential AD biomarker in blood plasma. Due to the enormous attention given to cerebrospinal fluid (CSF) biomarkers for the past couple of decades, recently found blood-based AD biomarkers like CLU have not yet been reported for biosensors. Herein, we report the electrochemical detection of CLU for the first time using a screen-printed carbon electrode (SPCE) modified with 1-pyrenebutyric acid-hydroxysuccinimide ester (Pyr-NHS) and decorated with specific anti-CLU antibody fragments. This bifunctional linker molecule contains succinylimide ester to bind protein at one end while its pyrene moiety attaches to the carbon surface by means of π-π stacking. Cyclic voltammetric and square wave voltammetric studies showed the limit of detection down to 1 pg/mL and a linear concentration range of 1-100 pg/mL with good sensitivity. Detection of CLU in spiked human plasma was de...
We report on a label-free immunosensor based on graphene field effect transistors (G-FETs) for th... more We report on a label-free immunosensor based on graphene field effect transistors (G-FETs) for the ultrasensitive detection of Human Chorionic Gonadotrophin (hCG), as an indicator of pregnancy and related disorders, such as actopic pregnancy, choriocarcinoma and orchic teratoma. Pyrene based bioactive ester was non-covalently anchored onto the graphene channel in order to retain the sp² lattice. The G-FET transfer characteristics showed repeatable and reliable responses in all surface modifying steps using a direct current (DC) readout system. The hCG concentration gradient showed a detection limit of ~1 pg·mL(-1). The proposed method facilitates the cost-effective and viable production of graphene point-of-care devices for clinical diagnosis.
ABSTRACTVibrio choleraeand enterotoxigenicEscherichia coli(ETEC) are noninvasive mucosal pathogen... more ABSTRACTVibrio choleraeand enterotoxigenicEscherichia coli(ETEC) are noninvasive mucosal pathogens that cause acute watery diarrhea in people in developing countries. Direct assessment of the mucosal immune responses to these pathogens is problematic. Surrogate markers of local mucosal responses in blood are increasingly being studied to determine the mucosal immune responses after infection. However, the volume of blood available in children and infants has limited this approach. We assessed whether an approach that first isolates β7-positive cells from a small volume of blood would allow measurement of the antigen-specific immune responses in patients with cholera and ETEC infection. β7 is a cell surface marker associated with mucosal homing. We isolated β7-expressing cells from blood on days 2, 7, and 30 and used an enzyme-linked immunosorbent spot (ELISPOT) assay to assess the gut-homing antibody-secreting cells (ASCs) specific to pathogen antigens. Patients with ETEC diarrhea s...
Arsenic (As) and Chromium (Cr) toxicity often occurs concurrently in agricultural soils, which le... more Arsenic (As) and Chromium (Cr) toxicity often occurs concurrently in agricultural soils, which lead to a significant decline in crop growth and yield. A pot experiment was conducted to investigate the effects of As and Cr in the soil on the uptake of mineral elements as well as As and Cr in the two jute varieties differing in Cr tolerance during May to October, 2013. Here we report the effects of combined As and Cr stresses on plant biomass, photosynthesis, metal and nutrient uptake compared to As or Cr stress alone. Chromium tolerant variety, O-795, had significantly (p≤0.05) higher Cr and As levels in roots, stems and leaf tissues than Cr sensitive variety, O-9897. Roots had much higher As and Cr contents than above-ground parts. Arsenic stress reduced potassium (K +), magnesium (Mg 2+), iron (Fe 3+), copper (Cu 2+), manganese (Mn 2+) and zinc (Zn 2+) contents in the roots and inhibited calcium (Ca 2+), and from being translocated into shoots and leaves. Chromium stress resulted i...
Epilachna vigintioctopunctata is an important pest that causes considerable economic losses to ma... more Epilachna vigintioctopunctata is an important pest that causes considerable economic losses to many crops including egg-plants. The crude aqueous extracts of leaves from three indigenous plants namely Ricinus communis, Calotropis procera and Datura metel were used against this beetle aiming at its control under laboratory conditions. Larvicidal bioassays of the extracts showed the following order of toxicity: R. communis (LC50=18.40%)…
Uploads
Papers by Kamrul islam