IntroductionHuman papillomavirus (HPV) infection is common in women of reproductive age. Infectio... more IntroductionHuman papillomavirus (HPV) infection is common in women of reproductive age. Infection and inflammation are leading causes for preterm delivery (PTD), but the role of HPV infection in PTD and prelabor rupture of membranes (PROM) is unclear. We aimed to explore whether HPV infection during pregnancy in general, and high‐risk‐HPV (HR‐HPV) infection specifically, increased the risk of PTD, preterm prelabor rupture of membranes (PPROM), PROM at term, and/or chorioamnionitis.Material and MethodsIn pregnant women, who were participating in a prospective multicenter cohort study from a general population in Norway and Sweden (PreventADALL, ClinicalTrials.gov NCT02449850), HPV DNA was analyzed in available urine samples at mid‐gestation (16–22 weeks) and at delivery, and in the placenta after delivery with Seegene Anyplex II HPV28 PCR assay. The risk of PTD, PPROM, PROM, and chorioamnionitis was analyzed using unadjusted and adjusted logistic regression analyses for any 28 HPV g...
Objective. Development of a reliable questionnaire to quantify habit of substance abuse with deve... more Objective. Development of a reliable questionnaire to quantify habit of substance abuse with development of oral submucous fibrosis. Materials and methods. The questionnaire, substance abuse and precancer evaluation (SAPE) tool, was designed to assess the association of the habit of substance abuse with development of oral submucous fibrosis, a precancerous condition and various physical, social, psychological factors. Health professionals confirmed the content validity. Face validity was established by a participant focus group. The questionnaire was applied to 1100 participants with or without habit of substance abuse. Results. A total of 52 validated items were applied to the participants. Principal component analysis yielded 8 components having eigenvalues ≥2.0. Reliability was obtained by Cronbach’s α. The validity was measured by computing product–moment correlation coefficient between the diagnosis and the scores on the selected components. Conclusions. Preliminary reliabilit...
Table S1. The cervical microbiota in the LEEP group and the Reference group in women aged <46 ... more Table S1. The cervical microbiota in the LEEP group and the Reference group in women aged <46 years. Table S2. The cervical microbiota six months post treatment in the LEEP group and the cervical microbiota in the Reference group. Table S3. The cervical microbiota 12 months post treatment in the LEEP group and the cervical microbiota in the Reference group. (DOC 88 kb)
Department of Obstetrics and Gynaecology, Akershus University Hospital, Norway, Department of Obs... more Department of Obstetrics and Gynaecology, Akershus University Hospital, Norway, Department of Obstetrics and Gynaecology, Oestfold Hospital Trust, Norway, Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway, Faculty of Medicine, University of Oslo, Norway, Specialist Virology Center, Department of Laboratory Medicine Royal Infirmary of Edinburgh of Edinburg,UK, Institute of Population-based Cancer Research, Oslo, Norway, Department of Medical Microbiology, Akershus University Hospital, Lørenskog, Norway, Department of Pathology, Akershus University Hospital, Lørenskog, Norway, Department of Medicine,Oestfold Hospital Trust, Norway
International Journal of Infectious Diseases, 2021
OBJECTIVES Human papillomavirus (HPV) infections are common, especially during women's reprod... more OBJECTIVES Human papillomavirus (HPV) infections are common, especially during women's reproductive years, with unclear obstetrical impact. This study aimed to identify HPV prevalence at mid-gestation and delivery, type-specific persistence from mid-gestation to delivery, and risk factors for HPV infection and persistence. METHODS In 757 women from a Scandinavian prospective mother-child cohort, HPV was analyzed in first-void urine samples at mid-gestation and delivery. We used Seegene Anyplex II HPV28 PCR assay for genotyping and semi-quantifying 28 genital HPV genotypes, including 12 High-Risk HPVs (HR-HPV). Socio-demographic and health data were collected through e-questionnaires. RESULTS Any-HPV genotype (any of 28 assessed) was detected in 38% at mid-gestation and 28% at delivery, and HR-HPVs in 24% and 16%, respectively. The most prevalent genotype was HPV16: 6% at mid-gestation and 4% at delivery. Persistence of Any-HPV genotype was 52%, as was HR-HPV genotype-specific persistence. Short pre-conceptional relation to offspring's father and alcohol intake during pregnancy increased the risk of HPV infection at both time points. Low viral load at mid-gestation was associated with clearance of HPV infections at delivery. CONCLUSION The HPV prevalence was higher at mid-gestation compared to delivery, and low viral load was associated with clearance of HPV at delivery.
BackgroundMaternal stress during pregnancy may negatively affect the health of mother and child. ... more BackgroundMaternal stress during pregnancy may negatively affect the health of mother and child. We therefore aimed to identify the proportion of women reporting high maternal stress in mid and late pregnancy and explore whether symptoms of maternal allergic disease are associated with perceived maternal stress in late pregnancy.MethodThe population-based Preventing Atopic Dermatitis and Allergy in Children (PreventADALL) study enrolled 2697 pregnant women at their 18-week routine ultrasound examination in Norway and Sweden. Information about sociodemographic factors, symptoms and doctor-diagnosed asthma, allergic rhinitis, atopic dermatitis, food allergy, and anaphylaxis and stress using the 14-item perceived stress scale (PSS) was collected at 18 weeks (mid) and 34 weeks (late) pregnancy. High stress was defined as a PSS score ≥29. Scores were analysed using multivariate logistic and linear regression.ResultsAmong the 2164 women with complete PSS data, 17% reported asthma, 20% ato...
RationaleWhile recent studies show that maternal use of snus during pregnancy is increasing, the ... more RationaleWhile recent studies show that maternal use of snus during pregnancy is increasing, the potential effects on infant birth size is less investigated, with conflicting results.ObjectivesWe aimed to determine if maternal use of snus during pregnancy influences the infant anthropometric and proportional size measures at birth.MethodsIn 2313 mother–child pairs from the population-based, mother–child birth cohort PreventADALL (Preventing Atopic Dermatitis and ALLergies) in Norway and Sweden, we assessed nicotine exposure by electronic questionnaire(s) at 18 and 34 weeks of pregnancy, and anthropometric measurements at birth. Associations between snus exposure and birth size outcomes were analysed by general linear regression.ResultsBirthweight was not significantly different in infants exposed to snus in general, and up to 18 weeks of pregnancy in particular, when adjusting for relevant confounders including maternal age, gestational age at birth, pre-pregnancy body mass index, p...
In young women, the use of snus increases in parallel with decreasing smoking rates but the use ... more In young women, the use of snus increases in parallel with decreasing smoking rates but the use in pregnancy is unclear. Our aims were to determine the prevalence of snus use, smoking and other nicotine-containing product use during pregnancy, and to identify predictors for snus use in pregnancy.Prevalence was determined for 2528 women in Norway and Sweden based on the Preventing Atopic Dermatitis and ALLergies (PreventADALL) study, a population-based, mother–child birth cohort. Electronic questionnaires were completed in pregnancy week 18 and/or week 34, and potential predictors of snus use were analysed using logistic regression models.Ever use of any snus, tobacco or nicotine-containing products was reported by 35.7% of women, with similar rates of snus use (22.5%) and smoking (22.6%). Overall, 11.3% of women reported any use of nicotine-containing products in pregnancy up to 34 weeks, most often snus alone (6.5%). Most women (87.2%) stopped using snus by week 6 of pregnancy.Snu...
Reversing or aborting the increase in allergic and other immune-related non-communicable diseases... more Reversing or aborting the increase in allergic and other immune-related non-communicable diseases (NCDs) in the western world, first observed for allergic rhinitis from the 1890ies , requires primary prevention strategies, probably on a general population level. The diseases are likely to be related to changes in lifestyle, environment or both , including reduced microbial diversity, increased use of xenobiotics in industrial and consumer products, exposure to tobacco or nicotinic products and variations in diets and nutritional elements. While some primary allergy preventive strategies may be effective in high risk children , the relevance for preventive strategies on a population level is unclear . This article is protected by copyright. All rights reserved.
In the present study we investigated the cross-sectional positivity for DNA and E6/E7 mRNA from h... more In the present study we investigated the cross-sectional positivity for DNA and E6/E7 mRNA from high-risk human papillomavirus (HPV) types in 643 women with high-grade cervical neoplasia (135 cases of cervical intraepithelial neoplasia grade 2 [CIN2], 495 cases of CIN3/adenocarcinoma in situ [ACIS], and 13 cases of invasive carcinoma) and in 736 women with normal cytology by using the Amplicor and PreTect HPV-Proofer assays. In addition, genotyping was performed using Linear Array for women with normal cytology and a positive HPV test and in all women with histologically confirmed CIN2+. In women with normal cytology, 8.3% (61/736) were Amplicor positive and 3.3% (24/736) were PreTect HPV-Proofer positive ( P < 0.001). Concordant results between the Amplicor and PreTect HPV-Proofer tests were present in 90.3% (665/736). In women with CIN2+ lesions 96.4% (620/643) were positive by Amplicor, 98.4% (633/643) by linear array, and 64.1% (412/643) by PreTect HPV-Proofer. Concordant res...
IntroductionHuman papillomavirus (HPV) infection is common in women of reproductive age. Infectio... more IntroductionHuman papillomavirus (HPV) infection is common in women of reproductive age. Infection and inflammation are leading causes for preterm delivery (PTD), but the role of HPV infection in PTD and prelabor rupture of membranes (PROM) is unclear. We aimed to explore whether HPV infection during pregnancy in general, and high‐risk‐HPV (HR‐HPV) infection specifically, increased the risk of PTD, preterm prelabor rupture of membranes (PPROM), PROM at term, and/or chorioamnionitis.Material and MethodsIn pregnant women, who were participating in a prospective multicenter cohort study from a general population in Norway and Sweden (PreventADALL, ClinicalTrials.gov NCT02449850), HPV DNA was analyzed in available urine samples at mid‐gestation (16–22 weeks) and at delivery, and in the placenta after delivery with Seegene Anyplex II HPV28 PCR assay. The risk of PTD, PPROM, PROM, and chorioamnionitis was analyzed using unadjusted and adjusted logistic regression analyses for any 28 HPV g...
Objective. Development of a reliable questionnaire to quantify habit of substance abuse with deve... more Objective. Development of a reliable questionnaire to quantify habit of substance abuse with development of oral submucous fibrosis. Materials and methods. The questionnaire, substance abuse and precancer evaluation (SAPE) tool, was designed to assess the association of the habit of substance abuse with development of oral submucous fibrosis, a precancerous condition and various physical, social, psychological factors. Health professionals confirmed the content validity. Face validity was established by a participant focus group. The questionnaire was applied to 1100 participants with or without habit of substance abuse. Results. A total of 52 validated items were applied to the participants. Principal component analysis yielded 8 components having eigenvalues ≥2.0. Reliability was obtained by Cronbach’s α. The validity was measured by computing product–moment correlation coefficient between the diagnosis and the scores on the selected components. Conclusions. Preliminary reliabilit...
Table S1. The cervical microbiota in the LEEP group and the Reference group in women aged <46 ... more Table S1. The cervical microbiota in the LEEP group and the Reference group in women aged <46 years. Table S2. The cervical microbiota six months post treatment in the LEEP group and the cervical microbiota in the Reference group. Table S3. The cervical microbiota 12 months post treatment in the LEEP group and the cervical microbiota in the Reference group. (DOC 88 kb)
Department of Obstetrics and Gynaecology, Akershus University Hospital, Norway, Department of Obs... more Department of Obstetrics and Gynaecology, Akershus University Hospital, Norway, Department of Obstetrics and Gynaecology, Oestfold Hospital Trust, Norway, Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway, Faculty of Medicine, University of Oslo, Norway, Specialist Virology Center, Department of Laboratory Medicine Royal Infirmary of Edinburgh of Edinburg,UK, Institute of Population-based Cancer Research, Oslo, Norway, Department of Medical Microbiology, Akershus University Hospital, Lørenskog, Norway, Department of Pathology, Akershus University Hospital, Lørenskog, Norway, Department of Medicine,Oestfold Hospital Trust, Norway
International Journal of Infectious Diseases, 2021
OBJECTIVES Human papillomavirus (HPV) infections are common, especially during women's reprod... more OBJECTIVES Human papillomavirus (HPV) infections are common, especially during women's reproductive years, with unclear obstetrical impact. This study aimed to identify HPV prevalence at mid-gestation and delivery, type-specific persistence from mid-gestation to delivery, and risk factors for HPV infection and persistence. METHODS In 757 women from a Scandinavian prospective mother-child cohort, HPV was analyzed in first-void urine samples at mid-gestation and delivery. We used Seegene Anyplex II HPV28 PCR assay for genotyping and semi-quantifying 28 genital HPV genotypes, including 12 High-Risk HPVs (HR-HPV). Socio-demographic and health data were collected through e-questionnaires. RESULTS Any-HPV genotype (any of 28 assessed) was detected in 38% at mid-gestation and 28% at delivery, and HR-HPVs in 24% and 16%, respectively. The most prevalent genotype was HPV16: 6% at mid-gestation and 4% at delivery. Persistence of Any-HPV genotype was 52%, as was HR-HPV genotype-specific persistence. Short pre-conceptional relation to offspring's father and alcohol intake during pregnancy increased the risk of HPV infection at both time points. Low viral load at mid-gestation was associated with clearance of HPV infections at delivery. CONCLUSION The HPV prevalence was higher at mid-gestation compared to delivery, and low viral load was associated with clearance of HPV at delivery.
BackgroundMaternal stress during pregnancy may negatively affect the health of mother and child. ... more BackgroundMaternal stress during pregnancy may negatively affect the health of mother and child. We therefore aimed to identify the proportion of women reporting high maternal stress in mid and late pregnancy and explore whether symptoms of maternal allergic disease are associated with perceived maternal stress in late pregnancy.MethodThe population-based Preventing Atopic Dermatitis and Allergy in Children (PreventADALL) study enrolled 2697 pregnant women at their 18-week routine ultrasound examination in Norway and Sweden. Information about sociodemographic factors, symptoms and doctor-diagnosed asthma, allergic rhinitis, atopic dermatitis, food allergy, and anaphylaxis and stress using the 14-item perceived stress scale (PSS) was collected at 18 weeks (mid) and 34 weeks (late) pregnancy. High stress was defined as a PSS score ≥29. Scores were analysed using multivariate logistic and linear regression.ResultsAmong the 2164 women with complete PSS data, 17% reported asthma, 20% ato...
RationaleWhile recent studies show that maternal use of snus during pregnancy is increasing, the ... more RationaleWhile recent studies show that maternal use of snus during pregnancy is increasing, the potential effects on infant birth size is less investigated, with conflicting results.ObjectivesWe aimed to determine if maternal use of snus during pregnancy influences the infant anthropometric and proportional size measures at birth.MethodsIn 2313 mother–child pairs from the population-based, mother–child birth cohort PreventADALL (Preventing Atopic Dermatitis and ALLergies) in Norway and Sweden, we assessed nicotine exposure by electronic questionnaire(s) at 18 and 34 weeks of pregnancy, and anthropometric measurements at birth. Associations between snus exposure and birth size outcomes were analysed by general linear regression.ResultsBirthweight was not significantly different in infants exposed to snus in general, and up to 18 weeks of pregnancy in particular, when adjusting for relevant confounders including maternal age, gestational age at birth, pre-pregnancy body mass index, p...
In young women, the use of snus increases in parallel with decreasing smoking rates but the use ... more In young women, the use of snus increases in parallel with decreasing smoking rates but the use in pregnancy is unclear. Our aims were to determine the prevalence of snus use, smoking and other nicotine-containing product use during pregnancy, and to identify predictors for snus use in pregnancy.Prevalence was determined for 2528 women in Norway and Sweden based on the Preventing Atopic Dermatitis and ALLergies (PreventADALL) study, a population-based, mother–child birth cohort. Electronic questionnaires were completed in pregnancy week 18 and/or week 34, and potential predictors of snus use were analysed using logistic regression models.Ever use of any snus, tobacco or nicotine-containing products was reported by 35.7% of women, with similar rates of snus use (22.5%) and smoking (22.6%). Overall, 11.3% of women reported any use of nicotine-containing products in pregnancy up to 34 weeks, most often snus alone (6.5%). Most women (87.2%) stopped using snus by week 6 of pregnancy.Snu...
Reversing or aborting the increase in allergic and other immune-related non-communicable diseases... more Reversing or aborting the increase in allergic and other immune-related non-communicable diseases (NCDs) in the western world, first observed for allergic rhinitis from the 1890ies , requires primary prevention strategies, probably on a general population level. The diseases are likely to be related to changes in lifestyle, environment or both , including reduced microbial diversity, increased use of xenobiotics in industrial and consumer products, exposure to tobacco or nicotinic products and variations in diets and nutritional elements. While some primary allergy preventive strategies may be effective in high risk children , the relevance for preventive strategies on a population level is unclear . This article is protected by copyright. All rights reserved.
In the present study we investigated the cross-sectional positivity for DNA and E6/E7 mRNA from h... more In the present study we investigated the cross-sectional positivity for DNA and E6/E7 mRNA from high-risk human papillomavirus (HPV) types in 643 women with high-grade cervical neoplasia (135 cases of cervical intraepithelial neoplasia grade 2 [CIN2], 495 cases of CIN3/adenocarcinoma in situ [ACIS], and 13 cases of invasive carcinoma) and in 736 women with normal cytology by using the Amplicor and PreTect HPV-Proofer assays. In addition, genotyping was performed using Linear Array for women with normal cytology and a positive HPV test and in all women with histologically confirmed CIN2+. In women with normal cytology, 8.3% (61/736) were Amplicor positive and 3.3% (24/736) were PreTect HPV-Proofer positive ( P < 0.001). Concordant results between the Amplicor and PreTect HPV-Proofer tests were present in 90.3% (665/736). In women with CIN2+ lesions 96.4% (620/643) were positive by Amplicor, 98.4% (633/643) by linear array, and 64.1% (412/643) by PreTect HPV-Proofer. Concordant res...
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