Due to their anti-inflammatory and immunomodulatory capabilities, mesenchymal stem cells (MSCs) a... more Due to their anti-inflammatory and immunomodulatory capabilities, mesenchymal stem cells (MSCs) are being widely used in cell-based therapies for the treatment of a wide spectrum of inflammatory disorders. Despite their promises, substantial cell loss post transplantation leads to compromised therapeutic benefits in clinical trials, which remains a challenge to overcome. Inflammatory microenvironment comprises the presence of pro-inflammatory cytokines, elevated temperature, etc., which could hamper MSC viability following transplantation. Thus, identifying the underlying molecular factors controlling survival mechanism under such stress conditions, thereby, improving MSC survival becomes important for optimising MSC-based therapy. Also, since MSCs from different origins have significantly varied biology, choosing the appropriate MSC source could be crucial in determining the fate of transplanted MSCs in stressful milieu.As extracellular matrix (ECM) components can mediate cell surv...
International Journal of Engineering Applied Sciences and Technology
The art of encrypting a hidden message within a public message is known as steganography. Traditi... more The art of encrypting a hidden message within a public message is known as steganography. Traditionally methods like LSB (least significant bit) modification, the five-modulus method and other algorithms have been utilized to encode a lower quality image into a higher resolution image via steganography. This research aims to implement a novel text in image steganography using pixel-based algorithms where the security of the text is enhanced by integrating encryption before embedding secret messages. We use the Chinese Remainder Algorithm (CRT) to cryptographically secure the secret message inside the image and the least significant bit algorithm to store the message inside the image. A novel method is propounded for the key generation of the CRT algorithm and the results have been studied and compared with the results of the methods in existing studies.
In early December 2019, the coronavirus disease (COVID-19) caused by severe acute respiratory syn... more In early December 2019, the coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged in Wuhan, China. As of May 10th, 2020, a total of over 4 million COVID-19 cases and 280,000 deaths have been reported globally, reflecting the raised infectivity and severity of this virus. Amongst hospitalised COVID-19 patients, there is a high prevalence of established cardiovascular disease (CVD). There is evidence showing that COVID-19 may exacerbate cardiovascular risk factors and preexisting CVD or may lead to cardiovascular complications. With intensive care units operating at maximum capacity and such staggering mortality rates reported, it is imperative during this time-sensitive COVID-19 outbreak to identify patients with an increased risk of adverse outcomes and/or myocardial injury. Preliminary findings from COVID-19 studies have shown the association of biomarkers of acute cardiac injury and coagulation with worse prognosis. Whi...
Objectives: Tricuspid annuloplasty is the optimal surgical repair technique for tricuspid regurgi... more Objectives: Tricuspid annuloplasty is the optimal surgical repair technique for tricuspid regurgitation which improves mortality and morbidity. Ring annuloplasties is the techniques of choice. Here, we evaluate the efficacy and durability of a new method of interrupted pledgeted suture annuloplasty. Methods: Between 2011 and 2018, 39 eligible patients underwent tricuspid valve repair using this novel technique. Indication for repair was a grade of regurgitation at moderate or greater, or an annular diameter >40 mm. Patients were assessed both preoperatively and postoperatively by echocardiogram. Follow-up results were split into the first postoperative echocardiogram and most recent postoperative echocardiogram undertaken. Results: There were two in-hospital mortalities and two patients required permanent pacemaker implantation following surgery. At the time of the first postoperative echocardiogram undertaken (median 3 months postoperatively), freedom from moderate-severe regurg...
Due to their anti-inflammatory and immunomodulatory capabilities, mesenchymal stem cells (MSCs) a... more Due to their anti-inflammatory and immunomodulatory capabilities, mesenchymal stem cells (MSCs) are being widely used in cell-based therapies for the treatment of a wide spectrum of inflammatory disorders. Despite their promises, substantial cell loss post transplantation leads to compromised therapeutic benefits in clinical trials, which remains a challenge to overcome. Inflammatory microenvironment comprises the presence of pro-inflammatory cytokines, elevated temperature, etc., which could hamper MSC viability following transplantation. Thus, identifying the underlying molecular factors controlling survival mechanism under such stress conditions, thereby, improving MSC survival becomes important for optimising MSC-based therapy. Also, since MSCs from different origins have significantly varied biology, choosing the appropriate MSC source could be crucial in determining the fate of transplanted MSCs in stressful milieu.As extracellular matrix (ECM) components can mediate cell surv...
International Journal of Engineering Applied Sciences and Technology
The art of encrypting a hidden message within a public message is known as steganography. Traditi... more The art of encrypting a hidden message within a public message is known as steganography. Traditionally methods like LSB (least significant bit) modification, the five-modulus method and other algorithms have been utilized to encode a lower quality image into a higher resolution image via steganography. This research aims to implement a novel text in image steganography using pixel-based algorithms where the security of the text is enhanced by integrating encryption before embedding secret messages. We use the Chinese Remainder Algorithm (CRT) to cryptographically secure the secret message inside the image and the least significant bit algorithm to store the message inside the image. A novel method is propounded for the key generation of the CRT algorithm and the results have been studied and compared with the results of the methods in existing studies.
In early December 2019, the coronavirus disease (COVID-19) caused by severe acute respiratory syn... more In early December 2019, the coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged in Wuhan, China. As of May 10th, 2020, a total of over 4 million COVID-19 cases and 280,000 deaths have been reported globally, reflecting the raised infectivity and severity of this virus. Amongst hospitalised COVID-19 patients, there is a high prevalence of established cardiovascular disease (CVD). There is evidence showing that COVID-19 may exacerbate cardiovascular risk factors and preexisting CVD or may lead to cardiovascular complications. With intensive care units operating at maximum capacity and such staggering mortality rates reported, it is imperative during this time-sensitive COVID-19 outbreak to identify patients with an increased risk of adverse outcomes and/or myocardial injury. Preliminary findings from COVID-19 studies have shown the association of biomarkers of acute cardiac injury and coagulation with worse prognosis. Whi...
Objectives: Tricuspid annuloplasty is the optimal surgical repair technique for tricuspid regurgi... more Objectives: Tricuspid annuloplasty is the optimal surgical repair technique for tricuspid regurgitation which improves mortality and morbidity. Ring annuloplasties is the techniques of choice. Here, we evaluate the efficacy and durability of a new method of interrupted pledgeted suture annuloplasty. Methods: Between 2011 and 2018, 39 eligible patients underwent tricuspid valve repair using this novel technique. Indication for repair was a grade of regurgitation at moderate or greater, or an annular diameter >40 mm. Patients were assessed both preoperatively and postoperatively by echocardiogram. Follow-up results were split into the first postoperative echocardiogram and most recent postoperative echocardiogram undertaken. Results: There were two in-hospital mortalities and two patients required permanent pacemaker implantation following surgery. At the time of the first postoperative echocardiogram undertaken (median 3 months postoperatively), freedom from moderate-severe regurg...
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