A three‐component one‐pot condensation reaction of chroman‐4‐one with ethyl 2‐cyanoacetate and va... more A three‐component one‐pot condensation reaction of chroman‐4‐one with ethyl 2‐cyanoacetate and various aldehydes in the presence of ammonium acetate afforded a series of 2‐oxo‐4‐phenyl‐1,5‐dihydro‐2H‐chromeno[4,3‐b]pyridine‐3‐carbonitrile. These heterocycles have been converted to chloropyridine derivatives and appended to macrocyclic calix[4]arene scaffold through aromatic nucleophilic substitution under microwave irradiation. In this study, the microwave‐assisted functionalization of the lower rim of calix[4]arene has been considered the only appropriate tool because the conventional heating did not lead to any new product after 72 hours of heating under thermal condition.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A new series of heterocyclic systems, including azole, azolopyrimidine, and pyridopyrimidine deri... more A new series of heterocyclic systems, including azole, azolopyrimidine, and pyridopyrimidine derivatives, attached to 2H-chromene scaffold, was prepared by a convenient procedure through the reactions of (E)-2-dimethylamino-methylene chromanone with different nitrogen binucleophiles. Various substituted chromeno[4,3-b]pyridine derivatives were also prepared through the reactions of (E)-2-dimethylaminomethylene chromanone with a series of active methylene compounds.
In this work, we report on the synthesis and preliminary biological activity screening of several... more In this work, we report on the synthesis and preliminary biological activity screening of several heterocyclic derivatives 2, 3, 4, 5, 6, 7, 8, 9, 10, 10a, 10b, 11, 11a, 11b, 12, 12a, 12b, 13, 13a, 13b, 14, 15 based on N2′,N6′-diphenylthiosemi-carbazide pyridine-2,6-dicarbohydrazide 2, which has been obtained from the corresponding dihydrazide 1. The biological screening showed that many of these compounds have good antimicrobial activities. The structure of the new compounds has been established on the bases of chemical and spectroscopic evidences. J. Heterocyclic Chem., (2011).
A three‐component one‐pot condensation reaction of chroman‐4‐one with ethyl 2‐cyanoacetate and va... more A three‐component one‐pot condensation reaction of chroman‐4‐one with ethyl 2‐cyanoacetate and various aldehydes in the presence of ammonium acetate afforded a series of 2‐oxo‐4‐phenyl‐1,5‐dihydro‐2H‐chromeno[4,3‐b]pyridine‐3‐carbonitrile. These heterocycles have been converted to chloropyridine derivatives and appended to macrocyclic calix[4]arene scaffold through aromatic nucleophilic substitution under microwave irradiation. In this study, the microwave‐assisted functionalization of the lower rim of calix[4]arene has been considered the only appropriate tool because the conventional heating did not lead to any new product after 72 hours of heating under thermal condition.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A new series of heterocyclic systems, including azole, azolopyrimidine, and pyridopyrimidine deri... more A new series of heterocyclic systems, including azole, azolopyrimidine, and pyridopyrimidine derivatives, attached to 2H-chromene scaffold, was prepared by a convenient procedure through the reactions of (E)-2-dimethylamino-methylene chromanone with different nitrogen binucleophiles. Various substituted chromeno[4,3-b]pyridine derivatives were also prepared through the reactions of (E)-2-dimethylaminomethylene chromanone with a series of active methylene compounds.
In this work, we report on the synthesis and preliminary biological activity screening of several... more In this work, we report on the synthesis and preliminary biological activity screening of several heterocyclic derivatives 2, 3, 4, 5, 6, 7, 8, 9, 10, 10a, 10b, 11, 11a, 11b, 12, 12a, 12b, 13, 13a, 13b, 14, 15 based on N2′,N6′-diphenylthiosemi-carbazide pyridine-2,6-dicarbohydrazide 2, which has been obtained from the corresponding dihydrazide 1. The biological screening showed that many of these compounds have good antimicrobial activities. The structure of the new compounds has been established on the bases of chemical and spectroscopic evidences. J. Heterocyclic Chem., (2011).
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