According to Ayurveda Tridosha and Panchamahabhuta are the functional and structural entity of bo... more According to Ayurveda Tridosha and Panchamahabhuta are the functional and structural entity of body so the anatomy, physiology, pathology and treatment are based upon the principle of Tridosha and Panchamahabhut Siddhanta and these principles are formulating the concept of Aayu, Bala, Prakriti and Koshtha. The line of treatment, drug selection, dose determination as well as indication and contraindication of Aahar and Vihar are based upon the above concept. So, a huge study is needed to explore the above concept by the anatomical, physiological, pathological and clinical approach. Out of them the concept of Kohstha can be explore by the study of Koshtha and its anatomical determination, physiology of Koshtha, Koshtha Pariksha and utility of Koshtha in Sodhana and shaman Chikitsa
Journal of emerging technologies and innovative research, 2016
Mild Steel is one of the major construction materials used in the industries. Corrosion is one of... more Mild Steel is one of the major construction materials used in the industries. Corrosion is one of the serious problem affecting ship, pipe line and aviation industries. It affects the body of ship and thickness of pipe and an Aeroplane wings, surface, between joints and fasteners with the increased utilization of this metal in the manufacturing and construction firms, one of the major problems encountered is the control of corrosion rate when exposed to different corrosive environments. Corrosion is a natural process that reduces the binding energy in metals with the end result involving a metal being oxidized as the bulk metal losses one or more electrons During the thickness measurement of any corrode plate, Any material whose thickness is lower than the low limit of the probe due to corrosion of metal piece will cause Measurement errors. Sometimes the displayed reading is twice as big as the actual thickness. To prevent these errors, the critical thin Materials should be measured...
International journal of pharma and bio sciences, 2013
Parkinson’s disease PARK1, caused by mutations in the SNCA gene, which codes for the protein alph... more Parkinson’s disease PARK1, caused by mutations in the SNCA gene, which codes for the protein alpha-synuclein. SNCA gene is analysed by different NCBI tools and bioinformatics softwares (ORF, Map Viewer, e-PCR, Vec screen, Genscan, BLAST, FASTA, MSA, ClustalW, bioedit software and phylodraw software). Then protein information and protein structures are analysed by different proteomics tools and different softwares (Protparam, Protscale, GOR, SOPMA, SignalP, NetNGly, NetOGly, NetAcet, NetPhos, sulfinator, SOSUI, bioedit software, SPDBV software, RASMOL 3D analysis software). Homology modelling of the protein is done using SPDBV (SWISS PDB VIEWER). Active site analysis is done through Q-site finder method and the active site amino acids are noted. Standard available market drugs targeting the protein were identified as Carbidopa, Dopamine, Levodopa, Memantine, and Apomorphine. 16 similar molecules for these standard molecules were modelled using Argus Lab software. A database is create...
Mild Steel is one of the major construction materials used in the industries. Corrosion is one of... more Mild Steel is one of the major construction materials used in the industries. Corrosion is one of the serious problem affecting ship, pipe line and aviation industries. It affects the body of ship and thickness of pipe and an Aeroplane wings, surface, between joints and fasteners with the increased utilization of this metal in the manufacturing and construction firms, one of the major problems encountered is the control of corrosion rate when exposed to different corrosive environments. Corrosion is a natural process that reduces the binding energy in metals with the end result involving a metal being oxidized as the bulk metal losses one or more electrons. During the thickness measurement of any corrode plate, Any material whose thickness is lower than the low limit of the probe due to corrosion of metal piece will cause Measurement errors. Sometimes the displayed reading is twice as big as the actual thickness. To prevent these errors, the critical thin Materials should be measure...
ABSTRACT: From this current research, Syk (spleen tyrosine kinase) protein and gene information i... more ABSTRACT: From this current research, Syk (spleen tyrosine kinase) protein and gene information is analyzed by different genomics, proteomics tools & databases. One crystal ligand 4DFL was collected from protein data bank (pdb). From different literature review 131 syk protein inhibitors were collected. Molecular modeling of these 131 molecules was done through Accelrys discovery studio (ADS). Choose appropriate force-field & minimization (Smart, Stephent Descent, and Conjugate Gradient) according to selected molecules. Then collected crystal ligand is purified by protein purification method and used appropriate conformation (BEST, FAST, and CAESAR). Docking methods were analyzed with protein, crystal ligand and similar inhibitors to know the best protein-ligand interaction. Pharmacophore research is done through HIPHOP and HYPOGEN method. Protein with final compound docking method is done after completion of virtual screening method. Pharmacophore research with final molecule was d...
Objective: Abnormality of ApolipoproteinE (APOE) causes Alzheimer Disease Type 2 (AD2). Mutation ... more Objective: Abnormality of ApolipoproteinE (APOE) causes Alzheimer Disease Type 2 (AD2). Mutation in chromosome 19 and the location is 19q13.2 of APOE gene is responsible for AD. Methods: Gene and protein information were analyzed by NCBI tools, genomics tools and proteomics tools (ORF, Map Viewer, e-PCR, VecScreen, Genscan, BLAST, FASTA, MSA, ClustalW, Protparam, protscale, GOR, SOPMA, signal, NetNGly, NetOGly, NetAcet, NetPhos, Sulfinator, SOSUI, Bioedit software, SPDBV, Accelrys Discovery Studio Visulizer (ADSV) software). Homology modeling results obtained from Ramchandran plot of ADSV software to know the amino acid presence before loop build procedure. Protein with entire surface cavity obtained through active site analysis, from different literature search market available drugs and similar protein inhibitors were collected. Molecular modeling of these molecules was designed by ADSV and SPDBV software. All similar market available drugs with protein docking method are obtained...
According to Ayurveda Tridosha and Panchamahabhuta are the functional and structural entity of bo... more According to Ayurveda Tridosha and Panchamahabhuta are the functional and structural entity of body so the anatomy, physiology, pathology and treatment are based upon the principle of Tridosha and Panchamahabhut Siddhanta and these principles are formulating the concept of Aayu, Bala, Prakriti and Koshtha. The line of treatment, drug selection, dose determination as well as indication and contraindication of Aahar and Vihar are based upon the above concept. So, a huge study is needed to explore the above concept by the anatomical, physiological, pathological and clinical approach. Out of them the concept of Kohstha can be explore by the study of Koshtha and its anatomical determination, physiology of Koshtha, Koshtha Pariksha and utility of Koshtha in Sodhana and shaman Chikitsa
Journal of emerging technologies and innovative research, 2016
Mild Steel is one of the major construction materials used in the industries. Corrosion is one of... more Mild Steel is one of the major construction materials used in the industries. Corrosion is one of the serious problem affecting ship, pipe line and aviation industries. It affects the body of ship and thickness of pipe and an Aeroplane wings, surface, between joints and fasteners with the increased utilization of this metal in the manufacturing and construction firms, one of the major problems encountered is the control of corrosion rate when exposed to different corrosive environments. Corrosion is a natural process that reduces the binding energy in metals with the end result involving a metal being oxidized as the bulk metal losses one or more electrons During the thickness measurement of any corrode plate, Any material whose thickness is lower than the low limit of the probe due to corrosion of metal piece will cause Measurement errors. Sometimes the displayed reading is twice as big as the actual thickness. To prevent these errors, the critical thin Materials should be measured...
International journal of pharma and bio sciences, 2013
Parkinson’s disease PARK1, caused by mutations in the SNCA gene, which codes for the protein alph... more Parkinson’s disease PARK1, caused by mutations in the SNCA gene, which codes for the protein alpha-synuclein. SNCA gene is analysed by different NCBI tools and bioinformatics softwares (ORF, Map Viewer, e-PCR, Vec screen, Genscan, BLAST, FASTA, MSA, ClustalW, bioedit software and phylodraw software). Then protein information and protein structures are analysed by different proteomics tools and different softwares (Protparam, Protscale, GOR, SOPMA, SignalP, NetNGly, NetOGly, NetAcet, NetPhos, sulfinator, SOSUI, bioedit software, SPDBV software, RASMOL 3D analysis software). Homology modelling of the protein is done using SPDBV (SWISS PDB VIEWER). Active site analysis is done through Q-site finder method and the active site amino acids are noted. Standard available market drugs targeting the protein were identified as Carbidopa, Dopamine, Levodopa, Memantine, and Apomorphine. 16 similar molecules for these standard molecules were modelled using Argus Lab software. A database is create...
Mild Steel is one of the major construction materials used in the industries. Corrosion is one of... more Mild Steel is one of the major construction materials used in the industries. Corrosion is one of the serious problem affecting ship, pipe line and aviation industries. It affects the body of ship and thickness of pipe and an Aeroplane wings, surface, between joints and fasteners with the increased utilization of this metal in the manufacturing and construction firms, one of the major problems encountered is the control of corrosion rate when exposed to different corrosive environments. Corrosion is a natural process that reduces the binding energy in metals with the end result involving a metal being oxidized as the bulk metal losses one or more electrons. During the thickness measurement of any corrode plate, Any material whose thickness is lower than the low limit of the probe due to corrosion of metal piece will cause Measurement errors. Sometimes the displayed reading is twice as big as the actual thickness. To prevent these errors, the critical thin Materials should be measure...
ABSTRACT: From this current research, Syk (spleen tyrosine kinase) protein and gene information i... more ABSTRACT: From this current research, Syk (spleen tyrosine kinase) protein and gene information is analyzed by different genomics, proteomics tools & databases. One crystal ligand 4DFL was collected from protein data bank (pdb). From different literature review 131 syk protein inhibitors were collected. Molecular modeling of these 131 molecules was done through Accelrys discovery studio (ADS). Choose appropriate force-field & minimization (Smart, Stephent Descent, and Conjugate Gradient) according to selected molecules. Then collected crystal ligand is purified by protein purification method and used appropriate conformation (BEST, FAST, and CAESAR). Docking methods were analyzed with protein, crystal ligand and similar inhibitors to know the best protein-ligand interaction. Pharmacophore research is done through HIPHOP and HYPOGEN method. Protein with final compound docking method is done after completion of virtual screening method. Pharmacophore research with final molecule was d...
Objective: Abnormality of ApolipoproteinE (APOE) causes Alzheimer Disease Type 2 (AD2). Mutation ... more Objective: Abnormality of ApolipoproteinE (APOE) causes Alzheimer Disease Type 2 (AD2). Mutation in chromosome 19 and the location is 19q13.2 of APOE gene is responsible for AD. Methods: Gene and protein information were analyzed by NCBI tools, genomics tools and proteomics tools (ORF, Map Viewer, e-PCR, VecScreen, Genscan, BLAST, FASTA, MSA, ClustalW, Protparam, protscale, GOR, SOPMA, signal, NetNGly, NetOGly, NetAcet, NetPhos, Sulfinator, SOSUI, Bioedit software, SPDBV, Accelrys Discovery Studio Visulizer (ADSV) software). Homology modeling results obtained from Ramchandran plot of ADSV software to know the amino acid presence before loop build procedure. Protein with entire surface cavity obtained through active site analysis, from different literature search market available drugs and similar protein inhibitors were collected. Molecular modeling of these molecules was designed by ADSV and SPDBV software. All similar market available drugs with protein docking method are obtained...
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