Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2020
PURPOSE The effect of botulinum toxin type A (BTX-A) on fracture healing of the long bones is con... more PURPOSE The effect of botulinum toxin type A (BTX-A) on fracture healing of the long bones is controversial, and no controlled clinical or experimental study has investigated the effect of BTX-A on mandibular fractures. The purpose of this study was to investigate whether BTX-A injection into the masseter muscles affects bone healing by reducing the displacing forces in an unfavorable mandibular fracture model. MATERIALS AND METHODS Forty-eight male New Zealand white rabbits were used. Ten units of BTX-A was injected into each masseter muscle in the animals in the BTX-A group, whereas saline solution was injected in the animals in the control group. A unilateral osteotomy and fixation with a microplate were performed. Bone healing was evaluated by radiodensitometric, biomechanical, histologic, and histomorphometric methods after 21 days. RESULTS The mean bone mineral density in the fracture area was significantly higher in the BTX-A group (P = .038). The mean failure load and bendin...
Assessment of Osteointegration of CortossTM in Cranioplasty: An Experimental Study in Rabbits Gal... more Assessment of Osteointegration of CortossTM in Cranioplasty: An Experimental Study in Rabbits Galip Zihni SANUS, Mustafa Onur ULU, Fatma OZLEN, Huseyin BICEROGLU, Baris KUCUKYURUK, Cihan ISLER, Mustafa Ilker YASSA, Sait ALBAYRAM, Ahmet BAS, Buge OZ, Mehmet KURKCU, Taner TANRIVERDI Istanbul University, Cerrahpasa Medical Faculty, Department of Neurosurgery, Istanbul, Türkiye Bakirkoy Prof.Dr. Mazhar Osman Education and Research Hospital, Department of Neurosurgery, Istanbul, Türkiye Istanbul University, Cerrahpasa Medical Faculty, Department of Radiology, Istanbul, Türkiye Istanbul University, Cerrahpasa Medical Faculty, Department of Pathology, Istanbul, Türkiye Cukurova University Medical Faculty, Department of Oral and Maxillofacial Surgery, Adana, Türkiye
PURPOSE Orthognathic surgery not only corrects dentofacial deformities but also affects some vita... more PURPOSE Orthognathic surgery not only corrects dentofacial deformities but also affects some vital structures involving voice production. The primary aim of this study was to analyze the effects of bimaxillary orthognathic surgery on voice characteristics of patients with class II and III skeletal deformities; the second aim was to evaluate possible associations among acoustic parameters, pharyngeal airway, and skeletal changes after surgery. MATERIALS AND METHODS Using prospective cohort study design, we enrolled a sample of patients who underwent bimaxillary orthognathic surgery in the university hospital between January 2018 and January 2019. Voice records and CBCT scans of the patients were acquired before surgery and 6 months after surgery. Pharyngeal airway volume, minimum cross-sectional area, hyoid bone position, and skeletal movements of maxilla and mandible were assessed with Dolphin Imaging software using CBCT data as predictor variables. Acoustic analysis of voice samples (vowel/a/) were performed with Praat software as outcome variables. The within-group and between-group differences in data were analyzed using paired-sample and independent-sample t tests. The degree of relationship between voice and CBCT parameters was assessed using Pearson correlation and multiple regression analysis. RESULTS The study sample comprised 33 patients; 14 patients had class II skeletal deformity and 19 patients had class III skeletal deformity. Orthognathic surgery in both patients with class II and III skeletal deformities resulted in significant changes in all the voice parameters (All P < .05). Only patients with class II skeletal deformity showed significant changes in airway parameters (increase; all P < .001) and hyoid bone positions (anterosuperior movement; P = .001 and P = .008, respectively). Multiple regression analysis showed that some specific structural changes significantly affected some specific acoustic parameters. CONCLUSIONS Bimaxillary orthognathic surgery significantly changed the acoustic parameters of voice in patients with class II and III skeletal deformities. Some of the structural changes were significantly associated with some of the acoustic parameters.
Journal of applied oral science : revista FOB, Jan 10, 2018
To evaluate whether hyperbaric oxygen (HBO) treatment has a favorable effect on implant osseointe... more To evaluate whether hyperbaric oxygen (HBO) treatment has a favorable effect on implant osseointegration in diabetic rabbits. An experimental diabetes model was induced in 32 New Zealand rabbits through IV injection of alloxan. After the state of diabetes had been confirmed, one dental implant was placed in the metaphysical region of each animal's tibia. After the implants' placements, the animals were divided into two groups. Half of the animals underwent HBO treatment, while the other group did not receive HBO treatment and served as the control group. The animals were euthanized at the 4th and 8th weeks. The osseointegration of the implants were compared by histomorphometry and resonance frequency analysis (RFA). The Bone Implant Contact (BIC) values were significantly higher in the HBO group than in the control group at the 4th week. There was no difference in the BIC values between the groups at the 8th week. There was no significant difference in the RFA scores between...
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, Jan 27, 2018
The purpose of this study was to answer the research question of whether maxillary expansion prov... more The purpose of this study was to answer the research question of whether maxillary expansion provides enough postgraft stimulation to decrease the volume loss of alveolar bone grafts in patients with cleft lip and palate (CLP) who missed the appropriate treatment time. This study was designed as a prospective controlled clinical trial. Thirty patients in the permanent-dentition stage with unilateral CLP were divided into 2 groups: In group I (mean age, 19.33 ± 5.16 years), slow maxillary expansion was performed before secondary alveolar bone grafting (SABG); in group II (mean age, 19.93 ± 3.99 years), slow maxillary expansion was performed 6 weeks after SABG. The iliac crest was preferred as a donor site for autogenous bone graft harvesting. Cone beam computed tomography images were taken 1 week, 6 months, and 12 months postoperatively. The volume and density of the alveolar bone graft were calculated using Mimics software (version 13.1; Materialise, Ann Arbor, MI), and SPSS softwar...
International journal of implant dentistry, Jan 19, 2018
The aim of this study was to histomorphometrically compare the implant-host integration between r... more The aim of this study was to histomorphometrically compare the implant-host integration between retrieved implants and new implants. Jaws in 10 male beagle dogs were divided into four groups, and 36 dental implants were inserted into the jaws. In groups 1 and 2, experimental peri-implantitis was induced within 2 months after implant insertion. In group 1, surface decontamination of implants was achieved using air-flow and citric acid. In group 2, implants were sterilized with autoclave after air-flow and citric acid surface decontamination. Subsequently, these implants were inserted in contralateral jaws of the same dogs and a 3-month period was allowed for osseointegration. In group 3, the implants were removed from human jaws due to peri-implantitis and were inserted into dog jaws following surface cleaning protocol and sterilization with autoclave and a 3-month period was allowed for osseointegration. Group 4 was set as the control group. After the osseointegration period, all th...
Clinical implant dentistry and related research, Jan 10, 2017
Immediate or early loading of dental implants becomes a clinically feasible concept. The aim was ... more Immediate or early loading of dental implants becomes a clinically feasible concept. The aim was to evaluate the effects of different loading protocols (immediate, early, and delayed) on secondary stability and peri-implant bone density of single implants in the posterior maxilla. Thirty-nine implants (Dentium, South-Korea) were placed in 39 patients. After placement, implant stability values (ISQ) and baseline peri-implant bone density values derived from cone-beam computed tomography were recorded. Thirteen implants were included randomly in each loading groups. The secondary ISQ values were recorded during follow-up visits. Peri-implant bone density values were measured 1 year after placement again. Data was statistically analyzed. Immediate-loaded group showed the lowest ISQ values, 1 month after placement. During the next follow-up visits, delayed-loaded group showed the lowest ISQ values while other groups showed comparable results. Early loading increased the peri-implant bon...
The aim of this study was to investigate the healing of artificially created peri-implant circumf... more The aim of this study was to investigate the healing of artificially created peri-implant circumferential bone defects using three bone-regeneration techniques. Rabbit tibias (24 rabbits), in which bone defects (9-mm diameter, 4-mm depth) were created and implant beds (3-mm diameter, 6-mm depth) were prepared in the middle of the created defects, were used as the experimental model. Dental implants (3.0 × 10 mm) were inserted, and the peri-implant bone defects were grafted with demineralized freeze-dried bone allograft (DFDBA) plus saline solution, DFDBA plus platelet-rich fibrin (PRF), or DFDBA plus rifamycin. After 4 weeks, the animals were euthanized and the implants with surrounding bone were removed. Undecalcified histomorphometric examinations with toluidine blue staining were performed, and the bone-to-implant contact (BIC) and percentage of new bone formation were evaluated. The BIC was 50.94% ± 24.39% in the DFDBA-plus-saline solution group, 60.07% ± 4.91% in the DFDBA-plus-rifamycin group, and 73.43% ± 3.86% in the DFDBA-plus-PRF group. The percentage of new bone formation at the defect area was 37.61% ± 1.70% in the DFDBA-plus-saline solution group, 48.51% ± 2.80% in the DFDBA-plus-rifamycin group, and 63.09% ± 2.10% in the DFDBA-plus-PRF group. In terms of new bone formation and BIC, the DFDBA-plus-PRF and DFDBA-plus-rifamycin groups were significantly different from the DFDBA-plus-saline solution group. The difference between the DFDBA-plus-PRF and DFDBA-plus-rifamycin groups was also statistically significant. The addition of PRF or rifamycin to DFDBA had a significant positive effect on bone healing in peri-implant bone defects. The DFDBA-plus-PRF group showed the highest percentages of new bone formation and BIC.
Journal of back and musculoskeletal rehabilitation, Jan 19, 2016
Data regarding the effectiveness of Kinesio Taping in temporomandibular disorders (TMD) is scarce... more Data regarding the effectiveness of Kinesio Taping in temporomandibular disorders (TMD) is scarce. To determine the efficacy of Kinesio Taping (KT) in patients with TMD. Patients with TMDs were randomized into experimental and control groups. The experimental group (n= 14) received KT in combination with counseling and jaw exercise, whilst controls (n= 14) were given the regimen of counseling and exercise alone. Jaw movements, Visual analogue scale (VAS) scores and self-reported measures (functional limitation and masticatory efficiency) were evaluated at baseline, first and sixth weeks of the treatment. Biobehavioral questionnaire was filled out at baseline and at sixth week. Active mouth opening improved more in the experimental group than controls (p= 0.003). In the experimental group, VAS for temporomandibular joint, masticatory efficiency and functional limitation improved significantly at the sixth week when compared to baseline (p= 0.011, p= 0.001 and p= 0.001, respectively),...
Th e aim of this study was to evaluate the genotoxic eff ect of a bovine bone-derived hydroxyapat... more Th e aim of this study was to evaluate the genotoxic eff ect of a bovine bone-derived hydroxyapatite (HA), Boneplus-xs (B-P-XS). Th e genotoxicity of B-P-XS was investigated by examining the potential of the xenograft (B-P-XS) to induce gene mutation (evaluated using the Ames test), in vitro chromosome aberration (CA), and sister chromatid exchange (SCE) with tests in cultured human peripheral lymphocytes. Counts of reverse mutations in Salmonella typhimurium TA98 and TA100 strains were not found to be signifi cantly increased aft er treatment with B-P-XS (P > 0.05). Th e presence of B-P-XS in peripheral blood culture for 24 and 48 h did not lead to a signifi cant increase in the frequency of CAs (P > 0.05) and SCEs (P > 0.05) when compared to the solvent control (dimethyl sulfoxide). When compared with the control group (untreated), B-P-XS signifi cantly decreased the mitotic index; however, the decrement was not statistically signifi cant when compared with the solvent co...
The International journal of oral & maxillofacial implants
The aim of this study was to compare two different forms of bovine-derived hydroxyapatite (HA) in... more The aim of this study was to compare two different forms of bovine-derived hydroxyapatite (HA) in sinus augmentation and simultaneous implant placement. The schneiderian membranes of 12 domestic pigs were elevated bilaterally through an extraoral approach. One sinus of each pig was grafted with bovine-derived granular HA (GHA) and the other was grafted with bovine-derived spongiosa block HA (BHA) (Unilab Surgibone). One dental implant was placed simultaneously into each grafted sinus. Animals were sacrificed after 6 months of healing. Primary implant stability (ISQi) and secondary implant stability (ISQf) were measured by resonance frequency analysis. Undecalcified sections were prepared for histomorphometric analysis. Mean ISQi values for implants placed in sinuses grafted with BHA and GHA were 68.8 +/- 5.0 and 68.2 +/- 3.7, respectively (P > .05). The mean ISQf value for implants in GHA increased to 72.0 +/- 5.1 and for implants in BHA decreased to 52.3 +/- 8.8 (P < .01). Th...
Objective. The purpose of the present study is to evaluate the effects of systemically administer... more Objective. The purpose of the present study is to evaluate the effects of systemically administered zoledronic acid (ZA) on the physiological bone remodeling and the microarchitectural parameters of the condylar part of TMJ in a rabbit model.Study Design. Thirty skeletally mature male New Zealand white rabbits were randomly divided into two groups. The experimental group was administered an intravenous, single dose of 0.1 mg/kg ZA diluted with 15 mL of saline in a 15-minute perfusion with an infusion pump. The control group was administered only saline infusion for 15 minutes. All rabbits were sacrificed on the 21st postoperative day. Radiodensitometric and histomorphometric examinations were performed on the harvested mandibular condyles. The data were analyzed statistically.Results. Radiodensitometric findings showed that ZA treatment resulted in a significant increase in the mineralization of mandibular condyle. This result was supported by the histomorphometric findings.Conclusi...
The purpose of this study was to evaluate the effects of different laser dose and force levels on... more The purpose of this study was to evaluate the effects of different laser dose and force levels on the stability of orthodontic mini screws used for anchorage, by histomorphometric analyses. Low-level laser therapy speeds up blood flow, improves the mechanism of the revitalization processes, reduces the risk of infection, boosts metabolic activities, and accelerates the healing of the damaged tissue. Although there are many research studies about low-level laser therapy applications in a variety of areas, no investigations were found concerning mini screw stability using various laser dose levels with different force level applications. Seventeen New Zealand white rabbits were used. A total of 68 cylindrical, self-drilling orthodontic mini screws were threaded at the fibula. Experimental subjects were divided into six groups; force application was not performed in the first three groups, whereas 150 g of force was applied via nickel-titanium closed-coil springs placed between two mini screws in the other three groups. Measurements of the initial torque values (10 Ncm) were manipulated by a digital portable torque gauge. Various low-level laser doses were applied to the groups during the postoperative 10 days. After 4 weeks, bone-to-implant contact and cortical bone thickness were histomorphometrically analyzed. In the 150 g force plus 20 J/cm(2) dosage group, the highest bone-to-implant contact values were observed. (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05) There were no statistically significant correlations between cortical bone thickness and bone-to-implant contact values; on the other hand, no significant difference was found among the same groups in terms of cortical bone thickness values (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;0.05). Low-level laser therapy was noticed to induce the mini screw-bone contact area. Low-level laser therapy may be a supplementary treatment method to increase the stability of the orthodontic mini screw.
Th e aim of this study was to evaluate the genotoxic eff ect of a bovine bone-derived hydroxyapat... more Th e aim of this study was to evaluate the genotoxic eff ect of a bovine bone-derived hydroxyapatite (HA), Boneplus-xs (B-P-XS). Th e genotoxicity of B-P-XS was investigated by examining the potential of the xenograft (B-P-XS) to induce gene mutation (evaluated using the Ames test), in vitro chromosome aberration (CA), and sister chromatid exchange (SCE) with tests in cultured human peripheral lymphocytes. Counts of reverse mutations in Salmonella typhimurium TA98 and TA100 strains were not found to be signifi cantly increased aft er treatment with B-PXS (P > 0.05). Th e presence of B-P-XS in peripheral blood culture for 24 and 48 h did not lead to a signifi cant increase in the frequency of CAs (P > 0.05) and SCEs (P > 0.05) when compared to the solvent control (dimethyl sulfoxide). When compared with the control group (untreated), B-P-XS signifi cantly decreased the mitotic index; however, the decrement was not statistically signifi cant when compared with the solvent con...
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2020
PURPOSE The effect of botulinum toxin type A (BTX-A) on fracture healing of the long bones is con... more PURPOSE The effect of botulinum toxin type A (BTX-A) on fracture healing of the long bones is controversial, and no controlled clinical or experimental study has investigated the effect of BTX-A on mandibular fractures. The purpose of this study was to investigate whether BTX-A injection into the masseter muscles affects bone healing by reducing the displacing forces in an unfavorable mandibular fracture model. MATERIALS AND METHODS Forty-eight male New Zealand white rabbits were used. Ten units of BTX-A was injected into each masseter muscle in the animals in the BTX-A group, whereas saline solution was injected in the animals in the control group. A unilateral osteotomy and fixation with a microplate were performed. Bone healing was evaluated by radiodensitometric, biomechanical, histologic, and histomorphometric methods after 21 days. RESULTS The mean bone mineral density in the fracture area was significantly higher in the BTX-A group (P = .038). The mean failure load and bendin...
Assessment of Osteointegration of CortossTM in Cranioplasty: An Experimental Study in Rabbits Gal... more Assessment of Osteointegration of CortossTM in Cranioplasty: An Experimental Study in Rabbits Galip Zihni SANUS, Mustafa Onur ULU, Fatma OZLEN, Huseyin BICEROGLU, Baris KUCUKYURUK, Cihan ISLER, Mustafa Ilker YASSA, Sait ALBAYRAM, Ahmet BAS, Buge OZ, Mehmet KURKCU, Taner TANRIVERDI Istanbul University, Cerrahpasa Medical Faculty, Department of Neurosurgery, Istanbul, Türkiye Bakirkoy Prof.Dr. Mazhar Osman Education and Research Hospital, Department of Neurosurgery, Istanbul, Türkiye Istanbul University, Cerrahpasa Medical Faculty, Department of Radiology, Istanbul, Türkiye Istanbul University, Cerrahpasa Medical Faculty, Department of Pathology, Istanbul, Türkiye Cukurova University Medical Faculty, Department of Oral and Maxillofacial Surgery, Adana, Türkiye
PURPOSE Orthognathic surgery not only corrects dentofacial deformities but also affects some vita... more PURPOSE Orthognathic surgery not only corrects dentofacial deformities but also affects some vital structures involving voice production. The primary aim of this study was to analyze the effects of bimaxillary orthognathic surgery on voice characteristics of patients with class II and III skeletal deformities; the second aim was to evaluate possible associations among acoustic parameters, pharyngeal airway, and skeletal changes after surgery. MATERIALS AND METHODS Using prospective cohort study design, we enrolled a sample of patients who underwent bimaxillary orthognathic surgery in the university hospital between January 2018 and January 2019. Voice records and CBCT scans of the patients were acquired before surgery and 6 months after surgery. Pharyngeal airway volume, minimum cross-sectional area, hyoid bone position, and skeletal movements of maxilla and mandible were assessed with Dolphin Imaging software using CBCT data as predictor variables. Acoustic analysis of voice samples (vowel/a/) were performed with Praat software as outcome variables. The within-group and between-group differences in data were analyzed using paired-sample and independent-sample t tests. The degree of relationship between voice and CBCT parameters was assessed using Pearson correlation and multiple regression analysis. RESULTS The study sample comprised 33 patients; 14 patients had class II skeletal deformity and 19 patients had class III skeletal deformity. Orthognathic surgery in both patients with class II and III skeletal deformities resulted in significant changes in all the voice parameters (All P < .05). Only patients with class II skeletal deformity showed significant changes in airway parameters (increase; all P < .001) and hyoid bone positions (anterosuperior movement; P = .001 and P = .008, respectively). Multiple regression analysis showed that some specific structural changes significantly affected some specific acoustic parameters. CONCLUSIONS Bimaxillary orthognathic surgery significantly changed the acoustic parameters of voice in patients with class II and III skeletal deformities. Some of the structural changes were significantly associated with some of the acoustic parameters.
Journal of applied oral science : revista FOB, Jan 10, 2018
To evaluate whether hyperbaric oxygen (HBO) treatment has a favorable effect on implant osseointe... more To evaluate whether hyperbaric oxygen (HBO) treatment has a favorable effect on implant osseointegration in diabetic rabbits. An experimental diabetes model was induced in 32 New Zealand rabbits through IV injection of alloxan. After the state of diabetes had been confirmed, one dental implant was placed in the metaphysical region of each animal's tibia. After the implants' placements, the animals were divided into two groups. Half of the animals underwent HBO treatment, while the other group did not receive HBO treatment and served as the control group. The animals were euthanized at the 4th and 8th weeks. The osseointegration of the implants were compared by histomorphometry and resonance frequency analysis (RFA). The Bone Implant Contact (BIC) values were significantly higher in the HBO group than in the control group at the 4th week. There was no difference in the BIC values between the groups at the 8th week. There was no significant difference in the RFA scores between...
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, Jan 27, 2018
The purpose of this study was to answer the research question of whether maxillary expansion prov... more The purpose of this study was to answer the research question of whether maxillary expansion provides enough postgraft stimulation to decrease the volume loss of alveolar bone grafts in patients with cleft lip and palate (CLP) who missed the appropriate treatment time. This study was designed as a prospective controlled clinical trial. Thirty patients in the permanent-dentition stage with unilateral CLP were divided into 2 groups: In group I (mean age, 19.33 ± 5.16 years), slow maxillary expansion was performed before secondary alveolar bone grafting (SABG); in group II (mean age, 19.93 ± 3.99 years), slow maxillary expansion was performed 6 weeks after SABG. The iliac crest was preferred as a donor site for autogenous bone graft harvesting. Cone beam computed tomography images were taken 1 week, 6 months, and 12 months postoperatively. The volume and density of the alveolar bone graft were calculated using Mimics software (version 13.1; Materialise, Ann Arbor, MI), and SPSS softwar...
International journal of implant dentistry, Jan 19, 2018
The aim of this study was to histomorphometrically compare the implant-host integration between r... more The aim of this study was to histomorphometrically compare the implant-host integration between retrieved implants and new implants. Jaws in 10 male beagle dogs were divided into four groups, and 36 dental implants were inserted into the jaws. In groups 1 and 2, experimental peri-implantitis was induced within 2 months after implant insertion. In group 1, surface decontamination of implants was achieved using air-flow and citric acid. In group 2, implants were sterilized with autoclave after air-flow and citric acid surface decontamination. Subsequently, these implants were inserted in contralateral jaws of the same dogs and a 3-month period was allowed for osseointegration. In group 3, the implants were removed from human jaws due to peri-implantitis and were inserted into dog jaws following surface cleaning protocol and sterilization with autoclave and a 3-month period was allowed for osseointegration. Group 4 was set as the control group. After the osseointegration period, all th...
Clinical implant dentistry and related research, Jan 10, 2017
Immediate or early loading of dental implants becomes a clinically feasible concept. The aim was ... more Immediate or early loading of dental implants becomes a clinically feasible concept. The aim was to evaluate the effects of different loading protocols (immediate, early, and delayed) on secondary stability and peri-implant bone density of single implants in the posterior maxilla. Thirty-nine implants (Dentium, South-Korea) were placed in 39 patients. After placement, implant stability values (ISQ) and baseline peri-implant bone density values derived from cone-beam computed tomography were recorded. Thirteen implants were included randomly in each loading groups. The secondary ISQ values were recorded during follow-up visits. Peri-implant bone density values were measured 1 year after placement again. Data was statistically analyzed. Immediate-loaded group showed the lowest ISQ values, 1 month after placement. During the next follow-up visits, delayed-loaded group showed the lowest ISQ values while other groups showed comparable results. Early loading increased the peri-implant bon...
The aim of this study was to investigate the healing of artificially created peri-implant circumf... more The aim of this study was to investigate the healing of artificially created peri-implant circumferential bone defects using three bone-regeneration techniques. Rabbit tibias (24 rabbits), in which bone defects (9-mm diameter, 4-mm depth) were created and implant beds (3-mm diameter, 6-mm depth) were prepared in the middle of the created defects, were used as the experimental model. Dental implants (3.0 × 10 mm) were inserted, and the peri-implant bone defects were grafted with demineralized freeze-dried bone allograft (DFDBA) plus saline solution, DFDBA plus platelet-rich fibrin (PRF), or DFDBA plus rifamycin. After 4 weeks, the animals were euthanized and the implants with surrounding bone were removed. Undecalcified histomorphometric examinations with toluidine blue staining were performed, and the bone-to-implant contact (BIC) and percentage of new bone formation were evaluated. The BIC was 50.94% ± 24.39% in the DFDBA-plus-saline solution group, 60.07% ± 4.91% in the DFDBA-plus-rifamycin group, and 73.43% ± 3.86% in the DFDBA-plus-PRF group. The percentage of new bone formation at the defect area was 37.61% ± 1.70% in the DFDBA-plus-saline solution group, 48.51% ± 2.80% in the DFDBA-plus-rifamycin group, and 63.09% ± 2.10% in the DFDBA-plus-PRF group. In terms of new bone formation and BIC, the DFDBA-plus-PRF and DFDBA-plus-rifamycin groups were significantly different from the DFDBA-plus-saline solution group. The difference between the DFDBA-plus-PRF and DFDBA-plus-rifamycin groups was also statistically significant. The addition of PRF or rifamycin to DFDBA had a significant positive effect on bone healing in peri-implant bone defects. The DFDBA-plus-PRF group showed the highest percentages of new bone formation and BIC.
Journal of back and musculoskeletal rehabilitation, Jan 19, 2016
Data regarding the effectiveness of Kinesio Taping in temporomandibular disorders (TMD) is scarce... more Data regarding the effectiveness of Kinesio Taping in temporomandibular disorders (TMD) is scarce. To determine the efficacy of Kinesio Taping (KT) in patients with TMD. Patients with TMDs were randomized into experimental and control groups. The experimental group (n= 14) received KT in combination with counseling and jaw exercise, whilst controls (n= 14) were given the regimen of counseling and exercise alone. Jaw movements, Visual analogue scale (VAS) scores and self-reported measures (functional limitation and masticatory efficiency) were evaluated at baseline, first and sixth weeks of the treatment. Biobehavioral questionnaire was filled out at baseline and at sixth week. Active mouth opening improved more in the experimental group than controls (p= 0.003). In the experimental group, VAS for temporomandibular joint, masticatory efficiency and functional limitation improved significantly at the sixth week when compared to baseline (p= 0.011, p= 0.001 and p= 0.001, respectively),...
Th e aim of this study was to evaluate the genotoxic eff ect of a bovine bone-derived hydroxyapat... more Th e aim of this study was to evaluate the genotoxic eff ect of a bovine bone-derived hydroxyapatite (HA), Boneplus-xs (B-P-XS). Th e genotoxicity of B-P-XS was investigated by examining the potential of the xenograft (B-P-XS) to induce gene mutation (evaluated using the Ames test), in vitro chromosome aberration (CA), and sister chromatid exchange (SCE) with tests in cultured human peripheral lymphocytes. Counts of reverse mutations in Salmonella typhimurium TA98 and TA100 strains were not found to be signifi cantly increased aft er treatment with B-P-XS (P > 0.05). Th e presence of B-P-XS in peripheral blood culture for 24 and 48 h did not lead to a signifi cant increase in the frequency of CAs (P > 0.05) and SCEs (P > 0.05) when compared to the solvent control (dimethyl sulfoxide). When compared with the control group (untreated), B-P-XS signifi cantly decreased the mitotic index; however, the decrement was not statistically signifi cant when compared with the solvent co...
The International journal of oral & maxillofacial implants
The aim of this study was to compare two different forms of bovine-derived hydroxyapatite (HA) in... more The aim of this study was to compare two different forms of bovine-derived hydroxyapatite (HA) in sinus augmentation and simultaneous implant placement. The schneiderian membranes of 12 domestic pigs were elevated bilaterally through an extraoral approach. One sinus of each pig was grafted with bovine-derived granular HA (GHA) and the other was grafted with bovine-derived spongiosa block HA (BHA) (Unilab Surgibone). One dental implant was placed simultaneously into each grafted sinus. Animals were sacrificed after 6 months of healing. Primary implant stability (ISQi) and secondary implant stability (ISQf) were measured by resonance frequency analysis. Undecalcified sections were prepared for histomorphometric analysis. Mean ISQi values for implants placed in sinuses grafted with BHA and GHA were 68.8 +/- 5.0 and 68.2 +/- 3.7, respectively (P > .05). The mean ISQf value for implants in GHA increased to 72.0 +/- 5.1 and for implants in BHA decreased to 52.3 +/- 8.8 (P < .01). Th...
Objective. The purpose of the present study is to evaluate the effects of systemically administer... more Objective. The purpose of the present study is to evaluate the effects of systemically administered zoledronic acid (ZA) on the physiological bone remodeling and the microarchitectural parameters of the condylar part of TMJ in a rabbit model.Study Design. Thirty skeletally mature male New Zealand white rabbits were randomly divided into two groups. The experimental group was administered an intravenous, single dose of 0.1 mg/kg ZA diluted with 15 mL of saline in a 15-minute perfusion with an infusion pump. The control group was administered only saline infusion for 15 minutes. All rabbits were sacrificed on the 21st postoperative day. Radiodensitometric and histomorphometric examinations were performed on the harvested mandibular condyles. The data were analyzed statistically.Results. Radiodensitometric findings showed that ZA treatment resulted in a significant increase in the mineralization of mandibular condyle. This result was supported by the histomorphometric findings.Conclusi...
The purpose of this study was to evaluate the effects of different laser dose and force levels on... more The purpose of this study was to evaluate the effects of different laser dose and force levels on the stability of orthodontic mini screws used for anchorage, by histomorphometric analyses. Low-level laser therapy speeds up blood flow, improves the mechanism of the revitalization processes, reduces the risk of infection, boosts metabolic activities, and accelerates the healing of the damaged tissue. Although there are many research studies about low-level laser therapy applications in a variety of areas, no investigations were found concerning mini screw stability using various laser dose levels with different force level applications. Seventeen New Zealand white rabbits were used. A total of 68 cylindrical, self-drilling orthodontic mini screws were threaded at the fibula. Experimental subjects were divided into six groups; force application was not performed in the first three groups, whereas 150 g of force was applied via nickel-titanium closed-coil springs placed between two mini screws in the other three groups. Measurements of the initial torque values (10 Ncm) were manipulated by a digital portable torque gauge. Various low-level laser doses were applied to the groups during the postoperative 10 days. After 4 weeks, bone-to-implant contact and cortical bone thickness were histomorphometrically analyzed. In the 150 g force plus 20 J/cm(2) dosage group, the highest bone-to-implant contact values were observed. (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05) There were no statistically significant correlations between cortical bone thickness and bone-to-implant contact values; on the other hand, no significant difference was found among the same groups in terms of cortical bone thickness values (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;0.05). Low-level laser therapy was noticed to induce the mini screw-bone contact area. Low-level laser therapy may be a supplementary treatment method to increase the stability of the orthodontic mini screw.
Th e aim of this study was to evaluate the genotoxic eff ect of a bovine bone-derived hydroxyapat... more Th e aim of this study was to evaluate the genotoxic eff ect of a bovine bone-derived hydroxyapatite (HA), Boneplus-xs (B-P-XS). Th e genotoxicity of B-P-XS was investigated by examining the potential of the xenograft (B-P-XS) to induce gene mutation (evaluated using the Ames test), in vitro chromosome aberration (CA), and sister chromatid exchange (SCE) with tests in cultured human peripheral lymphocytes. Counts of reverse mutations in Salmonella typhimurium TA98 and TA100 strains were not found to be signifi cantly increased aft er treatment with B-PXS (P > 0.05). Th e presence of B-P-XS in peripheral blood culture for 24 and 48 h did not lead to a signifi cant increase in the frequency of CAs (P > 0.05) and SCEs (P > 0.05) when compared to the solvent control (dimethyl sulfoxide). When compared with the control group (untreated), B-P-XS signifi cantly decreased the mitotic index; however, the decrement was not statistically signifi cant when compared with the solvent con...
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