BackgroundPatients with rheumatic and musculoskeletal diseases (RMDs) require a tailored follow-u... more BackgroundPatients with rheumatic and musculoskeletal diseases (RMDs) require a tailored follow-up, which may be limited by the healthcare resources. Innovative tools that save time need to be implemented effectively in the clinical care of patients with RMDs.ObjectivesTo test the feasibility of a digital solution for real-time monitoring of electronic patient reported outcomes (ePROs) in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA).MethodsDigireuma was a bicentric 6-month prospective study including patients with RA and SpA, using a digital solution, namely Adhera Rheumatology Digital Program. During follow-up, patients had a hybrid follow-up: face-to-face -baseline and 6 months visits-and digital. In the digital follow-up, patients were asked to report disease specific ePROs on a pre-established basis in the mobile solution- including at least one assessment per week. In addition, flares and incidences with medication were available to be reported at any tim...
BackgroundInterstitial lung disease (ILD) is one of the most frequent extra-articular manifestati... more BackgroundInterstitial lung disease (ILD) is one of the most frequent extra-articular manifestations of rheumatoid arthritis (RA) and leads to a significantly increased risk for morbidity and mortality compared with RA alone [1]. The analysis of Electronic Health Records (ERHs) using machine learning (ML) and Natural Language Processing (NLP) holds great promise to better characterize the disease in real-world settings.ObjectivesThis study aims to a) estimate the prevalence of RA in Spain, b) determine the frequency of RA-ILD among RA patients, and c) describe the demographic and clinical characteristics in RA/RA-ILD patients.MethodsObservational, retrospective, and multicenter study based on the secondary use of unstructured clinical data in EHRs from 6 Spanish hospitals between January 1, 2014 and December 31, 2019. The free-text information from patients’ records was captured with SAVANA’s EHRead, a validated NLP technology which extracts clinical information from EHRs and standa...
BackgroundPatients with rheumatic and musculoskeletal diseases (RMDs) require a tailored follow-u... more BackgroundPatients with rheumatic and musculoskeletal diseases (RMDs) require a tailored follow-up that is limited by the capacity of healthcare professionals. Innovative tools need to be implemented effectively in the clinical care of patients with RMDs.ObjectivesTo test the feasibility of a Precision Digital Companion Platform™ for real-time monitoring of disease outcomes in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA).MethodsDigireuma was a prospective study including patients with RA and SpA, using the digital Precision Digital Companion Platform, Adhera for Rheumatology (ISRCTN11896540). During a follow-up of 3 months, patients were asked to report disease specific electronic patient reported outcomes (ePROs) on a regular basis in the mobile solution. Two rheumatologists monitored these ePROs and, patients were contacted for online or face-to-face interventions when deemed necessary by clinicians (Figure 1). Assessment measures included patient global ass...
Background: Gout is the most common nontraumatic arthritis. With a prevalence in Spain of 2.4% an... more Background: Gout is the most common nontraumatic arthritis. With a prevalence in Spain of 2.4% and an increasing incidence, many gout patients are treated in Rheumatology. Different comorbidities complicate the management of this disease that not only attacks joints, but also induces kidney damage and accelerated atherosclerosis. This, together with a poor adherence to urate-lowering therapies and a suboptimal management, justifies its relevant morbidity and mortality, with high socioeconomic impact. Some studies suggest enhancing the role of the Clinical Nurse Specialist (CNS) in the care of gout to combat therapeutic failure Objectives: To determine the factors that affect the perceived quality and satisfaction of gout patients treated in Rheumatology with CNS support and identify areas for improvement Methods: In 2018, we implemented the following nurse-supported visit protocol - 1st (rheumatologist and nurse; face-to-face): clinical history, joint examination, vital signs, anthr...
Background: Anterior uveitis is the most frequent form of presentation of uveitis. An important p... more Background: Anterior uveitis is the most frequent form of presentation of uveitis. An important part of patients do not associate extraocular manifestations, so more information about the clinical profile is needed to optimize therapeutic decisions. Objectives: To describe the clinical profile of patients with anterior uveitis related and not related to the antigen HLA-B27. Compare both groups to establish differences. Methods: Retrospective cohort study. Consecutive patients diagnosed with non-infectious anterior uveitis, assessed in the multidisciplinary uveitis unit of the Infanta Leonor University Hospital (Madrid) from its establishment in October 2017 to December 2019, were included. To compare categorical variables Chi square was used and the test of Fisher; and Student’s T or Mann-Whitney U test for continuous variables. Finally, a multivariate analysis was performed to established differences between the two groups. A value of p Results: 62 patients with anterior uveitis, 2...
Patients with different autoimmune inflammatory diseases (AIID) on biological therapy are at risk... more Patients with different autoimmune inflammatory diseases (AIID) on biological therapy are at risk of pneumococcal disease. Adults with inflammatory arthropathies, connective tissue diseases, psoriasis, or inflammatory bowel disease on biological therapy such as anti-TNFα, rituximab, tocilizumab, abatacept, or anakinra were included in this study. Patients completed a protocol combining the pneumococcal vaccines PCV13 and PPV23. Immune response against pneumococcal serotypes 1, 3, 7F, 14, 19A, and 19F were assessed evaluating functional antibodies by an opsonophagocytosis killing assay (OPKA). In this study, 182 patients with AIID completed the sequential vaccination protocol. Patients on etanercept tended to achieve OPKA titers against a larger number of serotypes than the rest of patients on other biological therapies, while adalimumab was associated to a lower number of serotypes with OPKA titers. Rituximab was not associated with a worse response when compared with the rest of bi...
BackgroundPatients with rheumatic and musculoskeletal diseases (RMDs) require a tailored follow-u... more BackgroundPatients with rheumatic and musculoskeletal diseases (RMDs) require a tailored follow-up, which may be limited by the healthcare resources. Innovative tools that save time need to be implemented effectively in the clinical care of patients with RMDs.ObjectivesTo test the feasibility of a digital solution for real-time monitoring of electronic patient reported outcomes (ePROs) in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA).MethodsDigireuma was a bicentric 6-month prospective study including patients with RA and SpA, using a digital solution, namely Adhera Rheumatology Digital Program. During follow-up, patients had a hybrid follow-up: face-to-face -baseline and 6 months visits-and digital. In the digital follow-up, patients were asked to report disease specific ePROs on a pre-established basis in the mobile solution- including at least one assessment per week. In addition, flares and incidences with medication were available to be reported at any tim...
BackgroundInterstitial lung disease (ILD) is one of the most frequent extra-articular manifestati... more BackgroundInterstitial lung disease (ILD) is one of the most frequent extra-articular manifestations of rheumatoid arthritis (RA) and leads to a significantly increased risk for morbidity and mortality compared with RA alone [1]. The analysis of Electronic Health Records (ERHs) using machine learning (ML) and Natural Language Processing (NLP) holds great promise to better characterize the disease in real-world settings.ObjectivesThis study aims to a) estimate the prevalence of RA in Spain, b) determine the frequency of RA-ILD among RA patients, and c) describe the demographic and clinical characteristics in RA/RA-ILD patients.MethodsObservational, retrospective, and multicenter study based on the secondary use of unstructured clinical data in EHRs from 6 Spanish hospitals between January 1, 2014 and December 31, 2019. The free-text information from patients’ records was captured with SAVANA’s EHRead, a validated NLP technology which extracts clinical information from EHRs and standa...
BackgroundPatients with rheumatic and musculoskeletal diseases (RMDs) require a tailored follow-u... more BackgroundPatients with rheumatic and musculoskeletal diseases (RMDs) require a tailored follow-up that is limited by the capacity of healthcare professionals. Innovative tools need to be implemented effectively in the clinical care of patients with RMDs.ObjectivesTo test the feasibility of a Precision Digital Companion Platform™ for real-time monitoring of disease outcomes in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA).MethodsDigireuma was a prospective study including patients with RA and SpA, using the digital Precision Digital Companion Platform, Adhera for Rheumatology (ISRCTN11896540). During a follow-up of 3 months, patients were asked to report disease specific electronic patient reported outcomes (ePROs) on a regular basis in the mobile solution. Two rheumatologists monitored these ePROs and, patients were contacted for online or face-to-face interventions when deemed necessary by clinicians (Figure 1). Assessment measures included patient global ass...
Background: Gout is the most common nontraumatic arthritis. With a prevalence in Spain of 2.4% an... more Background: Gout is the most common nontraumatic arthritis. With a prevalence in Spain of 2.4% and an increasing incidence, many gout patients are treated in Rheumatology. Different comorbidities complicate the management of this disease that not only attacks joints, but also induces kidney damage and accelerated atherosclerosis. This, together with a poor adherence to urate-lowering therapies and a suboptimal management, justifies its relevant morbidity and mortality, with high socioeconomic impact. Some studies suggest enhancing the role of the Clinical Nurse Specialist (CNS) in the care of gout to combat therapeutic failure Objectives: To determine the factors that affect the perceived quality and satisfaction of gout patients treated in Rheumatology with CNS support and identify areas for improvement Methods: In 2018, we implemented the following nurse-supported visit protocol - 1st (rheumatologist and nurse; face-to-face): clinical history, joint examination, vital signs, anthr...
Background: Anterior uveitis is the most frequent form of presentation of uveitis. An important p... more Background: Anterior uveitis is the most frequent form of presentation of uveitis. An important part of patients do not associate extraocular manifestations, so more information about the clinical profile is needed to optimize therapeutic decisions. Objectives: To describe the clinical profile of patients with anterior uveitis related and not related to the antigen HLA-B27. Compare both groups to establish differences. Methods: Retrospective cohort study. Consecutive patients diagnosed with non-infectious anterior uveitis, assessed in the multidisciplinary uveitis unit of the Infanta Leonor University Hospital (Madrid) from its establishment in October 2017 to December 2019, were included. To compare categorical variables Chi square was used and the test of Fisher; and Student’s T or Mann-Whitney U test for continuous variables. Finally, a multivariate analysis was performed to established differences between the two groups. A value of p Results: 62 patients with anterior uveitis, 2...
Patients with different autoimmune inflammatory diseases (AIID) on biological therapy are at risk... more Patients with different autoimmune inflammatory diseases (AIID) on biological therapy are at risk of pneumococcal disease. Adults with inflammatory arthropathies, connective tissue diseases, psoriasis, or inflammatory bowel disease on biological therapy such as anti-TNFα, rituximab, tocilizumab, abatacept, or anakinra were included in this study. Patients completed a protocol combining the pneumococcal vaccines PCV13 and PPV23. Immune response against pneumococcal serotypes 1, 3, 7F, 14, 19A, and 19F were assessed evaluating functional antibodies by an opsonophagocytosis killing assay (OPKA). In this study, 182 patients with AIID completed the sequential vaccination protocol. Patients on etanercept tended to achieve OPKA titers against a larger number of serotypes than the rest of patients on other biological therapies, while adalimumab was associated to a lower number of serotypes with OPKA titers. Rituximab was not associated with a worse response when compared with the rest of bi...
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