MD, Prof. and Chair, Baskent University School of Medicine Dep. of ORL-HNS. Director of Oto-Neuroto. ClinicBahcelievler, Cankaya, AnkaraTURKEYCerrahpasa School of Medicine-Med SchoolHacettepe University School of Med. ENT department-ResidncyBaylor College of Medicine, Houston, TX 1992-1993Areas of Interest: Ear, Vertigo, Skull Base
Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
In this study, we aimed to assess whether outer hair cell function in patients with pseudoexfolia... more In this study, we aimed to assess whether outer hair cell function in patients with pseudoexfoliation syndrome (PES) was affected or not. Thirty-two patients (21 males, 11 females; mean age 69.8+/-9.3 years; range 49 to 86 years) with the diagnosis of PES and 23 healthy subjects (12 males, 11 females; mean age 65.3+/-9.1 year; range 51 to 79 years) as control group were included in the study. All of the subjects were evaluated with pure tone audiometry, tympanometry, and transient otoacoustic emission tests. Sensorineural hearing loss was present in 28 patients with PES and in 13 healthy subjects (p<0.05). Transient otoacoustic emissions were present in 42 ears of patients with PES and in 32 ears of healthy subjects and there was no statistically significant difference between these two groups (p>0.05). Signal to noise ratios for PES and control groups were 5.1+/-4.4 dB and 5.2+/-4.2 dB, respectively (p>0.05). Our results confirmed the presence of sensorineural hearing loss...
Objective: Recently, people have shown great interest in digital portable music players. Therefor... more Objective: Recently, people have shown great interest in digital portable music players. Therefore, an increase has been observed in the rate of sound exposure of the young population.While the number of publications on the risk of permanent hearing loss that is caused by individual music players has been increasing, there is still insufficient literature on precaution and information. In our study, individual earphones, high level voice that reaches directly to the ear in an unnatural way and accordingly auditory system damage have been examined.Material and Methods: A questionnaire about music listening habits has been conducted on 215 students studying at Baskent University randomly. Music listening time and level of sound determined by questionnaire and relationship between these paramaters with hearing levels of individuals has been studied. Survey forms of the study group were filed under direct observation by the researcher. Hearing thresholds were obtained in the sound isola...
... rol&quot;ü bile zor geldi! (14:58) Konya&#x27;ya üçüncü tıp fakültesi. (13:59) Bakanl... more ... rol&quot;ü bile zor geldi! (14:58) Konya&#x27;ya üçüncü tıp fakültesi. (13:59) Bakanlıktan sözleşmeli personelin nöbet ücreti hakkında duyuru. (13:30) MR&#x27;ın faydası tartışma konusu. Devamı... KBB Dergisi Yıl: 2001 / Cilt: 1 / Sayı: 2. Akut Otitis Media Babür AKKUZU * , Levent N. ÖZLÜOĞLU ...
Clinical and experimental otorhinolaryngology, 2013
Our goal was to find the clinical value of cervical vestibular evoked myogenic potential (VEMP) i... more Our goal was to find the clinical value of cervical vestibular evoked myogenic potential (VEMP) in Ménière's disease (MD) and to evaluate whether the VEMP results can be useful in assessing the stage of MD. Furthermore, we tried to evaluate the clinical effectiveness of VEMP in predicting hearing outcomes. The amplitude, peak latency and interaural amplitude difference (IAD) ratio were obtained using cervical VEMP. The VEMP results of MD were compared with those of normal subjects, and the MD stages were compared with the IAD ratio. Finally, the hearing changes were analyzed according to their VEMP results. In clinically definite unilateral MD (n=41), the prevalence of cervical VEMP abnormality in the IAD ratio was 34.1%. When compared with normal subjects (n=33), the VEMP profile of MD patients showed a low amplitude and a similar latency. The mean IAD ratio in MD was 23%, which was significantly different from that of normal subjects (P=0.01). As the stage increased, the IAD r...
Objective: We evaluated functional results after stapedotomy in terms of the influence of preoper... more Objective: We evaluated functional results after stapedotomy in terms of the influence of preoperative hearing threshold. Study Design: Case series and chart review. Subjects and Methods: We classified 141 patients according to preoperative mean air-conduction threshold: 40 to 54 dB, group 1; 55 to 69 dB, group 2; and 70 to 89 dB, group 3. Speech discrimination scores also were noted. Results: All groups showed significant improvement. The greatest increase in postoperative speech discrimination score was seen in group 3. Group 1 improved from moderate hearing loss (mean, 49 dB) to normal (mean, 24 dB); group 2, from moderately severe loss (mean, 61.2 dB) to mild (mean, 28 dB); and group 3, from severe loss (mean, 76.4 dB) to moderate (mean, 41.1 dB). Conclusion: Success in treating otosclerosis does not depend on extent of preoperative hearing loss. Patients with severe loss improved to moderate, increasing the benefit from use of a hearing aid. The patients attained good auditory ...
Endolymphatic sac papillary tumor (endolymphatic sac adenoma, temporal-mastoid bone adenoma or ad... more Endolymphatic sac papillary tumor (endolymphatic sac adenoma, temporal-mastoid bone adenoma or adenocarcinoma, low-grade adenocarcinoma of potential endolymphatic sac origin, aggressive papillary tumor of the temporal bone, Heffner&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s tumor) is a rare lesion that involves the temporal bone. This tumor usually appears alone, but in 11-30% of afflicted individuals, it is accompanied by von Hippel-Lindau disease. Endolymphatic sac papillary tumors are destructive tumors that exhibit locally aggressive behavior. They slowly grow into the posteromedial section of petrous temporal bone. The main symptoms produced by these lesions include hearing loss and cranial nerve deficits. Endolymphatic sac papillary tumors develop in two principal patterns that histopathologically form follicular and papillary or solid structures. Those two patterns are usually manifested in the same tumor. Immunochemical analysis of these tumors usually reveals cytokeratin, vimentin, epithelial membrane antigen, and (less frequently) S-100 protein and neuron-specific enolase. Local excision is curative for endolymphatic sac papillary tumors. The currently favored method of treatment consists of excision and long-term follow-up. The role of adjuvant radiotherapy as treatment is controversial. This case report describes an endolymphatic sac tumor in a 22-year-old woman without von Hippel-Lindau disease who had a number of complaints, including deafness in her left ear, complete left-sided facial paralysis, and hoarseness of approximately 8 years&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; duration.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Li... more This is an Open Access article distributed under the terms of the Creative Commons Attribution License
Introduction: The cochlear cells in kidney and inner ear have similar anatomic, physiologic, immu... more Introduction: The cochlear cells in kidney and inner ear have similar anatomic, physiologic, immunologic and pathologic properties in microscopic view. Renal glomerule is similar to stria vascularis as compared with the tubules. For this reason nephrotoxic drugs, electrolyte imbalances, biochemical, immunological, osmotic and vascular differences may influence on middleinner ear and central pathway. Here, we aimed to evaluate the middle ear mechanism, outer hairy cell function in inner ear and hearing threshold in renal transplant (RT) patients. Methods: From November 1975 to December 2019, we performed 3071 renal transplant procedures in Başkent University. In this prospective study; 30 RT recipients (60 ears; study group) and 30 healthy volunteers (60 ears; control group) were included. All patients underwent audiologic assessment by means of pure-tone audiometry, otoacoustic emission (OAEs) and contralateral suppression TEOAEs (CS-TEOAEs) measurements. Results: Mean follow-up time after RT was 6.8 ± 6.1years (1-20 years). Hearing performance for the four frequency averages between groups was significantly different (p=0.002). When the cochlea outer hairy cells were evaluated, the signal-to-noise ratio was significantly lower at frequencies of 1000 and 1400 Hz between the patient and the control group (p=0.000, p=0.008). When the frequency-specific suppressions were assessed, there was no significantly lower suppression in all frequency in the RT group, but significantly lower suppression was found in all frequencies (for all frequency, p=0000). Conclusion: Our results support the presence of auditory dysfunction in RT recipients. Low levels of OAEs support that RT recipients are prone to cochlear dysfunction. Therefore, audiometric evaluation of patients should be done before and after RT. P-11.154
Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
We investigated the utility of fine-needle aspiration biopsy (FNAB) for head and neck masses, and... more We investigated the utility of fine-needle aspiration biopsy (FNAB) for head and neck masses, and compared FNAB results with histopathologic diagnoses. In a group of 352 patients (168 males, 184 females; mean age 44+/-19 years; range 2 to 94 years) who were operated on for head and neck masses, FNAB was performed in 167 patients (47.4%). The results of FNAB were compared with histopathologic diagnoses in four groups of localization: parotid, thyroid, submandibular gland, and cervical levels. Sensitivity, specificity, positive predictive and negative predictive rates of FNAB were calculated for each group. There were 64 parotid (38.3%), 29 thyroid (17.4%), 19 level V (11.4%), 18 level II (10.8%), 14 level III (8.4%), 9 level I (5.4%), and 7 submandibular gland (4.2%) masses. The overall correlation of FNAB with histopathologic diagnoses was 71.9%, being 76.6% in parotid, 75.9% in thyroid, 57.1% in submandibular gland, and 67.2% in neck (levels I-VI) masses. The highest sensitivity, s...
Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
In this study, we aimed to assess whether outer hair cell function in patients with pseudoexfolia... more In this study, we aimed to assess whether outer hair cell function in patients with pseudoexfoliation syndrome (PES) was affected or not. Thirty-two patients (21 males, 11 females; mean age 69.8+/-9.3 years; range 49 to 86 years) with the diagnosis of PES and 23 healthy subjects (12 males, 11 females; mean age 65.3+/-9.1 year; range 51 to 79 years) as control group were included in the study. All of the subjects were evaluated with pure tone audiometry, tympanometry, and transient otoacoustic emission tests. Sensorineural hearing loss was present in 28 patients with PES and in 13 healthy subjects (p<0.05). Transient otoacoustic emissions were present in 42 ears of patients with PES and in 32 ears of healthy subjects and there was no statistically significant difference between these two groups (p>0.05). Signal to noise ratios for PES and control groups were 5.1+/-4.4 dB and 5.2+/-4.2 dB, respectively (p>0.05). Our results confirmed the presence of sensorineural hearing loss...
Objective: Recently, people have shown great interest in digital portable music players. Therefor... more Objective: Recently, people have shown great interest in digital portable music players. Therefore, an increase has been observed in the rate of sound exposure of the young population.While the number of publications on the risk of permanent hearing loss that is caused by individual music players has been increasing, there is still insufficient literature on precaution and information. In our study, individual earphones, high level voice that reaches directly to the ear in an unnatural way and accordingly auditory system damage have been examined.Material and Methods: A questionnaire about music listening habits has been conducted on 215 students studying at Baskent University randomly. Music listening time and level of sound determined by questionnaire and relationship between these paramaters with hearing levels of individuals has been studied. Survey forms of the study group were filed under direct observation by the researcher. Hearing thresholds were obtained in the sound isola...
... rol&quot;ü bile zor geldi! (14:58) Konya&#x27;ya üçüncü tıp fakültesi. (13:59) Bakanl... more ... rol&quot;ü bile zor geldi! (14:58) Konya&#x27;ya üçüncü tıp fakültesi. (13:59) Bakanlıktan sözleşmeli personelin nöbet ücreti hakkında duyuru. (13:30) MR&#x27;ın faydası tartışma konusu. Devamı... KBB Dergisi Yıl: 2001 / Cilt: 1 / Sayı: 2. Akut Otitis Media Babür AKKUZU * , Levent N. ÖZLÜOĞLU ...
Clinical and experimental otorhinolaryngology, 2013
Our goal was to find the clinical value of cervical vestibular evoked myogenic potential (VEMP) i... more Our goal was to find the clinical value of cervical vestibular evoked myogenic potential (VEMP) in Ménière's disease (MD) and to evaluate whether the VEMP results can be useful in assessing the stage of MD. Furthermore, we tried to evaluate the clinical effectiveness of VEMP in predicting hearing outcomes. The amplitude, peak latency and interaural amplitude difference (IAD) ratio were obtained using cervical VEMP. The VEMP results of MD were compared with those of normal subjects, and the MD stages were compared with the IAD ratio. Finally, the hearing changes were analyzed according to their VEMP results. In clinically definite unilateral MD (n=41), the prevalence of cervical VEMP abnormality in the IAD ratio was 34.1%. When compared with normal subjects (n=33), the VEMP profile of MD patients showed a low amplitude and a similar latency. The mean IAD ratio in MD was 23%, which was significantly different from that of normal subjects (P=0.01). As the stage increased, the IAD r...
Objective: We evaluated functional results after stapedotomy in terms of the influence of preoper... more Objective: We evaluated functional results after stapedotomy in terms of the influence of preoperative hearing threshold. Study Design: Case series and chart review. Subjects and Methods: We classified 141 patients according to preoperative mean air-conduction threshold: 40 to 54 dB, group 1; 55 to 69 dB, group 2; and 70 to 89 dB, group 3. Speech discrimination scores also were noted. Results: All groups showed significant improvement. The greatest increase in postoperative speech discrimination score was seen in group 3. Group 1 improved from moderate hearing loss (mean, 49 dB) to normal (mean, 24 dB); group 2, from moderately severe loss (mean, 61.2 dB) to mild (mean, 28 dB); and group 3, from severe loss (mean, 76.4 dB) to moderate (mean, 41.1 dB). Conclusion: Success in treating otosclerosis does not depend on extent of preoperative hearing loss. Patients with severe loss improved to moderate, increasing the benefit from use of a hearing aid. The patients attained good auditory ...
Endolymphatic sac papillary tumor (endolymphatic sac adenoma, temporal-mastoid bone adenoma or ad... more Endolymphatic sac papillary tumor (endolymphatic sac adenoma, temporal-mastoid bone adenoma or adenocarcinoma, low-grade adenocarcinoma of potential endolymphatic sac origin, aggressive papillary tumor of the temporal bone, Heffner&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s tumor) is a rare lesion that involves the temporal bone. This tumor usually appears alone, but in 11-30% of afflicted individuals, it is accompanied by von Hippel-Lindau disease. Endolymphatic sac papillary tumors are destructive tumors that exhibit locally aggressive behavior. They slowly grow into the posteromedial section of petrous temporal bone. The main symptoms produced by these lesions include hearing loss and cranial nerve deficits. Endolymphatic sac papillary tumors develop in two principal patterns that histopathologically form follicular and papillary or solid structures. Those two patterns are usually manifested in the same tumor. Immunochemical analysis of these tumors usually reveals cytokeratin, vimentin, epithelial membrane antigen, and (less frequently) S-100 protein and neuron-specific enolase. Local excision is curative for endolymphatic sac papillary tumors. The currently favored method of treatment consists of excision and long-term follow-up. The role of adjuvant radiotherapy as treatment is controversial. This case report describes an endolymphatic sac tumor in a 22-year-old woman without von Hippel-Lindau disease who had a number of complaints, including deafness in her left ear, complete left-sided facial paralysis, and hoarseness of approximately 8 years&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; duration.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Li... more This is an Open Access article distributed under the terms of the Creative Commons Attribution License
Introduction: The cochlear cells in kidney and inner ear have similar anatomic, physiologic, immu... more Introduction: The cochlear cells in kidney and inner ear have similar anatomic, physiologic, immunologic and pathologic properties in microscopic view. Renal glomerule is similar to stria vascularis as compared with the tubules. For this reason nephrotoxic drugs, electrolyte imbalances, biochemical, immunological, osmotic and vascular differences may influence on middleinner ear and central pathway. Here, we aimed to evaluate the middle ear mechanism, outer hairy cell function in inner ear and hearing threshold in renal transplant (RT) patients. Methods: From November 1975 to December 2019, we performed 3071 renal transplant procedures in Başkent University. In this prospective study; 30 RT recipients (60 ears; study group) and 30 healthy volunteers (60 ears; control group) were included. All patients underwent audiologic assessment by means of pure-tone audiometry, otoacoustic emission (OAEs) and contralateral suppression TEOAEs (CS-TEOAEs) measurements. Results: Mean follow-up time after RT was 6.8 ± 6.1years (1-20 years). Hearing performance for the four frequency averages between groups was significantly different (p=0.002). When the cochlea outer hairy cells were evaluated, the signal-to-noise ratio was significantly lower at frequencies of 1000 and 1400 Hz between the patient and the control group (p=0.000, p=0.008). When the frequency-specific suppressions were assessed, there was no significantly lower suppression in all frequency in the RT group, but significantly lower suppression was found in all frequencies (for all frequency, p=0000). Conclusion: Our results support the presence of auditory dysfunction in RT recipients. Low levels of OAEs support that RT recipients are prone to cochlear dysfunction. Therefore, audiometric evaluation of patients should be done before and after RT. P-11.154
Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
We investigated the utility of fine-needle aspiration biopsy (FNAB) for head and neck masses, and... more We investigated the utility of fine-needle aspiration biopsy (FNAB) for head and neck masses, and compared FNAB results with histopathologic diagnoses. In a group of 352 patients (168 males, 184 females; mean age 44+/-19 years; range 2 to 94 years) who were operated on for head and neck masses, FNAB was performed in 167 patients (47.4%). The results of FNAB were compared with histopathologic diagnoses in four groups of localization: parotid, thyroid, submandibular gland, and cervical levels. Sensitivity, specificity, positive predictive and negative predictive rates of FNAB were calculated for each group. There were 64 parotid (38.3%), 29 thyroid (17.4%), 19 level V (11.4%), 18 level II (10.8%), 14 level III (8.4%), 9 level I (5.4%), and 7 submandibular gland (4.2%) masses. The overall correlation of FNAB with histopathologic diagnoses was 71.9%, being 76.6% in parotid, 75.9% in thyroid, 57.1% in submandibular gland, and 67.2% in neck (levels I-VI) masses. The highest sensitivity, s...
Uploads