Background and objectiveThe objective of this study is to describe the incidence of hepatic dysfu... more Background and objectiveThe objective of this study is to describe the incidence of hepatic dysfunction (HD) in our hospital and evaluate the possible risk factors associated with HD development as an improvement of the caring process received by patients treated with parenteral nutrition (PN).
The aim of this study was to identify the determinants of a shorter emergency department time (ED... more The aim of this study was to identify the determinants of a shorter emergency department time (EDt) in patients with severe trauma (STPs) admitted to the intensive care unit and determine whether EDt influences mortality. A prospective observational study of STPs (2005-2007) was conducted. With the variables available from the ED, 2 multiple logistic regression models (MLRM) were created: one for the factors associated with EDt less than or equal to median and the other with mortality. A total of 243 patients were included. The mean age was 43 years; 76% were male. The overall mortality rate was 20%. The median EDt was 120 minutes. The independent factors that were associated with the MLRM for an EDt of 120 minutes or less included age less than 60 years, mechanical ventilation, severe traumatic brain injury, and a trauma and injury severity score of 20 or higher. The MLRM for mortality was age greater than 60 years, mechanical ventilation, traumatic brain injury and shock. An EDt of 120 minutes or less was associated with an increased risk of death in the univariate analysis but not in the MLRM. Patients in the ED with indicators of high trauma severity have a reduced EDt but a higher mortality rate. Advanced age increases both mortality and EDt. With the factors included in the model, EDt was not an independent factor for mortality in STPs.
Dermatological problems are not usually related to intensive medicine because they are considered... more Dermatological problems are not usually related to intensive medicine because they are considered to have a low impact on the evolution of critical patients. Despite this, dermatological manifestations (DMs) are relatively frequent in critically ill patients. In rare cases, DMs will be the main diagnosis and will require intensive treatment due to acute skin failure. In contrast, DMs can be a reflection of underlying systemic diseases, and their identification may be key to their diagnosis. On other occasions, DMs are lesions that appear in the evolution of critical patients and are due to factors derived from the stay or intensive treatment. Lastly, DMs can accompany patients and must be taken into account in the comprehensive pathology management. Several factors must be considered when addressing DMs: on the one hand, the moment of appearance, morphology, location, and associated treatment and, on the other hand, aetiopathogenesis and classification of the cutaneous lesion. DMs c...
Background: The present research aimed to evaluate the effect on outcomes of immunonutrition (IMN... more Background: The present research aimed to evaluate the effect on outcomes of immunonutrition (IMN) enteral formulas during the intensive care unit (ICU) stay. Methods: A multicenter prospective observational study was performed. Patient characteristics, disease severity, nutritional status, type of nutritional therapy and outcomes, and laboratory parameters were collected in a database. Statistical differences were analyzed according to the administration of IMN or other types of enteral formulas. Results: In total, 406 patients were included in the analysis, of whom 15.02% (61) received IMN. Univariate analysis showed that patients treated with IMN formulas received higher mean caloric and protein intake, and better 28-day survival (85.2% vs. 73.3%; p = 0.014. Unadjusted Hazard Ratio (HR): 0.15; 95% CI (Confidence Interval): 0.06–0.36; p < 0.001). Once adjusted for confounding factors, multivariate analysis showed a lower need for vasopressor support (OR: 0.49; 95% CI: 0.26–0.91...
Additional file 1: Screenshots of the web application and the list of variables collected in RETR... more Additional file 1: Screenshots of the web application and the list of variables collected in RETRAUCI.
Though circulating antioxidant capacity in plasma is homeostatically regulated, it is not known w... more Though circulating antioxidant capacity in plasma is homeostatically regulated, it is not known whether acute stressors (i.e. trauma) affecting different anatomical locations could have quantitatively different impacts. For this reason, we evaluated the relationship between the anatomical location of trauma and plasma total antioxidant capacity (TAC) in a prospective study, where the anatomical locations of trauma in polytraumatic patients (n = 66) were categorized as primary affecting the brain -traumatic brain injury (TBI)-, thorax, abdomen and pelvis or extremities. We measured the following: plasma TAC by 2 independent methods, the contribution of selected antioxidant molecules (uric acid, bilirubin and albumin) to these values and changes after 1 week of progression. Surprisingly, TBI lowered TAC (919 ± 335 μM Trolox equivalents (TE)) in comparison with other groups (thoracic trauma 1187 ± 270 μM TE; extremities 1025 ± 276 μM TE; p = 0.004). The latter 2 presented higher hypoxi...
Additional file 3: Comparative analysis between temporal and random partitions in the selection o... more Additional file 3: Comparative analysis between temporal and random partitions in the selection of variables and calculated coefficients.
Background and objectiveThe objective of this study is to describe the incidence of hepatic dysfu... more Background and objectiveThe objective of this study is to describe the incidence of hepatic dysfunction (HD) in our hospital and evaluate the possible risk factors associated with HD development as an improvement of the caring process received by patients treated with parenteral nutrition (PN).
The aim of this study was to identify the determinants of a shorter emergency department time (ED... more The aim of this study was to identify the determinants of a shorter emergency department time (EDt) in patients with severe trauma (STPs) admitted to the intensive care unit and determine whether EDt influences mortality. A prospective observational study of STPs (2005-2007) was conducted. With the variables available from the ED, 2 multiple logistic regression models (MLRM) were created: one for the factors associated with EDt less than or equal to median and the other with mortality. A total of 243 patients were included. The mean age was 43 years; 76% were male. The overall mortality rate was 20%. The median EDt was 120 minutes. The independent factors that were associated with the MLRM for an EDt of 120 minutes or less included age less than 60 years, mechanical ventilation, severe traumatic brain injury, and a trauma and injury severity score of 20 or higher. The MLRM for mortality was age greater than 60 years, mechanical ventilation, traumatic brain injury and shock. An EDt of 120 minutes or less was associated with an increased risk of death in the univariate analysis but not in the MLRM. Patients in the ED with indicators of high trauma severity have a reduced EDt but a higher mortality rate. Advanced age increases both mortality and EDt. With the factors included in the model, EDt was not an independent factor for mortality in STPs.
Dermatological problems are not usually related to intensive medicine because they are considered... more Dermatological problems are not usually related to intensive medicine because they are considered to have a low impact on the evolution of critical patients. Despite this, dermatological manifestations (DMs) are relatively frequent in critically ill patients. In rare cases, DMs will be the main diagnosis and will require intensive treatment due to acute skin failure. In contrast, DMs can be a reflection of underlying systemic diseases, and their identification may be key to their diagnosis. On other occasions, DMs are lesions that appear in the evolution of critical patients and are due to factors derived from the stay or intensive treatment. Lastly, DMs can accompany patients and must be taken into account in the comprehensive pathology management. Several factors must be considered when addressing DMs: on the one hand, the moment of appearance, morphology, location, and associated treatment and, on the other hand, aetiopathogenesis and classification of the cutaneous lesion. DMs c...
Background: The present research aimed to evaluate the effect on outcomes of immunonutrition (IMN... more Background: The present research aimed to evaluate the effect on outcomes of immunonutrition (IMN) enteral formulas during the intensive care unit (ICU) stay. Methods: A multicenter prospective observational study was performed. Patient characteristics, disease severity, nutritional status, type of nutritional therapy and outcomes, and laboratory parameters were collected in a database. Statistical differences were analyzed according to the administration of IMN or other types of enteral formulas. Results: In total, 406 patients were included in the analysis, of whom 15.02% (61) received IMN. Univariate analysis showed that patients treated with IMN formulas received higher mean caloric and protein intake, and better 28-day survival (85.2% vs. 73.3%; p = 0.014. Unadjusted Hazard Ratio (HR): 0.15; 95% CI (Confidence Interval): 0.06–0.36; p < 0.001). Once adjusted for confounding factors, multivariate analysis showed a lower need for vasopressor support (OR: 0.49; 95% CI: 0.26–0.91...
Additional file 1: Screenshots of the web application and the list of variables collected in RETR... more Additional file 1: Screenshots of the web application and the list of variables collected in RETRAUCI.
Though circulating antioxidant capacity in plasma is homeostatically regulated, it is not known w... more Though circulating antioxidant capacity in plasma is homeostatically regulated, it is not known whether acute stressors (i.e. trauma) affecting different anatomical locations could have quantitatively different impacts. For this reason, we evaluated the relationship between the anatomical location of trauma and plasma total antioxidant capacity (TAC) in a prospective study, where the anatomical locations of trauma in polytraumatic patients (n = 66) were categorized as primary affecting the brain -traumatic brain injury (TBI)-, thorax, abdomen and pelvis or extremities. We measured the following: plasma TAC by 2 independent methods, the contribution of selected antioxidant molecules (uric acid, bilirubin and albumin) to these values and changes after 1 week of progression. Surprisingly, TBI lowered TAC (919 ± 335 μM Trolox equivalents (TE)) in comparison with other groups (thoracic trauma 1187 ± 270 μM TE; extremities 1025 ± 276 μM TE; p = 0.004). The latter 2 presented higher hypoxi...
Additional file 3: Comparative analysis between temporal and random partitions in the selection o... more Additional file 3: Comparative analysis between temporal and random partitions in the selection of variables and calculated coefficients.
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