AIM The aim of this study was to create an alternative synthetic dural graft using a parenteral s... more AIM The aim of this study was to create an alternative synthetic dural graft using a parenteral solution bag made of polyvinyl chloride/polypropylene (PVC/PP). MATERIAL AND METHODS Twenty-two albino rats were divided into the Sham, DC and BAG groups. Except for the Sham group animals, the right parietal bone of the rats was totally drilled in a diameter of 1.0 x 0.5 mm. Then, the PVC/PP BAG was layered over the craniectomized bone of the BAG group animals. Thirty days later, all animals were sacrificed, and inflammatory processes consisting of polymorphonuclear cell infiltration, inflammation, edema, hyperemia, lymphocytosis, histiocytosis, vascular proliferation, and fibrosis were graded at the craniectomy site. RESULTS The grade values of inflammation, edema, histiocytosis, and fibrosis were found different among the groups (p 0.017). It was observed that placing a synthetic graft to the surgical site undergoing craniectomy could prevent fibrotic adhesions that might occur between the brain tissue and scalp in the chronic period. Furthermore, it was considered that this synthetic material did not increase inflammatory processes secondary to surgery at the surgical site and did not produce a foreign body reaction, toxicity, or infection. CONCLUSION As a result of this study, it was argued that the synthetic material used in this study could be compatible with dermal and neural tissues and reduce adhesions at the craniectomy field. Therefore, it was considered that this material could be used as an alternative synthetic dural graft in decompressive craniectomy in human subjects after detailed toxicity studies.
Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, Apr 30, 2019
Boyun fleksiyonu ile ekstremitelere ve gövdeye yayılan elektriklenme hissi Lhermitte bulgusu olar... more Boyun fleksiyonu ile ekstremitelere ve gövdeye yayılan elektriklenme hissi Lhermitte bulgusu olarak tanımlanmaktadır ve spinal kordun servikal bölgede etkilenmiş olabileceğini düşündürmektedir. Altmış dokuz yaşında erkek hastaya servikal spinal stenoz ve myelopati nedeniyle yapılan C3-4-5 unilateral hemilaminektomi bilateral dekompresyon sonrası 12. saatte hastanı kollara ve bacaklara yayılan elektriklenme hissi tariflemesi üzerine yapılan servikal manyetik rezonans görüntülemesinde operasyon bölgesinde hematom görülmesi üzerine tekrar operasyona alındı. Hematom boşaltılmasını takiben bu bulgu kayboldu. Lhermitte bulgusunun görüldüğü klinik durumlar çok çeşitli olabilmektedir. Servikal kordun posterior kısımlarındaki demiyelinizasyon sonucu ortaya çıktığı düşünülür. Sensitif bir bulgu olmamasına rağmen servikal kompresif myelopati için spesifitesi yüksektir. Operasyon sonrası Lhermitte bulgusunun görülmesi kord kompresyonuna işaret edebileceğinden dikkatli olunmalı ve ileri tetkikler düşünülmelidir.
Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, Aug 31, 2019
Objective: In the current literature, there are few accepted pharmacological treatment methods fo... more Objective: In the current literature, there are few accepted pharmacological treatment methods for acute ischemic stroke. This study was conducted to investigate the effects of progesterone on transient ischemia / reperfusion injury in male rats.Material and Methods: A total of 25 Wistar albino male and young rats were divided into 5 groups called Control group, acute stage groups (Sham-A and PRG-A), and chronic stage groups (Sham-C and PRG-C), randomly and their internal carotid arteries were compressed using temporary aneurysm clips for 30 minutes. At 4 hours after removal of the clips, progesterone was injected to the animals of the PRG-A and PRG-C group via intraperitoneal route. After sacrifice of all animals, pyknotic and necrotic neuronal cells were counted in hippocampal cornu amnonis (CA)1, CA2, CA3 and parietal cortical regions, histopathologically. Tissue interleukin (IL)-6, IL-10, caspase-3, and hypoxia-inducible factor-1 (HIF1) gene expression levels were evaluated using real time polymerase chain reaction assay.Results: Histopathological and biochemical findings revealed that progesterone has no healing effects on ischaemic neuronal tissue damage in either acute or chronic period. Moreover, progesterone was found to significantly increase symptoms of ischaemia in both acute and chronic periods compared to healthy control group and even compared to Sham groups where I/R injury was applied and no experimental agent was administered.Conclusion: At the end of this study, it was thought that progesterone had no therapeutic effect on cerebral ischemia / reperfusion injury in male sex rats and it could lead to increase it further, unfortunately.
Journal of health sciences and medicine, Sep 22, 2019
Akut travmatik subdural hematom nöroşirurji pratiğinde travma sonrası hastalarda görülen önemli b... more Akut travmatik subdural hematom nöroşirurji pratiğinde travma sonrası hastalarda görülen önemli bir morbitide ve mortalite sebebidir. Nörolojik kusur varlığında, acil cerrahi tedavi düşünülmelidir. Diğer yandan nörolojik tablonun daha iyi olduğu, dikkatli seçilmiş bazı hastalarda ise cerrahi girişim her zaman gerekmeyebilir. Yakın takip ile akut travmatik subdural hematomlarda spontan hızlı rezolüsyonun olabileceği bildirilmiştir. Boks müsabakasında yüzüne aldığı darbe sonrası akut travmatik subdural hematom tanısı konan hastanın 20. saat kontrol tomografisinde subdural hematomun tamamen gerilediği görüldü. Akut travmatik subdural hematomun hızlı rezolüsyonu için literatürde çeşitli mekanizmalar ve prediktif bulgular öne sürülmüştür fakat patofizyolojiyi açıklamada ileri çalışmalara ihtiyaç duyulmaktadır.
AIM The aim of this study was to create an alternative synthetic dural graft using a parenteral s... more AIM The aim of this study was to create an alternative synthetic dural graft using a parenteral solution bag made of polyvinyl chloride/polypropylene (PVC/PP). MATERIAL AND METHODS Twenty-two albino rats were divided into the Sham, DC and BAG groups. Except for the Sham group animals, the right parietal bone of the rats was totally drilled in a diameter of 1.0 x 0.5 mm. Then, the PVC/PP BAG was layered over the craniectomized bone of the BAG group animals. Thirty days later, all animals were sacrificed, and inflammatory processes consisting of polymorphonuclear cell infiltration, inflammation, edema, hyperemia, lymphocytosis, histiocytosis, vascular proliferation, and fibrosis were graded at the craniectomy site. RESULTS The grade values of inflammation, edema, histiocytosis, and fibrosis were found different among the groups (p 0.017). It was observed that placing a synthetic graft to the surgical site undergoing craniectomy could prevent fibrotic adhesions that might occur between the brain tissue and scalp in the chronic period. Furthermore, it was considered that this synthetic material did not increase inflammatory processes secondary to surgery at the surgical site and did not produce a foreign body reaction, toxicity, or infection. CONCLUSION As a result of this study, it was argued that the synthetic material used in this study could be compatible with dermal and neural tissues and reduce adhesions at the craniectomy field. Therefore, it was considered that this material could be used as an alternative synthetic dural graft in decompressive craniectomy in human subjects after detailed toxicity studies.
Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, Apr 30, 2019
Boyun fleksiyonu ile ekstremitelere ve gövdeye yayılan elektriklenme hissi Lhermitte bulgusu olar... more Boyun fleksiyonu ile ekstremitelere ve gövdeye yayılan elektriklenme hissi Lhermitte bulgusu olarak tanımlanmaktadır ve spinal kordun servikal bölgede etkilenmiş olabileceğini düşündürmektedir. Altmış dokuz yaşında erkek hastaya servikal spinal stenoz ve myelopati nedeniyle yapılan C3-4-5 unilateral hemilaminektomi bilateral dekompresyon sonrası 12. saatte hastanı kollara ve bacaklara yayılan elektriklenme hissi tariflemesi üzerine yapılan servikal manyetik rezonans görüntülemesinde operasyon bölgesinde hematom görülmesi üzerine tekrar operasyona alındı. Hematom boşaltılmasını takiben bu bulgu kayboldu. Lhermitte bulgusunun görüldüğü klinik durumlar çok çeşitli olabilmektedir. Servikal kordun posterior kısımlarındaki demiyelinizasyon sonucu ortaya çıktığı düşünülür. Sensitif bir bulgu olmamasına rağmen servikal kompresif myelopati için spesifitesi yüksektir. Operasyon sonrası Lhermitte bulgusunun görülmesi kord kompresyonuna işaret edebileceğinden dikkatli olunmalı ve ileri tetkikler düşünülmelidir.
Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, Aug 31, 2019
Objective: In the current literature, there are few accepted pharmacological treatment methods fo... more Objective: In the current literature, there are few accepted pharmacological treatment methods for acute ischemic stroke. This study was conducted to investigate the effects of progesterone on transient ischemia / reperfusion injury in male rats.Material and Methods: A total of 25 Wistar albino male and young rats were divided into 5 groups called Control group, acute stage groups (Sham-A and PRG-A), and chronic stage groups (Sham-C and PRG-C), randomly and their internal carotid arteries were compressed using temporary aneurysm clips for 30 minutes. At 4 hours after removal of the clips, progesterone was injected to the animals of the PRG-A and PRG-C group via intraperitoneal route. After sacrifice of all animals, pyknotic and necrotic neuronal cells were counted in hippocampal cornu amnonis (CA)1, CA2, CA3 and parietal cortical regions, histopathologically. Tissue interleukin (IL)-6, IL-10, caspase-3, and hypoxia-inducible factor-1 (HIF1) gene expression levels were evaluated using real time polymerase chain reaction assay.Results: Histopathological and biochemical findings revealed that progesterone has no healing effects on ischaemic neuronal tissue damage in either acute or chronic period. Moreover, progesterone was found to significantly increase symptoms of ischaemia in both acute and chronic periods compared to healthy control group and even compared to Sham groups where I/R injury was applied and no experimental agent was administered.Conclusion: At the end of this study, it was thought that progesterone had no therapeutic effect on cerebral ischemia / reperfusion injury in male sex rats and it could lead to increase it further, unfortunately.
Journal of health sciences and medicine, Sep 22, 2019
Akut travmatik subdural hematom nöroşirurji pratiğinde travma sonrası hastalarda görülen önemli b... more Akut travmatik subdural hematom nöroşirurji pratiğinde travma sonrası hastalarda görülen önemli bir morbitide ve mortalite sebebidir. Nörolojik kusur varlığında, acil cerrahi tedavi düşünülmelidir. Diğer yandan nörolojik tablonun daha iyi olduğu, dikkatli seçilmiş bazı hastalarda ise cerrahi girişim her zaman gerekmeyebilir. Yakın takip ile akut travmatik subdural hematomlarda spontan hızlı rezolüsyonun olabileceği bildirilmiştir. Boks müsabakasında yüzüne aldığı darbe sonrası akut travmatik subdural hematom tanısı konan hastanın 20. saat kontrol tomografisinde subdural hematomun tamamen gerilediği görüldü. Akut travmatik subdural hematomun hızlı rezolüsyonu için literatürde çeşitli mekanizmalar ve prediktif bulgular öne sürülmüştür fakat patofizyolojiyi açıklamada ileri çalışmalara ihtiyaç duyulmaktadır.
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