Het dimensionele dynamische stress-kwetsbaarheidsmodel (hoofdstuk 1, Inleiding) laat zien dat str... more Het dimensionele dynamische stress-kwetsbaarheidsmodel (hoofdstuk 1, Inleiding) laat zien dat stress of last ervaren van bepaalde zaken varieert in ernst, frequentie en impact. De grootte en de snelheid van de variatie in ernst, frequentie en impact wordt bepaald door de dynamiek tussen externe stimuli (prikkels), de betekenisverlening aan die stimuli en de – daaruit voorkomende – stress of ervaren last.
Ook dit hoofdstuk gaat over zorg. Meer specifiek over de organisatie van zorg. Een inkijkje in de... more Ook dit hoofdstuk gaat over zorg. Meer specifiek over de organisatie van zorg. Een inkijkje in de organisatiekunde is daartoe onontbeerlijk. De lezer zal merken dat het loont om daar iets van te begrijpen. Want een goede of slechte organisatie van zorg heeft een enorme impact op de kwaliteit van zorg.
BackgroundAlcohol consumption, smoking and mood disorders are leading contributors to the global ... more BackgroundAlcohol consumption, smoking and mood disorders are leading contributors to the global burden of disease and are highly comorbid. Yet, their interrelationships have remained elusive. The aim of this study was to examine the multi-cross-sectional and longitudinal associations between (change in) smoking and alcohol use and (change in) number of depressive symptoms.MethodsIn this prospective, longitudinal study, 6646 adults from the general population were included with follow-up measurements after 3 and 6 years. Linear mixed-effects models were used to test multi-cross-sectional and longitudinal associations, with smoking behaviour, alcohol use and genetic risk scores for smoking and alcohol use as independent variables and depressive symptoms as dependent variables.ResultsIn the multi-cross-sectional analysis, smoking status and number of cigarettes per day were positively associated with depressive symptoms (p < 0.001). Moderate drinking was associated with less sympto...
Background In recent years, antipsychotic-induced weight gain (AIWG) has gained more attention in... more Background In recent years, antipsychotic-induced weight gain (AIWG) has gained more attention in research. Although interventions to prevent weight gain are currently being investigated, AIWG remains a major problem for both patients and clinicians and often results in poor treatment adherence, a decrease in quality of life. Furthermore, schizophrenia is associated with higher mortality rates and a decreased life expectancy. Recently, some new antipsychotic drugs have been introduced that are hypothesised to entail no or low incidences of clinically relevant weight gain (CRWG), and high incidences of clinically relevant weight loss (CRWL). Here ‘clinically relevant’ is defined as >7% weight change. In this meta-analysis, we aim to give a complete overview of both CRWG and CRWL, including these newer antipsychotics. Methods We searched Pubmed, Embase and Psychinfo for randomized clinical trials of antipsychotics that reported 7% weight change in study populations aged 18 years or...
Het dimensionele dynamische stress-kwetsbaarheidsmodel (hoofdstuk 1, Inleiding) laat zien dat str... more Het dimensionele dynamische stress-kwetsbaarheidsmodel (hoofdstuk 1, Inleiding) laat zien dat stress of last ervaren van bepaalde zaken varieert in ernst, frequentie en impact. De grootte en de snelheid van de variatie in ernst, frequentie en impact wordt bepaald door de dynamiek tussen externe stimuli (prikkels), de betekenisverlening aan die stimuli en de – daaruit voorkomende – stress of ervaren last.
Ook dit hoofdstuk gaat over zorg. Meer specifiek over de organisatie van zorg. Een inkijkje in de... more Ook dit hoofdstuk gaat over zorg. Meer specifiek over de organisatie van zorg. Een inkijkje in de organisatiekunde is daartoe onontbeerlijk. De lezer zal merken dat het loont om daar iets van te begrijpen. Want een goede of slechte organisatie van zorg heeft een enorme impact op de kwaliteit van zorg.
BackgroundAlcohol consumption, smoking and mood disorders are leading contributors to the global ... more BackgroundAlcohol consumption, smoking and mood disorders are leading contributors to the global burden of disease and are highly comorbid. Yet, their interrelationships have remained elusive. The aim of this study was to examine the multi-cross-sectional and longitudinal associations between (change in) smoking and alcohol use and (change in) number of depressive symptoms.MethodsIn this prospective, longitudinal study, 6646 adults from the general population were included with follow-up measurements after 3 and 6 years. Linear mixed-effects models were used to test multi-cross-sectional and longitudinal associations, with smoking behaviour, alcohol use and genetic risk scores for smoking and alcohol use as independent variables and depressive symptoms as dependent variables.ResultsIn the multi-cross-sectional analysis, smoking status and number of cigarettes per day were positively associated with depressive symptoms (p < 0.001). Moderate drinking was associated with less sympto...
Background In recent years, antipsychotic-induced weight gain (AIWG) has gained more attention in... more Background In recent years, antipsychotic-induced weight gain (AIWG) has gained more attention in research. Although interventions to prevent weight gain are currently being investigated, AIWG remains a major problem for both patients and clinicians and often results in poor treatment adherence, a decrease in quality of life. Furthermore, schizophrenia is associated with higher mortality rates and a decreased life expectancy. Recently, some new antipsychotic drugs have been introduced that are hypothesised to entail no or low incidences of clinically relevant weight gain (CRWG), and high incidences of clinically relevant weight loss (CRWL). Here ‘clinically relevant’ is defined as >7% weight change. In this meta-analysis, we aim to give a complete overview of both CRWG and CRWL, including these newer antipsychotics. Methods We searched Pubmed, Embase and Psychinfo for randomized clinical trials of antipsychotics that reported 7% weight change in study populations aged 18 years or...
Uploads