Detection of hepatocellular damage. By - Maarten FCM Knapen, Eric AP Steegers, Theo PJ Mulder, Wi... more Detection of hepatocellular damage. By - Maarten FCM Knapen, Eric AP Steegers, Theo PJ Mulder, Wilbert HM Peters.
Detection of hepatocellular damage. By - Maarten FCM Knapen, Eric AP Steegers, Theo PJ Mulder, Wi... more Detection of hepatocellular damage. By - Maarten FCM Knapen, Eric AP Steegers, Theo PJ Mulder, Wilbert HM Peters.
... 5. AM Gülmezoglu, MMJ Oosthuizen and GJ Hofmeyr, Placental malondialdehyde and glutathione le... more ... 5. AM Gülmezoglu, MMJ Oosthuizen and GJ Hofmeyr, Placental malondialdehyde and glutathione levels in a controlled trial of antioxidant treatment in ... 9. CA Hubel, JM Roberts, RN Taylor, TJ Musci, GM Rodgers and MK McLaughlin, Lipid peroxidation in pregnancy: new ...
OBJECTIVE To investigate the value of plasma glutathione S-transferase Pi1-1(GSTP1-1) measurement... more OBJECTIVE To investigate the value of plasma glutathione S-transferase Pi1-1(GSTP1-1) measurements in the assessment of hemolysis in hypertensive disorders of pregnancy. METHODS Plasma GSTP1-1 and haptoglobin levels and serum lactate dehydrogenase (LDH) activity were measured in 81 healthy nonpregnant female blood donors between 20 and 40 years of age, 41 women during uncomplicated normotensive pregnancy, 35 women with pregnancy-induced hypertension, 67 women with preeclampsia, and 34 women with the HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome. Levels in hypertensive pregnancies were compared to levels in normotensive pregnancy, and levels in normotensive pregnancy were compared to levels in blood donors by the Mann-Whitney U-test. RESULTS Median GSTP1-1 and LDH levels were significantly increased (p < 0.01) and haptoglobin significantly decreased (p < 0.01) in preeclampsia and the HELLP syndrome as compared to normotensive pregnancy. Both GSTP1-1 and LDH levels were significantly higher in normotensive pregnant women as compared to nonpregnant women (p < 0.0001). The percentage of preeclamptic patients (26.9%) or patients with the HELLP syndrome (73.5%) with elevated GSTP1-1 levels was lower than those with elevated LDH (38.8% and 100%, respectively) or decreased haptoglobin levels (41.8% and 97%, respectively). CONCLUSIONS We conclude that plasma GSTP1-1 levels may provide useful information on hemolysis in hypertensive disorders of pregnancy in addition to serum LDH activity and plasma haptoglobin levels and that the degree of hemolysis in hypertensive disorders of pregnancy, especially in the HELLP syndrome, is probably less prominent than generally assumed.
ObjectiveTo report uptake of genetic counseling (GC) and prenatal genetic testing after the findi... more ObjectiveTo report uptake of genetic counseling (GC) and prenatal genetic testing after the finding of atypical genitalia on prenatal ultrasound (US) and the clinical and genetic findings of these pregnancies.MethodsA retrospective cohort study (2017–2019) of atypical fetal genitalia in a large expert center for disorders/differences of sex development. We describe counseling aspects, invasive prenatal testing, genetic and clinical outcome of fetuses apparently without [group 1, n = 22 (38%)] or with [group 2, n = 36 (62%)] additional anomalies on US.ResultsIn group 1, 86% of parents opted for GC versus 72% in group 2, and respectively 58% and 15% of these parents refrained from invasive testing. Atypical genitalia were postnatally confirmed in 91% (group 1) and 64% (group 2), indicating a high rate of false positive US diagnosis of ambiguous genitalia. Four genetic diagnoses were established in group 1 (18%) and 10 in group 2 (28%). The total genetic diagnostic yield was 24%. No te...
Detection of hepatocellular damage. By - Maarten FCM Knapen, Eric AP Steegers, Theo PJ Mulder, Wi... more Detection of hepatocellular damage. By - Maarten FCM Knapen, Eric AP Steegers, Theo PJ Mulder, Wilbert HM Peters.
Detection of hepatocellular damage. By - Maarten FCM Knapen, Eric AP Steegers, Theo PJ Mulder, Wi... more Detection of hepatocellular damage. By - Maarten FCM Knapen, Eric AP Steegers, Theo PJ Mulder, Wilbert HM Peters.
... 5. AM Gülmezoglu, MMJ Oosthuizen and GJ Hofmeyr, Placental malondialdehyde and glutathione le... more ... 5. AM Gülmezoglu, MMJ Oosthuizen and GJ Hofmeyr, Placental malondialdehyde and glutathione levels in a controlled trial of antioxidant treatment in ... 9. CA Hubel, JM Roberts, RN Taylor, TJ Musci, GM Rodgers and MK McLaughlin, Lipid peroxidation in pregnancy: new ...
OBJECTIVE To investigate the value of plasma glutathione S-transferase Pi1-1(GSTP1-1) measurement... more OBJECTIVE To investigate the value of plasma glutathione S-transferase Pi1-1(GSTP1-1) measurements in the assessment of hemolysis in hypertensive disorders of pregnancy. METHODS Plasma GSTP1-1 and haptoglobin levels and serum lactate dehydrogenase (LDH) activity were measured in 81 healthy nonpregnant female blood donors between 20 and 40 years of age, 41 women during uncomplicated normotensive pregnancy, 35 women with pregnancy-induced hypertension, 67 women with preeclampsia, and 34 women with the HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome. Levels in hypertensive pregnancies were compared to levels in normotensive pregnancy, and levels in normotensive pregnancy were compared to levels in blood donors by the Mann-Whitney U-test. RESULTS Median GSTP1-1 and LDH levels were significantly increased (p < 0.01) and haptoglobin significantly decreased (p < 0.01) in preeclampsia and the HELLP syndrome as compared to normotensive pregnancy. Both GSTP1-1 and LDH levels were significantly higher in normotensive pregnant women as compared to nonpregnant women (p < 0.0001). The percentage of preeclamptic patients (26.9%) or patients with the HELLP syndrome (73.5%) with elevated GSTP1-1 levels was lower than those with elevated LDH (38.8% and 100%, respectively) or decreased haptoglobin levels (41.8% and 97%, respectively). CONCLUSIONS We conclude that plasma GSTP1-1 levels may provide useful information on hemolysis in hypertensive disorders of pregnancy in addition to serum LDH activity and plasma haptoglobin levels and that the degree of hemolysis in hypertensive disorders of pregnancy, especially in the HELLP syndrome, is probably less prominent than generally assumed.
ObjectiveTo report uptake of genetic counseling (GC) and prenatal genetic testing after the findi... more ObjectiveTo report uptake of genetic counseling (GC) and prenatal genetic testing after the finding of atypical genitalia on prenatal ultrasound (US) and the clinical and genetic findings of these pregnancies.MethodsA retrospective cohort study (2017–2019) of atypical fetal genitalia in a large expert center for disorders/differences of sex development. We describe counseling aspects, invasive prenatal testing, genetic and clinical outcome of fetuses apparently without [group 1, n = 22 (38%)] or with [group 2, n = 36 (62%)] additional anomalies on US.ResultsIn group 1, 86% of parents opted for GC versus 72% in group 2, and respectively 58% and 15% of these parents refrained from invasive testing. Atypical genitalia were postnatally confirmed in 91% (group 1) and 64% (group 2), indicating a high rate of false positive US diagnosis of ambiguous genitalia. Four genetic diagnoses were established in group 1 (18%) and 10 in group 2 (28%). The total genetic diagnostic yield was 24%. No te...
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