Objectives Abha Guggulu (AG) is a traditional Ayurvedic herbal formulation used for treating join... more Objectives Abha Guggulu (AG) is a traditional Ayurvedic herbal formulation used for treating joint disorders and bone fractures. Individually, the ingredients are known for their promising anti-inflammatory and rejuvenating actions. The present study attempts to explore the anti–arthritic potential of AG through an exploratory clinical trial. Methods The study was conducted using a quasi-experimental model. The clinical trial has been registered in Clinical Trials Registry of India (registration number: CTRI/2019/09/021354). Osteoarthritis patients of both genders (n=12, 40–70 years age group), meeting the inclusion/exclusion criteria, were recruited in the single arm study. AG was administered in tablet form in a dose of 1.5 g, twice daily. The WOMAC score was used as a primary outcome measure. The WOMAC scale of patients was recorded on 0th, 15th and 30th days of treatment. Results At the end of treatment, there was a significant difference in the scores of the outcome measure. As...
The market at present is flooded with a variety of analgesics to provide a patient with relief. A... more The market at present is flooded with a variety of analgesics to provide a patient with relief. Almost all the analgesic drugs are liable to have untoward effects on our body. Pain in the joints may not necessarily be fatal but it sure does cripple the life of the patients. Hence it is the need of the hour to provide mankind with near perfect solution to the joint pain which they suffer. The article enlists most of the herbal analgesics which are useful in treating joint pain and inflammation. It also highlights upon the issue of the side effects caused by modern analgesics. Article will help the reader to understand the role of herbal analgesics and thereby promote further research on the scope and usage of herbal medicines.
Gastropanel, serological ELISA test comprising of stomach biomarkers; serum pepsinogen I, pepsino... more Gastropanel, serological ELISA test comprising of stomach biomarkers; serum pepsinogen I, pepsinogen II, gastrin-17, and Helicobacter pylori antibody depicts clearly the morphological and functional status of stomach mucosa in patients suffering from dyspepsia. Although the traditional system of medicine is a huge resource of efficient formulations useful in gastrointestinal disorders such as functional dyspepsia, lack of robust scientific evidence, and qualitative/subjective parameters like symptom scores do not suffice the need for the same. This study was thus planned to assess usefulness of gastropanel tests to validate efficacy of Avipattikar choorna, well-known antacid remedy in functional dyspepsia. A. choorna was given to patients of dyspeptic disorders following which gastropanel was performed pre- and post-treatment. The gastropanel findings obtained, prior and post-interventions were compared using Wilcoxon MPSR test and a level of P < 0.05 was considered for statistic...
Objective: To find the efficacy of Shiva gutika with Saraswatarishta in management of Age Associa... more Objective: To find the efficacy of Shiva gutika with Saraswatarishta in management of Age Associated Mild Cognitive Impairment (AAMCI). To review the literature of mild cognitive impairment, Jara, and aging as per modern science and Ayurveda. To observe side effects of the drug if any. To access effect of drug on other signs and symptoms of Jara.
CONTEXT: Acid peptic disorders. AIMS: This study aimed to assess the efficacy and acceptability o... more CONTEXT: Acid peptic disorders. AIMS: This study aimed to assess the efficacy and acceptability of pomegranate effervescent granules (PEGs) in dyspeptic patients. SETTINGS AND DESIGN: It was a single-arm, open-labeled prospective multicentric clinical study, done at 3 centers: Vishwanand Kendra, Pune; Bharati Ayurved Hospital, Bharati Vidyapeeth, Pune, and M. A. Podar Medical Ayurved Hospital, Mumbai. The co-ordinating site was Interactive Research School for Health Affairs, Bharati Vidyapeeth, Pune. MATERIALS AND METHODS: The granules, prepared from peel extract of pomegranate, were made available in sachets of 2.5 g with dose of, 1 sachet dissolved in 200 ml (1 cup) of water, twice a day after meals for 28 days. Gastrointestinal Symptom Rating Scale (GSRS) scores to assess symptoms of acid peptic disorders at day 0, 15, and 29 along with the taste of formulation were the main study outcomes. STATISTICAL ANALYSIS USED: Parametric data, presented as mean ± standard deviation, were analyzed using paired t-test, while nonparametric data presented as median (range) was analyzed using Wilcoxon rank-sum test. Categorical data were analyzed using Chi-square test. RESULTS: The median GSRS score reduced from 14 on day 0–10 and then 5 on day 15 and day 29, respectively, with statistical significance. The formulation was found to taste good by ~80% of patients, while ~20% reported it to be palatable and none found it to be bad in taste. CONCLUSION: PEGs proved to be palatable, patient-friendly, safe, and efficacious in resolving symptoms of dyspepsia in acid peptic disorders. CTRI Registration: The trial was registered retrospectively in the Clinical Registry of India [CTRI/2017/07/008999].
Irritable bowel syndrome (IBS) is a gastrointestinal disorder in which there is functional derang... more Irritable bowel syndrome (IBS) is a gastrointestinal disorder in which there is functional derangement of the gastrointestinal tract without any organic cause. IBS is characterized by a group of symptoms such as abdominal pain, discomfort and a change in bowel habits. The presently available treatment modalities include anti diarrheal, antispasmodics and antidepressants with limited benefits. This calls for the need to explore effective treatment modalities. Herbal medicines have proved efficacious in the treatment of gastrointestinal disorders since ancient time. Herewith we report a case series of patients suffering with IBS-D (diarrhea) type treated with Cap Ibomic a proprietary herbal formulation manufactured by Shree Baidyanath Ayurveda Bhavan for the treatment of IBS. We observed that there was a decrease in median scores of the symptoms such as abdominal pain, discomfort, bloating, stress and fatigue. There was a decrease in the mean frequency of motions per day and improveme...
Aging is a progressive generalized impairment of functions resulting in the loss of adaptive resp... more Aging is a progressive generalized impairment of functions resulting in the loss of adaptive response to stress and increasing risk of age related diseases. Though aging doesn’t spare anybody one can make it less apprehensive. The man with the empowerment of knowledge and resources had always a quest for immortality and youthfulness. This leads his Endeavour to search a tool which could protect him from aging or at least minimizing the effect of aging. Rasayan is the tool for it. One of the critical areas that need to be addressed is concerned with neuro-psychological health. Neurodegenerative diseases are characterized by progressive impairment of brain functions in brain aging. Objective of the work is to understand how ageing changes takes place in brain and how to regulate, retard these changes.Vata, Pitta, Rasa, Rakta,Majja,Ojus and Beejabhagaavayava are the influencing factors for brain aging. Decreased cognition, intellect,vision, enthusiasm, wisdom are the signs of brain ag...
International Journal of Ayurveda and Pharma Research, 2015
It is since the Vedic era that the use of natural substances for medicine has been used. Ayurveda... more It is since the Vedic era that the use of natural substances for medicine has been used. Ayurveda , the ancient Indian science gives a detailed explanation of these uses. Medicated milk i.e., Siddha ksheera has a high and prominent medicinal value. This article encloses all the various formulations of medicated milk along with their role in diseases contents of the medicated milk as per Acharya Charak. Ksheerpaka are supposed to nourish tissues and have more anabolic effects. An effort has been made to compile and represent for a better and easy understanding of various Siddha ksheer yogas mentioned in Charaka samhita . Use of Ksheer is highly recommended in certain Vyadhis like Pandu , Amlapitta , Gulma , Udara roga , Yoni roga , Shukra roga, Vata roga , etc. Ksheerpaka i.e. milk used in the medicated form is the unique feature of Ayurveda. Nowadays, for Ksheerpaka preparation, method stated by Sharangadhara is generally followed. Role of Siddha ksheer in various Vyadhis like Jwara...
Ageing means growing old, maturing, progressive changes related to the passage of time. .Memory c... more Ageing means growing old, maturing, progressive changes related to the passage of time. .Memory complaints are ubiquitous in our aging population. Mild cognitive impairment (MCI) is considered by many as an intermediary stage for dementia. Many older adults fear that today’s forgetfulness will usher in tomorrow’s dementia. It is characterized by deterioration of memory, attention, and cognitive function that is beyond what is expected based on age and educational level. MCI does not interfere significantly with individuals’ daily activities. It may act as a transitional level of evolving dementia with a range of conversion of 10%–15% per year. The preventive interventions and appropriate treatments should improve cognitive performance, and retard or prevent progressive deficits. The avoidance of toxins, reduction of stress, prevention of somatic diseases, implementation of mental and physical exercises, as well as the use of dietary compounds like antioxidants and supplements can be...
Objective: To find the efficacy of Shiva gutika with Saraswatarishta in management of Age Associa... more Objective: To find the efficacy of Shiva gutika with Saraswatarishta in management of Age Associated Mild Cognitive Impairment (AAMCI). To review the literature of mild cognitive impairment, Jara , and aging as per modern science and Ayurveda . To observe side effects of the drug if any. To access effect of drug on other signs and symptoms of Jara . Method: Open Trial study was conducted on 25 patients having AAMCI and were selected for the study randomly. The patients received 1gm Shiva gutika once a day with 40ml Saraswatarista as Anupan for 3 months. Assessment Criteria: Improvement in all the six cerebral higher functions on the basis of various tests such as MMSE, CAMCOG (CAMDEX), ADL/IADL, GDS. Follow up: 0, 15th, 30th, 45th, 60th, 75th, 90th day. Duration: Total duration study was 90 Days. This study was carried out in Bharati Vidyapeeth Deemed University College of Ayurved & Hospital Pune in Year 2010 and 2011. Results: Comparing all the symptoms before and after treatment h...
The market at present is flooded with a variety of anti-diabetic drugs to provide diabetic patien... more The market at present is flooded with a variety of anti-diabetic drugs to provide diabetic patients with relief. Almost all the anti-diabetic drugs are liable to have untoward effects on our body. Iit is the need of the hour to provide mankind with near perfect solution to patients suffering from diabetes. The article enlists the action of the herbal drug haridra on type 2 diabetes. It also highlights upon the issue of the side effects caused by modern antidiabetic drugs. Article will help the reader to understand the role of haridra on type 2 diabetes and thereby promote further research on the scope and usage of herbal medicines and haridra in particular.
In order to understand the concept of ayurvedic musculoskeletal diseases one should first underst... more In order to understand the concept of ayurvedic musculoskeletal diseases one should first understand the rachanatmak and kriyatmak aspect of the sandhi. Likewise multiple references regarding musculoskeletal diseases have been found in our ancient classical texts. The article encompasses all the references from the classical text Charak samhita regarding shoola and shotha of any joint, sandhi. The related signs and symptoms and condition or stages in which they occur have also been mentioned. No satisfactory results have been made till date in the light of curing or atleast providing relief rather giving analgesic i.e. pain relieving treatment has been made. An effort has been made to guide all keen readers to first understand and to arrive at the proper diagnosis of a patient of MSD. Thorough knowledge of differential diagnosis is the key to conclusive diagnosis.
In order to understand any skin disease. (twacharoga) a detailed study of the structure and funct... more In order to understand any skin disease. (twacharoga) a detailed study of the structure and function of skin is necessary. The conceptual aspect of skin needs to be understood because skin disorder is outer exhibition of some kind of internal pathology. No satisfactory results have been made till date in the aspect of curing skin disease (twacharoga). The ancient science of life Ayurveda provides valuable information regarding various herbs which are useful in curing various skin ailments.
Immunity has become an important aspect of concern, as the spread of corona virus, is on the rise... more Immunity has become an important aspect of concern, as the spread of corona virus, is on the rise. The strategies to boost and modulate the immunity have therefore become need of the hour. The present study was carried out to evaluate the effect of Charak immunity Tablets (CIT) on innate and adaptive immune response in healthy individuals. It was a single-blind, randomized, placebo-controlled, exploratory study. After obtaining Ethics Committee permission, 36 healthy individuals of either sex aged 18-35 years with prior consent were recruited in the study. They were randomly divided into 2 groups to receive either CIT or Placebo in 2:1 ratio. Both the interventions were given in a dose of 1 tab (500 mg) twice daily. The assessment variables were vitals [temperature, pulse, and blood pressure], respiratory health [respiratory rate, oxygen saturation and peak expiratory flow rate], questionnaire based assessment of immune status, perceived stress and quality of life along with objecti...
Objectives Abha Guggulu (AG) is a traditional Ayurvedic herbal formulation used for treating join... more Objectives Abha Guggulu (AG) is a traditional Ayurvedic herbal formulation used for treating joint disorders and bone fractures. Individually, the ingredients are known for their promising anti-inflammatory and rejuvenating actions. The present study attempts to explore the anti–arthritic potential of AG through an exploratory clinical trial. Methods The study was conducted using a quasi-experimental model. The clinical trial has been registered in Clinical Trials Registry of India (registration number: CTRI/2019/09/021354). Osteoarthritis patients of both genders (n=12, 40–70 years age group), meeting the inclusion/exclusion criteria, were recruited in the single arm study. AG was administered in tablet form in a dose of 1.5 g, twice daily. The WOMAC score was used as a primary outcome measure. The WOMAC scale of patients was recorded on 0th, 15th and 30th days of treatment. Results At the end of treatment, there was a significant difference in the scores of the outcome measure. As...
The market at present is flooded with a variety of analgesics to provide a patient with relief. A... more The market at present is flooded with a variety of analgesics to provide a patient with relief. Almost all the analgesic drugs are liable to have untoward effects on our body. Pain in the joints may not necessarily be fatal but it sure does cripple the life of the patients. Hence it is the need of the hour to provide mankind with near perfect solution to the joint pain which they suffer. The article enlists most of the herbal analgesics which are useful in treating joint pain and inflammation. It also highlights upon the issue of the side effects caused by modern analgesics. Article will help the reader to understand the role of herbal analgesics and thereby promote further research on the scope and usage of herbal medicines.
Gastropanel, serological ELISA test comprising of stomach biomarkers; serum pepsinogen I, pepsino... more Gastropanel, serological ELISA test comprising of stomach biomarkers; serum pepsinogen I, pepsinogen II, gastrin-17, and Helicobacter pylori antibody depicts clearly the morphological and functional status of stomach mucosa in patients suffering from dyspepsia. Although the traditional system of medicine is a huge resource of efficient formulations useful in gastrointestinal disorders such as functional dyspepsia, lack of robust scientific evidence, and qualitative/subjective parameters like symptom scores do not suffice the need for the same. This study was thus planned to assess usefulness of gastropanel tests to validate efficacy of Avipattikar choorna, well-known antacid remedy in functional dyspepsia. A. choorna was given to patients of dyspeptic disorders following which gastropanel was performed pre- and post-treatment. The gastropanel findings obtained, prior and post-interventions were compared using Wilcoxon MPSR test and a level of P < 0.05 was considered for statistic...
Objective: To find the efficacy of Shiva gutika with Saraswatarishta in management of Age Associa... more Objective: To find the efficacy of Shiva gutika with Saraswatarishta in management of Age Associated Mild Cognitive Impairment (AAMCI). To review the literature of mild cognitive impairment, Jara, and aging as per modern science and Ayurveda. To observe side effects of the drug if any. To access effect of drug on other signs and symptoms of Jara.
CONTEXT: Acid peptic disorders. AIMS: This study aimed to assess the efficacy and acceptability o... more CONTEXT: Acid peptic disorders. AIMS: This study aimed to assess the efficacy and acceptability of pomegranate effervescent granules (PEGs) in dyspeptic patients. SETTINGS AND DESIGN: It was a single-arm, open-labeled prospective multicentric clinical study, done at 3 centers: Vishwanand Kendra, Pune; Bharati Ayurved Hospital, Bharati Vidyapeeth, Pune, and M. A. Podar Medical Ayurved Hospital, Mumbai. The co-ordinating site was Interactive Research School for Health Affairs, Bharati Vidyapeeth, Pune. MATERIALS AND METHODS: The granules, prepared from peel extract of pomegranate, were made available in sachets of 2.5 g with dose of, 1 sachet dissolved in 200 ml (1 cup) of water, twice a day after meals for 28 days. Gastrointestinal Symptom Rating Scale (GSRS) scores to assess symptoms of acid peptic disorders at day 0, 15, and 29 along with the taste of formulation were the main study outcomes. STATISTICAL ANALYSIS USED: Parametric data, presented as mean ± standard deviation, were analyzed using paired t-test, while nonparametric data presented as median (range) was analyzed using Wilcoxon rank-sum test. Categorical data were analyzed using Chi-square test. RESULTS: The median GSRS score reduced from 14 on day 0–10 and then 5 on day 15 and day 29, respectively, with statistical significance. The formulation was found to taste good by ~80% of patients, while ~20% reported it to be palatable and none found it to be bad in taste. CONCLUSION: PEGs proved to be palatable, patient-friendly, safe, and efficacious in resolving symptoms of dyspepsia in acid peptic disorders. CTRI Registration: The trial was registered retrospectively in the Clinical Registry of India [CTRI/2017/07/008999].
Irritable bowel syndrome (IBS) is a gastrointestinal disorder in which there is functional derang... more Irritable bowel syndrome (IBS) is a gastrointestinal disorder in which there is functional derangement of the gastrointestinal tract without any organic cause. IBS is characterized by a group of symptoms such as abdominal pain, discomfort and a change in bowel habits. The presently available treatment modalities include anti diarrheal, antispasmodics and antidepressants with limited benefits. This calls for the need to explore effective treatment modalities. Herbal medicines have proved efficacious in the treatment of gastrointestinal disorders since ancient time. Herewith we report a case series of patients suffering with IBS-D (diarrhea) type treated with Cap Ibomic a proprietary herbal formulation manufactured by Shree Baidyanath Ayurveda Bhavan for the treatment of IBS. We observed that there was a decrease in median scores of the symptoms such as abdominal pain, discomfort, bloating, stress and fatigue. There was a decrease in the mean frequency of motions per day and improveme...
Aging is a progressive generalized impairment of functions resulting in the loss of adaptive resp... more Aging is a progressive generalized impairment of functions resulting in the loss of adaptive response to stress and increasing risk of age related diseases. Though aging doesn’t spare anybody one can make it less apprehensive. The man with the empowerment of knowledge and resources had always a quest for immortality and youthfulness. This leads his Endeavour to search a tool which could protect him from aging or at least minimizing the effect of aging. Rasayan is the tool for it. One of the critical areas that need to be addressed is concerned with neuro-psychological health. Neurodegenerative diseases are characterized by progressive impairment of brain functions in brain aging. Objective of the work is to understand how ageing changes takes place in brain and how to regulate, retard these changes.Vata, Pitta, Rasa, Rakta,Majja,Ojus and Beejabhagaavayava are the influencing factors for brain aging. Decreased cognition, intellect,vision, enthusiasm, wisdom are the signs of brain ag...
International Journal of Ayurveda and Pharma Research, 2015
It is since the Vedic era that the use of natural substances for medicine has been used. Ayurveda... more It is since the Vedic era that the use of natural substances for medicine has been used. Ayurveda , the ancient Indian science gives a detailed explanation of these uses. Medicated milk i.e., Siddha ksheera has a high and prominent medicinal value. This article encloses all the various formulations of medicated milk along with their role in diseases contents of the medicated milk as per Acharya Charak. Ksheerpaka are supposed to nourish tissues and have more anabolic effects. An effort has been made to compile and represent for a better and easy understanding of various Siddha ksheer yogas mentioned in Charaka samhita . Use of Ksheer is highly recommended in certain Vyadhis like Pandu , Amlapitta , Gulma , Udara roga , Yoni roga , Shukra roga, Vata roga , etc. Ksheerpaka i.e. milk used in the medicated form is the unique feature of Ayurveda. Nowadays, for Ksheerpaka preparation, method stated by Sharangadhara is generally followed. Role of Siddha ksheer in various Vyadhis like Jwara...
Ageing means growing old, maturing, progressive changes related to the passage of time. .Memory c... more Ageing means growing old, maturing, progressive changes related to the passage of time. .Memory complaints are ubiquitous in our aging population. Mild cognitive impairment (MCI) is considered by many as an intermediary stage for dementia. Many older adults fear that today’s forgetfulness will usher in tomorrow’s dementia. It is characterized by deterioration of memory, attention, and cognitive function that is beyond what is expected based on age and educational level. MCI does not interfere significantly with individuals’ daily activities. It may act as a transitional level of evolving dementia with a range of conversion of 10%–15% per year. The preventive interventions and appropriate treatments should improve cognitive performance, and retard or prevent progressive deficits. The avoidance of toxins, reduction of stress, prevention of somatic diseases, implementation of mental and physical exercises, as well as the use of dietary compounds like antioxidants and supplements can be...
Objective: To find the efficacy of Shiva gutika with Saraswatarishta in management of Age Associa... more Objective: To find the efficacy of Shiva gutika with Saraswatarishta in management of Age Associated Mild Cognitive Impairment (AAMCI). To review the literature of mild cognitive impairment, Jara , and aging as per modern science and Ayurveda . To observe side effects of the drug if any. To access effect of drug on other signs and symptoms of Jara . Method: Open Trial study was conducted on 25 patients having AAMCI and were selected for the study randomly. The patients received 1gm Shiva gutika once a day with 40ml Saraswatarista as Anupan for 3 months. Assessment Criteria: Improvement in all the six cerebral higher functions on the basis of various tests such as MMSE, CAMCOG (CAMDEX), ADL/IADL, GDS. Follow up: 0, 15th, 30th, 45th, 60th, 75th, 90th day. Duration: Total duration study was 90 Days. This study was carried out in Bharati Vidyapeeth Deemed University College of Ayurved & Hospital Pune in Year 2010 and 2011. Results: Comparing all the symptoms before and after treatment h...
The market at present is flooded with a variety of anti-diabetic drugs to provide diabetic patien... more The market at present is flooded with a variety of anti-diabetic drugs to provide diabetic patients with relief. Almost all the anti-diabetic drugs are liable to have untoward effects on our body. Iit is the need of the hour to provide mankind with near perfect solution to patients suffering from diabetes. The article enlists the action of the herbal drug haridra on type 2 diabetes. It also highlights upon the issue of the side effects caused by modern antidiabetic drugs. Article will help the reader to understand the role of haridra on type 2 diabetes and thereby promote further research on the scope and usage of herbal medicines and haridra in particular.
In order to understand the concept of ayurvedic musculoskeletal diseases one should first underst... more In order to understand the concept of ayurvedic musculoskeletal diseases one should first understand the rachanatmak and kriyatmak aspect of the sandhi. Likewise multiple references regarding musculoskeletal diseases have been found in our ancient classical texts. The article encompasses all the references from the classical text Charak samhita regarding shoola and shotha of any joint, sandhi. The related signs and symptoms and condition or stages in which they occur have also been mentioned. No satisfactory results have been made till date in the light of curing or atleast providing relief rather giving analgesic i.e. pain relieving treatment has been made. An effort has been made to guide all keen readers to first understand and to arrive at the proper diagnosis of a patient of MSD. Thorough knowledge of differential diagnosis is the key to conclusive diagnosis.
In order to understand any skin disease. (twacharoga) a detailed study of the structure and funct... more In order to understand any skin disease. (twacharoga) a detailed study of the structure and function of skin is necessary. The conceptual aspect of skin needs to be understood because skin disorder is outer exhibition of some kind of internal pathology. No satisfactory results have been made till date in the aspect of curing skin disease (twacharoga). The ancient science of life Ayurveda provides valuable information regarding various herbs which are useful in curing various skin ailments.
Immunity has become an important aspect of concern, as the spread of corona virus, is on the rise... more Immunity has become an important aspect of concern, as the spread of corona virus, is on the rise. The strategies to boost and modulate the immunity have therefore become need of the hour. The present study was carried out to evaluate the effect of Charak immunity Tablets (CIT) on innate and adaptive immune response in healthy individuals. It was a single-blind, randomized, placebo-controlled, exploratory study. After obtaining Ethics Committee permission, 36 healthy individuals of either sex aged 18-35 years with prior consent were recruited in the study. They were randomly divided into 2 groups to receive either CIT or Placebo in 2:1 ratio. Both the interventions were given in a dose of 1 tab (500 mg) twice daily. The assessment variables were vitals [temperature, pulse, and blood pressure], respiratory health [respiratory rate, oxygen saturation and peak expiratory flow rate], questionnaire based assessment of immune status, perceived stress and quality of life along with objecti...
Uploads
Papers by Madhavi Mahajan