Objective: Hearing plays a crucial role in the performance of a soldier and is important for comm... more Objective: Hearing plays a crucial role in the performance of a soldier and is important for communication and speech processing. Service personnel are constantly exposed to high levels of noise and hence predisposed to occupational health disabilities, principally noise-induced hearing loss (NIHL) and tinnitus. NIHL is a significantly common impairment in the military and can affect the warfare performances. Parochial awareness about the effects of uproarious noise which exacerbates their hearing, acceptance rate of use of hearing protection devices and follow-up audiological tests have become the major drawback for prevention of NIHL and are less pondered upon. Method: The present study focuses on the effects of noise on the hearing of service crew operating and maintaining military equipment and explores the efficacy of DPOAE’s to substitute pure tone audiometry as a quick, easy to operate and implementable test technique for monitoring of hearing status. Results: The results sug...
Chronic/non-healing cutaneous wounds pose a debilitating burden on patients and healthcare system... more Chronic/non-healing cutaneous wounds pose a debilitating burden on patients and healthcare system. Presently, treatment modalities are rapidly shifting pace from conventional methods to advanced wound care involving cell-based therapies. Mesenchymal stem cells (MSCs) have come across as a prospective option due to its pleiotropic functions viz. non-immunogenicity, multipotency, multi-lineage plasticity and secretion of growth factors, cytokines, microRNAs (miRNA), exosomes, and microvesicles as part of their secretome for assisting wound healing. We outline the therapeutic role played by MSCs and its secretome in suppressing tissue inflammation, causing immunomodulation, aiding angiogenesis and assisting in scar-free wound healing. We further assess the mechanism of action by which MSCs contribute in manifesting tissue repair. The review flows ahead in exploring factors that influence healing behavior including effect of multiple donor sites, donor age and health status, tissue microenvironment, and in vitro expansion capability. Moving ahead, we overview the advancements achieved in extending the lifespan of cells upon implantation, influence of genetic modifications aimed at altering MSC cargo, and evaluating bioengineered matrix-assisted delivery methods toward faster healing in preclinical and clinical models. We also contribute toward highlighting the challenges faced in commercializing cell-based therapies as standard of care treatment regimens. Finally, we strongly advocate and highlight its application as a futuristic technology for revolutionizing tissue regeneration. Graphical abstract
Objective: Hearing plays a crucial role in the performance of a soldier and is important for comm... more Objective: Hearing plays a crucial role in the performance of a soldier and is important for communication and speech processing. Service personnel are constantly exposed to high levels of noise and hence predisposed to occupational health disabilities, principally noise-induced hearing loss (NIHL) and tinnitus. NIHL is a significantly common impairment in the military and can affect the warfare performances. Parochial awareness about the effects of uproarious noise which exacerbates their hearing, acceptance rate of use of hearing protection devices and follow-up audiological tests have become the major drawback for prevention of NIHL and are less pondered upon. Method: The present study focuses on the effects of noise on the hearing of service crew operating and maintaining military equipment and explores the efficacy of DPOAE’s to substitute pure tone audiometry as a quick, easy to operate and implementable test technique for monitoring of hearing status. Results: The results sug...
Chronic/non-healing cutaneous wounds pose a debilitating burden on patients and healthcare system... more Chronic/non-healing cutaneous wounds pose a debilitating burden on patients and healthcare system. Presently, treatment modalities are rapidly shifting pace from conventional methods to advanced wound care involving cell-based therapies. Mesenchymal stem cells (MSCs) have come across as a prospective option due to its pleiotropic functions viz. non-immunogenicity, multipotency, multi-lineage plasticity and secretion of growth factors, cytokines, microRNAs (miRNA), exosomes, and microvesicles as part of their secretome for assisting wound healing. We outline the therapeutic role played by MSCs and its secretome in suppressing tissue inflammation, causing immunomodulation, aiding angiogenesis and assisting in scar-free wound healing. We further assess the mechanism of action by which MSCs contribute in manifesting tissue repair. The review flows ahead in exploring factors that influence healing behavior including effect of multiple donor sites, donor age and health status, tissue microenvironment, and in vitro expansion capability. Moving ahead, we overview the advancements achieved in extending the lifespan of cells upon implantation, influence of genetic modifications aimed at altering MSC cargo, and evaluating bioengineered matrix-assisted delivery methods toward faster healing in preclinical and clinical models. We also contribute toward highlighting the challenges faced in commercializing cell-based therapies as standard of care treatment regimens. Finally, we strongly advocate and highlight its application as a futuristic technology for revolutionizing tissue regeneration. Graphical abstract
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