Introduction: Due to the growing prevalence of obesity, more women are overweight in early pregna... more Introduction: Due to the growing prevalence of obesity, more women are overweight in early pregnancy (1). Previous studies demonstrated that pre-obesity/obesity is associated with adverse neonatal and obstetric outcomes, namely pre-eclampsia, cesarean delivery, prematurity, macrosomia, neonatal intensive care unit admissions and stillbirth (2,3). There is also evidence that excessive gestational weight gain is associated with an increased risk of gestational hypertension, gestational diabetes (and, inclusively, pharmacological therapy), delivery by cesarean section, postpartum weight retention, macrosomia and neonatal intensive care unit admissions (4,5). Some studies also shown that obese women tend to have an earlier gestational diabetes, more insulin resistance with increased risk of type 2 diabetes, which might lead to a poorer long-term prognosis (6). Objective: To evaluate the influence of maternal pre-pregnancy body mass index and gestational weight gain on blood glucose leve...
Thyroid cancer’s incidence has increased in the last decades, and its diagnosis can be a challeng... more Thyroid cancer’s incidence has increased in the last decades, and its diagnosis can be a challenge. Further and complementary testing based in biochemical alterations may be important to correctly identify thyroid cancer and prevent unnecessary surgery. Fourier-transform infrared (FTIR) spectroscopy is a metabolomic technique that has already shown promising results in cancer metabolome analysis of neoplastic thyroid tissue, in the identification and classification of prostate tumor tissues and of breast carcinoma, among others. This work aims to gather and discuss published information on the ability of FTIR spectroscopy to be used in metabolomic studies of the thyroid, including discriminating between benign and malignant thyroid samples and grading and classifying different types of thyroid tumors.
Introduction: Due to the growing prevalence of obesity, more women are overweight in early pregna... more Introduction: Due to the growing prevalence of obesity, more women are overweight in early pregnancy (1). Previous studies demonstrated that pre-obesity/obesity is associated with adverse neonatal and obstetric outcomes, namely pre-eclampsia, cesarean delivery, prematurity, macrosomia, neonatal intensive care unit admissions and stillbirth (2,3). There is also evidence that excessive gestational weight gain is associated with an increased risk of gestational hypertension, gestational diabetes (and, inclusively, pharmacological therapy), delivery by cesarean section, postpartum weight retention, macrosomia and neonatal intensive care unit admissions (4,5). Some studies also shown that obese women tend to have an earlier gestational diabetes, more insulin resistance with increased risk of type 2 diabetes, which might lead to a poorer long-term prognosis (6). Objective: To evaluate the influence of maternal pre-pregnancy body mass index and gestational weight gain on blood glucose leve...
Thyroid cancer’s incidence has increased in the last decades, and its diagnosis can be a challeng... more Thyroid cancer’s incidence has increased in the last decades, and its diagnosis can be a challenge. Further and complementary testing based in biochemical alterations may be important to correctly identify thyroid cancer and prevent unnecessary surgery. Fourier-transform infrared (FTIR) spectroscopy is a metabolomic technique that has already shown promising results in cancer metabolome analysis of neoplastic thyroid tissue, in the identification and classification of prostate tumor tissues and of breast carcinoma, among others. This work aims to gather and discuss published information on the ability of FTIR spectroscopy to be used in metabolomic studies of the thyroid, including discriminating between benign and malignant thyroid samples and grading and classifying different types of thyroid tumors.
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