The objective of this paper was to evaluate the effect of high voltage stimulation (HVS) on the p... more The objective of this paper was to evaluate the effect of high voltage stimulation (HVS) on the process of healing of crural ulceration. Three comparative groups of patients, A, B and C, were drawn at random from patients with venous crural ulceration. Thirty-three patients in group A were subjected to treatment with HVS. In the course of treatment, doubled-peak monophasic impulses of a total duration of 0.1 ms and frequency of 100 Hz were applied. The voltage was 100 V. Group B, made up of 32 patients treated with topically applied medicine, and group C, made up of 14 patients treated with Unna's boot were used as control. In all patients in all groups (A, B and C) a significant reduction in wound size in relation to baseline was found. The rate of wound area change was highest in group A. The rate of pus cleansing was significantly highest in group A. The degree of granulation after 2 weeks was significantly greater in group A than in the other groups (P<0.003). High voltage stimulation was an efficient method of enhancement of the healing of crural ulceration.
SummaryAim: The study of the influence of sulodexide in the treatment of venous leg ulcers. Patie... more SummaryAim: The study of the influence of sulodexide in the treatment of venous leg ulcers. Patients and method: 44 patients with chronic venous ulceration were randomly divided into two groups. Group I: 21 patients (ulceration area: 12.7-18.9 cm2), Group II: 23 patients (ulceration size: 12.1-20.3 cm2). Both groups were treated by using Unna’s boot. This dressing was changed every seven days until the ulcer had healed. Additionally, the patients in group II received the systemic pharmacological treatment with sulodexide. Results: After 7 weeks of treatment ulcers of seven patients (35%) from group I had healed, and 3 weeks later the ulceration of two more patients had healed completely. After further 7 weeks the ulcers of 12 patients had healed completely. Whereas in group II after 7 weeks of treatment ulceration of 16 (70%, p <0.05) patient had healed completely and after further 3 weeks the ulcers of the remaining 7 patients had healed, too. Conclusion: The use of sulodexide in patients with chronic venous leg ulcers accelerates the healing process.
The concentrations of Fe, Cu, Zn and Se in cancerous and benign tissues of breast, lung and intes... more The concentrations of Fe, Cu, Zn and Se in cancerous and benign tissues of breast, lung and intestine (colon) have been determined. In the cases when the element concentration has not been determined in all samples the Kaplan-Meier method has been used for the reconstruction of the original concentration distributions and estimation of the true mean concentrations and medians. Finally, the log-rank test has been applied to compare the elemental concentration distributions between cancerous and benign tissues of the same organ, between cancerous tissues and between benign tissues taken from different organs. Comparing benign and malignant neoplastic tissues, statistically significant differences have been found between Fe and Se concentration distributions of breast as well as for Cu and Zn in the case of lung tissues and in the case of colon tissues for Zn. The concentrations of all elements have been found to be statistically different in cancer tissues as well as in benign ones when comparing the different organs, i.e. groups 'breast-colon' and 'breast-lung'. Concentrations of Fe and Cu have been found to be statistically different in lung and colon cancerous tissues. For benign tissues of lung and colon a statistically significant difference has been found only for Zn.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, May 1, 2006
The aim of the study was to evaluate the influence of a high voltage stimulation, sonotherapy and... more The aim of the study was to evaluate the influence of a high voltage stimulation, sonotherapy and laser biostimulation on the process of healing of venous leg ulcers. Four comparative groups--A, B, C and D--were made at a random from 92 patients with venous leg ulcers. The group A consisted of 26 patients, the group B--21 patients, the group C--21 patients, and the group D--24 patients. The patients in all comparative groups were treated pharmacologically. Ulcerations at the patients in the group A were additionally treated with the high voltage stimulation. However, ulcerations at the patients in the group B were treated with the sonotherapy. Ulcerations at the patients in the group C were treated with the laser biostimulation. Changes of the area, length, width and volume of the tissue defekt after above physical therapies were assessed. Changes of the pus decontamination and granulation processes were observed too. After treatment concluded, high voltage stimulation and ultrasound therapy had been more efficient at enhancing healing of venous leg ulcers than topical pharmacology. No significant effect of laser biostimulation on healing process was observed.
The aim of the study was to evaluate the influence of a high voltage stimulation, sonotherapy and... more The aim of the study was to evaluate the influence of a high voltage stimulation, sonotherapy and laser biostimulation on the process of healing of venous leg ulcers. Material and methods: Four comparative groups--A, B, C and D--were made at a random from 92 patients with venous leg ulcers. The group A consisted of 26 patients, the group B--21 patients, the group C--21 patients, and the group D--24 patients. The patients in all comparative groups were treated pharmacologically. Ulcerations at the patients in the group A were additionally treated with the high voltage stimulation. However, ulcerations at the patients in the group B were treated with the sonotherapy. Ulcerations at the patients in the group C were treated with the laser biostimulation. Changes of the area, length, width and volume of the tissue defekt after above physical therapies were assessed. Changes of the pus decontamination and granulation processes were observed too. Conclusions: After treatment concluded, high voltage stimulation and ultrasound therapy had been more efficient at enhancing healing of venous leg ulcers than topical pharmacology. No significant effect of laser biostimulation on healing process was observed.
The objective of this paper was to evaluate the effect of high voltage stimulation (HVS) on the p... more The objective of this paper was to evaluate the effect of high voltage stimulation (HVS) on the process of healing of crural ulceration. Three comparative groups of patients, A, B and C, were drawn at random from patients with venous crural ulceration. Thirty-three patients in group A were subjected to treatment with HVS. In the course of treatment, doubled-peak monophasic impulses of a total duration of 0.1 ms and frequency of 100 Hz were applied. The voltage was 100 V. Group B, made up of 32 patients treated with topically applied medicine, and group C, made up of 14 patients treated with Unna's boot were used as control. In all patients in all groups (A, B and C) a significant reduction in wound size in relation to baseline was found. The rate of wound area change was highest in group A. The rate of pus cleansing was significantly highest in group A. The degree of granulation after 2 weeks was significantly greater in group A than in the other groups (P<0.003). High voltage stimulation was an efficient method of enhancement of the healing of crural ulceration.
SummaryAim: The study of the influence of sulodexide in the treatment of venous leg ulcers. Patie... more SummaryAim: The study of the influence of sulodexide in the treatment of venous leg ulcers. Patients and method: 44 patients with chronic venous ulceration were randomly divided into two groups. Group I: 21 patients (ulceration area: 12.7-18.9 cm2), Group II: 23 patients (ulceration size: 12.1-20.3 cm2). Both groups were treated by using Unna’s boot. This dressing was changed every seven days until the ulcer had healed. Additionally, the patients in group II received the systemic pharmacological treatment with sulodexide. Results: After 7 weeks of treatment ulcers of seven patients (35%) from group I had healed, and 3 weeks later the ulceration of two more patients had healed completely. After further 7 weeks the ulcers of 12 patients had healed completely. Whereas in group II after 7 weeks of treatment ulceration of 16 (70%, p <0.05) patient had healed completely and after further 3 weeks the ulcers of the remaining 7 patients had healed, too. Conclusion: The use of sulodexide in patients with chronic venous leg ulcers accelerates the healing process.
The concentrations of Fe, Cu, Zn and Se in cancerous and benign tissues of breast, lung and intes... more The concentrations of Fe, Cu, Zn and Se in cancerous and benign tissues of breast, lung and intestine (colon) have been determined. In the cases when the element concentration has not been determined in all samples the Kaplan-Meier method has been used for the reconstruction of the original concentration distributions and estimation of the true mean concentrations and medians. Finally, the log-rank test has been applied to compare the elemental concentration distributions between cancerous and benign tissues of the same organ, between cancerous tissues and between benign tissues taken from different organs. Comparing benign and malignant neoplastic tissues, statistically significant differences have been found between Fe and Se concentration distributions of breast as well as for Cu and Zn in the case of lung tissues and in the case of colon tissues for Zn. The concentrations of all elements have been found to be statistically different in cancer tissues as well as in benign ones when comparing the different organs, i.e. groups 'breast-colon' and 'breast-lung'. Concentrations of Fe and Cu have been found to be statistically different in lung and colon cancerous tissues. For benign tissues of lung and colon a statistically significant difference has been found only for Zn.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, May 1, 2006
The aim of the study was to evaluate the influence of a high voltage stimulation, sonotherapy and... more The aim of the study was to evaluate the influence of a high voltage stimulation, sonotherapy and laser biostimulation on the process of healing of venous leg ulcers. Four comparative groups--A, B, C and D--were made at a random from 92 patients with venous leg ulcers. The group A consisted of 26 patients, the group B--21 patients, the group C--21 patients, and the group D--24 patients. The patients in all comparative groups were treated pharmacologically. Ulcerations at the patients in the group A were additionally treated with the high voltage stimulation. However, ulcerations at the patients in the group B were treated with the sonotherapy. Ulcerations at the patients in the group C were treated with the laser biostimulation. Changes of the area, length, width and volume of the tissue defekt after above physical therapies were assessed. Changes of the pus decontamination and granulation processes were observed too. After treatment concluded, high voltage stimulation and ultrasound therapy had been more efficient at enhancing healing of venous leg ulcers than topical pharmacology. No significant effect of laser biostimulation on healing process was observed.
The aim of the study was to evaluate the influence of a high voltage stimulation, sonotherapy and... more The aim of the study was to evaluate the influence of a high voltage stimulation, sonotherapy and laser biostimulation on the process of healing of venous leg ulcers. Material and methods: Four comparative groups--A, B, C and D--were made at a random from 92 patients with venous leg ulcers. The group A consisted of 26 patients, the group B--21 patients, the group C--21 patients, and the group D--24 patients. The patients in all comparative groups were treated pharmacologically. Ulcerations at the patients in the group A were additionally treated with the high voltage stimulation. However, ulcerations at the patients in the group B were treated with the sonotherapy. Ulcerations at the patients in the group C were treated with the laser biostimulation. Changes of the area, length, width and volume of the tissue defekt after above physical therapies were assessed. Changes of the pus decontamination and granulation processes were observed too. Conclusions: After treatment concluded, high voltage stimulation and ultrasound therapy had been more efficient at enhancing healing of venous leg ulcers than topical pharmacology. No significant effect of laser biostimulation on healing process was observed.
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Papers by Marek Kucharzewski