Full Professor - University of São Paulo Medical School (São Paulo, Brazil)Research focused on the molecular bases for cell proliferation and differentiation, using mammalian cell lines, stem cells, iPSCs and cell transplantation.Advised over 40 PhD and 15 Master´s students and over 30 pos-docs.Coordinated the Cell and Molecular Therapy Center (NUCEL - www.usp.br) of the Univ. of São Paulo for over 10 years.
Human adipose tissue-derived stem cells (hASC) secretome display various therapeutically relevant... more Human adipose tissue-derived stem cells (hASC) secretome display various therapeutically relevant effects in regenerative medicine, such as induction of angiogenesis and tissue repair. The benefits of hASC secretome are primarily orchestrated by trophic factors that mediate autocrine and paracrine effects in host cells. However, the composition and the innate characteristics of hASC secretome can be highly variable depending on the culture conditions. Here, we evaluated the combined effect of serum-free media and hypoxia preconditioning on the hASCs secretome composition and biological effects on angiogenesis and wound healing. The hASCs were cultured in serum-free media under normoxic (NCM) or hypoxic (HCM) preconditioning. The proteomic profile showed that pro- and anti-antiangiogenic factors were detected in NCM and HCM secretomes. In vitro studies demonstrated that hASCs secretomes enhanced endothelial proliferation, survival, migration, in vitro tube formation, and in vivo Matr...
ISLET TRANSPLANTATION Silveira, B.M.D.; Trombetta-Lima, M. ; Carreira A.C.O. ; Sogayar, M.C.; Mey... more ISLET TRANSPLANTATION Silveira, B.M.D.; Trombetta-Lima, M. ; Carreira A.C.O. ; Sogayar, M.C.; Meyer, R.; Fortuna, V. Health Science Institute, Federal university of Bahia, Bahia, Brazil. School of Medicine, NUCEL (Cell and Molecular Therapy Center) and NETCEM (Center for Studies in Cell and Molecular Therapy), Medical Clinics Department, University of São Paulo, SP, Brazil Biochemistry Department, Chemistry Institute, University of São Paulo, SP, Brazil
Human adipose tissue-derived stem cells (hASC) secretome display various therapeutically relevant... more Human adipose tissue-derived stem cells (hASC) secretome display various therapeutically relevant effects in regenerative medicine, such as induction of angiogenesis and tissue repair. The benefits of hASC secretome are primarily orchestrated by trophic factors that mediate autocrine and paracrine effects in host cells. However, the composition and the innate characteristics of hASC secretome can be highly variable depending on the culture conditions. Here, we evaluated the combined effect of serum-free media and hypoxia preconditioning on the hASCs secretome composition and biological effects on angiogenesis and wound healing. The hASCs were cultured in serum-free media under normoxic (NCM) or hypoxic (HCM) preconditioning. The proteomic profile showed that pro- and anti-antiangiogenic factors were detected in NCM and HCM secretomes. In vitro studies demonstrated that hASCs secretomes enhanced endothelial proliferation, survival, migration, in vitro tube formation, and in vivo Matr...
ISLET TRANSPLANTATION Silveira, B.M.D.; Trombetta-Lima, M. ; Carreira A.C.O. ; Sogayar, M.C.; Mey... more ISLET TRANSPLANTATION Silveira, B.M.D.; Trombetta-Lima, M. ; Carreira A.C.O. ; Sogayar, M.C.; Meyer, R.; Fortuna, V. Health Science Institute, Federal university of Bahia, Bahia, Brazil. School of Medicine, NUCEL (Cell and Molecular Therapy Center) and NETCEM (Center for Studies in Cell and Molecular Therapy), Medical Clinics Department, University of São Paulo, SP, Brazil Biochemistry Department, Chemistry Institute, University of São Paulo, SP, Brazil
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Papers by Mari Sogayar