Department of Laboratory Medicine, State University of Medicine and Pharmacy "Nicolae Testem... more Department of Laboratory Medicine, State University of Medicine and Pharmacy "Nicolae Testemiteanu" Chișinău, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltareIntroduction: In December 2019, a new coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), broke out in the Chinese province of Wuhan and rapidly infected hundreds of thousands of people worldwide. Infected patients mostly exhibit general signs of pneumonia (fever, dyspnea, coughing and desaturation) and a presumably significant number of infected patients are asymptomatic. Purpose: Study of literature data on biomarkers of liver damage in patients with COVID-19 infection that could provide information about liver damage. Material and methods: A study of the literature from the PubMed database was performed. The keywords ...
Background. Diabetes mellitus (DM) is a major risk factor for the development of pulmonary tuberc... more Background. Diabetes mellitus (DM) is a major risk factor for the development of pulmonary tuberculosis. Overall, approximately 15% of pulmonary TB cases are associated with diabetes. Patients with diabetes associated with pulmonary tuberculosis have changes in the adaptive immune response. Objective of the study. Analysis of specialty literature sources regarding the role of diabetes in association with pulmonary tuberculosis Material and Methods. Materials were analyzed using the Hinari, Google academic and Pub Med databases, with reference to diabetes, pulmonary tuberculosis, changes in the adaptive immune response. Results. Diabetes mellitus induces disfunction of the adaptive immune response to infection with M.tuberculosis in the initial stages. Patients with diabetes mellitus associated with pulmonary tuberculosis, monocytes and macrophages have lower phagocytic and antimicrobial activity against M. tuberculosis and produce less cytokines. Several studies have suggested that ...
Background. In December 2019, a novel coronavirus, the severe acute respiratory syndrome coronavi... more Background. In December 2019, a novel coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), broke out in the Chinese province of Wuhan and rapidly infected hundreds of thousands of people worldwide. Infected patients mostly exhibit general signs of pneumonia. Objective of the study. Study of literature data on liver biomarkers in patients with COVID-19 infection that could provide information about liver damage Material and Methods. Literature review study using database PubMed has been performed. In the search process keywords –„COVID-19” , „liver damage” and „biomarkers” have been used. Results. Lactate dehydrogenase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are often elevated in COVID-19 patients, indicating liver damage. Recent reports point to the fact that liver injury, by means of increased aminotransferase levels, more frequently occurred in severe COVID-19 cases compared to patients with mild symptoms. Conclusion. Further ...
Laboratory Medicine Department, Nicolae Testemitanu SUMPhBackground. The World Health Organizatio... more Laboratory Medicine Department, Nicolae Testemitanu SUMPhBackground. The World Health Organization (WHO) estimated in 2019 10 million cases of tuberculosis (TB) with 1.6 million deaths worldwide. Since 2020, COVID-19 is a respiratory disease that has spread globally with approximately 111 million cases reported to the WHO. Objective of the study. Studying data from the literature on the interaction of pulmonary tuberculosis and COVID-19 Material and Methods. Data from the literature were analyzed using the PUBMED, Google academic and HINARI databases, referring to pulmonary tuberculosis, COVID-19, TB / COVID-19. Results. The results of the studies indicate that COVID-19 induces an adaptive immune response specific to the SARS-CoV-2 antigen involving CD4, CD8 cells and B lymphocytes. In particular, SARS-CoV-2- specific CD4 + T cells are associated with a protective immune response, while an insufficient immune response is associated with increased severity of the disease. COVID-19 is...
Catedra Boli Infecțioase, Clinica Boli Infecțioase la Copii Valentina Halitov, USMF Nicolae Teste... more Catedra Boli Infecțioase, Clinica Boli Infecțioase la Copii Valentina Halitov, USMF Nicolae Testemițanu, IMSP Spitalul Clinic Municipal de Boli Contagioase de Copii, Universitatea de Stat de Medicină și Farmacie N. TestemițanuMeningococcal infection continue to be an actual problem that frequently affects children both in Republic of Moldova and in other countries. It’s one of the most serious infectious disease that evolve under different clinical forms such as localized, generalized, or associated one, also including central nervous system injuries. Thus in the last years were observed sporadic cases with meningococcal infection, it still remain a major problem, because young children often develop generalized forms with fulminant evolution and serious consequences. During the (2010-2015) years, we analysed in a retrospective and prospective way 43 cases with meningococcal infection in Municipal Infectious Diseases Hospital for Children and observed that more affected were childre...
Background: Currently, there is a growing interest in new copper (Cu2+) heterocyclic coordination... more Background: Currently, there is a growing interest in new copper (Cu2+) heterocyclic coordination compounds (CC), isothiosemicarbazide derivates, which demonstrated multiple beneficial properties, but their effect on reactions with free radicals such as the superoxide radical has not been investigated. Material and methods: The action of new micromolecular complexes of copper (Cu2+) chloride and bromide with methyl n- (prop-2-en-1-yl) -2- (pyridin2-ylmethylidene) hydrazine carbimidothioate on capturing activity of the superoxide radical was determined by the spectrophotometric method in vitro experiments. Results: It was established that the micromolecular complexes of copper (II) chloride and bromide with methyl n-(prop-2-en-1-yl)-2-(pyridin-2- ylmethylidene) hydrazine carbimidothioate have been found to possess strong superoxide radical inhibitor properties when interacting with a superoxide radical. In addition to this, the IC50 of the studied compounds depends on the nature of t...
Department of Laboratory Medicine, State University of Medicine and Pharmacy "Nicolae Testem... more Department of Laboratory Medicine, State University of Medicine and Pharmacy "Nicolae Testemiteanu" Chișinău, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltareIntroduction: In December 2019, a new coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), broke out in the Chinese province of Wuhan and rapidly infected hundreds of thousands of people worldwide. Infected patients mostly exhibit general signs of pneumonia (fever, dyspnea, coughing and desaturation) and a presumably significant number of infected patients are asymptomatic. Purpose: Study of literature data on biomarkers of liver damage in patients with COVID-19 infection that could provide information about liver damage. Material and methods: A study of the literature from the PubMed database was performed. The keywords ...
Background. Diabetes mellitus (DM) is a major risk factor for the development of pulmonary tuberc... more Background. Diabetes mellitus (DM) is a major risk factor for the development of pulmonary tuberculosis. Overall, approximately 15% of pulmonary TB cases are associated with diabetes. Patients with diabetes associated with pulmonary tuberculosis have changes in the adaptive immune response. Objective of the study. Analysis of specialty literature sources regarding the role of diabetes in association with pulmonary tuberculosis Material and Methods. Materials were analyzed using the Hinari, Google academic and Pub Med databases, with reference to diabetes, pulmonary tuberculosis, changes in the adaptive immune response. Results. Diabetes mellitus induces disfunction of the adaptive immune response to infection with M.tuberculosis in the initial stages. Patients with diabetes mellitus associated with pulmonary tuberculosis, monocytes and macrophages have lower phagocytic and antimicrobial activity against M. tuberculosis and produce less cytokines. Several studies have suggested that ...
Background. In December 2019, a novel coronavirus, the severe acute respiratory syndrome coronavi... more Background. In December 2019, a novel coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), broke out in the Chinese province of Wuhan and rapidly infected hundreds of thousands of people worldwide. Infected patients mostly exhibit general signs of pneumonia. Objective of the study. Study of literature data on liver biomarkers in patients with COVID-19 infection that could provide information about liver damage Material and Methods. Literature review study using database PubMed has been performed. In the search process keywords –„COVID-19” , „liver damage” and „biomarkers” have been used. Results. Lactate dehydrogenase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are often elevated in COVID-19 patients, indicating liver damage. Recent reports point to the fact that liver injury, by means of increased aminotransferase levels, more frequently occurred in severe COVID-19 cases compared to patients with mild symptoms. Conclusion. Further ...
Laboratory Medicine Department, Nicolae Testemitanu SUMPhBackground. The World Health Organizatio... more Laboratory Medicine Department, Nicolae Testemitanu SUMPhBackground. The World Health Organization (WHO) estimated in 2019 10 million cases of tuberculosis (TB) with 1.6 million deaths worldwide. Since 2020, COVID-19 is a respiratory disease that has spread globally with approximately 111 million cases reported to the WHO. Objective of the study. Studying data from the literature on the interaction of pulmonary tuberculosis and COVID-19 Material and Methods. Data from the literature were analyzed using the PUBMED, Google academic and HINARI databases, referring to pulmonary tuberculosis, COVID-19, TB / COVID-19. Results. The results of the studies indicate that COVID-19 induces an adaptive immune response specific to the SARS-CoV-2 antigen involving CD4, CD8 cells and B lymphocytes. In particular, SARS-CoV-2- specific CD4 + T cells are associated with a protective immune response, while an insufficient immune response is associated with increased severity of the disease. COVID-19 is...
Catedra Boli Infecțioase, Clinica Boli Infecțioase la Copii Valentina Halitov, USMF Nicolae Teste... more Catedra Boli Infecțioase, Clinica Boli Infecțioase la Copii Valentina Halitov, USMF Nicolae Testemițanu, IMSP Spitalul Clinic Municipal de Boli Contagioase de Copii, Universitatea de Stat de Medicină și Farmacie N. TestemițanuMeningococcal infection continue to be an actual problem that frequently affects children both in Republic of Moldova and in other countries. It’s one of the most serious infectious disease that evolve under different clinical forms such as localized, generalized, or associated one, also including central nervous system injuries. Thus in the last years were observed sporadic cases with meningococcal infection, it still remain a major problem, because young children often develop generalized forms with fulminant evolution and serious consequences. During the (2010-2015) years, we analysed in a retrospective and prospective way 43 cases with meningococcal infection in Municipal Infectious Diseases Hospital for Children and observed that more affected were childre...
Background: Currently, there is a growing interest in new copper (Cu2+) heterocyclic coordination... more Background: Currently, there is a growing interest in new copper (Cu2+) heterocyclic coordination compounds (CC), isothiosemicarbazide derivates, which demonstrated multiple beneficial properties, but their effect on reactions with free radicals such as the superoxide radical has not been investigated. Material and methods: The action of new micromolecular complexes of copper (Cu2+) chloride and bromide with methyl n- (prop-2-en-1-yl) -2- (pyridin2-ylmethylidene) hydrazine carbimidothioate on capturing activity of the superoxide radical was determined by the spectrophotometric method in vitro experiments. Results: It was established that the micromolecular complexes of copper (II) chloride and bromide with methyl n-(prop-2-en-1-yl)-2-(pyridin-2- ylmethylidene) hydrazine carbimidothioate have been found to possess strong superoxide radical inhibitor properties when interacting with a superoxide radical. In addition to this, the IC50 of the studied compounds depends on the nature of t...
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