An automated system for the detn. of radiochem. compn. of microcurie samples of medical radionucl... more An automated system for the detn. of radiochem. compn. of microcurie samples of medical radionuclides and/or radiopharmaceutical prepns. is described. The system incorporates a multichannel analyzer, a NaI (Tl) detector, a lead collimator, a motor-driven rack, and assocd. electronic components to provide a fast, accurate, and reproducible method for the identification of radiochem. species. When analyzing a radiochromatogram, the system provides both graphic and hard-copy qual. and quant. information. The system is applicable to the needs of most nuclear medicine and radiochem. labs., is easy to operate, reduces radiation exposure to personnel, enhances versatility, and decreases the time required to perform radiochem. quality control tests. This system provides better anal. data than the strip-counting technique and comparable quality information of more expensive systems. [on SciFinder(R)]
The International Journal of Applied Radiation and Isotopes, 1984
Abstract Targetry and a radiochemical process are reported for the production of no-carrier-added... more Abstract Targetry and a radiochemical process are reported for the production of no-carrier-added (NCA) 101mRh for use in the synthesis of radiopharmaceuticals. Proton-induced reactions on 103Rh targets were studied in order to evaluate the 103Rh(p,3n)101Pd→101mRh reaction as a source of high radionuclidic purity 101mRh. Cross sections (mb) and thin-target yields (mCi/μAh) for 101mRh, 101Rh, 100Rh, 101Pd, and 100Pd were measured at end-of-bombardment (EOB). The theoretical 101mRh cumulative yield from its 101Pd parent, at 32.7 h post EOB, was calculated as 4.71 ± 0.61 mCi/μAh, in the 67-to 15-MeV energy region. However, due to the production of the 20.8-h 100Rh, from its parent 3.63-d 100Pd, in the same energy region, a long decay time (> 170 h) is required to increase the radionuclidic purity of 101mRh to greater than 99%. The “effective” 101mRh yield is then reduced (to 1.0 mCi/μAh for a 4-h radiochemistry) due to decay losses. A radiochemical process used to prepare no-carrier-added (NCA) 101mRh is also explained, with emphasis on its effect on 101mRh yields.
A method is described for separating radioyttrium from strontium within 30−40 min. The yield of r... more A method is described for separating radioyttrium from strontium within 30−40 min. The yield of radioyttrium amounts to 97% and the strontium impurity occurs at 8.2 ppm level. Radioyttrium (containing 86Y, 87Y and 88Y) was produced by proton-induced nuclear reactions on natSrCO3 deposited on Cu backing. Irradiated target material was removed with acetone and 8 M HCl solution from copper substrate, followed by ethyl cellulose (EC) filter removal. Optimal radioyttrium separations from Cu and 65Zn activities were obtained by loading the mixture on Dowex-1×8 anion exchange resin and eluting with 8 M HCl, followed by precipitation of natSr as SrSO4 while radioyttrium passed through the filter paper.
An automated system for the detn. of radiochem. compn. of microcurie samples of medical radionucl... more An automated system for the detn. of radiochem. compn. of microcurie samples of medical radionuclides and/or radiopharmaceutical prepns. is described. The system incorporates a multichannel analyzer, a NaI (Tl) detector, a lead collimator, a motor-driven rack, and assocd. electronic components to provide a fast, accurate, and reproducible method for the identification of radiochem. species. When analyzing a radiochromatogram, the system provides both graphic and hard-copy qual. and quant. information. The system is applicable to the needs of most nuclear medicine and radiochem. labs., is easy to operate, reduces radiation exposure to personnel, enhances versatility, and decreases the time required to perform radiochem. quality control tests. This system provides better anal. data than the strip-counting technique and comparable quality information of more expensive systems. [on SciFinder(R)]
The International Journal of Applied Radiation and Isotopes, 1984
Abstract Targetry and a radiochemical process are reported for the production of no-carrier-added... more Abstract Targetry and a radiochemical process are reported for the production of no-carrier-added (NCA) 101mRh for use in the synthesis of radiopharmaceuticals. Proton-induced reactions on 103Rh targets were studied in order to evaluate the 103Rh(p,3n)101Pd→101mRh reaction as a source of high radionuclidic purity 101mRh. Cross sections (mb) and thin-target yields (mCi/μAh) for 101mRh, 101Rh, 100Rh, 101Pd, and 100Pd were measured at end-of-bombardment (EOB). The theoretical 101mRh cumulative yield from its 101Pd parent, at 32.7 h post EOB, was calculated as 4.71 ± 0.61 mCi/μAh, in the 67-to 15-MeV energy region. However, due to the production of the 20.8-h 100Rh, from its parent 3.63-d 100Pd, in the same energy region, a long decay time (> 170 h) is required to increase the radionuclidic purity of 101mRh to greater than 99%. The “effective” 101mRh yield is then reduced (to 1.0 mCi/μAh for a 4-h radiochemistry) due to decay losses. A radiochemical process used to prepare no-carrier-added (NCA) 101mRh is also explained, with emphasis on its effect on 101mRh yields.
A method is described for separating radioyttrium from strontium within 30−40 min. The yield of r... more A method is described for separating radioyttrium from strontium within 30−40 min. The yield of radioyttrium amounts to 97% and the strontium impurity occurs at 8.2 ppm level. Radioyttrium (containing 86Y, 87Y and 88Y) was produced by proton-induced nuclear reactions on natSrCO3 deposited on Cu backing. Irradiated target material was removed with acetone and 8 M HCl solution from copper substrate, followed by ethyl cellulose (EC) filter removal. Optimal radioyttrium separations from Cu and 65Zn activities were obtained by loading the mixture on Dowex-1×8 anion exchange resin and eluting with 8 M HCl, followed by precipitation of natSr as SrSO4 while radioyttrium passed through the filter paper.
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