Clinical Pharmacology and Therapeutics, Sep 1, 1982
The EEG effects of aspirin at single doses of 0.65 and 1.95 gm were studied in normal adult men. ... more The EEG effects of aspirin at single doses of 0.65 and 1.95 gm were studied in normal adult men. Compared to placebo, 1.95 gm affected the quantitative EEG, symptom self reports, and cognitive functions. The effects of 0.65 gm. were similar in direction and pattern, but failed measurable significance. The EEG profile of aspirin is distinct from that of other psychoactive substances. Its interaction with sedative substances should be considered in routine clinical use.
This study assessed the incidence, severity, and course of expressed suicidal intent in depressed... more This study assessed the incidence, severity, and course of expressed suicidal intent in depressed patients who were treated with ECT. The data are from the first phase of an ongoing, collaborative multicenter study, the overall aim of which was to compare continuation ECT with pharmacotherapy in the prevention of relapse after a successful course of ECT. Suicidal intent, as expressed by patients during an interview, was scored at baseline and before each ECT session with item 3 on the 24-item Hamilton Depression Rating Scale in 444 patients with unipolar depression. One hundred thirty-one patients (29.5%) reported suicidal thoughts and acts (score of 3 or 4) at baseline. Scores decreased to 0 after 1 week (three ECT sessions) in 38.2% of the patients, after 2 weeks (six ECT sessions) in 61.1%, and in 80.9% at the end of the course of treatment. Expressed suicidal intent in depressed patients was rapidly relieved with ECT. Evidence-based treatment algorithms for major depressive mood disorders should include dichotomization according to suicide risk, as assessed by interview. For patients at risk, ECT should be considered earlier than at its conventional "last resort" position.
The brain concentration of fluphenazine was measured in two groups of rats, one treated with flup... more The brain concentration of fluphenazine was measured in two groups of rats, one treated with fluphenazine and electroconvulsive shock, and the other with fluphenazine only. No difference was found in brain fluphenazine concentration between the two groups. The experiment was replicated with a larger number of rats and the same result was obtained. Electroconvulsive shock does not increase the concentration of fluphenazine in brain tissue.
Based on the early reports of the successful treatment of depressive states with chlorpromazine, ... more Based on the early reports of the successful treatment of depressive states with chlorpromazine, 35 consecutive voluntary hospitalized psychiatric patients referred for drug therapy were randomly assigned to one of three treatment regimens. 11 depressive patients received imipramine, 10 placebo and 14, a combination of chlorpromazine and procyclidine in a six-week, fixed dosage schedule.
SWARTZ Conrad M.; MCCLINTOCK Shawn M.; HUSAIN Mustafa M.; RUSH A. John; CLAASSEN Cynthia; BIGGS M... more SWARTZ Conrad M.; MCCLINTOCK Shawn M.; HUSAIN Mustafa M.; RUSH A. John; CLAASSEN Cynthia; BIGGS Melanie M.; KNAPP Rebecca G.; MUELLER Martina; FINK Max; BAILINE Samuel H.; RUMMANS Teresa A.; SAMPSON Shirlene; PETRIDES Georgios; ...
... Belling the Cat: ECT Practice Standards in the United States. Fink, Max MD*; Kellner, Charles... more ... Belling the Cat: ECT Practice Standards in the United States. Fink, Max MD*; Kellner, Charles H. MD. Article Outline. Collapse Box Author Information. ... Cited Here... 21. Rose D, Wykes T, Leese M, et al. Patients' perspectives on electroconvulsive therapy: systematic review. BMJ. ...
The electroencephalographic (EEG) and behavioral effects of oral doses of phenytoin from 100 mg t... more The electroencephalographic (EEG) and behavioral effects of oral doses of phenytoin from 100 mg to 1 g in normal male volunteers were measured. The electroencephalogram exhibited decreases in power in the slow frequencies and increases in the fast frequencies, accompanied by an increase in mean frequency. These changes are similar to those seen with psychostimulants. They occurred at average plasma levels of 8 micrograms/ml and above. The time course and the intensity of EEG effects parallel plasma levels. Drug-related EEG changes were bilaterally symmetric. EEG changes at plasma levels of 8--12 micrograms/ml were not associated with behavioral toxic signs. These findings suggest that future psychiatric studies of phenytoin as a psychostimulant should include monitoring for plasma levels, with a minimum of 8 micrograms/ml as a guide to clinical efficacy.
Clinical Pharmacology and Therapeutics, Sep 1, 1982
The EEG effects of aspirin at single doses of 0.65 and 1.95 gm were studied in normal adult men. ... more The EEG effects of aspirin at single doses of 0.65 and 1.95 gm were studied in normal adult men. Compared to placebo, 1.95 gm affected the quantitative EEG, symptom self reports, and cognitive functions. The effects of 0.65 gm. were similar in direction and pattern, but failed measurable significance. The EEG profile of aspirin is distinct from that of other psychoactive substances. Its interaction with sedative substances should be considered in routine clinical use.
This study assessed the incidence, severity, and course of expressed suicidal intent in depressed... more This study assessed the incidence, severity, and course of expressed suicidal intent in depressed patients who were treated with ECT. The data are from the first phase of an ongoing, collaborative multicenter study, the overall aim of which was to compare continuation ECT with pharmacotherapy in the prevention of relapse after a successful course of ECT. Suicidal intent, as expressed by patients during an interview, was scored at baseline and before each ECT session with item 3 on the 24-item Hamilton Depression Rating Scale in 444 patients with unipolar depression. One hundred thirty-one patients (29.5%) reported suicidal thoughts and acts (score of 3 or 4) at baseline. Scores decreased to 0 after 1 week (three ECT sessions) in 38.2% of the patients, after 2 weeks (six ECT sessions) in 61.1%, and in 80.9% at the end of the course of treatment. Expressed suicidal intent in depressed patients was rapidly relieved with ECT. Evidence-based treatment algorithms for major depressive mood disorders should include dichotomization according to suicide risk, as assessed by interview. For patients at risk, ECT should be considered earlier than at its conventional "last resort" position.
The brain concentration of fluphenazine was measured in two groups of rats, one treated with flup... more The brain concentration of fluphenazine was measured in two groups of rats, one treated with fluphenazine and electroconvulsive shock, and the other with fluphenazine only. No difference was found in brain fluphenazine concentration between the two groups. The experiment was replicated with a larger number of rats and the same result was obtained. Electroconvulsive shock does not increase the concentration of fluphenazine in brain tissue.
Based on the early reports of the successful treatment of depressive states with chlorpromazine, ... more Based on the early reports of the successful treatment of depressive states with chlorpromazine, 35 consecutive voluntary hospitalized psychiatric patients referred for drug therapy were randomly assigned to one of three treatment regimens. 11 depressive patients received imipramine, 10 placebo and 14, a combination of chlorpromazine and procyclidine in a six-week, fixed dosage schedule.
SWARTZ Conrad M.; MCCLINTOCK Shawn M.; HUSAIN Mustafa M.; RUSH A. John; CLAASSEN Cynthia; BIGGS M... more SWARTZ Conrad M.; MCCLINTOCK Shawn M.; HUSAIN Mustafa M.; RUSH A. John; CLAASSEN Cynthia; BIGGS Melanie M.; KNAPP Rebecca G.; MUELLER Martina; FINK Max; BAILINE Samuel H.; RUMMANS Teresa A.; SAMPSON Shirlene; PETRIDES Georgios; ...
... Belling the Cat: ECT Practice Standards in the United States. Fink, Max MD*; Kellner, Charles... more ... Belling the Cat: ECT Practice Standards in the United States. Fink, Max MD*; Kellner, Charles H. MD. Article Outline. Collapse Box Author Information. ... Cited Here... 21. Rose D, Wykes T, Leese M, et al. Patients' perspectives on electroconvulsive therapy: systematic review. BMJ. ...
The electroencephalographic (EEG) and behavioral effects of oral doses of phenytoin from 100 mg t... more The electroencephalographic (EEG) and behavioral effects of oral doses of phenytoin from 100 mg to 1 g in normal male volunteers were measured. The electroencephalogram exhibited decreases in power in the slow frequencies and increases in the fast frequencies, accompanied by an increase in mean frequency. These changes are similar to those seen with psychostimulants. They occurred at average plasma levels of 8 micrograms/ml and above. The time course and the intensity of EEG effects parallel plasma levels. Drug-related EEG changes were bilaterally symmetric. EEG changes at plasma levels of 8--12 micrograms/ml were not associated with behavioral toxic signs. These findings suggest that future psychiatric studies of phenytoin as a psychostimulant should include monitoring for plasma levels, with a minimum of 8 micrograms/ml as a guide to clinical efficacy.
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