The direct α‐Csp2H functionalization and thiomethylation of α‐oxoketene dithioacetals (DTAs) has... more The direct α‐Csp2H functionalization and thiomethylation of α‐oxoketene dithioacetals (DTAs) has been accomplished with dimethyl sulfoxide (DMSO) in the presence of iodine and a copper(I) salt for the first time. A prerequisite is the in situ iodination of the α‐Csp2 atom of dithioacetals that could offer other reaction channels. The operationally simple one‐pot protocol includes region‐defined consecutive iodination and sulfenylation of the challenging α‐Csp2H bond of dithioacetals employing cheap and readily available reagents. DMSO here plays a dual role as thiomethyl source and solvent.magnified image
An operationally simple, economical, and straightforward synthesis of diverse 4,5-disubstituted 1... more An operationally simple, economical, and straightforward synthesis of diverse 4,5-disubstituted 1,2,3-thiadiazoles from α-enolicdithioesters has been achieved via nitrosation/reduction/diazotization/cyclization sequence in one-pot through the formation of cascade 1–2 (N–S) and 3–4 (C–N) bonds. Importantly, this is the first straightforward entry to highly functionalized 1,2,3-thiadiazoles from dithioesters.
Catalyst-free one-pot sustainable synthesis of thiazoloquinoline and thiazolopyridine scaffolds i... more Catalyst-free one-pot sustainable synthesis of thiazoloquinoline and thiazolopyridine scaffolds is achievedviafour-component domino reactions in water–PEG.
Abstract An operationally simple and facile synthesis of α-hydroxyimino-β-oxodithioesters has bee... more Abstract An operationally simple and facile synthesis of α-hydroxyimino-β-oxodithioesters has been achieved by nitrosation of α-enolicdithioesters. They were further treated with internal alkynes to afford diverse 1,4-thiazin-3-ones via domino reduction/annulation strategy under mild reaction conditions. Importantly, this is the first straightforward entry to highly functionalized 1,4-thiazin-3-one derivatives from simple starting materials.
The direct α‐Csp2H functionalization and thiomethylation of α‐oxoketene dithioacetals (DTAs) has... more The direct α‐Csp2H functionalization and thiomethylation of α‐oxoketene dithioacetals (DTAs) has been accomplished with dimethyl sulfoxide (DMSO) in the presence of iodine and a copper(I) salt for the first time. A prerequisite is the in situ iodination of the α‐Csp2 atom of dithioacetals that could offer other reaction channels. The operationally simple one‐pot protocol includes region‐defined consecutive iodination and sulfenylation of the challenging α‐Csp2H bond of dithioacetals employing cheap and readily available reagents. DMSO here plays a dual role as thiomethyl source and solvent.magnified image
An operationally simple, economical, and straightforward synthesis of diverse 4,5-disubstituted 1... more An operationally simple, economical, and straightforward synthesis of diverse 4,5-disubstituted 1,2,3-thiadiazoles from α-enolicdithioesters has been achieved via nitrosation/reduction/diazotization/cyclization sequence in one-pot through the formation of cascade 1–2 (N–S) and 3–4 (C–N) bonds. Importantly, this is the first straightforward entry to highly functionalized 1,2,3-thiadiazoles from dithioesters.
Catalyst-free one-pot sustainable synthesis of thiazoloquinoline and thiazolopyridine scaffolds i... more Catalyst-free one-pot sustainable synthesis of thiazoloquinoline and thiazolopyridine scaffolds is achievedviafour-component domino reactions in water–PEG.
Abstract An operationally simple and facile synthesis of α-hydroxyimino-β-oxodithioesters has bee... more Abstract An operationally simple and facile synthesis of α-hydroxyimino-β-oxodithioesters has been achieved by nitrosation of α-enolicdithioesters. They were further treated with internal alkynes to afford diverse 1,4-thiazin-3-ones via domino reduction/annulation strategy under mild reaction conditions. Importantly, this is the first straightforward entry to highly functionalized 1,4-thiazin-3-one derivatives from simple starting materials.
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