We present the case of a woman with known risk factors for embolism with multiple kidney infarcti... more We present the case of a woman with known risk factors for embolism with multiple kidney infarctions. She was admitted with left renal colic, discrete hematuria and subfebrility. She was under acenocumarolum treatment but without efficient anticoagulation. Ultrasound performed at the emergency room revealed smaller right kidney (congenital hypoplasia) and moderately enlarged left kidney with hypoechoic areas in the parenchyma. Computer tomography scan with contrast agent revealed multiple avascular areas within the left kidney. Evolution was favorable after efficient anticoagulation. Contrast enhanced ultrasound performed two weeks later revealed only one residual avascular area. Differential diagnosis was made with acute pyelonephritis, cholesterol embolism and acute tubular necrosis in a diabetic patient.
Chronic obstructive pulmonary disease is a lung disorder characterized by chronic inflammation of... more Chronic obstructive pulmonary disease is a lung disorder characterized by chronic inflammation of the respiratory tract after exposure to pollutants, causing the obstruction of small respiratory tracts and the destruction of lung parenchyma. These changes ultimately lead to a limitation of air flux. We investigate the association between professional exposure and the risk of developing chronic obstructive pulmonary disease. This study presents the case of a non-smoker patient, aged 61, a mechanic locksmith by profession at a hospital in Mures County. He has been working with neutralization of medical waste for 13 years with exposure to pneumotropic and biological contaminants and to the overuse of osteoarticular apparatus, recently having been diagnosed with COPD after exposure to mixed powders and hospitalized at the occupational health clinic. Interruption of occupational exposure and establishment of treatment with topical corticotherapy has shown a significant improvement. Measurements of inhalable powder content in the work environment revealed that they exceed the allowed limit in case of neutralization of medical waste and there is an association between occupational exposure and increased risk of chronic obstructive pulmonary disease. Preventive methods should aim to reduce exposure at workplace.
Our paper presents the ultrasound (US) patterns of a rare kidney disease—medullary sponge kidney ... more Our paper presents the ultrasound (US) patterns of a rare kidney disease—medullary sponge kidney (MSK)—that have not been described before in comparison with other causes of medullary hyperechogenicity and correlates them with the severity of the disease and prognosis. This is a clinical observational study of all US examinations in the Nephrology Department over a period of 6 years. The abdominal US focused on the kidneys was recorded. US characteristics of the medulla and cortex were analyzed. We found 10 patients with characteristic daisy flower (DF) kidneys. Positive diagnosis in association with other renal risk factors, prognosis, and evolution were evaluated. Two patterns of medullary hyperechogenicity were found and were correlated with disease severity and kidney function. The first pattern is a homogenous echogenicity of the medulla described as a “daisy-like” appearance. The second pattern: calcifications associated with medullar echogenicity, stone production, nephrocalcinosis, and impaired kidney function: “atypical daisy-like.” Medullary hyperechogenicity can have more US patterns. In MSK, if the medullary echogenicity is homogenous the evolution is benign, whereas the second, inhomogeneous pattern, has a variable clinical presentation with nephrocalcinosis and the outcome is more severe, leading to chronic kidney disease and impairing the quality of life.
Aortic dissection (AD) is a severe cardiovascular condition that could have negative consequences... more Aortic dissection (AD) is a severe cardiovascular condition that could have negative consequences. Our study employed a prospective design and examined preoperative, perioperative, and postoperative data to evaluate the effects of gender on various medical conditions. We looked at how gender affected the results of aortic dissection (AD). In contrast to female patients who had more systemic hypertension (p=0.031), male patients had higher rates of hemopericardium (p=0.003), pulmonary hypertension (p=0.039), and hemopericardium (p=0.003). Dobutamine administration during surgery significantly raised the mortality risk (p=0.015). There were noticeably more women patients (p=0.01) in the 71 to 80 age group. Significant differences in age (p=0.004), eGFR at admission (p=0.009), and eGFR at discharge (p=0.006) were seen, however, there was no association between gender and mortality. In conclusion, our findings highlight that gender may no longer be such an important aspect of aortic dis...
Our paper presents the ultrasound (US) patterns of a rare kidney disease—medullary sponge kidney ... more Our paper presents the ultrasound (US) patterns of a rare kidney disease—medullary sponge kidney (MSK)—that have not been described before in comparison with other causes of medullary hyperechogenicity and correlates them with the severity of the disease and prognosis. This is a clinical observational study of all US examinations in the Nephrology Department over a period of 6 years. The abdominal US focused on the kidneys was recorded. US characteristics of the medulla and cortex were analyzed. We found 10 patients with characteristic daisy flower (DF) kidneys. Positive diagnosis in association with other renal risk factors, prognosis, and evolution were evaluated. Two patterns of medullary hyperechogenicity were found and were correlated with disease severity and kidney function. The first pattern is a homogenous echogenicity of the medulla described as a “daisy-like” appearance. The second pattern: calcifications associated with medullar echogenicity, stone production, nephrocalc...
Chronic kidney disease (CKD) is one of the clinical features characterized by progressive and irr... more Chronic kidney disease (CKD) is one of the clinical features characterized by progressive and irreversible loss of renal function. The incidence of this pathology is constantly increasing globally, due to the growing number of patients diagnosed with diabetes and hypertension, both diseases generating tubular fibrosis and kidney dysfunction. Through experimental models for the production of tubulo-interstitial fibrosis (TIF), we try to understand deeply and comprehensively the main pathogenic mechanisms that govern the onset, progression and worsening of CKD. Understanding the mechanisms underlying the production of this pathology, one can try therapeutic methods to produce an evolutionary slowdown in CKD and also translate the main benefits in clinical practice, based on these experimental models of basic research.
We present the case of a woman with known risk factors for embolism with multiple kidney infarcti... more We present the case of a woman with known risk factors for embolism with multiple kidney infarctions. She was admitted with left renal colic, discrete hematuria and subfebrility. She was under acenocumarolum treatment but without efficient anticoagulation. Ultrasound performed at the emergency room revealed smaller right kidney (congenital hypoplasia) and moderately enlarged left kidney with hypoechoic areas in the parenchyma. Computer tomography scan with contrast agent revealed multiple avascular areas within the left kidney. Evolution was favorable after efficient anticoagulation. Contrast enhanced ultrasound performed two weeks later revealed only one residual avascular area. Differential diagnosis was made with acute pyelonephritis, cholesterol embolism and acute tubular necrosis in a diabetic patient.
Chronic obstructive pulmonary disease is a lung disorder characterized by chronic inflammation of... more Chronic obstructive pulmonary disease is a lung disorder characterized by chronic inflammation of the respiratory tract after exposure to pollutants, causing the obstruction of small respiratory tracts and the destruction of lung parenchyma. These changes ultimately lead to a limitation of air flux. We investigate the association between professional exposure and the risk of developing chronic obstructive pulmonary disease. This study presents the case of a non-smoker patient, aged 61, a mechanic locksmith by profession at a hospital in Mures County. He has been working with neutralization of medical waste for 13 years with exposure to pneumotropic and biological contaminants and to the overuse of osteoarticular apparatus, recently having been diagnosed with COPD after exposure to mixed powders and hospitalized at the occupational health clinic. Interruption of occupational exposure and establishment of treatment with topical corticotherapy has shown a significant improvement. Measurements of inhalable powder content in the work environment revealed that they exceed the allowed limit in case of neutralization of medical waste and there is an association between occupational exposure and increased risk of chronic obstructive pulmonary disease. Preventive methods should aim to reduce exposure at workplace.
Our paper presents the ultrasound (US) patterns of a rare kidney disease—medullary sponge kidney ... more Our paper presents the ultrasound (US) patterns of a rare kidney disease—medullary sponge kidney (MSK)—that have not been described before in comparison with other causes of medullary hyperechogenicity and correlates them with the severity of the disease and prognosis. This is a clinical observational study of all US examinations in the Nephrology Department over a period of 6 years. The abdominal US focused on the kidneys was recorded. US characteristics of the medulla and cortex were analyzed. We found 10 patients with characteristic daisy flower (DF) kidneys. Positive diagnosis in association with other renal risk factors, prognosis, and evolution were evaluated. Two patterns of medullary hyperechogenicity were found and were correlated with disease severity and kidney function. The first pattern is a homogenous echogenicity of the medulla described as a “daisy-like” appearance. The second pattern: calcifications associated with medullar echogenicity, stone production, nephrocalcinosis, and impaired kidney function: “atypical daisy-like.” Medullary hyperechogenicity can have more US patterns. In MSK, if the medullary echogenicity is homogenous the evolution is benign, whereas the second, inhomogeneous pattern, has a variable clinical presentation with nephrocalcinosis and the outcome is more severe, leading to chronic kidney disease and impairing the quality of life.
Aortic dissection (AD) is a severe cardiovascular condition that could have negative consequences... more Aortic dissection (AD) is a severe cardiovascular condition that could have negative consequences. Our study employed a prospective design and examined preoperative, perioperative, and postoperative data to evaluate the effects of gender on various medical conditions. We looked at how gender affected the results of aortic dissection (AD). In contrast to female patients who had more systemic hypertension (p=0.031), male patients had higher rates of hemopericardium (p=0.003), pulmonary hypertension (p=0.039), and hemopericardium (p=0.003). Dobutamine administration during surgery significantly raised the mortality risk (p=0.015). There were noticeably more women patients (p=0.01) in the 71 to 80 age group. Significant differences in age (p=0.004), eGFR at admission (p=0.009), and eGFR at discharge (p=0.006) were seen, however, there was no association between gender and mortality. In conclusion, our findings highlight that gender may no longer be such an important aspect of aortic dis...
Our paper presents the ultrasound (US) patterns of a rare kidney disease—medullary sponge kidney ... more Our paper presents the ultrasound (US) patterns of a rare kidney disease—medullary sponge kidney (MSK)—that have not been described before in comparison with other causes of medullary hyperechogenicity and correlates them with the severity of the disease and prognosis. This is a clinical observational study of all US examinations in the Nephrology Department over a period of 6 years. The abdominal US focused on the kidneys was recorded. US characteristics of the medulla and cortex were analyzed. We found 10 patients with characteristic daisy flower (DF) kidneys. Positive diagnosis in association with other renal risk factors, prognosis, and evolution were evaluated. Two patterns of medullary hyperechogenicity were found and were correlated with disease severity and kidney function. The first pattern is a homogenous echogenicity of the medulla described as a “daisy-like” appearance. The second pattern: calcifications associated with medullar echogenicity, stone production, nephrocalc...
Chronic kidney disease (CKD) is one of the clinical features characterized by progressive and irr... more Chronic kidney disease (CKD) is one of the clinical features characterized by progressive and irreversible loss of renal function. The incidence of this pathology is constantly increasing globally, due to the growing number of patients diagnosed with diabetes and hypertension, both diseases generating tubular fibrosis and kidney dysfunction. Through experimental models for the production of tubulo-interstitial fibrosis (TIF), we try to understand deeply and comprehensively the main pathogenic mechanisms that govern the onset, progression and worsening of CKD. Understanding the mechanisms underlying the production of this pathology, one can try therapeutic methods to produce an evolutionary slowdown in CKD and also translate the main benefits in clinical practice, based on these experimental models of basic research.
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