Recent studies have shown a low adherence rate to maintenance treatment in patients with inflamma... more Recent studies have shown a low adherence rate to maintenance treatment in patients with inflammatory bowel disease (IBD). We sought to assess the medication-taking behavior in a cohort of patients with IBD. We prospectively included IBD patients from the outpatient clinic who agreed to answer a questionnaire about prescribed treatment and adherence. Physicians registered clinical data including prescribed medications. Two hundred fourteen patients (115 Crohn's disease/99 ulcerative colitis) were included. The most prescribed medications were oral mesalazine (56.5%) and immunomodulators (41.1%). Forty-three percent of patients admitted to occasionally forgetting to take their medication but only 7.5% of them did it voluntary. Oral mesalazine and azathioprine were the drugs with the poorest compliance, with nonadherence rates of 45% and 25% of the total prescribed doses, respectively. The only factor associated with a better adherence was a more complicated course of the disease—steroid dependency, steroid refractoriness, need for infliximab treatment, hospitalization, or surgery (P=.02). Twenty percent of patients admitted to self-medicating. An important proportion of patients with IBD admit to forget some doses of the prescribed medication in the setting of a specialized unit of a referral centre.
A total of 58 new archaeomagnetic directions has been determined from archaeological structures i... more A total of 58 new archaeomagnetic directions has been determined from archaeological structures in Spain. Together with five previous results they allow the compilation of the first archaeomagnetic catalogue for Spain, which includes 63 directions with ages ranging between the 2nd century BC and the 20th century AD. Characteristic remanence directions have been obtained from stepwise thermal and alternating field demagnetization. The hierarchical structure has been respected in the calculation of the mean site directions. Rock magnetic experiments reveal that the main magnetic carrier is magnetite or titanomagnetite with different titanium contents. The age estimate of the studied structures is generally well justified by archaeological constraints. For six structures the proposed date is also supported by physical methods. The data are in close agreement with the French secular variation (SV) curve. This catalogue represents the first step in the construction of a SV curve for the Iberian Peninsula, which will be of much use in archaeomagnetic dating and in modelling of the Earth's magnetic field in Western Europe.
The effect of pesticide treatments on small lakes in the vicinity of cultivated lands has been st... more The effect of pesticide treatments on small lakes in the vicinity of cultivated lands has been studied. Pesticides of widespread use in the selected area were determined in water and sediment samples from 27 different lakes, in different seasons, using multiresidue analysis methods. Many of the pesticides analyzed were found in the samples suggesting that these pesticides are mobile enough to reach the water in the small lakes. This must be considered because this water is used in some cases to irrigate the neighboring crops.
Aliment Pharmacol Ther 31, 553–560Aliment Pharmacol Ther 31, 553–560SummaryBackground Most avail... more Aliment Pharmacol Ther 31, 553–560Aliment Pharmacol Ther 31, 553–560SummaryBackground Most available data on infliximab therapy come from large, short-term, pivotal RCTs and concerns about long-term safety profile still remain.Aim To evaluate the long-term safety profile of infliximab in inflammatory bowel disease (IBD) in a clinical practice setting.Methods Since 1999, all IBD patients treated with infliximab were registered and clinical outcomes prospectively recorded up to March 2008, loss of follow-up or patient’s death. Infliximab regimens and preventive measures were in accordance with the prevalent guidelines or with the manufacturer’s recommendations.Results One hundred fifty-two patients were included (121 Crohn’s disease, 24 ulcerative colitis, 7 indeterminate colitis), with a median of 5 infliximab infusions (IQR 3–8) and 87% of patients received at least three infusions. Seventy-nine per cent of them received concomitant immunomodulators and 70% were pre-medicated with hydrocortisone from the first infusion. After a median follow-up of 142 weeks, 13% presented infusion reactions, 13% viral or bacterial infections and two patients developed neoplasia. The mortality rate was 2.6% (four patients).Conclusions Infliximab therapy is safe when the recommended preventive measures are implemented, with a rate of serious adverse events less than 10%. No new safety signals were found.Background Most available data on infliximab therapy come from large, short-term, pivotal RCTs and concerns about long-term safety profile still remain.Aim To evaluate the long-term safety profile of infliximab in inflammatory bowel disease (IBD) in a clinical practice setting.Methods Since 1999, all IBD patients treated with infliximab were registered and clinical outcomes prospectively recorded up to March 2008, loss of follow-up or patient’s death. Infliximab regimens and preventive measures were in accordance with the prevalent guidelines or with the manufacturer’s recommendations.Results One hundred fifty-two patients were included (121 Crohn’s disease, 24 ulcerative colitis, 7 indeterminate colitis), with a median of 5 infliximab infusions (IQR 3–8) and 87% of patients received at least three infusions. Seventy-nine per cent of them received concomitant immunomodulators and 70% were pre-medicated with hydrocortisone from the first infusion. After a median follow-up of 142 weeks, 13% presented infusion reactions, 13% viral or bacterial infections and two patients developed neoplasia. The mortality rate was 2.6% (four patients).Conclusions Infliximab therapy is safe when the recommended preventive measures are implemented, with a rate of serious adverse events less than 10%. No new safety signals were found.
Recent studies have shown a low adherence rate to maintenance treatment in patients with inflamma... more Recent studies have shown a low adherence rate to maintenance treatment in patients with inflammatory bowel disease (IBD). We sought to assess the medication-taking behavior in a cohort of patients with IBD. We prospectively included IBD patients from the outpatient clinic who agreed to answer a questionnaire about prescribed treatment and adherence. Physicians registered clinical data including prescribed medications. Two hundred fourteen patients (115 Crohn's disease/99 ulcerative colitis) were included. The most prescribed medications were oral mesalazine (56.5%) and immunomodulators (41.1%). Forty-three percent of patients admitted to occasionally forgetting to take their medication but only 7.5% of them did it voluntary. Oral mesalazine and azathioprine were the drugs with the poorest compliance, with nonadherence rates of 45% and 25% of the total prescribed doses, respectively. The only factor associated with a better adherence was a more complicated course of the disease—steroid dependency, steroid refractoriness, need for infliximab treatment, hospitalization, or surgery (P=.02). Twenty percent of patients admitted to self-medicating. An important proportion of patients with IBD admit to forget some doses of the prescribed medication in the setting of a specialized unit of a referral centre.
A total of 58 new archaeomagnetic directions has been determined from archaeological structures i... more A total of 58 new archaeomagnetic directions has been determined from archaeological structures in Spain. Together with five previous results they allow the compilation of the first archaeomagnetic catalogue for Spain, which includes 63 directions with ages ranging between the 2nd century BC and the 20th century AD. Characteristic remanence directions have been obtained from stepwise thermal and alternating field demagnetization. The hierarchical structure has been respected in the calculation of the mean site directions. Rock magnetic experiments reveal that the main magnetic carrier is magnetite or titanomagnetite with different titanium contents. The age estimate of the studied structures is generally well justified by archaeological constraints. For six structures the proposed date is also supported by physical methods. The data are in close agreement with the French secular variation (SV) curve. This catalogue represents the first step in the construction of a SV curve for the Iberian Peninsula, which will be of much use in archaeomagnetic dating and in modelling of the Earth's magnetic field in Western Europe.
The effect of pesticide treatments on small lakes in the vicinity of cultivated lands has been st... more The effect of pesticide treatments on small lakes in the vicinity of cultivated lands has been studied. Pesticides of widespread use in the selected area were determined in water and sediment samples from 27 different lakes, in different seasons, using multiresidue analysis methods. Many of the pesticides analyzed were found in the samples suggesting that these pesticides are mobile enough to reach the water in the small lakes. This must be considered because this water is used in some cases to irrigate the neighboring crops.
Aliment Pharmacol Ther 31, 553–560Aliment Pharmacol Ther 31, 553–560SummaryBackground Most avail... more Aliment Pharmacol Ther 31, 553–560Aliment Pharmacol Ther 31, 553–560SummaryBackground Most available data on infliximab therapy come from large, short-term, pivotal RCTs and concerns about long-term safety profile still remain.Aim To evaluate the long-term safety profile of infliximab in inflammatory bowel disease (IBD) in a clinical practice setting.Methods Since 1999, all IBD patients treated with infliximab were registered and clinical outcomes prospectively recorded up to March 2008, loss of follow-up or patient’s death. Infliximab regimens and preventive measures were in accordance with the prevalent guidelines or with the manufacturer’s recommendations.Results One hundred fifty-two patients were included (121 Crohn’s disease, 24 ulcerative colitis, 7 indeterminate colitis), with a median of 5 infliximab infusions (IQR 3–8) and 87% of patients received at least three infusions. Seventy-nine per cent of them received concomitant immunomodulators and 70% were pre-medicated with hydrocortisone from the first infusion. After a median follow-up of 142 weeks, 13% presented infusion reactions, 13% viral or bacterial infections and two patients developed neoplasia. The mortality rate was 2.6% (four patients).Conclusions Infliximab therapy is safe when the recommended preventive measures are implemented, with a rate of serious adverse events less than 10%. No new safety signals were found.Background Most available data on infliximab therapy come from large, short-term, pivotal RCTs and concerns about long-term safety profile still remain.Aim To evaluate the long-term safety profile of infliximab in inflammatory bowel disease (IBD) in a clinical practice setting.Methods Since 1999, all IBD patients treated with infliximab were registered and clinical outcomes prospectively recorded up to March 2008, loss of follow-up or patient’s death. Infliximab regimens and preventive measures were in accordance with the prevalent guidelines or with the manufacturer’s recommendations.Results One hundred fifty-two patients were included (121 Crohn’s disease, 24 ulcerative colitis, 7 indeterminate colitis), with a median of 5 infliximab infusions (IQR 3–8) and 87% of patients received at least three infusions. Seventy-nine per cent of them received concomitant immunomodulators and 70% were pre-medicated with hydrocortisone from the first infusion. After a median follow-up of 142 weeks, 13% presented infusion reactions, 13% viral or bacterial infections and two patients developed neoplasia. The mortality rate was 2.6% (four patients).Conclusions Infliximab therapy is safe when the recommended preventive measures are implemented, with a rate of serious adverse events less than 10%. No new safety signals were found.
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