Monatshefte Fuer Chemie Chemical Monthly, Oct 1, 1991
The iron(III) complexes with sulphathiazole, sulphamethoxazole, sulphadiazine, sulphapyridine and... more The iron(III) complexes with sulphathiazole, sulphamethoxazole, sulphadiazine, sulphapyridine and sulphadimidine having the stoichiometric ratio 1:2 (metal:ligand) were prepared and characterized on the basis of elemental analysis, conductivity measurements and electronic absorption spectra. The infrared spectra of the complexes revealed that the terminal amino group of the sulpha molecules is not involved in coordination. Similarities in the position of iron-nitrogen and iron-oxygen stretching modes indicate identical configuration of the complexes prepared. Conductivity measurements showed that they are nonelectrolytes. X-ray powder diffraction patterns showed that two of them are crystalline and others are amorphous. Electron spin resonance and iron-57 Mössbauer measurements indicated that the complexes contain high-spin Fe3+ species. Thermogravimetric analyses showed that all complexes contain coordinated water which is lost at 141–160°C. All the complexes proved to possess higher bacteriostatic activity than the corresponding ligand. Es wurden die (Metall:Ligand) 1:2 Eisen(III)-Komplexe von Sulfathiazol, Sulfamethoxazol, Sulfapyridin und Sulfadimidin hergestellt und mittels Elementaranalyse, Leitfähigkeitsmessungen und Elektronenabsorptionsspektroskopie charakterisiert. Die IR-Spektren der Komplexe zeigten, daß die Amino-Gruppen der Sulfa-Moleküle nicht an der Koordination beteiligt sind. Ähnlichkeiten im Bereich der Eisen-Stickstoff- und Eisen-Sauerstoff-Streckschwingungen zeigten idente Konfiguration der Komplexe an. Leitfähigkeitsmessungen beweisen den Nichtelektrolytcharakter. Röntgen-Pulverdiagramme zeigten, daß zwei der Komplexe kristallin, die anderen hingegen amorph waren. High-Spin Eisen(III)-Spezies wurden mittels Elektrononspinresonanz und Eisen-57-Mössbauer-Messungen nachgewiesen. Die thermogravimetrische Analyse zeigte, daß alle Komplexe koordiniertes Wasser enthielten, das zwischen 141 und 160°C verloren wurde. Alle Komplexe zeigten eine höhere bakteriostatische Aktivität als die entsprechenden Liganden allein.
Journal of the Egyptian Society of Parasitology, May 1, 2004
Liver biopsy is thought mandatory for management in patients with hepatitis C virus infection (HC... more Liver biopsy is thought mandatory for management in patients with hepatitis C virus infection (HCV) especially for histopathological grading and staging of the disease to assess suitability for treatment and monitoring disease progression. However, tracking of liver disease progression can't rely on repeated biopsies. The study aimed to evaluate two significant items, we try to develop and validate a non-invasive predictive tool to assess hepatic necro-inflammation and fibrosis. Also, to determine factors that associate severity of hepatic pathology in HCV infected Egyptian patients particularly at Sharkia G. The study included 109 patients with detectable HCV by Real Time-PCR. The patients were classified into three different pathological stages and grades according to the new concept of histopathoglical staging and grading. The different clinical, biochemical, virological and ultra-sonographic parameters were assessed and analyzed and the variables that showed significant association with histopathological staging and grading were included in multivariate logistic regression analysis. The regression model revealed that, platelet count, matrix metalloproteinase-9 (MMP-9), portal vein diameter, splenic longitudinal axis, alanine transaminase, aspartate transaminase and viral load were the factors that add significance to the model in decreasing order of significance. From these findings we generate a new score ranged from 0-9. The score model was applied to our patients to assess its validity where it proved to be accurate in discriminating patients with mild inflammation and fibrosis (sensitivity 81.8%, specificity 80.5% and accuracy 80.7%) and more accurate in detecting patients with cirrhosis (specificity 96.6%, sensitivity 80% & accuracy 93.6%) but less accurate in detecting patients with moderate to severe fibrosis (specificity 66.7%, sensitivity 68.7% & accuracy 67.9%). Also the results revealed that, co-infection with schistosomiasis, old age > or = 45 years and positive history of blood transfusion as a source of infection was significantly associated with severe hepatic pathology. It is concluded that, the score model can't completely replace liver biopsy but at least it could be used to substantially reduce the number of liver biopsies done in patients with HCV infection in assessing disease progression during follow up. Also, it can be used to make decisions about treatment in patients who have contraindications to or who refused liver biopsy. Co-infection with schistosomiasis, age > or = 45 and positive history of blood transfusion in patients with HCV warrant special attention with more intensive follow up. These factors may play a major role in forecasting the course of HCV as well as in determining the therapeutic approach in each case.
Journal of the Egyptian Society of Parasitology, May 1, 2004
The natural history of hepatitis C virus (HCV) infection has a highly variable course. Many patie... more The natural history of hepatitis C virus (HCV) infection has a highly variable course. Many patients develop chronic infection, with its consequent risk of cirrhosis, liver failure and hepatocellular carcinoma. A key question is whether patients at high risk of disease progression can be distinguished from those with relatively benign disease course. The disease progression is influenced by other factors such as duration of infection, age at infection, sex, co-infection with hepatitis B virus (HBV), Epstein Bar virus (EBV), cytomegalovirus (CMV), the level of HCV viraemia and its type. Other endemic infections in the community as bilharziasis may have a role in progression of the condition to serious complications. These factors are correlated with newly proposed grades and stages of the disease. The studied (109) cases were divided into 6 groups according to the concomitant infection with HCV. The result proved that groups 1, 3 & 5 had a higher level of viraemia than other groups, and to be the high-risk groups as 56.4% and 34.6% were in G2S2 and G3S3, respectively. All cases of liver cell dysplasia and hepatocellular carcinoma in this study were seen in these groups. The conclusion showed that these factors play an important role in the progression of HCV infection. Death of the patients of this progressive condition occurs in younger age and is more due to liver failure than to HCC.
To investigate the efficacy of anterolateral advancement pharyngoplasty to enlarge pharyngeal air... more To investigate the efficacy of anterolateral advancement pharyngoplasty to enlarge pharyngeal airspace and to decrease palatal and lateral pharyngeal wall collapse in the treatment of obstructive sleep apnea (OSA). Prospective study. University medical hospital. Forty-one patients underwent an anterolateral advancement pharyngoplasty procedure according to the following criteria: body mass index <30 kg/m(2), Friedman stage II or III, type I Fujita, nocturnal polysomnography diagnostic of OSA, retropalatal and lateral pharyngeal collapse, and diagnosis with flexible nasoendoscopy during a Müller's maneuver based on a 5-point scale. Patients with retroglossal airway collapse were excluded from the study. The principle of this technique is to advance and fix the palatopharyngeus muscle with the superior pharyngeus constrictor muscle without transecting any of their fascicules anterolateral to the pterygomandibular raphe and anterosuperior to the levator veli palatine muscle. Pre- and postoperative polysomnography findings (mean ± SD) showed significant statistical differences: apnea hypopnea index (AHI) decreased from 42.1 ± 16.34 to 16.3 ± 10.3 (P ≤ .001); percentage of time with oxyhemoglobin saturation <90% decreased from 18.5% ± 4.2% to 10.1% ± 1.3% (P ≤ .001); and lowest oxygen saturation level increased from 79.9% ± 14.8% to 89.3% ± 11.1% (P ≤ .05). The mean time for patients to return to a normal diet was 12.2 days. There was no postoperative bleeding, velopharyngeal insufficiency, speech alternations, or taste loss. Based on a threshold of a 50% reduction in AHI and AHI <20, surgical success was 86.8%. Anterolateral advancement pharyngoplasty appears to be an effective technique with a high surgical success rate in the treatment of OSA patients with lateral pharyngeal wall collapse.
Journal of the Egyptian Society of Parasitology, May 1, 2004
Because many persons with chronic hepatitis C virus (HCV) infection are asymptomatic, population ... more Because many persons with chronic hepatitis C virus (HCV) infection are asymptomatic, population based serologic studies are needed to estimate the prevalence of infection and to develop and evaluate prevention efforts. A sample of 1422 individuals was included in the study by using multistage sampling technique. Their age ranged from 4-78 years with a mean age (34.7 +/- 18.5), 782 were males (55%) and 640 were females (45%). Exposures and demographic characteristics were obtained through a predesigned questionnaire. Antibody to HCV was assessed using micro-particle enzyme immunoassay (MEIA) enzyme assay by IMX, and the HCV RNA was tested by Real-time PCR technique using ABI Prism 7700 system. The seroprevalence of antibodies to HCV were 23.4% and 27.4% in urban and rural areas respectively, with an overall prevalence (25.8%). This reflects prior HCV infection but not necessarily a current liver disease. Prevalence was higher among males than females and increased sharply with age, from 4.8% in those < 20 years old to (41.9%) in older ages (> or = 40 years). Those who were not educated and farmers had a significantly high prevalence. The significant predictors of HCV infection were previous parenteral therapy for schistosomiasis (OR = 4.3, 95% CI = 3.6-7.9), among those over 20 years of age (3.5, 2.18-5.8), blood transfusion (4.1, 2.4-6.9), invasive procedures (surgery and endoscopy), and use of contaminated syringes and needles. Also, shaving at community barbers added significance to the model. Exposures not significantly related to HCV seropositivity were gender, active infection with Schistosoma mansoni, sutures or intravenous and urinary catheterization, water pipe "goza" smoking in group.
Journal of Engineering and Technology Management, 2008
... In a few words, the suggested framework gives a practical guide that should help managers i... more ... In a few words, the suggested framework gives a practical guide that should help managers in the definition of all the elements of a PMS, in accordance with the overall company's strategy. Then, the framework is applied to a specific case study, with the aim of: 1. verifying the ...
... Ahmed S. Bream, Department of Zoology, Faculty of Arts and Sciences, Omar Al-Mkhtar Universit... more ... Ahmed S. Bream, Department of Zoology, Faculty of Arts and Sciences, Omar Al-Mkhtar University, El-Beida, Libya, Tarek MY El-Sheikh, Mohamad A. Fouda, and Mostafa I. Hassan, Department of Zoology, Faculty of Sciences, Al-Azhar University, Egypt ...
Monatshefte Fuer Chemie Chemical Monthly, Oct 1, 1991
The iron(III) complexes with sulphathiazole, sulphamethoxazole, sulphadiazine, sulphapyridine and... more The iron(III) complexes with sulphathiazole, sulphamethoxazole, sulphadiazine, sulphapyridine and sulphadimidine having the stoichiometric ratio 1:2 (metal:ligand) were prepared and characterized on the basis of elemental analysis, conductivity measurements and electronic absorption spectra. The infrared spectra of the complexes revealed that the terminal amino group of the sulpha molecules is not involved in coordination. Similarities in the position of iron-nitrogen and iron-oxygen stretching modes indicate identical configuration of the complexes prepared. Conductivity measurements showed that they are nonelectrolytes. X-ray powder diffraction patterns showed that two of them are crystalline and others are amorphous. Electron spin resonance and iron-57 Mössbauer measurements indicated that the complexes contain high-spin Fe3+ species. Thermogravimetric analyses showed that all complexes contain coordinated water which is lost at 141–160°C. All the complexes proved to possess higher bacteriostatic activity than the corresponding ligand. Es wurden die (Metall:Ligand) 1:2 Eisen(III)-Komplexe von Sulfathiazol, Sulfamethoxazol, Sulfapyridin und Sulfadimidin hergestellt und mittels Elementaranalyse, Leitfähigkeitsmessungen und Elektronenabsorptionsspektroskopie charakterisiert. Die IR-Spektren der Komplexe zeigten, daß die Amino-Gruppen der Sulfa-Moleküle nicht an der Koordination beteiligt sind. Ähnlichkeiten im Bereich der Eisen-Stickstoff- und Eisen-Sauerstoff-Streckschwingungen zeigten idente Konfiguration der Komplexe an. Leitfähigkeitsmessungen beweisen den Nichtelektrolytcharakter. Röntgen-Pulverdiagramme zeigten, daß zwei der Komplexe kristallin, die anderen hingegen amorph waren. High-Spin Eisen(III)-Spezies wurden mittels Elektrononspinresonanz und Eisen-57-Mössbauer-Messungen nachgewiesen. Die thermogravimetrische Analyse zeigte, daß alle Komplexe koordiniertes Wasser enthielten, das zwischen 141 und 160°C verloren wurde. Alle Komplexe zeigten eine höhere bakteriostatische Aktivität als die entsprechenden Liganden allein.
Journal of the Egyptian Society of Parasitology, May 1, 2004
Liver biopsy is thought mandatory for management in patients with hepatitis C virus infection (HC... more Liver biopsy is thought mandatory for management in patients with hepatitis C virus infection (HCV) especially for histopathological grading and staging of the disease to assess suitability for treatment and monitoring disease progression. However, tracking of liver disease progression can't rely on repeated biopsies. The study aimed to evaluate two significant items, we try to develop and validate a non-invasive predictive tool to assess hepatic necro-inflammation and fibrosis. Also, to determine factors that associate severity of hepatic pathology in HCV infected Egyptian patients particularly at Sharkia G. The study included 109 patients with detectable HCV by Real Time-PCR. The patients were classified into three different pathological stages and grades according to the new concept of histopathoglical staging and grading. The different clinical, biochemical, virological and ultra-sonographic parameters were assessed and analyzed and the variables that showed significant association with histopathological staging and grading were included in multivariate logistic regression analysis. The regression model revealed that, platelet count, matrix metalloproteinase-9 (MMP-9), portal vein diameter, splenic longitudinal axis, alanine transaminase, aspartate transaminase and viral load were the factors that add significance to the model in decreasing order of significance. From these findings we generate a new score ranged from 0-9. The score model was applied to our patients to assess its validity where it proved to be accurate in discriminating patients with mild inflammation and fibrosis (sensitivity 81.8%, specificity 80.5% and accuracy 80.7%) and more accurate in detecting patients with cirrhosis (specificity 96.6%, sensitivity 80% & accuracy 93.6%) but less accurate in detecting patients with moderate to severe fibrosis (specificity 66.7%, sensitivity 68.7% & accuracy 67.9%). Also the results revealed that, co-infection with schistosomiasis, old age > or = 45 years and positive history of blood transfusion as a source of infection was significantly associated with severe hepatic pathology. It is concluded that, the score model can't completely replace liver biopsy but at least it could be used to substantially reduce the number of liver biopsies done in patients with HCV infection in assessing disease progression during follow up. Also, it can be used to make decisions about treatment in patients who have contraindications to or who refused liver biopsy. Co-infection with schistosomiasis, age > or = 45 and positive history of blood transfusion in patients with HCV warrant special attention with more intensive follow up. These factors may play a major role in forecasting the course of HCV as well as in determining the therapeutic approach in each case.
Journal of the Egyptian Society of Parasitology, May 1, 2004
The natural history of hepatitis C virus (HCV) infection has a highly variable course. Many patie... more The natural history of hepatitis C virus (HCV) infection has a highly variable course. Many patients develop chronic infection, with its consequent risk of cirrhosis, liver failure and hepatocellular carcinoma. A key question is whether patients at high risk of disease progression can be distinguished from those with relatively benign disease course. The disease progression is influenced by other factors such as duration of infection, age at infection, sex, co-infection with hepatitis B virus (HBV), Epstein Bar virus (EBV), cytomegalovirus (CMV), the level of HCV viraemia and its type. Other endemic infections in the community as bilharziasis may have a role in progression of the condition to serious complications. These factors are correlated with newly proposed grades and stages of the disease. The studied (109) cases were divided into 6 groups according to the concomitant infection with HCV. The result proved that groups 1, 3 & 5 had a higher level of viraemia than other groups, and to be the high-risk groups as 56.4% and 34.6% were in G2S2 and G3S3, respectively. All cases of liver cell dysplasia and hepatocellular carcinoma in this study were seen in these groups. The conclusion showed that these factors play an important role in the progression of HCV infection. Death of the patients of this progressive condition occurs in younger age and is more due to liver failure than to HCC.
To investigate the efficacy of anterolateral advancement pharyngoplasty to enlarge pharyngeal air... more To investigate the efficacy of anterolateral advancement pharyngoplasty to enlarge pharyngeal airspace and to decrease palatal and lateral pharyngeal wall collapse in the treatment of obstructive sleep apnea (OSA). Prospective study. University medical hospital. Forty-one patients underwent an anterolateral advancement pharyngoplasty procedure according to the following criteria: body mass index <30 kg/m(2), Friedman stage II or III, type I Fujita, nocturnal polysomnography diagnostic of OSA, retropalatal and lateral pharyngeal collapse, and diagnosis with flexible nasoendoscopy during a Müller's maneuver based on a 5-point scale. Patients with retroglossal airway collapse were excluded from the study. The principle of this technique is to advance and fix the palatopharyngeus muscle with the superior pharyngeus constrictor muscle without transecting any of their fascicules anterolateral to the pterygomandibular raphe and anterosuperior to the levator veli palatine muscle. Pre- and postoperative polysomnography findings (mean ± SD) showed significant statistical differences: apnea hypopnea index (AHI) decreased from 42.1 ± 16.34 to 16.3 ± 10.3 (P ≤ .001); percentage of time with oxyhemoglobin saturation <90% decreased from 18.5% ± 4.2% to 10.1% ± 1.3% (P ≤ .001); and lowest oxygen saturation level increased from 79.9% ± 14.8% to 89.3% ± 11.1% (P ≤ .05). The mean time for patients to return to a normal diet was 12.2 days. There was no postoperative bleeding, velopharyngeal insufficiency, speech alternations, or taste loss. Based on a threshold of a 50% reduction in AHI and AHI <20, surgical success was 86.8%. Anterolateral advancement pharyngoplasty appears to be an effective technique with a high surgical success rate in the treatment of OSA patients with lateral pharyngeal wall collapse.
Journal of the Egyptian Society of Parasitology, May 1, 2004
Because many persons with chronic hepatitis C virus (HCV) infection are asymptomatic, population ... more Because many persons with chronic hepatitis C virus (HCV) infection are asymptomatic, population based serologic studies are needed to estimate the prevalence of infection and to develop and evaluate prevention efforts. A sample of 1422 individuals was included in the study by using multistage sampling technique. Their age ranged from 4-78 years with a mean age (34.7 +/- 18.5), 782 were males (55%) and 640 were females (45%). Exposures and demographic characteristics were obtained through a predesigned questionnaire. Antibody to HCV was assessed using micro-particle enzyme immunoassay (MEIA) enzyme assay by IMX, and the HCV RNA was tested by Real-time PCR technique using ABI Prism 7700 system. The seroprevalence of antibodies to HCV were 23.4% and 27.4% in urban and rural areas respectively, with an overall prevalence (25.8%). This reflects prior HCV infection but not necessarily a current liver disease. Prevalence was higher among males than females and increased sharply with age, from 4.8% in those < 20 years old to (41.9%) in older ages (> or = 40 years). Those who were not educated and farmers had a significantly high prevalence. The significant predictors of HCV infection were previous parenteral therapy for schistosomiasis (OR = 4.3, 95% CI = 3.6-7.9), among those over 20 years of age (3.5, 2.18-5.8), blood transfusion (4.1, 2.4-6.9), invasive procedures (surgery and endoscopy), and use of contaminated syringes and needles. Also, shaving at community barbers added significance to the model. Exposures not significantly related to HCV seropositivity were gender, active infection with Schistosoma mansoni, sutures or intravenous and urinary catheterization, water pipe "goza" smoking in group.
Journal of Engineering and Technology Management, 2008
... In a few words, the suggested framework gives a practical guide that should help managers i... more ... In a few words, the suggested framework gives a practical guide that should help managers in the definition of all the elements of a PMS, in accordance with the overall company's strategy. Then, the framework is applied to a specific case study, with the aim of: 1. verifying the ...
... Ahmed S. Bream, Department of Zoology, Faculty of Arts and Sciences, Omar Al-Mkhtar Universit... more ... Ahmed S. Bream, Department of Zoology, Faculty of Arts and Sciences, Omar Al-Mkhtar University, El-Beida, Libya, Tarek MY El-Sheikh, Mohamad A. Fouda, and Mostafa I. Hassan, Department of Zoology, Faculty of Sciences, Al-Azhar University, Egypt ...
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