In this study, we evaluated the predictive value of circulating tumour DNA (ctDNA) to inform ther... more In this study, we evaluated the predictive value of circulating tumour DNA (ctDNA) to inform therapeutic outcomes in metastatic melanoma patients receiving systemic therapies. We analysed 142 plasma samples from metastatic melanoma patients prior to commencement of systemic therapy: 70 were treated with BRAF/MEK inhibitors and 72 with immunotherapies. Patient-specific droplet digital polymerase chain reaction assays were designed for ctDNA detection. Plasma ctDNA was detected in 56% of patients prior to first-line anti-PD1 and/or anti-CTLA-4 treatment. The detection rate in the immunotherapy cohort was comparably lower than those with BRAF inhibitors (76%, p = 0.0149). Decreasing ctDNA levels within 12 weeks of treatment was strongly concordant with treatment response (Cohen’s k = 0.798, p < 0.001) and predictive of longer progression free survival. Notably, a slower kinetic of ctDNA decline was observed in patients treated with immunotherapy compared to those on BRAF/MEK inhibit...
This paper presents a novel technique based on Hybrid Spatial Distance Reduction Algorithm (HSDRA... more This paper presents a novel technique based on Hybrid Spatial Distance Reduction Algorithm (HSDRA), to compensate the effects of deformity and mutual coupling occurred due to surface change in conformal arrays. This antenna surface deformation shifts the position of null points and loss of the main beam resulting in reduced antenna gain along with substantial undesirable effects on the antenna performance. The proposed algorithm, which cumulatively incorporates the Linearly Constraint Least Square Optimization (LCLSO) and Quadratically Constraint Least Square Optimization (QCLSO) techniques, is formulated to minimize/reduce the absolute distance between the actual (simulated/measured) radiation pattern and the desired radiation pattern while keeping the direction of main beam and nulls position under control. In particular, a 4x4 conformal microstrip phased array from planar surface is deformed to prescribe spherical-shape surface with various radii of curvature, is validated. For t...
10000 Background: We conducted the phase 3 double-blind EORTC 1325/KEYNOTE-054 trial to evaluate ... more 10000 Background: We conducted the phase 3 double-blind EORTC 1325/KEYNOTE-054 trial to evaluate pembrolizumab vs placebo in patients (pts) with resected high-risk stage III melanoma. Based on 351 recurrence-free survival (RFS) events and at a median follow-up of 1.25 years (yrs), pembrolizumab improved RFS (hazard ratio (HR) 0.57, P<0.0001) as compared to placebo (Eggermont, NEJM 2018). This led to the approval of pembrolizumab adjuvant treatment by EMA and FDA. Methods: Eligible pts included those ≥18 yrs of age with complete resection of cutaneous melanoma metastatic to lymph node(s), classified as AJCC-7 stage IIIA (at least one lymph node metastasis >1 mm), IIIB or IIIC (without in-transit metastasis). A total of 1019 pts were randomized (stratification by stage and region) to pembrolizumab at a flat dose of 200 mg (N=514) or placebo (N=505) every 3 weeks for a total of 18 doses (~1 year) or until disease recurrence or unacceptable toxicity. The 2 co-primary endpoints wer...
Obesity is a major risk for diabetes. Brown adipose tissue (BAT) mediates production of heat whil... more Obesity is a major risk for diabetes. Brown adipose tissue (BAT) mediates production of heat while white adipose tissue (WAT) function in the storage of fat. Roles of BAT in the treatment of obesity and related disorders warrants more investigation. Peroxisome proliferator activator receptor gamma (PPAR-γ) is the master regulator of both BAT and WAT adipogenesis and has roles in glucose and fatty acid metabolism. Adipose tissue is the major expression site for PPAR-γ. In this study, the effects of rosiglitazone on the brown adipogenesis and the association of MAPK and PI3K pathways was investigated during the in vitro adipogenic differentiation of telomerase transformed mesenchymal stromal cells (iMSCs). Our data indicate that 2 µM rosiglitazone enhanced adipogenesis by over-expression of PPAR-γ and C/EBP-α. More specifically, brown adipogenesis was enhanced by the upregulation of EBF2 and UCP-1 and evidenced by multilocular fatty droplets morphology of the differentiated adipocytes...
2517 Background: Several studies suggested that patients (pts) with an immune-related adverse eve... more 2517 Background: Several studies suggested that patients (pts) with an immune-related adverse event (irAE) during immunotherapy have better outcomes than those without. It remains uncertain whether these observations can be explained by guarantee-time bias or the role of irAE as an indicator of drug activity. Here, we investigated the association between irAEs and recurrence-free survival (RFS) in the double-blind EORTC 1325/KEYNOTE-054 trial that compared pembrolizumab and placebo in high-risk stage III melanoma pts. Methods: Eligible pts included adults with complete resection of cutaneous melanoma metastatic to lymph node(s), classified as stage IIIA (lymph node metastasis > 1 mm), IIIB or IIIC (without in-transit metastasis) and with no active autoimmune disease that required systemic treatment in past 2 years. We used a Cox model adjusted for sex, age, and stage with a time-varying covariate taking a value zero before the irAE onset and a value one afterwards to estimate the...
Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-... more Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metastatic disease. Therefore, there is a need to understand the correlation between ctDNA levels and the patients' overall metabolic tumour burden (MTB). Thirty-two treatment naïve metastatic melanoma patients were included in the study. MTB and metabolic tumour volume (MTV) was measured by 18F-fluoro-D-glucose positron emission tomography/computed tomography (FDG PET/CT). Plasma ctDNA was quantified using droplet digital PCR (ddPCR). CtDNA was detected in 23 of 32 patients. Overall, a significant correlation was observed between ctDNA levels and MTB (p < 0.001). CtDNA was not detectable in patients with an MTB of ≤10, defining this value as the lower limit of tumour burden that can be detected through ctDNA analysis by ddPCR. We showed that ctDNA levels measured by ddPCR co...
Anti-PD-1 monoclonal antibodies have shown durable long-term survival benefit in patients with me... more Anti-PD-1 monoclonal antibodies have shown durable long-term survival benefit in patients with metastatic melanoma. Limited evidence exists on the safety and efficacy of PD-1 inhibitors in patients with hepatitis B virus (HBV) and hepatitis C virus (HCV) infections as these patients have traditionally been excluded from clinical trials because of a theoretical risk of immune reconstitution inflammatory syndrome. We aim to determine the safety and efficacy of treatment with PD-1 inhibitors in seven patients with HBV/HCV infection and concurrent metastatic melanoma or non-small-cell lung cancer (NSCLC). We describe seven patients treated with PD-1 inhibitors nivolumab and pembrolizumab for either metastatic melanoma or metastatic NSCLC in the setting of chronic or past HBV/HCV infection. The safety and efficacy of treatment were analysed retrospectively by examining response to treatment, alanine transaminase (ALT) trends and viral load trends. One patient showed an increase in ALT of Common Terminology Criteria for Adverse Events (CTCAE) grade 2 severity that returned to the normal range following treatment of his HCV infection with ledipasvir 90 mg/sofosbuvir 400 mg. An additional four patients showed an increase in ALT of CTCAE grade 1 severity. The remaining two patients experienced no hepatic toxicity, with stable disease continuing after more than 24 cycles of nivolumab. Efficacy was similar to the data of published trials. Our results indicate that patients with metastatic melanoma and NSCLC can be treated safely with PD-1 inhibitors in the context of HBV/HCV infection. However, we recommend that those with active viral hepatitis be monitored closely in consultation with a hepatologist and treated with antiviral therapy if indicated.
Market conditions in emerging economies are often reported as less stable and volatile. The busin... more Market conditions in emerging economies are often reported as less stable and volatile. The business sector, especially Small and Medium Enterprises (SMEs) in emerging economies, face several shortcomings including lack of resources, lack of finance, lack of support and lack of human skills, etc. Hence, they look to international support and resources to survive in a long run in the dynamic markets. This research examines the role of international finance, international technology, international experience and international network in SME firms’ Sustainable Competitive Performance (SCP) in Pakistan. SMEs are a major source of employment and value creation and, therefore, are very relevant to Pakistan economic and social development and improved sustainability. Hypotheses were tested on the data set collected from 304 emerging SMEs. After Structural Equation Modelling (SEM) was applied in Analysis of a Moment Structures (AMOS), the results indicate that international finance, interna...
Thyroid : official journal of the American Thyroid Association, Jan 12, 2018
Background Keeping the rural-urban disparities in Pakistan in mind, this study aimed at assessing... more Background Keeping the rural-urban disparities in Pakistan in mind, this study aimed at assessing the regional influence on nutritional iodine status of pregnant women, the most vulnerable group for iodine deficiency. Methods Data were collected from 1246 pregnant women in all trimesters of pregnancy who visited pre-natal clinics for routine checkups in five districts of the Khyber Pakhtunkhwa province. Information on iodized salt intake and knowledge on iodine deficiency disorders (IDD) were obtained through an interview questionnaire. Goiter and urinary iodine excretion levels were assessed by the palpation method and the Sandell-Kolthoff reaction, respectively. Logistic regression analysis was used for quantifying an association of residence (rural/urban), trimester of pregnancy and previous miscarriage on the outcomes; knowledge about IDD, iodized salt intake, presence of goiter and urinary iodine concentration (UIC) <150 μg/L. Results Overall, 87.7% of pregnant women had no ...
The objective of the study was to identify prevalence, types and predictors of potential drug-dru... more The objective of the study was to identify prevalence, types and predictors of potential drug-drug interactions (pDDIs) in pulmonology ward and to report common interactions. Medical records of 400 randomly-selected patients were reviewed for pDDIs using Micromedex Drug-Reax software. Logisticregression was applied to determine predictors of pDDIs. We identified 126 interacting-combinations that encountered in total 558 pDDIs with median number of 01 pDDI per patient. Overall 45% patients had at least one pDDI; 24.25% were ...
Environmental science and pollution research international, Jan 19, 2017
The present study was conducted to evaluate the impact of marble industry effluents on the accumu... more The present study was conducted to evaluate the impact of marble industry effluents on the accumulation of heavy metals in selected tissues of mahaseer (Tor putitora) in Barandu River. Fish samples were collected from three selected sites (upstream (US), effluents/industrial (IS), and downstream (DS) sites) on monthly basis for 8 months. Heavy metal concentrations were determined in fish tissues using Atomic Absorption Spectrophotometer. Liver accumulated the highest level of metal concentrations while the lowest concentrations were found in muscles in T. putitora. Among metals, Fe was reported in the highest amount whereas the lowest was Cd in all the fish organs. In all the months, the metal concentrations were significantly higher (P < 0.05) at IS than the other two selected sites and also very often the metal concentrations at DS were found significantly higher (P < 0.05) compared to the US. The obtained results revealed that discharging industrial effluents caused an incr...
Circulating Tumour Cells (CTCs) are promising cancer biomarkers. Several methods have been develo... more Circulating Tumour Cells (CTCs) are promising cancer biomarkers. Several methods have been developed to isolate CTCs from blood samples. However, the isolation of melanoma CTCs is very challenging as a result of their extraordinary heterogeneity, which has hindered their biological and clinical study. Thus, methods that isolate CTCs based on their physical properties, rather than surface marker expression, such as microfluidic devices, are greatly needed in melanoma. Here, we assessed the ability of the slanted spiral microfluidic device to isolate melanoma CTCs via label-free enrichment. We demonstrated that this device yields recovery rates of spiked melanoma cells of over 80% and 55%, after one or two rounds of enrichment, respectively. Concurrently, a two to three log reduction of white blood cells was achieved with one or two rounds of enrichment, respectively. We characterised the isolated CTCs using multimarker flow cytometry, immunocytochemistry and gene expression. The resu...
Cyclophilin A (CypA), a peptidylprolyl cis-trans isomerase, is a ubiquitous and multifunctional p... more Cyclophilin A (CypA), a peptidylprolyl cis-trans isomerase, is a ubiquitous and multifunctional protein. In addition to its role as a host-cell receptor for cyclosporine A, CypA has diverse functions in inflammatory conditions and diseases. CypA secreted in response to inflammatory stimuli binds to the cell surface via its receptor CD147 and induces secretion of various inflammatory cytokines. However, silencing and inhibition of either CypA or CD147 inhibits inflammatory cytokine expression and inflammation. This report reviews the literature related to the mechanism of CypA-dependent cytokine secretion and discusses this factor as a possible therapeutic target in inflammatory diseases.
In this study, we evaluated the predictive value of circulating tumour DNA (ctDNA) to inform ther... more In this study, we evaluated the predictive value of circulating tumour DNA (ctDNA) to inform therapeutic outcomes in metastatic melanoma patients receiving systemic therapies. We analysed 142 plasma samples from metastatic melanoma patients prior to commencement of systemic therapy: 70 were treated with BRAF/MEK inhibitors and 72 with immunotherapies. Patient-specific droplet digital polymerase chain reaction assays were designed for ctDNA detection. Plasma ctDNA was detected in 56% of patients prior to first-line anti-PD1 and/or anti-CTLA-4 treatment. The detection rate in the immunotherapy cohort was comparably lower than those with BRAF inhibitors (76%, p = 0.0149). Decreasing ctDNA levels within 12 weeks of treatment was strongly concordant with treatment response (Cohen’s k = 0.798, p < 0.001) and predictive of longer progression free survival. Notably, a slower kinetic of ctDNA decline was observed in patients treated with immunotherapy compared to those on BRAF/MEK inhibit...
This paper presents a novel technique based on Hybrid Spatial Distance Reduction Algorithm (HSDRA... more This paper presents a novel technique based on Hybrid Spatial Distance Reduction Algorithm (HSDRA), to compensate the effects of deformity and mutual coupling occurred due to surface change in conformal arrays. This antenna surface deformation shifts the position of null points and loss of the main beam resulting in reduced antenna gain along with substantial undesirable effects on the antenna performance. The proposed algorithm, which cumulatively incorporates the Linearly Constraint Least Square Optimization (LCLSO) and Quadratically Constraint Least Square Optimization (QCLSO) techniques, is formulated to minimize/reduce the absolute distance between the actual (simulated/measured) radiation pattern and the desired radiation pattern while keeping the direction of main beam and nulls position under control. In particular, a 4x4 conformal microstrip phased array from planar surface is deformed to prescribe spherical-shape surface with various radii of curvature, is validated. For t...
10000 Background: We conducted the phase 3 double-blind EORTC 1325/KEYNOTE-054 trial to evaluate ... more 10000 Background: We conducted the phase 3 double-blind EORTC 1325/KEYNOTE-054 trial to evaluate pembrolizumab vs placebo in patients (pts) with resected high-risk stage III melanoma. Based on 351 recurrence-free survival (RFS) events and at a median follow-up of 1.25 years (yrs), pembrolizumab improved RFS (hazard ratio (HR) 0.57, P<0.0001) as compared to placebo (Eggermont, NEJM 2018). This led to the approval of pembrolizumab adjuvant treatment by EMA and FDA. Methods: Eligible pts included those ≥18 yrs of age with complete resection of cutaneous melanoma metastatic to lymph node(s), classified as AJCC-7 stage IIIA (at least one lymph node metastasis >1 mm), IIIB or IIIC (without in-transit metastasis). A total of 1019 pts were randomized (stratification by stage and region) to pembrolizumab at a flat dose of 200 mg (N=514) or placebo (N=505) every 3 weeks for a total of 18 doses (~1 year) or until disease recurrence or unacceptable toxicity. The 2 co-primary endpoints wer...
Obesity is a major risk for diabetes. Brown adipose tissue (BAT) mediates production of heat whil... more Obesity is a major risk for diabetes. Brown adipose tissue (BAT) mediates production of heat while white adipose tissue (WAT) function in the storage of fat. Roles of BAT in the treatment of obesity and related disorders warrants more investigation. Peroxisome proliferator activator receptor gamma (PPAR-γ) is the master regulator of both BAT and WAT adipogenesis and has roles in glucose and fatty acid metabolism. Adipose tissue is the major expression site for PPAR-γ. In this study, the effects of rosiglitazone on the brown adipogenesis and the association of MAPK and PI3K pathways was investigated during the in vitro adipogenic differentiation of telomerase transformed mesenchymal stromal cells (iMSCs). Our data indicate that 2 µM rosiglitazone enhanced adipogenesis by over-expression of PPAR-γ and C/EBP-α. More specifically, brown adipogenesis was enhanced by the upregulation of EBF2 and UCP-1 and evidenced by multilocular fatty droplets morphology of the differentiated adipocytes...
2517 Background: Several studies suggested that patients (pts) with an immune-related adverse eve... more 2517 Background: Several studies suggested that patients (pts) with an immune-related adverse event (irAE) during immunotherapy have better outcomes than those without. It remains uncertain whether these observations can be explained by guarantee-time bias or the role of irAE as an indicator of drug activity. Here, we investigated the association between irAEs and recurrence-free survival (RFS) in the double-blind EORTC 1325/KEYNOTE-054 trial that compared pembrolizumab and placebo in high-risk stage III melanoma pts. Methods: Eligible pts included adults with complete resection of cutaneous melanoma metastatic to lymph node(s), classified as stage IIIA (lymph node metastasis > 1 mm), IIIB or IIIC (without in-transit metastasis) and with no active autoimmune disease that required systemic treatment in past 2 years. We used a Cox model adjusted for sex, age, and stage with a time-varying covariate taking a value zero before the irAE onset and a value one afterwards to estimate the...
Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-... more Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metastatic disease. Therefore, there is a need to understand the correlation between ctDNA levels and the patients' overall metabolic tumour burden (MTB). Thirty-two treatment naïve metastatic melanoma patients were included in the study. MTB and metabolic tumour volume (MTV) was measured by 18F-fluoro-D-glucose positron emission tomography/computed tomography (FDG PET/CT). Plasma ctDNA was quantified using droplet digital PCR (ddPCR). CtDNA was detected in 23 of 32 patients. Overall, a significant correlation was observed between ctDNA levels and MTB (p < 0.001). CtDNA was not detectable in patients with an MTB of ≤10, defining this value as the lower limit of tumour burden that can be detected through ctDNA analysis by ddPCR. We showed that ctDNA levels measured by ddPCR co...
Anti-PD-1 monoclonal antibodies have shown durable long-term survival benefit in patients with me... more Anti-PD-1 monoclonal antibodies have shown durable long-term survival benefit in patients with metastatic melanoma. Limited evidence exists on the safety and efficacy of PD-1 inhibitors in patients with hepatitis B virus (HBV) and hepatitis C virus (HCV) infections as these patients have traditionally been excluded from clinical trials because of a theoretical risk of immune reconstitution inflammatory syndrome. We aim to determine the safety and efficacy of treatment with PD-1 inhibitors in seven patients with HBV/HCV infection and concurrent metastatic melanoma or non-small-cell lung cancer (NSCLC). We describe seven patients treated with PD-1 inhibitors nivolumab and pembrolizumab for either metastatic melanoma or metastatic NSCLC in the setting of chronic or past HBV/HCV infection. The safety and efficacy of treatment were analysed retrospectively by examining response to treatment, alanine transaminase (ALT) trends and viral load trends. One patient showed an increase in ALT of Common Terminology Criteria for Adverse Events (CTCAE) grade 2 severity that returned to the normal range following treatment of his HCV infection with ledipasvir 90 mg/sofosbuvir 400 mg. An additional four patients showed an increase in ALT of CTCAE grade 1 severity. The remaining two patients experienced no hepatic toxicity, with stable disease continuing after more than 24 cycles of nivolumab. Efficacy was similar to the data of published trials. Our results indicate that patients with metastatic melanoma and NSCLC can be treated safely with PD-1 inhibitors in the context of HBV/HCV infection. However, we recommend that those with active viral hepatitis be monitored closely in consultation with a hepatologist and treated with antiviral therapy if indicated.
Market conditions in emerging economies are often reported as less stable and volatile. The busin... more Market conditions in emerging economies are often reported as less stable and volatile. The business sector, especially Small and Medium Enterprises (SMEs) in emerging economies, face several shortcomings including lack of resources, lack of finance, lack of support and lack of human skills, etc. Hence, they look to international support and resources to survive in a long run in the dynamic markets. This research examines the role of international finance, international technology, international experience and international network in SME firms’ Sustainable Competitive Performance (SCP) in Pakistan. SMEs are a major source of employment and value creation and, therefore, are very relevant to Pakistan economic and social development and improved sustainability. Hypotheses were tested on the data set collected from 304 emerging SMEs. After Structural Equation Modelling (SEM) was applied in Analysis of a Moment Structures (AMOS), the results indicate that international finance, interna...
Thyroid : official journal of the American Thyroid Association, Jan 12, 2018
Background Keeping the rural-urban disparities in Pakistan in mind, this study aimed at assessing... more Background Keeping the rural-urban disparities in Pakistan in mind, this study aimed at assessing the regional influence on nutritional iodine status of pregnant women, the most vulnerable group for iodine deficiency. Methods Data were collected from 1246 pregnant women in all trimesters of pregnancy who visited pre-natal clinics for routine checkups in five districts of the Khyber Pakhtunkhwa province. Information on iodized salt intake and knowledge on iodine deficiency disorders (IDD) were obtained through an interview questionnaire. Goiter and urinary iodine excretion levels were assessed by the palpation method and the Sandell-Kolthoff reaction, respectively. Logistic regression analysis was used for quantifying an association of residence (rural/urban), trimester of pregnancy and previous miscarriage on the outcomes; knowledge about IDD, iodized salt intake, presence of goiter and urinary iodine concentration (UIC) <150 μg/L. Results Overall, 87.7% of pregnant women had no ...
The objective of the study was to identify prevalence, types and predictors of potential drug-dru... more The objective of the study was to identify prevalence, types and predictors of potential drug-drug interactions (pDDIs) in pulmonology ward and to report common interactions. Medical records of 400 randomly-selected patients were reviewed for pDDIs using Micromedex Drug-Reax software. Logisticregression was applied to determine predictors of pDDIs. We identified 126 interacting-combinations that encountered in total 558 pDDIs with median number of 01 pDDI per patient. Overall 45% patients had at least one pDDI; 24.25% were ...
Environmental science and pollution research international, Jan 19, 2017
The present study was conducted to evaluate the impact of marble industry effluents on the accumu... more The present study was conducted to evaluate the impact of marble industry effluents on the accumulation of heavy metals in selected tissues of mahaseer (Tor putitora) in Barandu River. Fish samples were collected from three selected sites (upstream (US), effluents/industrial (IS), and downstream (DS) sites) on monthly basis for 8 months. Heavy metal concentrations were determined in fish tissues using Atomic Absorption Spectrophotometer. Liver accumulated the highest level of metal concentrations while the lowest concentrations were found in muscles in T. putitora. Among metals, Fe was reported in the highest amount whereas the lowest was Cd in all the fish organs. In all the months, the metal concentrations were significantly higher (P < 0.05) at IS than the other two selected sites and also very often the metal concentrations at DS were found significantly higher (P < 0.05) compared to the US. The obtained results revealed that discharging industrial effluents caused an incr...
Circulating Tumour Cells (CTCs) are promising cancer biomarkers. Several methods have been develo... more Circulating Tumour Cells (CTCs) are promising cancer biomarkers. Several methods have been developed to isolate CTCs from blood samples. However, the isolation of melanoma CTCs is very challenging as a result of their extraordinary heterogeneity, which has hindered their biological and clinical study. Thus, methods that isolate CTCs based on their physical properties, rather than surface marker expression, such as microfluidic devices, are greatly needed in melanoma. Here, we assessed the ability of the slanted spiral microfluidic device to isolate melanoma CTCs via label-free enrichment. We demonstrated that this device yields recovery rates of spiked melanoma cells of over 80% and 55%, after one or two rounds of enrichment, respectively. Concurrently, a two to three log reduction of white blood cells was achieved with one or two rounds of enrichment, respectively. We characterised the isolated CTCs using multimarker flow cytometry, immunocytochemistry and gene expression. The resu...
Cyclophilin A (CypA), a peptidylprolyl cis-trans isomerase, is a ubiquitous and multifunctional p... more Cyclophilin A (CypA), a peptidylprolyl cis-trans isomerase, is a ubiquitous and multifunctional protein. In addition to its role as a host-cell receptor for cyclosporine A, CypA has diverse functions in inflammatory conditions and diseases. CypA secreted in response to inflammatory stimuli binds to the cell surface via its receptor CD147 and induces secretion of various inflammatory cytokines. However, silencing and inhibition of either CypA or CD147 inhibits inflammatory cytokine expression and inflammation. This report reviews the literature related to the mechanism of CypA-dependent cytokine secretion and discusses this factor as a possible therapeutic target in inflammatory diseases.
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Papers by Muhammad Khattak