ALECSYS, an implementation of a learning classifier system (LCS) on a net of transputers was util... more ALECSYS, an implementation of a learning classifier system (LCS) on a net of transputers was utilised to train a robot arm to solve a light approaching task. This task, as well as more complicated ones, has already been learnt by ALECSYS implemented on AutonoMouse, a small ...
Abstract. Classically, risk is characterised by a point value probability indicating the likeliho... more Abstract. Classically, risk is characterised by a point value probability indicating the likelihood of occurrence of an adverse effect. However, there are domains where the attainability of objective numerical risk characterisations is increasingly being questioned. This paper reviews the ...
Cocaine is a potent dopamine agonist that frequently stimulates the central nervous system and is... more Cocaine is a potent dopamine agonist that frequently stimulates the central nervous system and is often manifested by increased psychomotor activity, impulsivity, euphoria, and rapid thoughts. Attention deficit disorder (ADD) and bipolar disorder also present with physical restlessness, racing thoughts, distractibility, and mood instability. Although these three disorders rarely appear in the same individual, they are important differential diagnoses when considering any one illness with the above symptom complexes. We report two cases of cocaine abuse with ADD residual type in patients who were previously diagnosed as having atypical bipolar disorder. The adverse effects were reversed by the dopamine agonist bromocriptine.
Recent studies of nonneutropenic patients with candidemia or candidiasis suggest that fluconazole... more Recent studies of nonneutropenic patients with candidemia or candidiasis suggest that fluconazole pharmacodynamic parameters correlate with clinical outcomes; however, additional data of correlation to mortality in patients with candidemia would be valuable. We assessed the impact of MICs for Candida, fluconazole pharmacodynamics, and patient characteristics on all-cause mortality with use of a prospective cohort of 96 hospitalized patients with candidemia. Among 84 patients for whom Candida isolates were available for testing, the most frequent Candida species isolated were Candida albicans (44%), followed by Candida parapsilosis (20.2%), and Candida glabrata (20.2%). Fluconazole resistance (MIC of ≥64 μg/ml) was present in 7 (8.3%) to 10 (11.9%) of 84 isolates, depending on the MIC endpoint determination method (50% or 80% inhibition read at 24 or 48 h). Overall mortality occurred in 27 (28.1%) of 96 patients, and nonsurvivors were more likely to have fluconazole-resistant isolates (25% versus 6.7%; P = 0.02). Multivariable analysis demonstrated an association between fluconazole resistance and mortality, but it did not reach statistical significance (odds ratio, 5.3; 95% confidence interval, 0.8 to 33.4; P = 0.08). By pharmacodynamic analysis, a fluconazole area under the concentration-time curve/MIC of <11.5 or MIC of ≥64 was associated with increased patient mortality (P ≤ 0.09). These data support previous findings of an antifungal exposure-response relationship to mortality in patients with candidemia. In addition, similar MICs were obtained using a 24- or 48-h MIC endpoint determination, thus providing the opportunity to assess earlier the impact of isolate susceptibility on therapy.
In the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial, a... more In the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial, a clinical trial sponsored by the National Institute of Mental Health designed to compare the effectiveness of antipsychotic drugs, subjects were administered the MacArthur Competence ...
Linezolid, the first drug in the oxazolidinone class, was approved for use in the United States i... more Linezolid, the first drug in the oxazolidinone class, was approved for use in the United States in March 2000 for the treatment of infections due to gram-positive cocci, including vancomycin-resistant enterococci. Despite widespread usage over the past 6 years, ...
Methicillin-resistant Staphylococcus aureus (MRSA) infections have become common among both hospi... more Methicillin-resistant Staphylococcus aureus (MRSA) infections have become common among both hospitalized and nonhospitalized patients. Optimal outpatient therapy for MRSA infections has yet to be determined, but this matter is complicated by the possibility of inducible ...
Industrial automation calls for behavioral intelligence, that is, a mixture of flexibility, robus... more Industrial automation calls for behavioral intelligence, that is, a mixture of flexibility, robustness and adaptiveness of robot behavior. We argue that efficient machine learning techniques can be a valuable tool for achieving behavioral intelligence. As a case study we apply ALECSYS, an implementation of a learning classifier system on a net of transputers, to a gross-motion problem for an industrial manipulator (an IBM 7547 with a SCARA geometry).
Competitive models give superiority to maximize only the buyer’s profit which does not satisfy al... more Competitive models give superiority to maximize only the buyer’s profit which does not satisfy all members in supply chain whereas Coordinative models give superiority to whole supply chain over buyer’s profit. In this paper, we have considered coopetition in supply chain. The competition in one buyer - multiple suppliers system for the supplier selection process has been considered by applying mixed-integer nonlinear programming in first phase. On the other hand, the total cost of the supply chain is minimized rather than only the buyer’s cost to implement cooperation. Artificial Bee Colony and Chaotic Bee Colony are used separately in the second phase as optimization technique. Finally, the proposed model is illustrated by a numerical example from literature. A better result is found for buyer’s cost by applying the proposed twophase method while it’s giving comparable result for total supply chain cost.
... Page 8. 298 PEEYUSH BHARDWAJ et al. There was not any significant effect of solvent ratio (di... more ... Page 8. 298 PEEYUSH BHARDWAJ et al. There was not any significant effect of solvent ratio (dichloromethane : ethanol) on cumulative drug release (Fig. ... J. Pharm. 220, 13 (2001). 2. Arora S., Ali J., Ahuja A., Khar RK, Baboota S.: AAPS PharmSciTech. 47, 6 (2005). ...
Our study prospectively examined the use of real-time antifungal susceptibility testing among 119... more Our study prospectively examined the use of real-time antifungal susceptibility testing among 119 patients with candidemia at a large tertiary university medical center over a 1-year period. Susceptibility results to fluconazole were reported to physicians a mean of 5.1 days after the initial positive blood culture for Candida. Physicians believed that receiving antifungal susceptibility testing results was helpful and not infrequently altered therapy on the basis of results. Outcomes, including mortality and resolution of infection, among 20 (17%) patients with fluconazole-resistant and fluconazole-susceptible dose-dependent isolates were relatively poor compared to those among patients with fluconazole-susceptible isolates, but probably reflect severity of illness. Routine susceptibility testing as an adjunct to the treatment of candidemia has significant potential and warrants further study.
C 4 photosynthesis typically requires two specialized leaf cell types, bundle sheath (bs) and mes... more C 4 photosynthesis typically requires two specialized leaf cell types, bundle sheath (bs) and mesophyll (mp), which provide the foundation for this highly efficient carbon assimilation pathway. In leaves of Flaveria bidentis, a dicotyledonous C 4 plant, ribulose 1,5-...
... Catalytic Aerobic Oxidation by a Trianionic Pincer Cr III /Cr V Couple. Matthew O&amp;amp... more ... Catalytic Aerobic Oxidation by a Trianionic Pincer Cr III /Cr V Couple. Matthew O&amp;amp;amp;amp;amp;#x27;Reilly, Joseph M. Falkowski, Vasanth Ramachandran, Mekhala Pati, Khalil A. Abboud, Naresh S. Dalal, Thomas G. Gray and Adam S. Veige. Inorganic Chemistry 2009 48 (23), 10901-10903. ...
Quarterly Journal of Experimental Psychology: Section A, Sep 1, 1992
Stenning, Shepherd, and Levy (1988) showed that when simple texts switch reference predictably be... more Stenning, Shepherd, and Levy (1988) showed that when simple texts switch reference predictably between individuals, changes of reference neither cost reading time nor degrade memory performance. The present experiments examine the effects of unpredictable referential change. Experiment 1 demonstrates that unpredictable reference change does cost processing time, as a function of the amount known about the referent to which attention shifts. Analysis reveals a distinction between primary and secondary ...
ALECSYS, an implementation of a learning classifier system (LCS) on a net of transputers was util... more ALECSYS, an implementation of a learning classifier system (LCS) on a net of transputers was utilised to train a robot arm to solve a light approaching task. This task, as well as more complicated ones, has already been learnt by ALECSYS implemented on AutonoMouse, a small ...
Abstract. Classically, risk is characterised by a point value probability indicating the likeliho... more Abstract. Classically, risk is characterised by a point value probability indicating the likelihood of occurrence of an adverse effect. However, there are domains where the attainability of objective numerical risk characterisations is increasingly being questioned. This paper reviews the ...
Cocaine is a potent dopamine agonist that frequently stimulates the central nervous system and is... more Cocaine is a potent dopamine agonist that frequently stimulates the central nervous system and is often manifested by increased psychomotor activity, impulsivity, euphoria, and rapid thoughts. Attention deficit disorder (ADD) and bipolar disorder also present with physical restlessness, racing thoughts, distractibility, and mood instability. Although these three disorders rarely appear in the same individual, they are important differential diagnoses when considering any one illness with the above symptom complexes. We report two cases of cocaine abuse with ADD residual type in patients who were previously diagnosed as having atypical bipolar disorder. The adverse effects were reversed by the dopamine agonist bromocriptine.
Recent studies of nonneutropenic patients with candidemia or candidiasis suggest that fluconazole... more Recent studies of nonneutropenic patients with candidemia or candidiasis suggest that fluconazole pharmacodynamic parameters correlate with clinical outcomes; however, additional data of correlation to mortality in patients with candidemia would be valuable. We assessed the impact of MICs for Candida, fluconazole pharmacodynamics, and patient characteristics on all-cause mortality with use of a prospective cohort of 96 hospitalized patients with candidemia. Among 84 patients for whom Candida isolates were available for testing, the most frequent Candida species isolated were Candida albicans (44%), followed by Candida parapsilosis (20.2%), and Candida glabrata (20.2%). Fluconazole resistance (MIC of ≥64 μg/ml) was present in 7 (8.3%) to 10 (11.9%) of 84 isolates, depending on the MIC endpoint determination method (50% or 80% inhibition read at 24 or 48 h). Overall mortality occurred in 27 (28.1%) of 96 patients, and nonsurvivors were more likely to have fluconazole-resistant isolates (25% versus 6.7%; P = 0.02). Multivariable analysis demonstrated an association between fluconazole resistance and mortality, but it did not reach statistical significance (odds ratio, 5.3; 95% confidence interval, 0.8 to 33.4; P = 0.08). By pharmacodynamic analysis, a fluconazole area under the concentration-time curve/MIC of <11.5 or MIC of ≥64 was associated with increased patient mortality (P ≤ 0.09). These data support previous findings of an antifungal exposure-response relationship to mortality in patients with candidemia. In addition, similar MICs were obtained using a 24- or 48-h MIC endpoint determination, thus providing the opportunity to assess earlier the impact of isolate susceptibility on therapy.
In the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial, a... more In the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial, a clinical trial sponsored by the National Institute of Mental Health designed to compare the effectiveness of antipsychotic drugs, subjects were administered the MacArthur Competence ...
Linezolid, the first drug in the oxazolidinone class, was approved for use in the United States i... more Linezolid, the first drug in the oxazolidinone class, was approved for use in the United States in March 2000 for the treatment of infections due to gram-positive cocci, including vancomycin-resistant enterococci. Despite widespread usage over the past 6 years, ...
Methicillin-resistant Staphylococcus aureus (MRSA) infections have become common among both hospi... more Methicillin-resistant Staphylococcus aureus (MRSA) infections have become common among both hospitalized and nonhospitalized patients. Optimal outpatient therapy for MRSA infections has yet to be determined, but this matter is complicated by the possibility of inducible ...
Industrial automation calls for behavioral intelligence, that is, a mixture of flexibility, robus... more Industrial automation calls for behavioral intelligence, that is, a mixture of flexibility, robustness and adaptiveness of robot behavior. We argue that efficient machine learning techniques can be a valuable tool for achieving behavioral intelligence. As a case study we apply ALECSYS, an implementation of a learning classifier system on a net of transputers, to a gross-motion problem for an industrial manipulator (an IBM 7547 with a SCARA geometry).
Competitive models give superiority to maximize only the buyer’s profit which does not satisfy al... more Competitive models give superiority to maximize only the buyer’s profit which does not satisfy all members in supply chain whereas Coordinative models give superiority to whole supply chain over buyer’s profit. In this paper, we have considered coopetition in supply chain. The competition in one buyer - multiple suppliers system for the supplier selection process has been considered by applying mixed-integer nonlinear programming in first phase. On the other hand, the total cost of the supply chain is minimized rather than only the buyer’s cost to implement cooperation. Artificial Bee Colony and Chaotic Bee Colony are used separately in the second phase as optimization technique. Finally, the proposed model is illustrated by a numerical example from literature. A better result is found for buyer’s cost by applying the proposed twophase method while it’s giving comparable result for total supply chain cost.
... Page 8. 298 PEEYUSH BHARDWAJ et al. There was not any significant effect of solvent ratio (di... more ... Page 8. 298 PEEYUSH BHARDWAJ et al. There was not any significant effect of solvent ratio (dichloromethane : ethanol) on cumulative drug release (Fig. ... J. Pharm. 220, 13 (2001). 2. Arora S., Ali J., Ahuja A., Khar RK, Baboota S.: AAPS PharmSciTech. 47, 6 (2005). ...
Our study prospectively examined the use of real-time antifungal susceptibility testing among 119... more Our study prospectively examined the use of real-time antifungal susceptibility testing among 119 patients with candidemia at a large tertiary university medical center over a 1-year period. Susceptibility results to fluconazole were reported to physicians a mean of 5.1 days after the initial positive blood culture for Candida. Physicians believed that receiving antifungal susceptibility testing results was helpful and not infrequently altered therapy on the basis of results. Outcomes, including mortality and resolution of infection, among 20 (17%) patients with fluconazole-resistant and fluconazole-susceptible dose-dependent isolates were relatively poor compared to those among patients with fluconazole-susceptible isolates, but probably reflect severity of illness. Routine susceptibility testing as an adjunct to the treatment of candidemia has significant potential and warrants further study.
C 4 photosynthesis typically requires two specialized leaf cell types, bundle sheath (bs) and mes... more C 4 photosynthesis typically requires two specialized leaf cell types, bundle sheath (bs) and mesophyll (mp), which provide the foundation for this highly efficient carbon assimilation pathway. In leaves of Flaveria bidentis, a dicotyledonous C 4 plant, ribulose 1,5-...
... Catalytic Aerobic Oxidation by a Trianionic Pincer Cr III /Cr V Couple. Matthew O&amp;amp... more ... Catalytic Aerobic Oxidation by a Trianionic Pincer Cr III /Cr V Couple. Matthew O&amp;amp;amp;amp;amp;#x27;Reilly, Joseph M. Falkowski, Vasanth Ramachandran, Mekhala Pati, Khalil A. Abboud, Naresh S. Dalal, Thomas G. Gray and Adam S. Veige. Inorganic Chemistry 2009 48 (23), 10901-10903. ...
Quarterly Journal of Experimental Psychology: Section A, Sep 1, 1992
Stenning, Shepherd, and Levy (1988) showed that when simple texts switch reference predictably be... more Stenning, Shepherd, and Levy (1988) showed that when simple texts switch reference predictably between individuals, changes of reference neither cost reading time nor degrade memory performance. The present experiments examine the effects of unpredictable referential change. Experiment 1 demonstrates that unpredictable reference change does cost processing time, as a function of the amount known about the referent to which attention shifts. Analysis reveals a distinction between primary and secondary ...
Uploads