We report a case of morning glory syndrome (MGS) associated with persistent hyperplastic primary ... more We report a case of morning glory syndrome (MGS) associated with persistent hyperplastic primary vitreous (PHPV) and Peters’ anomaly. A 2-day-old girl, born at term with a birth weight of 3,350 g was diagnosed with Peters’ anomaly, cataract, microphthalmia, PHPV, and MGS. A right limbal lensectomy and vitrectomy with stalk cauterization was performed 8 days later. No early postoperative complication occurred, the family was discharged with advice on medication, and follow-up examination was scheduled. The case report reveals the coexistence of PHPV, Peters’ anomaly, and MGS, which may suggest a genetic link.
Purpose: To investigate choriocapillaris flow voids (FV) with a new optical coherence tomography ... more Purpose: To investigate choriocapillaris flow voids (FV) with a new optical coherence tomography angiography (OCTA) image processing strategy to exclude artifacts due to vitreous opacities, subretinal pigment epithelium (sub-RPE) fluid and deposits, and subretinal fluid (SRF) by thresholding the en-face OCT image of the outer retina.Methods: This retrospective study included 15 eyes with drusen and 15 eyes with SRF. Number (FVn), average area (FVav), and maximum area (FVmax) of FV and the percentage of the nonperfused choriocapillaris area (PNPCA) obtained using the proposed strategy were compared with those obtained by removing only artifacts due to superficial capillary plexus (SCP).Results: There were three eyes with autosomal dominant drusen and 12 eyes with drusen secondary to non-exudative AMD in the drusen group. SRF group included 15 eyes with active central serous chorioretinopathy. PNPCA, FVav, FVmax, and FVn obtained using the algorithm were significantly lower than those...
... was created using the Hansatome (Baush & Lomb, Claremont, CA) and excimer laser a... more ... was created using the Hansatome (Baush & Lomb, Claremont, CA) and excimer laser ablation (Summit SVS Apex, Summit Technology, Waltham, MA ... Our study demonstrated decreased tear secretion as measured by the Schirmer tear test without anes-thesia 4 weeks following ...
Ophthalmic Surgery, Lasers and Imaging Retina, 2001
To investigate the penetration of cefepime (a fourth generation cephalosporin) into the aqueous h... more To investigate the penetration of cefepime (a fourth generation cephalosporin) into the aqueous humor after single-dose intravenous administration in humans. Before receiving cataract surgery, 30 patients received randomly 1 g (group 1, 15 patients) and 2 g (group 2, 15 patients) single intravenous injection of cefepime before surgery. Samples of aqueous humor and serum were obtained at 0.5, 1, 2, 4, and 12 hours after injection. Three patients were sampled each time for 1 g and 2 g of cefepime. Samples were assayed for cefepime concentrations with high performance liquid chromatography (HPLC). All the patients had detectable cefepime in their aqueous humor and serum measurable by HPLC. A mean peak aqueous humor level was 5.16 +/- 0.88 microg/mL in group 1 and 5.87 +/- 1.64 microg/mL in group 2 at 0.5 hour after injection. The mean level of cefepime in aqueous humor decreased after 0.5-hour measurements in both groups and was measured as 0.82 +/- 0.21 microg/mL in group 1 and 2.04 +/- 0.30 microg/mL in group 2 at 12 hours after injection. Aqueous humor levels of cefepime after single IV injection were above the minimum inhibitory concentration (MIC90) for most ocular pathogens, but the duration of exposure to an antibiotic was not sufficient for therapeutic effect.
We demonstrate that Borrelia burgdorferi infection in the rhesus monkey mimics the early and earl... more We demonstrate that Borrelia burgdorferi infection in the rhesus monkey mimics the early and early disseminated phases of human Lyme disease. Clinical, bacteriological, immunological, and pathological signs of infection were investigated during 13 weeks after inoculation of the spirochete. Three animals were given B. burgdorferi (strain JD1) by needle inoculations, six animals were exposed to the bite of B. burgdorferi-infected Ixodes dammini ticks, and three animals were uninfected controls. B. burgdorferi could be recovered from all animals that were given the spirochete. Bacteria were detectable until week 6 postinoculation (p.i.) in blood, until week 8 p.i. in skin biopsies, and at 10 weeks p.i. in the conjunctiva of one of two animals which developed conjunctivitis. Erythema migrans (EM) appeared in one of the three animals infected by needle inoculation and in five of the six animals infected by ticks. Deep dermal perivascular lymphocytic infiltrations (characteristic of human...
Purpose To determine macular sensitivity and fixation characteristics in eyes with central serous... more Purpose To determine macular sensitivity and fixation characteristics in eyes with central serous chorioretinopathy (CSC) using fundus-related microperimetry. Methods The authors reviewed 19 eyes with serous elevation within the central 10° due to CSC and 15 normal healthy eyes that had undergone fundus-related microperimetry. The macular sensitivity was measured using the fundus-related microperimeter, MP-1. The best-corrected visual acuity (BCVA), mean retinal sensitivity in the central 10° (central microperimetry, cMP-1) and in the paracentral 10° to 20° (paracentral microperimetry, pMP-1), and fixation stability and location were determined and compared with that of control eyes. Results Eyes with CSC showed significantly lower logMAR BCVA (p<0.001), cMP-1, and pMP-1 sensitivity than control eyes (p<0.001, p<0.01, respectively). Eyes with CSC were not significantly different in fixation location (p=1.00) or fixation stability than control eyes (p=0.45). Fixation locatio...
Dear editor and readers, this letter is written to make you aware that the original version of th... more Dear editor and readers, this letter is written to make you aware that the original version of this article unfortunately contained a mistake.
To evaluate ultrasonography outcomes in eyes with stage 5 retinopathy of prematurity (ROP). Patie... more To evaluate ultrasonography outcomes in eyes with stage 5 retinopathy of prematurity (ROP). Patients with bilateral stage 5 ROP were evaluated retrospectively. Ultrasonography examination was performed in all cases. Patients' demographic features and ultrasonography findings such as axial eye length, funnel configuration, subretinal hemorrhage, anterior loop traction, retinal cyst, and calcification were assessed, and correlations between variables were analyzed. Three hundred eyes of 150 patients were included. Sixty-one patients (40.7%) were female. The mean gestational age was 28.8 weeks ± 2.6 weeks, and the mean birth weight was 1,277 g ± 360 g. The mean axial eye length was 14.7 mm ± 1.8 mm. Two hundred forty-five eyes (81.7%) had closed-closed retinal detachment configuration, 32 (10.7%) had open-closed retinal detachment configuration, 17 (5.7%) had open-open retinal detachment configuration, and six (2%) had closed-open retinal detachment configuration. Subretinal hemorr...
The British journal of ophthalmology, Sep 16, 2015
To evaluate the incidence of and factors contributing to intraoperative and postoperative complic... more To evaluate the incidence of and factors contributing to intraoperative and postoperative complications of eyes with previous pars plana vitrectomy (PPV) undergoing phacoemulsification and intraocular lens (IOL) implantation for cataract. The intraoperative and postoperative complications and observations in 513 eyes of 485 patients with previous PPV undergoing sutured and sutureless cataract surgery were assessed. Associations between preoperative characteristics and complications during and after the surgery were explored. The median interval from PPV to cataract surgery was 15.7±19.5 months. The mean follow-up period was 35.1±31.4 months. Intraoperative complications and observations were: posterior capsular plaque in 50 eyes (9.7%), posterior capsule rupture in 28 eyes (5.5%), loss of nuclear material into vitreous in 17 eyes (3.3%), and zonular dialysis in 12 eyes (2.3%). The most common postoperative complication was posterior capsular opacification (PCO) in 171 eyes (33.3%). ...
Very few reports have addressed methods of treatment for idiopathic serous (IS) pigment epithelia... more Very few reports have addressed methods of treatment for idiopathic serous (IS) pigment epithelial detachment (PED). The purpose of this report was to describe clinical courses of two patients with ISPED in whom reduced-fluence photodynamic therapy (RFPDT) was performed. Two patients (a 38-year-old woman and a 42-year-old man) were diagnosed with ISPED. In both patients, indocyanine green angiography revealed an area of choroidal vascular hyperpermeability including hyperfluorescent PED, which was evident at the subfoveal area. Both patients underwent RFPDT at an energy of 25 J/cm(2). The PED was seen to have resolved 1 month after the treatment and visual acuity was maintained or improved. There was no posttreatment recurrence of PED after 6 months to 1 year, and no treatment-related adverse events were observed. RFPDT may be an effective and safe method of treatment for ISPED with choroidal vascular hyperpermeability.
We report a case of morning glory syndrome (MGS) associated with persistent hyperplastic primary ... more We report a case of morning glory syndrome (MGS) associated with persistent hyperplastic primary vitreous (PHPV) and Peters’ anomaly. A 2-day-old girl, born at term with a birth weight of 3,350 g was diagnosed with Peters’ anomaly, cataract, microphthalmia, PHPV, and MGS. A right limbal lensectomy and vitrectomy with stalk cauterization was performed 8 days later. No early postoperative complication occurred, the family was discharged with advice on medication, and follow-up examination was scheduled. The case report reveals the coexistence of PHPV, Peters’ anomaly, and MGS, which may suggest a genetic link.
Purpose: To investigate choriocapillaris flow voids (FV) with a new optical coherence tomography ... more Purpose: To investigate choriocapillaris flow voids (FV) with a new optical coherence tomography angiography (OCTA) image processing strategy to exclude artifacts due to vitreous opacities, subretinal pigment epithelium (sub-RPE) fluid and deposits, and subretinal fluid (SRF) by thresholding the en-face OCT image of the outer retina.Methods: This retrospective study included 15 eyes with drusen and 15 eyes with SRF. Number (FVn), average area (FVav), and maximum area (FVmax) of FV and the percentage of the nonperfused choriocapillaris area (PNPCA) obtained using the proposed strategy were compared with those obtained by removing only artifacts due to superficial capillary plexus (SCP).Results: There were three eyes with autosomal dominant drusen and 12 eyes with drusen secondary to non-exudative AMD in the drusen group. SRF group included 15 eyes with active central serous chorioretinopathy. PNPCA, FVav, FVmax, and FVn obtained using the algorithm were significantly lower than those...
... was created using the Hansatome (Baush &amp;amp; Lomb, Claremont, CA) and excimer laser a... more ... was created using the Hansatome (Baush &amp;amp; Lomb, Claremont, CA) and excimer laser ablation (Summit SVS Apex, Summit Technology, Waltham, MA ... Our study demonstrated decreased tear secretion as measured by the Schirmer tear test without anes-thesia 4 weeks following ...
Ophthalmic Surgery, Lasers and Imaging Retina, 2001
To investigate the penetration of cefepime (a fourth generation cephalosporin) into the aqueous h... more To investigate the penetration of cefepime (a fourth generation cephalosporin) into the aqueous humor after single-dose intravenous administration in humans. Before receiving cataract surgery, 30 patients received randomly 1 g (group 1, 15 patients) and 2 g (group 2, 15 patients) single intravenous injection of cefepime before surgery. Samples of aqueous humor and serum were obtained at 0.5, 1, 2, 4, and 12 hours after injection. Three patients were sampled each time for 1 g and 2 g of cefepime. Samples were assayed for cefepime concentrations with high performance liquid chromatography (HPLC). All the patients had detectable cefepime in their aqueous humor and serum measurable by HPLC. A mean peak aqueous humor level was 5.16 +/- 0.88 microg/mL in group 1 and 5.87 +/- 1.64 microg/mL in group 2 at 0.5 hour after injection. The mean level of cefepime in aqueous humor decreased after 0.5-hour measurements in both groups and was measured as 0.82 +/- 0.21 microg/mL in group 1 and 2.04 +/- 0.30 microg/mL in group 2 at 12 hours after injection. Aqueous humor levels of cefepime after single IV injection were above the minimum inhibitory concentration (MIC90) for most ocular pathogens, but the duration of exposure to an antibiotic was not sufficient for therapeutic effect.
We demonstrate that Borrelia burgdorferi infection in the rhesus monkey mimics the early and earl... more We demonstrate that Borrelia burgdorferi infection in the rhesus monkey mimics the early and early disseminated phases of human Lyme disease. Clinical, bacteriological, immunological, and pathological signs of infection were investigated during 13 weeks after inoculation of the spirochete. Three animals were given B. burgdorferi (strain JD1) by needle inoculations, six animals were exposed to the bite of B. burgdorferi-infected Ixodes dammini ticks, and three animals were uninfected controls. B. burgdorferi could be recovered from all animals that were given the spirochete. Bacteria were detectable until week 6 postinoculation (p.i.) in blood, until week 8 p.i. in skin biopsies, and at 10 weeks p.i. in the conjunctiva of one of two animals which developed conjunctivitis. Erythema migrans (EM) appeared in one of the three animals infected by needle inoculation and in five of the six animals infected by ticks. Deep dermal perivascular lymphocytic infiltrations (characteristic of human...
Purpose To determine macular sensitivity and fixation characteristics in eyes with central serous... more Purpose To determine macular sensitivity and fixation characteristics in eyes with central serous chorioretinopathy (CSC) using fundus-related microperimetry. Methods The authors reviewed 19 eyes with serous elevation within the central 10° due to CSC and 15 normal healthy eyes that had undergone fundus-related microperimetry. The macular sensitivity was measured using the fundus-related microperimeter, MP-1. The best-corrected visual acuity (BCVA), mean retinal sensitivity in the central 10° (central microperimetry, cMP-1) and in the paracentral 10° to 20° (paracentral microperimetry, pMP-1), and fixation stability and location were determined and compared with that of control eyes. Results Eyes with CSC showed significantly lower logMAR BCVA (p<0.001), cMP-1, and pMP-1 sensitivity than control eyes (p<0.001, p<0.01, respectively). Eyes with CSC were not significantly different in fixation location (p=1.00) or fixation stability than control eyes (p=0.45). Fixation locatio...
Dear editor and readers, this letter is written to make you aware that the original version of th... more Dear editor and readers, this letter is written to make you aware that the original version of this article unfortunately contained a mistake.
To evaluate ultrasonography outcomes in eyes with stage 5 retinopathy of prematurity (ROP). Patie... more To evaluate ultrasonography outcomes in eyes with stage 5 retinopathy of prematurity (ROP). Patients with bilateral stage 5 ROP were evaluated retrospectively. Ultrasonography examination was performed in all cases. Patients' demographic features and ultrasonography findings such as axial eye length, funnel configuration, subretinal hemorrhage, anterior loop traction, retinal cyst, and calcification were assessed, and correlations between variables were analyzed. Three hundred eyes of 150 patients were included. Sixty-one patients (40.7%) were female. The mean gestational age was 28.8 weeks ± 2.6 weeks, and the mean birth weight was 1,277 g ± 360 g. The mean axial eye length was 14.7 mm ± 1.8 mm. Two hundred forty-five eyes (81.7%) had closed-closed retinal detachment configuration, 32 (10.7%) had open-closed retinal detachment configuration, 17 (5.7%) had open-open retinal detachment configuration, and six (2%) had closed-open retinal detachment configuration. Subretinal hemorr...
The British journal of ophthalmology, Sep 16, 2015
To evaluate the incidence of and factors contributing to intraoperative and postoperative complic... more To evaluate the incidence of and factors contributing to intraoperative and postoperative complications of eyes with previous pars plana vitrectomy (PPV) undergoing phacoemulsification and intraocular lens (IOL) implantation for cataract. The intraoperative and postoperative complications and observations in 513 eyes of 485 patients with previous PPV undergoing sutured and sutureless cataract surgery were assessed. Associations between preoperative characteristics and complications during and after the surgery were explored. The median interval from PPV to cataract surgery was 15.7±19.5 months. The mean follow-up period was 35.1±31.4 months. Intraoperative complications and observations were: posterior capsular plaque in 50 eyes (9.7%), posterior capsule rupture in 28 eyes (5.5%), loss of nuclear material into vitreous in 17 eyes (3.3%), and zonular dialysis in 12 eyes (2.3%). The most common postoperative complication was posterior capsular opacification (PCO) in 171 eyes (33.3%). ...
Very few reports have addressed methods of treatment for idiopathic serous (IS) pigment epithelia... more Very few reports have addressed methods of treatment for idiopathic serous (IS) pigment epithelial detachment (PED). The purpose of this report was to describe clinical courses of two patients with ISPED in whom reduced-fluence photodynamic therapy (RFPDT) was performed. Two patients (a 38-year-old woman and a 42-year-old man) were diagnosed with ISPED. In both patients, indocyanine green angiography revealed an area of choroidal vascular hyperpermeability including hyperfluorescent PED, which was evident at the subfoveal area. Both patients underwent RFPDT at an energy of 25 J/cm(2). The PED was seen to have resolved 1 month after the treatment and visual acuity was maintained or improved. There was no posttreatment recurrence of PED after 6 months to 1 year, and no treatment-related adverse events were observed. RFPDT may be an effective and safe method of treatment for ISPED with choroidal vascular hyperpermeability.
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