A green and convenient approach for the synthesis of 2,4,6 derivatives, and ammonium acetate in l... more A green and convenient approach for the synthesis of 2,4,6 derivatives, and ammonium acetate in lactic acid under solvent free condition is described. This method provides several adva such as environmental friendliness, shorter reaction time, excellent yields, and simple workup procedure.
Maltose as an efficient, available, cheap and eco-friendly catalyst has been applied for the synt... more Maltose as an efficient, available, cheap and eco-friendly catalyst has been applied for the synthesis of 3,4,5-substituted furan-2(5H)one derivatives via a one-pot three-component reaction of arylamines, aromatic aldehydes and dialkyl acetylenedicarboxylates in water. This method has notable advantages in terms of simple workup, no need for column chromatography, short reaction time and high yields.
An efficient and simple protocol for the one-pot three-component synthesis of 3,4-dihydropyrano[3... more An efficient and simple protocol for the one-pot three-component synthesis of 3,4-dihydropyrano[3,2-c]chromenes 4 is described, via the reaction of aromatic aldehydes 1, malononitril 2 and 4-hydroxycumarin 3 in the presence of 10 mol% of piperidine as catalyst, in ethanol (EtOH) at ambient temperature. Short reaction times, environmentally friendly procedure and excellent yields are the main advantages of this procedure, which makes it more economical than other environmentfriendly methods.
Cellulose was applied as a reusable and green catalyst for the facile four-component synthesis of... more Cellulose was applied as a reusable and green catalyst for the facile four-component synthesis of 6-amino-4-aryl-3-methyl-1,4dihydropyrano[2,3-c]pyrazole-5-carbonitrile derivatives using hydrazine monohydrate, ethyl acetoacetate, malononitrile and aryl aldehydes, under solvent-free and thermal conditions. The use of non-toxic and inexpensive catalyst, short reaction time, clean work-up and good yields of the products are advantages of this method.
Heterocycles, are an important group of organic compounds that have important role in the drug in... more Heterocycles, are an important group of organic compounds that have important role in the drug industry. Among the widespread heterocyclic compounds, nitrogen heterocycles have a distinct position because of their wide natural abundance and broad biological as well as pharmaceutical significance. A convenient and practical methodology for the one-pot, fivecomponent synthesis of highly substituted piperidines has been developed via the condensation between arylaldehydes, amines and β-ketoesters in the presence of a catalytic amount of cobalt (II) nitrate hexahydrate at room temperature. In addition 1,8-dioxodecahydroacridine derivatives have been synthesis via the reaction between arylaldehydes, amines/ammonium acetate and dimedone in the presence of cobalt (II) nitrate hexahydrate as an efficient catalyst at thermal condition. One of the chief advantages of this methodology is high yields, short reaction times and simple work-up.
Quarterly Journal of Applied Chemical Research, 2018
An efficient one-pot four-component protocol for the synthesis of pyrano[2,3-c]pyrazolederivative... more An efficient one-pot four-component protocol for the synthesis of pyrano[2,3-c]pyrazolederivatives has been demonstrated using Y(NO3)3.6H2O as catalyst under mild condition. This isa general synthetic protocol which could be applicable to a wide range of carbonyl compoundsincluding aromatic aldehydes, isatins and acenaphthenequinone. All The reactions proceededsmoothly, high-yielding and purity via an easy work-up procedure.
An environmentally friendly, one-pot, three-component synthesis of 8,10-dimethyl-12-aryl-12H-naph... more An environmentally friendly, one-pot, three-component synthesis of 8,10-dimethyl-12-aryl-12H-naphtho[1′,2′:5,6]pyrano[2,3-d]pyrimidine-9,11-diones was achieved via coupling aromatic of aldehydes, β-naphthol and 6-amino-1,3-dimethyl uracil in the presence of formic acid as a catalyst under solvent-free conditions at 90 °C. This method has several advantages, such as efficiency, good yield, short reaction time, cleaner reaction profiles, ease of product isolation, operational simplicity and inexpensive, effective and catalyst.
A green and facile saccharin-catalyzed procedure is developed for the one-pot convenient synthesi... more A green and facile saccharin-catalyzed procedure is developed for the one-pot convenient synthesis of dihydropyrano[2,3-c]pyrazole, tetrahydrobenzo[b]pyran and pyrano[2,3-d]pyrimidinone scaffolds via multi-component tandem Knoevenagel cyclocondensation reaction. This procedure has the chief advantages of green, inexpensive and readily available catalyst, high atom-economy, high to quantitative yields and the reaction procedure is mild and involves facile workup procedure to obtain the desired products in short reaction times.
Stable crystalline phosphorus ylides are obtained in excellent yields from the 1:1:1 addition rea... more Stable crystalline phosphorus ylides are obtained in excellent yields from the 1:1:1 addition reaction between triphenylphosphine and dialkyl acetylenedicarboxylate in the presence of a strong NH-acid, such as 2-indolinone, 3-acetylindole and saccharine. These stable ylides exist in solution as a mixture of two geometrical isomers as a result of restricted rotation around the carbon–carbon partial double bond resulting from conjugation of the ylide moiety with the adjacent carbonyl group. Dynamic effects are observed in 1H NMR spectra. The calculated free-energy of activation for interconversion of the rotational isomers in 2-indolinone amounts to about 68.2±2 J/mol.
Polarised olefinic systems are synthesised from the reaction between alkyl or aryl isocyanides an... more Polarised olefinic systems are synthesised from the reaction between alkyl or aryl isocyanides and N,N′-dimethylbarbituric acid in 62–74% yield.
A green and convenient approach for the synthesis of 2,4,6 derivatives, and ammonium acetate in l... more A green and convenient approach for the synthesis of 2,4,6 derivatives, and ammonium acetate in lactic acid under solvent free condition is described. This method provides several adva such as environmental friendliness, shorter reaction time, excellent yields, and simple workup procedure.
Maltose as an efficient, available, cheap and eco-friendly catalyst has been applied for the synt... more Maltose as an efficient, available, cheap and eco-friendly catalyst has been applied for the synthesis of 3,4,5-substituted furan-2(5H)one derivatives via a one-pot three-component reaction of arylamines, aromatic aldehydes and dialkyl acetylenedicarboxylates in water. This method has notable advantages in terms of simple workup, no need for column chromatography, short reaction time and high yields.
An efficient and simple protocol for the one-pot three-component synthesis of 3,4-dihydropyrano[3... more An efficient and simple protocol for the one-pot three-component synthesis of 3,4-dihydropyrano[3,2-c]chromenes 4 is described, via the reaction of aromatic aldehydes 1, malononitril 2 and 4-hydroxycumarin 3 in the presence of 10 mol% of piperidine as catalyst, in ethanol (EtOH) at ambient temperature. Short reaction times, environmentally friendly procedure and excellent yields are the main advantages of this procedure, which makes it more economical than other environmentfriendly methods.
Cellulose was applied as a reusable and green catalyst for the facile four-component synthesis of... more Cellulose was applied as a reusable and green catalyst for the facile four-component synthesis of 6-amino-4-aryl-3-methyl-1,4dihydropyrano[2,3-c]pyrazole-5-carbonitrile derivatives using hydrazine monohydrate, ethyl acetoacetate, malononitrile and aryl aldehydes, under solvent-free and thermal conditions. The use of non-toxic and inexpensive catalyst, short reaction time, clean work-up and good yields of the products are advantages of this method.
Heterocycles, are an important group of organic compounds that have important role in the drug in... more Heterocycles, are an important group of organic compounds that have important role in the drug industry. Among the widespread heterocyclic compounds, nitrogen heterocycles have a distinct position because of their wide natural abundance and broad biological as well as pharmaceutical significance. A convenient and practical methodology for the one-pot, fivecomponent synthesis of highly substituted piperidines has been developed via the condensation between arylaldehydes, amines and β-ketoesters in the presence of a catalytic amount of cobalt (II) nitrate hexahydrate at room temperature. In addition 1,8-dioxodecahydroacridine derivatives have been synthesis via the reaction between arylaldehydes, amines/ammonium acetate and dimedone in the presence of cobalt (II) nitrate hexahydrate as an efficient catalyst at thermal condition. One of the chief advantages of this methodology is high yields, short reaction times and simple work-up.
Quarterly Journal of Applied Chemical Research, 2018
An efficient one-pot four-component protocol for the synthesis of pyrano[2,3-c]pyrazolederivative... more An efficient one-pot four-component protocol for the synthesis of pyrano[2,3-c]pyrazolederivatives has been demonstrated using Y(NO3)3.6H2O as catalyst under mild condition. This isa general synthetic protocol which could be applicable to a wide range of carbonyl compoundsincluding aromatic aldehydes, isatins and acenaphthenequinone. All The reactions proceededsmoothly, high-yielding and purity via an easy work-up procedure.
An environmentally friendly, one-pot, three-component synthesis of 8,10-dimethyl-12-aryl-12H-naph... more An environmentally friendly, one-pot, three-component synthesis of 8,10-dimethyl-12-aryl-12H-naphtho[1′,2′:5,6]pyrano[2,3-d]pyrimidine-9,11-diones was achieved via coupling aromatic of aldehydes, β-naphthol and 6-amino-1,3-dimethyl uracil in the presence of formic acid as a catalyst under solvent-free conditions at 90 °C. This method has several advantages, such as efficiency, good yield, short reaction time, cleaner reaction profiles, ease of product isolation, operational simplicity and inexpensive, effective and catalyst.
A green and facile saccharin-catalyzed procedure is developed for the one-pot convenient synthesi... more A green and facile saccharin-catalyzed procedure is developed for the one-pot convenient synthesis of dihydropyrano[2,3-c]pyrazole, tetrahydrobenzo[b]pyran and pyrano[2,3-d]pyrimidinone scaffolds via multi-component tandem Knoevenagel cyclocondensation reaction. This procedure has the chief advantages of green, inexpensive and readily available catalyst, high atom-economy, high to quantitative yields and the reaction procedure is mild and involves facile workup procedure to obtain the desired products in short reaction times.
Stable crystalline phosphorus ylides are obtained in excellent yields from the 1:1:1 addition rea... more Stable crystalline phosphorus ylides are obtained in excellent yields from the 1:1:1 addition reaction between triphenylphosphine and dialkyl acetylenedicarboxylate in the presence of a strong NH-acid, such as 2-indolinone, 3-acetylindole and saccharine. These stable ylides exist in solution as a mixture of two geometrical isomers as a result of restricted rotation around the carbon–carbon partial double bond resulting from conjugation of the ylide moiety with the adjacent carbonyl group. Dynamic effects are observed in 1H NMR spectra. The calculated free-energy of activation for interconversion of the rotational isomers in 2-indolinone amounts to about 68.2±2 J/mol.
Polarised olefinic systems are synthesised from the reaction between alkyl or aryl isocyanides an... more Polarised olefinic systems are synthesised from the reaction between alkyl or aryl isocyanides and N,N′-dimethylbarbituric acid in 62–74% yield.
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Papers by Nourallah Hazeri