The paper presents two cases of familial hemophagocytic lymphohistiocytosis in one family. The fi... more The paper presents two cases of familial hemophagocytic lymphohistiocytosis in one family. The first case is the first-born female child with symptoms of an abrupt onset of hepatic failure and encephalopathy at the age of 2.5 months, and the second case is the third-born male child from the fourth pregnancy who died in his first month with a similar clinical manifestation. By means of histological examination, a diffuse proliferation of histiocytes of benign appearance with numerous phagocytized erythrocytes in the cytoplasm was found in both patients. These infiltrates existed in numerous organs and tissues of the body, but they were mostly visible in the spleen, liver, lymph nodes and in the bone marrow. The course of the disease is rapidly progressive with an up to now insufficiently explained etiology of the disease, with the existence of an autosomal recessive type of inheritance and defects in cellular and humoral immunity.
Introduction. Evaluation of the prognostic factors and the survival rate in oral squamous cell ca... more Introduction. Evaluation of the prognostic factors and the survival rate in oral squamous cell carcinoma is extremely important, because patients in the same tumor-node-metastasis stage may have a different survival rate. Numerous studies have been conducted on various clinical and pathological prognostic factors in order to develop a prognostic model for the survival rate of patients with oral cancer. Material and Methods. The study was designed as a prospective study including 65 consecutive patients (n = 65) of both sexes who underwent surgical treatment of oral cancer. The diagnosis of oral cancer was based on the medical history, physical examination, and biopsy. The clinical tumor-node-metastasis staging was determined based on clinical examination. The radiological tumor-node-metastasis staging was done by computed tomography of the head, neck, and chest. The tumor thickness was determined by computed tomography and histopathological analysis of surgical specimens. Results. T...
Serbian Journal of Dermatology and Venereology, 2015
Ulerythema ophryogenes and keratosis follicularis spinulosa decalvans are rare folliculocentric k... more Ulerythema ophryogenes and keratosis follicularis spinulosa decalvans are rare folliculocentric keratotic disorders, from the group of follicular genokeratoses, characterized by keratosis pilaris atrophicans: follicular keratotic papules, sometimes with surrounding erythema, which eventually result in fibrosis, atrophy, progressive scarring and permanent hair loss. Ulerythema ophryogenes begins at birth or soon thereafter; it involves the lateral eyebrows, spreads medially and eventually affects the entire eyebrows, cheeks, and less frequently, forehead and asjecebt scalp. Involvement of the scalp has apparently not been reported in cases in which the eyebrows were predominantly involved. In addition to sporadic cases, ulerythema ophryogenes has been reported among relatives. Keratosis follicularis spinulosa decalvans is also a genetically heterogeneous syndrome which begins in infancy or childhood by involving hair bearing skin, especially the scalp; rarely it is confined to the fa...
Serbian Journal of Dermatology and Venerology, 2013
The authors present a case of a patient with extramammary Paget’s disease in the pubic region tre... more The authors present a case of a patient with extramammary Paget’s disease in the pubic region treated by a dermatologist with a private practice for almost 4 years before incisional biopsy was performed. A thorough examination showed no evidence of malignancies of internal organs, whereas definite diagnosis was made by excision of the entire skin lesion and histopathological analysis. With regard to multiple criteria, findings in our patient were consistent with current literature data, but interestingly, the primary extramammary Paget’s disease has not spread into deeper tissues.
Serbian Journal of Dermatology and Venereology, 2020
Introduction. Nevus sebaceous is a rare congenital hamartoma, composed of epidermis, sebaceous gl... more Introduction. Nevus sebaceous is a rare congenital hamartoma, composed of epidermis, sebaceous glands, sweat glands and hair follicles. It is possible to develop secondary tumors in the area of nevus sebaceous during the lifetime, most often after puberty. Secondary lesions are most often benign, while malignant lesions may occur but significantly less frequently. Case report. We present the case of a 21-year-old patient who came for an examination due to the appearance of a nodule in the area of a yellowish lesion on the head. The yellowish lesion was present since birth, and the nodule appeared about a year before. The dermoscopic examination of the lesion was nonspecific. The final diagnosis of eccrine poroma as a secondary lesion in nevus sebaceous was made by pathohisto-logical analysis. Conclusion. Every secondary tumor in nevus sebaceous deserves full attention, with either close follow up, or excision with pathohistological analysis.
We report a case of congenital cytomegalovirus and Herpes simplex virus infection suspected via u... more We report a case of congenital cytomegalovirus and Herpes simplex virus infection suspected via ultrasound indicated by the presence of fetal cerebral abnormalities. The pregnancy was electively terminated at 31 weeks of gestation. The postmortem examination of the foetus showed brain with lissencephaly. The histopathological examination revealed numerous enlarged cells containing cytomegalic inclusions and multinucleated giant cells in multiple fetal organs and placenta. Documented evidence of histopathological detection of cytomegalovirus inclusions in multiple organs are very sparse in literature. This case highlights the causal relationship of viral infections in early pregnancy and abnormalities of the central nervous system.
Introduction. Congenital anomalies of the epididymis, detected either during orchiopexy or routin... more Introduction. Congenital anomalies of the epididymis, detected either during orchiopexy or routine herniectomy, as well as their importance in male fertility, have been described in many papers in clinical surgery. Clinical Considerations. The aim of this study was to report various types of epididymal congenital abnormalities registered in the clinical practice of pediatric surgery, to describe their basic characteristics and to classify them into three groups: (I) fusional anomalies of the epididymis and testis; (II) anatomic forms of anomalies; (III) congenital epididymal cysts. Conclusion. The clinical experience of pediatric surgeons indicates that during these surgical procedures, it is necessary to carefully examine the epididymis to detect anomalies, and it is of utmost importance to inform the patient and/or his parents. It is also recommended to follow the patients up to the age of fertility.
Introduction. Hypertensive ischemic leg ulcer, also known as Martorell ulcer, is not very rare, b... more Introduction. Hypertensive ischemic leg ulcer, also known as Martorell ulcer, is not very rare, but an under-recognized type of leg ulcer. It has specific clinical and histopathological characteristics. It occurs almost exclusively in patients with arterial hypertension. It is more common in women and in patients with type 2 diabetes. It is localized particularly in the laterodorsal distal third of the lower leg. This ulcer is extremely painful. Its clinical features may very much resemble pyoderma gangrenosum. Case Report. We are presenting a case of a 40-year-old obese male, who suffered from arterial hypertension during the past 26 years. His ulcer appeared spontaneously on the lateral aspect of the right lower leg and progressed gradually. From the very onset, the ulcer was extremely painful. At first, it was diagnosed as pyoderma gangrenosum and treated with systemic corticosteroids and immunosuppressants. Since the response to therapy was not satisfactory, the histopathology w...
At the end of the Second World War, the General State Hospital had seven departments, the same fa... more At the end of the Second World War, the General State Hospital had seven departments, the same facilities, and the same bed capacity as in the pre-war period. In the newly formed state of Yugoslavia, intensive growth and modernization of the hospital began, despite the great financial difficulties. The hospital became the Main Provincial Hospital and new departments and services were established. Mainly during the 1960s and 1970s, ten new surgery departments were established, which later became independent clinics. The surgery departments occupied pavilions 1, 2, 3 and 4. Complex and contemporary abdominal and thoracic surgeries were performed. The Department of Internal Diseases became the Clinic of Internal Diseases and in 1964 it was moved to a newly equipped four-story building. The Clinic of Gynecology and Obstetrics was founded and it was moved into a modern, purpose-built facility with a 230 bed capacity for adult patients and 105 for newborns. Rapid progress has also been ma...
Serbian Journal of Dermatology and Venereology, 2018
Syringoma is a benign adnexal tumor derived from intraepidermal eccrine ducts. The usual presenta... more Syringoma is a benign adnexal tumor derived from intraepidermal eccrine ducts. The usual presentation of syringoma is a small smooth skin-colored, yellowish or brownish papule with flattened or rounded top. Eruptive syringoma is a rarely reported form, where lesions are numerous and occur in successive crops. A case of a 57-year-old Caucasian male with a twenty four-year history of multiple asymptomatic, erythematous and brownish papules, predominantly over the anterior aspect of the trunk is presented. All lesions appeared after prolonged sun exposures within a few days and persisted without further changes afterwards. Contact non-polarized dermoscopy showed a fine light brown, regular pigment network on a light pink background, being the same in all lesions. History of the disease, clinical finding and dermoscopy were inconclusive, and biopsy was performed. Histopathology revealed signs of syringoma. Dermoscopic finding was thought to be intriguing and therefore is discussed in th...
The paper presents two cases of familial hemophagocytic lymphohistiocytosis in one family. The fi... more The paper presents two cases of familial hemophagocytic lymphohistiocytosis in one family. The first case is the first-born female child with symptoms of an abrupt onset of hepatic failure and encephalopathy at the age of 2.5 months, and the second case is the third-born male child from the fourth pregnancy who died in his first month with a similar clinical manifestation. By means of histological examination, a diffuse proliferation of histiocytes of benign appearance with numerous phagocytized erythrocytes in the cytoplasm was found in both patients. These infiltrates existed in numerous organs and tissues of the body, but they were mostly visible in the spleen, liver, lymph nodes and in the bone marrow. The course of the disease is rapidly progressive with an up to now insufficiently explained etiology of the disease, with the existence of an autosomal recessive type of inheritance and defects in cellular and humoral immunity.
Introduction. Evaluation of the prognostic factors and the survival rate in oral squamous cell ca... more Introduction. Evaluation of the prognostic factors and the survival rate in oral squamous cell carcinoma is extremely important, because patients in the same tumor-node-metastasis stage may have a different survival rate. Numerous studies have been conducted on various clinical and pathological prognostic factors in order to develop a prognostic model for the survival rate of patients with oral cancer. Material and Methods. The study was designed as a prospective study including 65 consecutive patients (n = 65) of both sexes who underwent surgical treatment of oral cancer. The diagnosis of oral cancer was based on the medical history, physical examination, and biopsy. The clinical tumor-node-metastasis staging was determined based on clinical examination. The radiological tumor-node-metastasis staging was done by computed tomography of the head, neck, and chest. The tumor thickness was determined by computed tomography and histopathological analysis of surgical specimens. Results. T...
Serbian Journal of Dermatology and Venereology, 2015
Ulerythema ophryogenes and keratosis follicularis spinulosa decalvans are rare folliculocentric k... more Ulerythema ophryogenes and keratosis follicularis spinulosa decalvans are rare folliculocentric keratotic disorders, from the group of follicular genokeratoses, characterized by keratosis pilaris atrophicans: follicular keratotic papules, sometimes with surrounding erythema, which eventually result in fibrosis, atrophy, progressive scarring and permanent hair loss. Ulerythema ophryogenes begins at birth or soon thereafter; it involves the lateral eyebrows, spreads medially and eventually affects the entire eyebrows, cheeks, and less frequently, forehead and asjecebt scalp. Involvement of the scalp has apparently not been reported in cases in which the eyebrows were predominantly involved. In addition to sporadic cases, ulerythema ophryogenes has been reported among relatives. Keratosis follicularis spinulosa decalvans is also a genetically heterogeneous syndrome which begins in infancy or childhood by involving hair bearing skin, especially the scalp; rarely it is confined to the fa...
Serbian Journal of Dermatology and Venerology, 2013
The authors present a case of a patient with extramammary Paget’s disease in the pubic region tre... more The authors present a case of a patient with extramammary Paget’s disease in the pubic region treated by a dermatologist with a private practice for almost 4 years before incisional biopsy was performed. A thorough examination showed no evidence of malignancies of internal organs, whereas definite diagnosis was made by excision of the entire skin lesion and histopathological analysis. With regard to multiple criteria, findings in our patient were consistent with current literature data, but interestingly, the primary extramammary Paget’s disease has not spread into deeper tissues.
Serbian Journal of Dermatology and Venereology, 2020
Introduction. Nevus sebaceous is a rare congenital hamartoma, composed of epidermis, sebaceous gl... more Introduction. Nevus sebaceous is a rare congenital hamartoma, composed of epidermis, sebaceous glands, sweat glands and hair follicles. It is possible to develop secondary tumors in the area of nevus sebaceous during the lifetime, most often after puberty. Secondary lesions are most often benign, while malignant lesions may occur but significantly less frequently. Case report. We present the case of a 21-year-old patient who came for an examination due to the appearance of a nodule in the area of a yellowish lesion on the head. The yellowish lesion was present since birth, and the nodule appeared about a year before. The dermoscopic examination of the lesion was nonspecific. The final diagnosis of eccrine poroma as a secondary lesion in nevus sebaceous was made by pathohisto-logical analysis. Conclusion. Every secondary tumor in nevus sebaceous deserves full attention, with either close follow up, or excision with pathohistological analysis.
We report a case of congenital cytomegalovirus and Herpes simplex virus infection suspected via u... more We report a case of congenital cytomegalovirus and Herpes simplex virus infection suspected via ultrasound indicated by the presence of fetal cerebral abnormalities. The pregnancy was electively terminated at 31 weeks of gestation. The postmortem examination of the foetus showed brain with lissencephaly. The histopathological examination revealed numerous enlarged cells containing cytomegalic inclusions and multinucleated giant cells in multiple fetal organs and placenta. Documented evidence of histopathological detection of cytomegalovirus inclusions in multiple organs are very sparse in literature. This case highlights the causal relationship of viral infections in early pregnancy and abnormalities of the central nervous system.
Introduction. Congenital anomalies of the epididymis, detected either during orchiopexy or routin... more Introduction. Congenital anomalies of the epididymis, detected either during orchiopexy or routine herniectomy, as well as their importance in male fertility, have been described in many papers in clinical surgery. Clinical Considerations. The aim of this study was to report various types of epididymal congenital abnormalities registered in the clinical practice of pediatric surgery, to describe their basic characteristics and to classify them into three groups: (I) fusional anomalies of the epididymis and testis; (II) anatomic forms of anomalies; (III) congenital epididymal cysts. Conclusion. The clinical experience of pediatric surgeons indicates that during these surgical procedures, it is necessary to carefully examine the epididymis to detect anomalies, and it is of utmost importance to inform the patient and/or his parents. It is also recommended to follow the patients up to the age of fertility.
Introduction. Hypertensive ischemic leg ulcer, also known as Martorell ulcer, is not very rare, b... more Introduction. Hypertensive ischemic leg ulcer, also known as Martorell ulcer, is not very rare, but an under-recognized type of leg ulcer. It has specific clinical and histopathological characteristics. It occurs almost exclusively in patients with arterial hypertension. It is more common in women and in patients with type 2 diabetes. It is localized particularly in the laterodorsal distal third of the lower leg. This ulcer is extremely painful. Its clinical features may very much resemble pyoderma gangrenosum. Case Report. We are presenting a case of a 40-year-old obese male, who suffered from arterial hypertension during the past 26 years. His ulcer appeared spontaneously on the lateral aspect of the right lower leg and progressed gradually. From the very onset, the ulcer was extremely painful. At first, it was diagnosed as pyoderma gangrenosum and treated with systemic corticosteroids and immunosuppressants. Since the response to therapy was not satisfactory, the histopathology w...
At the end of the Second World War, the General State Hospital had seven departments, the same fa... more At the end of the Second World War, the General State Hospital had seven departments, the same facilities, and the same bed capacity as in the pre-war period. In the newly formed state of Yugoslavia, intensive growth and modernization of the hospital began, despite the great financial difficulties. The hospital became the Main Provincial Hospital and new departments and services were established. Mainly during the 1960s and 1970s, ten new surgery departments were established, which later became independent clinics. The surgery departments occupied pavilions 1, 2, 3 and 4. Complex and contemporary abdominal and thoracic surgeries were performed. The Department of Internal Diseases became the Clinic of Internal Diseases and in 1964 it was moved to a newly equipped four-story building. The Clinic of Gynecology and Obstetrics was founded and it was moved into a modern, purpose-built facility with a 230 bed capacity for adult patients and 105 for newborns. Rapid progress has also been ma...
Serbian Journal of Dermatology and Venereology, 2018
Syringoma is a benign adnexal tumor derived from intraepidermal eccrine ducts. The usual presenta... more Syringoma is a benign adnexal tumor derived from intraepidermal eccrine ducts. The usual presentation of syringoma is a small smooth skin-colored, yellowish or brownish papule with flattened or rounded top. Eruptive syringoma is a rarely reported form, where lesions are numerous and occur in successive crops. A case of a 57-year-old Caucasian male with a twenty four-year history of multiple asymptomatic, erythematous and brownish papules, predominantly over the anterior aspect of the trunk is presented. All lesions appeared after prolonged sun exposures within a few days and persisted without further changes afterwards. Contact non-polarized dermoscopy showed a fine light brown, regular pigment network on a light pink background, being the same in all lesions. History of the disease, clinical finding and dermoscopy were inconclusive, and biopsy was performed. Histopathology revealed signs of syringoma. Dermoscopic finding was thought to be intriguing and therefore is discussed in th...
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