This research work is based on simple concepts on elementary geometry, driven by a pattern in num... more This research work is based on simple concepts on elementary geometry, driven by a pattern in numbers. The simplicity defies the diversity, it is through a combination of fixed, almost rigid and constant symmetry with limited, asymmetric variables. From the original computer generated imagery of DNA by the pioneering Robert Langridge over 20 years ago, we analyzed and subsequently deconstructed
ABSTRACT Buddlejol (1), a new sterol, has been isolated from the ethyl acetate soluble fraction o... more ABSTRACT Buddlejol (1), a new sterol, has been isolated from the ethyl acetate soluble fraction of the antispasmodic plant Buddleja asiatica along with stigmasterol (2), lignoceric acid (3), taraxerol (4) and α-amyrin (5), respectively. The structure of Buddlejol (1) was established as (24S)-stigmast-5,22-diene-7β-ethoxy-3β-ol by spectral analysis and comparison with closely related structures. Buddlejol revealed to be a competitive inhibitor of chymotrypsin with the Ki value of 10.60 µM as indicated by Lineweaver–Burk and Dixon plots and their re-plots against its chymotrypsin inhibition assay, while the other compounds showed less inhibitory potential. The bioassay-guided isolation was stimulated by the preliminary cytotoxic screening of various fractions of B. asiatica.
A 27-year-old man who received a HeartMate (Thoratec Corporation, USA) left ventricular assist de... more A 27-year-old man who received a HeartMate (Thoratec Corporation, USA) left ventricular assist device for progressive heart failure as a bridge to orthotopic heart transplantation is described in the present report. The device failed (mechanical failure) after almost 19 months. The porcine bioprosthetic valves in the inflow and outflow cannulae showed hemorrhage, cusp tears and inflammatory cells, located largely on the inflow valve cusps. The role of the inflammatory cell reaction in the bioprosthetic valve is discussed.
This research work is based on simple concepts on elementary geometry, driven by a pattern in num... more This research work is based on simple concepts on elementary geometry, driven by a pattern in numbers. The simplicity defies the diversity, it is through a combination of fixed, almost rigid and constant symmetry with limited, asymmetric variables. From the original computer generated imagery of DNA by the pioneering Robert Langridge over 20 years ago, we analyzed and subsequently deconstructed
ABSTRACT Buddlejol (1), a new sterol, has been isolated from the ethyl acetate soluble fraction o... more ABSTRACT Buddlejol (1), a new sterol, has been isolated from the ethyl acetate soluble fraction of the antispasmodic plant Buddleja asiatica along with stigmasterol (2), lignoceric acid (3), taraxerol (4) and α-amyrin (5), respectively. The structure of Buddlejol (1) was established as (24S)-stigmast-5,22-diene-7β-ethoxy-3β-ol by spectral analysis and comparison with closely related structures. Buddlejol revealed to be a competitive inhibitor of chymotrypsin with the Ki value of 10.60 µM as indicated by Lineweaver–Burk and Dixon plots and their re-plots against its chymotrypsin inhibition assay, while the other compounds showed less inhibitory potential. The bioassay-guided isolation was stimulated by the preliminary cytotoxic screening of various fractions of B. asiatica.
A 27-year-old man who received a HeartMate (Thoratec Corporation, USA) left ventricular assist de... more A 27-year-old man who received a HeartMate (Thoratec Corporation, USA) left ventricular assist device for progressive heart failure as a bridge to orthotopic heart transplantation is described in the present report. The device failed (mechanical failure) after almost 19 months. The porcine bioprosthetic valves in the inflow and outflow cannulae showed hemorrhage, cusp tears and inflammatory cells, located largely on the inflow valve cusps. The role of the inflammatory cell reaction in the bioprosthetic valve is discussed.
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