ABS TRACT The term chronic rhinosinusitis (CRS) is an umbrella term that covers different conditi... more ABS TRACT The term chronic rhinosinusitis (CRS) is an umbrella term that covers different conditions related with the paranasal sinus system. In recent years, effort was made to understand the underlying pathophysiology in terms of detecting its phenotypes and endotypes. These efforts resulted with the identification of biomarkers that have an important role in pathophysiology of CRS. CRS is mainly divided into two phenotypes: CRS without (sine) nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP). CRS with nasal polyposis share the same mechanisms with allergic rhinitis and asthma in which type 2 inflammation is predominant. Biological monoclonal antibodies have a long use for treatment of uncontrolled asthma. Based on previous experience with asthma and allergic diseases, biological treatments started to gain place in management of uncontrolled CRS which is difficult to treat against maximal treatment effort. Recently; European Position Paper on Rhinosinusitis and Nasal Polyps...
ABS TRACT The term chronic rhinosinusitis (CRS) is an umbrella term that covers different conditi... more ABS TRACT The term chronic rhinosinusitis (CRS) is an umbrella term that covers different conditions related with the paranasal sinus system. In recent years, effort was made to understand the underlying pathophysiology in terms of detecting its phenotypes and endotypes. These efforts resulted with the identification of biomarkers that have an important role in pathophysiology of CRS. CRS is mainly divided into two phenotypes: CRS without (sine) nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP). CRS with nasal polyposis share the same mechanisms with allergic rhinitis and asthma in which type 2 inflammation is predominant. Biological monoclonal antibodies have a long use for treatment of uncontrolled asthma. Based on previous experience with asthma and allergic diseases, biological treatments started to gain place in management of uncontrolled CRS which is difficult to treat against maximal treatment effort. Recently; European Position Paper on Rhinosinusitis and Nasal Polyps...
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