Multicellular organisms develop complex shapes from much simpler, single-celled zygotes through a... more Multicellular organisms develop complex shapes from much simpler, single-celled zygotes through a process commonly called morphogenesis. Morphogenesis involves an interplay between several factors, ranging from the gene regulatory networks determining cell fate and differentiation to the mechanical processes underlying cell and tissue shape changes. Thus, the study of morphogenesis has historically been based on multidisciplinary approaches at the interface of biology with physics and mathematics. Recent technological advances have further improved our ability to study morphogenesis by bridging the gap between the genetic and biophysical factors through the development of new tools for visualizing, analyzing, and perturbing these factors and their biochemical intermediaries. Here, we review how a combination of genetic, microscopic, biophysical, and biochemical approaches has aided our attempts to understand morphogenesis and discuss potential approaches that may be beneficial to su...
2019 International Conference on Automation, Computational and Technology Management (ICACTM), 2019
By assimilating concepts of advanced communications and future control technologies, Smart Grid h... more By assimilating concepts of advanced communications and future control technologies, Smart Grid has become the next generation power system. Due to its greater robustness, efficiency and flexibility over conventional power system, its gaining importance. As in modern electrical power system, need of resources and storage is increasing which can be dealt with cloud computing. It is a promising technology with functionality of using computing resources in scalable and virtualized manner. Cloud computing integrates the electrical power system resources through internal networks, thus improvement in robustness, load balancing and storage capacity is observed.
2019 IEEE International Conference on Advanced Robotics and its Social Impacts (ARSO), 2019
Social interaction is an intrinsic property of all human beings. From the last few decades, robot... more Social interaction is an intrinsic property of all human beings. From the last few decades, robots have been entering the personal space of human beings. Therefore, it is essential for the robot to possess intelligence enough to act socially like humans in such an environment. One such example of a socially active robot is a telepresence robot. In this paper we have proposed a low-cost design, for the case of a telepresence robot, which has been built from scratch. It is a three-wheel omni drive robot, which makes it easy to move in a wide range of directions. The robot operates in two different modes namely the teleoperation and autonomous modes. An ego-centric framework has been used for the purpose of tracking the person with whom the communication has to be established in the autonomous mode. This omits the factor of uncertainty of the position of the robot and the camera calibration factor. The person to be tracked is first recognised so that the robot just tracks the concerned person irrespective of other people in the background.
International Journal of Innovative Research in Science, Engineering and Technology, 2013
Palmprint recognition being one of the important aspects of biometric technology is one of the mo... more Palmprint recognition being one of the important aspects of biometric technology is one of the most reliable and successful identification methods. In this paper, several existing palmprint recognition algorithms have been studied and analyzed. A simple approach to preprocessing and roi extraction has been discussed. The available databases have also been analyzed and the most efficient of all will be used for the development of
In this paper, a miniaturized modified UWB antenna operating at sextuple rejection bands for use ... more In this paper, a miniaturized modified UWB antenna operating at sextuple rejection bands for use in Device-to-Device communication, wireless sensor networks, microwave imaging sensing applications, and Internet of things (IoT) is presented. This paper proposes a design inseminating four U-shaped rectangular slot resonators on the radiating patch and placing two split-ring resonators (SRR) near the 50 Ω. Crostrip feed line-patch junction of the traditional stair-cased ultra-wideband (UWB) antenna. The proposed antenna is printed on a low profile substrate Rogers RO5880 with dielectric constant 2.2. The simulated and measured results show that the traditional ultra-wideband (UWB) antenna specimen delivers a wide impedance bandwidth from 3 to 10 GHz. The presented antenna design possesses eminent return loss performance (−15 dB < S11 < −35 dB) for all operating frequencies and high rejection characteristics across all stop bands with an omnidirectional farfield radiation pattern ...
Various types of Hemoglobinopathies have been reported in different parts of world, among them si... more Various types of Hemoglobinopathies have been reported in different parts of world, among them sickle cell anemia is a major concern. Sickle cell anemia was originated in Africa but now it covers a wide area of globe. In our society various types of sanguinity exists so in such area its prevalence is dominant. But till date there is no effective treatment, only supporting treatment & counseling are used to provide relief and protection to the population. Now it is also established that among sickle patient the rate of free radical generation is very high which causes oxidative stress and related damage to DNA, protein, lipid peroxidation & organ damage. Due to this various types of genotoxicity appear among patient. To provide relief to sufferer proper assessment of oxidative stress and genotoxicity is need of the hour. Although some supporting methods are available viz. stem cell transplant, gene therapy, enhancement of hemoglobin production, hydration etc. but are not very effecti...
We introduce a method for learning the dynamics of complex nonlinear systems based on deep genera... more We introduce a method for learning the dynamics of complex nonlinear systems based on deep generative models over temporal segments of states and actions. Unlike dynamics models that operate over individual discrete timesteps, we learn the distribution over future state trajectories conditioned on past state, past action, and planned future action trajectories, as well as a latent prior over action trajectories. Our approach is based on convolutional autoregressive models and variational autoencoders. It makes stable and accurate predictions over long horizons for complex, stochastic systems, effectively expressing uncertainty and modeling the effects of collisions, sensory noise, and action delays. The learned dynamics model and action prior can be used for end-to-end, fully differentiable trajectory optimization and model-based policy optimization, which we use to evaluate the performance and sample-efficiency of our method.
Discrete element analysis based on the assumption of linear elastic contact stiffness has found w... more Discrete element analysis based on the assumption of linear elastic contact stiffness has found widespread use for numerical modeling of kinematic behaviors of particulate assemblies. Use of linear elastic contact stiffness models for intergranular normal and tangential contacts may be computationally advantageous for investigating applications where local contact stiffnesses are rather inconsequential (e.g., industrial feeding). In contrast, the mechanical stability of granular assemblies can be influenced by load-dependent contact stiffnesses, which determines contact deformations during and after the formation of force chains. Further, in modeling mechanically stable states of granular assemblies, the intergranular forces at equilibrium may vary with respect to the kinematics of discrete elements in contact. Thus, for discrete element analyses aimed at characterizing observational behaviors of granular materials (e.g., simulations of tri-axial compression tests), considerations a...
Autoregressive generative models consistently achieve the best results in density estimation task... more Autoregressive generative models consistently achieve the best results in density estimation tasks involving high dimensional data, such as images or audio. They pose density estimation as a sequence modeling task, where a recurrent neural network (RNN) models the conditional distribution over the next element conditioned on all previous elements. In this paradigm, the bottleneck is the extent to which the RNN can model long-range dependencies, and the most successful approaches rely on causal convolutions, which offer better access to earlier parts of the sequence than conventional RNNs. Taking inspiration from recent work in meta reinforcement learning, where dealing with long-range dependencies is also essential, we introduce a new generative model architecture that combines causal convolutions with self attention. In this note, we describe the resulting model and present state-of-the-art log-likelihood results on CIFAR-10 (2.85 bits per dim) and $32 \times 32$ ImageNet (3.80 bit...
Sickle cell disease is known to induce oxidative stress which is associated with increased produc... more Sickle cell disease is known to induce oxidative stress which is associated with increased production of oxidizing species leading to a variety of cytogenetic abnormalities. Micronuclei formation under the influence of oxidative stress under the influence of variety of toxicants is a well known fact. In the present study micronuclei frequency among sickled tr ibal (Halba & Gond) population (HbAS and HbSS) among different age groups (10 - 20, 20 - 30 and 30 - 40 years) has been estimated and compared with the control set of population from same age groups. The frequency of micronuclei was found significantly higher in both HbAS and HbSS population of all the corresponding age groups at P >0.05. Finding of the present work emphasize on genotoxicity among sickled population confirmed by micronuclei formation under influence of oxidative stress.
Andrographis paniculata is an herbaceous plant in the family Acanthaceae and is popularly known a... more Andrographis paniculata is an herbaceous plant in the family Acanthaceae and is popularly known as Kalmegh. In Chhattisgarh state, the plant is being used widely by traditional healers for treatment of different ailments, viz., cough, cold, jaundice, mental distress, diabetes etc. In the present study a database was prepared for wide application of the plant by the traditional healers of four tribal districts (Durg, Kanker, Bastar and Dantewada) of Chhattisgarh state on the basis of their experience. In the next step, major biochemical ingredients of the plant were investigated and a corelative study of its therapeutic significance was carried out. We found Cardiac glycoside, Terpanoid, Steroid, Saponin, Tannin, Flavonoid & Alkaloid from various parts of plant in different solvents. A TLC chromatogram for different phytocompounds was also prepared. Maximum 10 bands were obtained in the methanolic extract of stem with RF values ranging from 0.07 to 0.93 and minimum of only 1 band was...
We have worked on the As concentrations present in the groundwater samples in the Rajnandgaon reg... more We have worked on the As concentrations present in the groundwater samples in the Rajnandgaon region of India, as well as the clinical assessment of the impact of Arsenicosis on the human population. Out of twenty groundwater samples from eight villages, arsenic was found to be above the permissible limit in eighteen samples. The people in the affected area were found suffering from diffused and spotted melanosis, diffused and nodular keratosis, leucomelanosis, hepatomegaly, and splenomegaly. The hematological parameters, viz. low Hemoglobin, high ESR, and low PCV, with RBC, WBC, and Platelet counts adversely altered and increased Prothrombin time. The change in biochemical parameters reflects the toxic effect of prolonged exposure to arsenic viz. – low Serum Glucose, high LDL, HDL, and TG, decreased Total Protein, Albumin, and Globulin. Total Bilirubin, Creatinine, Urea, and SGPT were at higher levels, but the activity of Alkaline phosphatase was found lower. The study reveals the ...
Arsenic toxicity is a worldwide geogenic problem for large number of populations. The major probl... more Arsenic toxicity is a worldwide geogenic problem for large number of populations. The major problem of arsenicosis is generation of free radicals and related genotoxicity, In the present study three plants species Ocimum gratissimum L., Ocimum sanctum, Ocimum basilicum, were examined by both in vivo and in vitro methods in Oryctolagus cuniculus L to know the free radical scavenging property in Sodium Arsenite induced oxidative stress and related genotoxicity. Oxidative stress was evaluated considering MDA, GSH, SOD, CAT & GPx, and genotoxicity was examined by comet assay and RAPD test. In the present study, Na3AsO3 was found to generate free radicals in lymphocytes of O. cuniculus and best recovery was reported (MDA-4.78 ± 0.05; GSH-2.87 ± 0.50;SOD-1.78 ± 0.03;CAT-2.72 ± 0.02;GPx-7.43 ± 0.01) under exposure of ethanolic leaf extract of O. gratissimum. Na3AsO3 was also found to cause polymorphic bands and increased comet tail in lymphocytes which was found significantly recovered by ...
Background: Hypertension is the well-known risk factor for mortality and morbidity. About 7.1 mil... more Background: Hypertension is the well-known risk factor for mortality and morbidity. About 7.1 million population worldwide dies each year due to cause of hypertension. It directly effects persons quality of life. Methods: Total number of 128 Hypertension diagnosed Patient’s data were collected under this study who were admitted to the General Medicine wards of tertiary care teaching hospital. WHO BREF questionnaires were given and filled forms by patients were collected. Result: In physical health 42 Patients are with excellent health, 81 Patients are fall under the moderate health and 5 Patients are with poor physical health status. In psychological assessment 36 Patients are with excellent health 83 Patients are fall under the moderate health and 9 Patients are with poor physical health status. In Social relation, 15 Patients are with excellent health, 98 Patients are fall under the moderate health, and 15 Patients are with poor physical health status. In environmental assessment...
Caspases have functions other than in apoptosis. Here, we report that Caenorhabditis elegans CED... more Caspases have functions other than in apoptosis. Here, we report that Caenorhabditis elegans CED-3 caspase regulates asymmetric cell division. Many of the 131 cells that are “programmed” to die during C. elegans development are the smaller daughter of a neuroblast that divides asymmetrically by size and fate. We have previously shown that CED-3 caspase is activated in such neuroblasts, and that before neuroblast division, a gradient of CED-3 caspase activity is formed in a ced-1 MEGF10 (multiple EGF-like domains 10)-dependent manner. This results in the nonrandom segregation of active CED-3 caspase or “apoptotic potential” into the smaller daughter. We now show that CED-3 caspase is necessary for the ability of neuroblasts to divide asymmetrically by size. In addition, we provide evidence that a pig-1 MELK (maternal embryonic leucine zipper kinase)-dependent reciprocal gradient of “mitotic potential” is formed in the QL.p neuroblast, and that CED-3 caspase antagonizes this mitotic ...
We investigate the role of axonal transport in regulating neuronal mitochondrial density. We show... more We investigate the role of axonal transport in regulating neuronal mitochondrial density. We show that the density of mitochondria in the touch receptor neuron (TRN) of adult Caenorhabditis elegans is constant. Mitochondrial density and transport are controlled both by the Kinesin heavy chain and the Dynein-Dynactin complex. However, unlike in other models, the presence of mitochondria in C. elegans TRNs depends on a Kinesin light chain as well. Mutants in the three C. elegans miro genes do not alter mitochondrial density in the TRNs. Mutants in the Kinesin-1 associated proteins, UNC-16/JIP3 and UNC-76/FEZ1, show increased mitochondrial density and also have elevated levels of both the Kinesin Heavy and Light Chains in neurons. Genetic analyses suggest that, the increased mitochondrial density at the distal end of the neuronal process in unc-16 and unc-76 depends partly on Dynein. We observe a net anterograde bias in the ratio of anterograde to retrograde mitochondrial flux in the n...
Journal of Genetic Disorders & Genetic Reports, 2016
Prevalence of different abnormal hemoglobins (Hb) in Indian tribal and nontribal population group... more Prevalence of different abnormal hemoglobins (Hb) in Indian tribal and nontribal population groups is well established. Sickle cell hemoglobin (HbS) is mostly concentrated in Central and South Indian states, whereas HbD and Hb E is mostly found in North-North-West and North-North-East states respectively. HbJ, an alpha globin gene variant, is earlier reported in North India whereas; its presence in the tribal Chhattisgarh state is not well understood. HbE, a beta-globin gene variant was earlier reported in North Eastern states of India. Prevalence of both these abnormal hemoglobins in the Central India specifically in Durg, Chattisgarh is incompletely understood. In this study attempts were made to analyze the presence of abnormal hemoglobins during screening for sickle cell anemia. Briefly, blood samples (N=44) were analyzed for sickle cell anemia screening and confirmatory tests by solubility tests and cellulose acetate membrane electrophoresis at alkaline pH. Two samples showed an abnormal pattern of separation on cellulose acetate membrane other than HbS. Out of total 44 tested samples, five were sickle cell carriers (HbAS), one was heterozygous HbAJ and the another one was homozygous for HbE while remaining other were normal genotypes i.e. HbAA. In brief, a case of homozygous Hemoglobin E from Kurmi caste of other backward community (OBC) and a different heterozygote pattern, i.e. Hb AJ from Brahmin community is reported from Durg, Chattisgarh, Central India. This study provides possible indication of variation of different abnormal hemoglobins, other than HbS, present in the tribal state of Chhattisgarh.
Multicellular organisms develop complex shapes from much simpler, single-celled zygotes through a... more Multicellular organisms develop complex shapes from much simpler, single-celled zygotes through a process commonly called morphogenesis. Morphogenesis involves an interplay between several factors, ranging from the gene regulatory networks determining cell fate and differentiation to the mechanical processes underlying cell and tissue shape changes. Thus, the study of morphogenesis has historically been based on multidisciplinary approaches at the interface of biology with physics and mathematics. Recent technological advances have further improved our ability to study morphogenesis by bridging the gap between the genetic and biophysical factors through the development of new tools for visualizing, analyzing, and perturbing these factors and their biochemical intermediaries. Here, we review how a combination of genetic, microscopic, biophysical, and biochemical approaches has aided our attempts to understand morphogenesis and discuss potential approaches that may be beneficial to su...
2019 International Conference on Automation, Computational and Technology Management (ICACTM), 2019
By assimilating concepts of advanced communications and future control technologies, Smart Grid h... more By assimilating concepts of advanced communications and future control technologies, Smart Grid has become the next generation power system. Due to its greater robustness, efficiency and flexibility over conventional power system, its gaining importance. As in modern electrical power system, need of resources and storage is increasing which can be dealt with cloud computing. It is a promising technology with functionality of using computing resources in scalable and virtualized manner. Cloud computing integrates the electrical power system resources through internal networks, thus improvement in robustness, load balancing and storage capacity is observed.
2019 IEEE International Conference on Advanced Robotics and its Social Impacts (ARSO), 2019
Social interaction is an intrinsic property of all human beings. From the last few decades, robot... more Social interaction is an intrinsic property of all human beings. From the last few decades, robots have been entering the personal space of human beings. Therefore, it is essential for the robot to possess intelligence enough to act socially like humans in such an environment. One such example of a socially active robot is a telepresence robot. In this paper we have proposed a low-cost design, for the case of a telepresence robot, which has been built from scratch. It is a three-wheel omni drive robot, which makes it easy to move in a wide range of directions. The robot operates in two different modes namely the teleoperation and autonomous modes. An ego-centric framework has been used for the purpose of tracking the person with whom the communication has to be established in the autonomous mode. This omits the factor of uncertainty of the position of the robot and the camera calibration factor. The person to be tracked is first recognised so that the robot just tracks the concerned person irrespective of other people in the background.
International Journal of Innovative Research in Science, Engineering and Technology, 2013
Palmprint recognition being one of the important aspects of biometric technology is one of the mo... more Palmprint recognition being one of the important aspects of biometric technology is one of the most reliable and successful identification methods. In this paper, several existing palmprint recognition algorithms have been studied and analyzed. A simple approach to preprocessing and roi extraction has been discussed. The available databases have also been analyzed and the most efficient of all will be used for the development of
In this paper, a miniaturized modified UWB antenna operating at sextuple rejection bands for use ... more In this paper, a miniaturized modified UWB antenna operating at sextuple rejection bands for use in Device-to-Device communication, wireless sensor networks, microwave imaging sensing applications, and Internet of things (IoT) is presented. This paper proposes a design inseminating four U-shaped rectangular slot resonators on the radiating patch and placing two split-ring resonators (SRR) near the 50 Ω. Crostrip feed line-patch junction of the traditional stair-cased ultra-wideband (UWB) antenna. The proposed antenna is printed on a low profile substrate Rogers RO5880 with dielectric constant 2.2. The simulated and measured results show that the traditional ultra-wideband (UWB) antenna specimen delivers a wide impedance bandwidth from 3 to 10 GHz. The presented antenna design possesses eminent return loss performance (−15 dB < S11 < −35 dB) for all operating frequencies and high rejection characteristics across all stop bands with an omnidirectional farfield radiation pattern ...
Various types of Hemoglobinopathies have been reported in different parts of world, among them si... more Various types of Hemoglobinopathies have been reported in different parts of world, among them sickle cell anemia is a major concern. Sickle cell anemia was originated in Africa but now it covers a wide area of globe. In our society various types of sanguinity exists so in such area its prevalence is dominant. But till date there is no effective treatment, only supporting treatment & counseling are used to provide relief and protection to the population. Now it is also established that among sickle patient the rate of free radical generation is very high which causes oxidative stress and related damage to DNA, protein, lipid peroxidation & organ damage. Due to this various types of genotoxicity appear among patient. To provide relief to sufferer proper assessment of oxidative stress and genotoxicity is need of the hour. Although some supporting methods are available viz. stem cell transplant, gene therapy, enhancement of hemoglobin production, hydration etc. but are not very effecti...
We introduce a method for learning the dynamics of complex nonlinear systems based on deep genera... more We introduce a method for learning the dynamics of complex nonlinear systems based on deep generative models over temporal segments of states and actions. Unlike dynamics models that operate over individual discrete timesteps, we learn the distribution over future state trajectories conditioned on past state, past action, and planned future action trajectories, as well as a latent prior over action trajectories. Our approach is based on convolutional autoregressive models and variational autoencoders. It makes stable and accurate predictions over long horizons for complex, stochastic systems, effectively expressing uncertainty and modeling the effects of collisions, sensory noise, and action delays. The learned dynamics model and action prior can be used for end-to-end, fully differentiable trajectory optimization and model-based policy optimization, which we use to evaluate the performance and sample-efficiency of our method.
Discrete element analysis based on the assumption of linear elastic contact stiffness has found w... more Discrete element analysis based on the assumption of linear elastic contact stiffness has found widespread use for numerical modeling of kinematic behaviors of particulate assemblies. Use of linear elastic contact stiffness models for intergranular normal and tangential contacts may be computationally advantageous for investigating applications where local contact stiffnesses are rather inconsequential (e.g., industrial feeding). In contrast, the mechanical stability of granular assemblies can be influenced by load-dependent contact stiffnesses, which determines contact deformations during and after the formation of force chains. Further, in modeling mechanically stable states of granular assemblies, the intergranular forces at equilibrium may vary with respect to the kinematics of discrete elements in contact. Thus, for discrete element analyses aimed at characterizing observational behaviors of granular materials (e.g., simulations of tri-axial compression tests), considerations a...
Autoregressive generative models consistently achieve the best results in density estimation task... more Autoregressive generative models consistently achieve the best results in density estimation tasks involving high dimensional data, such as images or audio. They pose density estimation as a sequence modeling task, where a recurrent neural network (RNN) models the conditional distribution over the next element conditioned on all previous elements. In this paradigm, the bottleneck is the extent to which the RNN can model long-range dependencies, and the most successful approaches rely on causal convolutions, which offer better access to earlier parts of the sequence than conventional RNNs. Taking inspiration from recent work in meta reinforcement learning, where dealing with long-range dependencies is also essential, we introduce a new generative model architecture that combines causal convolutions with self attention. In this note, we describe the resulting model and present state-of-the-art log-likelihood results on CIFAR-10 (2.85 bits per dim) and $32 \times 32$ ImageNet (3.80 bit...
Sickle cell disease is known to induce oxidative stress which is associated with increased produc... more Sickle cell disease is known to induce oxidative stress which is associated with increased production of oxidizing species leading to a variety of cytogenetic abnormalities. Micronuclei formation under the influence of oxidative stress under the influence of variety of toxicants is a well known fact. In the present study micronuclei frequency among sickled tr ibal (Halba & Gond) population (HbAS and HbSS) among different age groups (10 - 20, 20 - 30 and 30 - 40 years) has been estimated and compared with the control set of population from same age groups. The frequency of micronuclei was found significantly higher in both HbAS and HbSS population of all the corresponding age groups at P >0.05. Finding of the present work emphasize on genotoxicity among sickled population confirmed by micronuclei formation under influence of oxidative stress.
Andrographis paniculata is an herbaceous plant in the family Acanthaceae and is popularly known a... more Andrographis paniculata is an herbaceous plant in the family Acanthaceae and is popularly known as Kalmegh. In Chhattisgarh state, the plant is being used widely by traditional healers for treatment of different ailments, viz., cough, cold, jaundice, mental distress, diabetes etc. In the present study a database was prepared for wide application of the plant by the traditional healers of four tribal districts (Durg, Kanker, Bastar and Dantewada) of Chhattisgarh state on the basis of their experience. In the next step, major biochemical ingredients of the plant were investigated and a corelative study of its therapeutic significance was carried out. We found Cardiac glycoside, Terpanoid, Steroid, Saponin, Tannin, Flavonoid & Alkaloid from various parts of plant in different solvents. A TLC chromatogram for different phytocompounds was also prepared. Maximum 10 bands were obtained in the methanolic extract of stem with RF values ranging from 0.07 to 0.93 and minimum of only 1 band was...
We have worked on the As concentrations present in the groundwater samples in the Rajnandgaon reg... more We have worked on the As concentrations present in the groundwater samples in the Rajnandgaon region of India, as well as the clinical assessment of the impact of Arsenicosis on the human population. Out of twenty groundwater samples from eight villages, arsenic was found to be above the permissible limit in eighteen samples. The people in the affected area were found suffering from diffused and spotted melanosis, diffused and nodular keratosis, leucomelanosis, hepatomegaly, and splenomegaly. The hematological parameters, viz. low Hemoglobin, high ESR, and low PCV, with RBC, WBC, and Platelet counts adversely altered and increased Prothrombin time. The change in biochemical parameters reflects the toxic effect of prolonged exposure to arsenic viz. – low Serum Glucose, high LDL, HDL, and TG, decreased Total Protein, Albumin, and Globulin. Total Bilirubin, Creatinine, Urea, and SGPT were at higher levels, but the activity of Alkaline phosphatase was found lower. The study reveals the ...
Arsenic toxicity is a worldwide geogenic problem for large number of populations. The major probl... more Arsenic toxicity is a worldwide geogenic problem for large number of populations. The major problem of arsenicosis is generation of free radicals and related genotoxicity, In the present study three plants species Ocimum gratissimum L., Ocimum sanctum, Ocimum basilicum, were examined by both in vivo and in vitro methods in Oryctolagus cuniculus L to know the free radical scavenging property in Sodium Arsenite induced oxidative stress and related genotoxicity. Oxidative stress was evaluated considering MDA, GSH, SOD, CAT & GPx, and genotoxicity was examined by comet assay and RAPD test. In the present study, Na3AsO3 was found to generate free radicals in lymphocytes of O. cuniculus and best recovery was reported (MDA-4.78 ± 0.05; GSH-2.87 ± 0.50;SOD-1.78 ± 0.03;CAT-2.72 ± 0.02;GPx-7.43 ± 0.01) under exposure of ethanolic leaf extract of O. gratissimum. Na3AsO3 was also found to cause polymorphic bands and increased comet tail in lymphocytes which was found significantly recovered by ...
Background: Hypertension is the well-known risk factor for mortality and morbidity. About 7.1 mil... more Background: Hypertension is the well-known risk factor for mortality and morbidity. About 7.1 million population worldwide dies each year due to cause of hypertension. It directly effects persons quality of life. Methods: Total number of 128 Hypertension diagnosed Patient’s data were collected under this study who were admitted to the General Medicine wards of tertiary care teaching hospital. WHO BREF questionnaires were given and filled forms by patients were collected. Result: In physical health 42 Patients are with excellent health, 81 Patients are fall under the moderate health and 5 Patients are with poor physical health status. In psychological assessment 36 Patients are with excellent health 83 Patients are fall under the moderate health and 9 Patients are with poor physical health status. In Social relation, 15 Patients are with excellent health, 98 Patients are fall under the moderate health, and 15 Patients are with poor physical health status. In environmental assessment...
Caspases have functions other than in apoptosis. Here, we report that Caenorhabditis elegans CED... more Caspases have functions other than in apoptosis. Here, we report that Caenorhabditis elegans CED-3 caspase regulates asymmetric cell division. Many of the 131 cells that are “programmed” to die during C. elegans development are the smaller daughter of a neuroblast that divides asymmetrically by size and fate. We have previously shown that CED-3 caspase is activated in such neuroblasts, and that before neuroblast division, a gradient of CED-3 caspase activity is formed in a ced-1 MEGF10 (multiple EGF-like domains 10)-dependent manner. This results in the nonrandom segregation of active CED-3 caspase or “apoptotic potential” into the smaller daughter. We now show that CED-3 caspase is necessary for the ability of neuroblasts to divide asymmetrically by size. In addition, we provide evidence that a pig-1 MELK (maternal embryonic leucine zipper kinase)-dependent reciprocal gradient of “mitotic potential” is formed in the QL.p neuroblast, and that CED-3 caspase antagonizes this mitotic ...
We investigate the role of axonal transport in regulating neuronal mitochondrial density. We show... more We investigate the role of axonal transport in regulating neuronal mitochondrial density. We show that the density of mitochondria in the touch receptor neuron (TRN) of adult Caenorhabditis elegans is constant. Mitochondrial density and transport are controlled both by the Kinesin heavy chain and the Dynein-Dynactin complex. However, unlike in other models, the presence of mitochondria in C. elegans TRNs depends on a Kinesin light chain as well. Mutants in the three C. elegans miro genes do not alter mitochondrial density in the TRNs. Mutants in the Kinesin-1 associated proteins, UNC-16/JIP3 and UNC-76/FEZ1, show increased mitochondrial density and also have elevated levels of both the Kinesin Heavy and Light Chains in neurons. Genetic analyses suggest that, the increased mitochondrial density at the distal end of the neuronal process in unc-16 and unc-76 depends partly on Dynein. We observe a net anterograde bias in the ratio of anterograde to retrograde mitochondrial flux in the n...
Journal of Genetic Disorders & Genetic Reports, 2016
Prevalence of different abnormal hemoglobins (Hb) in Indian tribal and nontribal population group... more Prevalence of different abnormal hemoglobins (Hb) in Indian tribal and nontribal population groups is well established. Sickle cell hemoglobin (HbS) is mostly concentrated in Central and South Indian states, whereas HbD and Hb E is mostly found in North-North-West and North-North-East states respectively. HbJ, an alpha globin gene variant, is earlier reported in North India whereas; its presence in the tribal Chhattisgarh state is not well understood. HbE, a beta-globin gene variant was earlier reported in North Eastern states of India. Prevalence of both these abnormal hemoglobins in the Central India specifically in Durg, Chattisgarh is incompletely understood. In this study attempts were made to analyze the presence of abnormal hemoglobins during screening for sickle cell anemia. Briefly, blood samples (N=44) were analyzed for sickle cell anemia screening and confirmatory tests by solubility tests and cellulose acetate membrane electrophoresis at alkaline pH. Two samples showed an abnormal pattern of separation on cellulose acetate membrane other than HbS. Out of total 44 tested samples, five were sickle cell carriers (HbAS), one was heterozygous HbAJ and the another one was homozygous for HbE while remaining other were normal genotypes i.e. HbAA. In brief, a case of homozygous Hemoglobin E from Kurmi caste of other backward community (OBC) and a different heterozygote pattern, i.e. Hb AJ from Brahmin community is reported from Durg, Chattisgarh, Central India. This study provides possible indication of variation of different abnormal hemoglobins, other than HbS, present in the tribal state of Chhattisgarh.
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