Clinical Perspectives and Targeted Therapies in Apoptosis
Abstract A proper balance between cell proliferation and cell death plays a critical role in orga... more Abstract A proper balance between cell proliferation and cell death plays a critical role in organ development and maintaining the integrity of structural elements. Failure to regulate apoptosis, leads to the development of several diseases, such as cancer, neurodegenerative diseases, and autoimmune disorders. In this aspect, the study of complex networks of regulatory factors involved in cell proliferation and its death has gained significant importance. Consequently, therapeutic agents, modulating the key molecules of apoptosis are currently been implemented to devise a more effective and rational therapy. In the past decade, substantial advances have been achieved in the development of novel therapeutics targeting apoptosis. Numerous novel approaches are already underway, that employ gene therapy, antisense strategies, and inhibition or activation of second messengers involved in apoptosis. This chapter outlines the recent advances made in the field of apoptosis-modulating therapies together with its clinical success for the management of different disease conditions.
This study aims to determine the anticancer efficacy of diosgenin encapsulated poly-glycerol mala... more This study aims to determine the anticancer efficacy of diosgenin encapsulated poly-glycerol malate co-dodecanedioate (PGMD) nanoparticles. Diosgenin loaded PGMD nanoparticles (variants 7:3 and 6:4) were synthesized by the nanoprecipitation method. The synthesis of PGMD nanoparticles was systematically optimized employing the Box-Behnken design and taking into account the influence of various independent variables such as concentrations of each PGMD, diosgenin and PF-68 on the responses such as size and PDI of the particles. Mathematical modeling was done using the Quadratic second order modeling method and response surface analysis was undertaken to elucidate the factor-response relationship. The obtained size of PGMD 7:3 and PGMD 6:4 nanoparticles were 133.6 nm and 121.4 nm, respectively, as measured through dynamic light scattering (DLS). The entrapment efficiency was in the range of 77–83%. The in vitro drug release studies showed diffusion and dissolution controlled drug releas...
Artificial cells, nanomedicine, and biotechnology, Jan 21, 2017
Cardiovascular diseases have been the major cause of mortality and morbidity all over the world a... more Cardiovascular diseases have been the major cause of mortality and morbidity all over the world accounting for more than 80% of the deaths from heart attacks and strokes. Hypercholesterolemia, an autosomal disorder of lipoprotein metabolism is one of the foremost causes of CVDs. An increased level of low-density lipoprotein cholesterol (LDL-C) in the plasma results in the rise of incidence rates in disease patients. Several conventional and combinational therapies have been proposed for lowering the LDL-C levels in the blood. These therapeutic agents are designed to target some crucial molecules that participates in the lipid metabolism such as apolipoprotein B, HMGCoA reductase, proprotein convertase subtilisin/kexin 9, etc. Although these therapies are effective but are associated with certain side effects. This article presents an overview on different conventional and nanotechnology-based approaches for the treatment and diagnosis of hypercholesterolemia. Numerous nanomaterial-b...
Journal of photochemistry and photobiology. B, Biology, 2017
The work represents the potent catalytic activity of silver nanoparticles synthesized from Cicer ... more The work represents the potent catalytic activity of silver nanoparticles synthesized from Cicer arietinum (chickpea) leaf extract (CAL-AgNPs). Here, silver nano-catalysts were used against the anthropogenic pollutants mainly involving nitro-amines and azo dyes. These pollutants are extremely harmful to our environment and causes severe health issues. The CAL-AgNPs have the potential to degrade harmful toxins and their by-products, thereby decreasing the pollutants from the environment. The green synthesis of nano-catalyst includes a simple, cost effective and eco-friendly method using the leaf extract from the plant. A systematic study was conducted, including synthesis, optimization and characterization of the silver particles. The AgNPs were further assessed through DLS and TEM for size and morphological evaluation. The obtained particles have shown spherical morphology with the size range of 88.8nm. Further, FTIR were performed for compositional and functional group analysis of ...
Journal of the Chemical Society, Dalton Transactions, 2002
J. Chem. Soc., Dalton Trans., 2002, 1631-1634 DOI:10.1039/B109729F (Paper). Molecular structure o... more J. Chem. Soc., Dalton Trans., 2002, 1631-1634 DOI:10.1039/B109729F (Paper). Molecular structure of bis(N-phenylsalicylideneiminato)aluminium-di(μ-isopropoxy) di(isopropoxo)aluminium(III) and its reactions with alkoxyalkanols. ...
Reactions of Me2SiCl2 in a 1:2 molar ratio with internally functionalized oximes in the presence ... more Reactions of Me2SiCl2 in a 1:2 molar ratio with internally functionalized oximes in the presence of Et3N in anhydrous benzene afford compounds of the type [Me2Si{ONC(R)Ar}2] {where R=Me, Ar=2-C5H4N (1), 2-C4H3O (2), 2-C4H3S (3); R=H, Ar=2-C5H4N (4), 2-C4H3O (5), 2-C4H3S (6)}. Molecular weight measurements of all these derivatives in freezing benzene and the FAB mass spectral studies of 1 and
ABSTRACT Modification of [VO(OPri)3] with oximes in different molar ratios, yielded new class of ... more ABSTRACT Modification of [VO(OPri)3] with oximes in different molar ratios, yielded new class of vanadia precursors, [VO{OPri}3−n{L}n] {where, n = 1–3 and LH = C9H16C=NOH (1–3) and (CH3)2C=NOH (4–6)}.All the products are yellow in colour. (1) and (2) are liquid/viscous liquid, while others are solids. Molecular weight measurements of all these derivatives and the ESI-mass spectral studies of (1), (2), (3) and (5) indicate their monomeric nature. 1H and 13C{1H} NMR spectra suggest that the oximato moieties are monodentate in solution which was further confirmed by the 51V NMR signals, appeared in the region expected for tetra-coordinated oxo-vanadium atoms. On ageing, a disproportionation reaction occurs in (1) and some crystals appeared. Single crystal X-ray diffraction analyses of the crystals obtained from (1) as well as from (3) were found to be the same and indicate the presence of side-on {dihapto η 2-(N, O)} binding modes of the oximato ligands, leading to the formation of seven coordination environment around the vanadium atom. Thermogravimetric curve of (1) exhibits multi-step decomposition with the formation of V2O5 as the final product at ~850 °C. Sol–gel transformation of (3) yielded (a) VO2 sintered at 300 °C and (b) V2O5 at 600 °C. Similarly, sol–gel transformations of (1) and (2) yielded V2O5 (c) and (d) at 600 °C, respectively. Formation of monoclinic phase in (a) and orthorhombic phase in (b), (c) and (d) were confirmed by powder XRD patterns.
Clinical Perspectives and Targeted Therapies in Apoptosis
Abstract A proper balance between cell proliferation and cell death plays a critical role in orga... more Abstract A proper balance between cell proliferation and cell death plays a critical role in organ development and maintaining the integrity of structural elements. Failure to regulate apoptosis, leads to the development of several diseases, such as cancer, neurodegenerative diseases, and autoimmune disorders. In this aspect, the study of complex networks of regulatory factors involved in cell proliferation and its death has gained significant importance. Consequently, therapeutic agents, modulating the key molecules of apoptosis are currently been implemented to devise a more effective and rational therapy. In the past decade, substantial advances have been achieved in the development of novel therapeutics targeting apoptosis. Numerous novel approaches are already underway, that employ gene therapy, antisense strategies, and inhibition or activation of second messengers involved in apoptosis. This chapter outlines the recent advances made in the field of apoptosis-modulating therapies together with its clinical success for the management of different disease conditions.
This study aims to determine the anticancer efficacy of diosgenin encapsulated poly-glycerol mala... more This study aims to determine the anticancer efficacy of diosgenin encapsulated poly-glycerol malate co-dodecanedioate (PGMD) nanoparticles. Diosgenin loaded PGMD nanoparticles (variants 7:3 and 6:4) were synthesized by the nanoprecipitation method. The synthesis of PGMD nanoparticles was systematically optimized employing the Box-Behnken design and taking into account the influence of various independent variables such as concentrations of each PGMD, diosgenin and PF-68 on the responses such as size and PDI of the particles. Mathematical modeling was done using the Quadratic second order modeling method and response surface analysis was undertaken to elucidate the factor-response relationship. The obtained size of PGMD 7:3 and PGMD 6:4 nanoparticles were 133.6 nm and 121.4 nm, respectively, as measured through dynamic light scattering (DLS). The entrapment efficiency was in the range of 77–83%. The in vitro drug release studies showed diffusion and dissolution controlled drug releas...
Artificial cells, nanomedicine, and biotechnology, Jan 21, 2017
Cardiovascular diseases have been the major cause of mortality and morbidity all over the world a... more Cardiovascular diseases have been the major cause of mortality and morbidity all over the world accounting for more than 80% of the deaths from heart attacks and strokes. Hypercholesterolemia, an autosomal disorder of lipoprotein metabolism is one of the foremost causes of CVDs. An increased level of low-density lipoprotein cholesterol (LDL-C) in the plasma results in the rise of incidence rates in disease patients. Several conventional and combinational therapies have been proposed for lowering the LDL-C levels in the blood. These therapeutic agents are designed to target some crucial molecules that participates in the lipid metabolism such as apolipoprotein B, HMGCoA reductase, proprotein convertase subtilisin/kexin 9, etc. Although these therapies are effective but are associated with certain side effects. This article presents an overview on different conventional and nanotechnology-based approaches for the treatment and diagnosis of hypercholesterolemia. Numerous nanomaterial-b...
Journal of photochemistry and photobiology. B, Biology, 2017
The work represents the potent catalytic activity of silver nanoparticles synthesized from Cicer ... more The work represents the potent catalytic activity of silver nanoparticles synthesized from Cicer arietinum (chickpea) leaf extract (CAL-AgNPs). Here, silver nano-catalysts were used against the anthropogenic pollutants mainly involving nitro-amines and azo dyes. These pollutants are extremely harmful to our environment and causes severe health issues. The CAL-AgNPs have the potential to degrade harmful toxins and their by-products, thereby decreasing the pollutants from the environment. The green synthesis of nano-catalyst includes a simple, cost effective and eco-friendly method using the leaf extract from the plant. A systematic study was conducted, including synthesis, optimization and characterization of the silver particles. The AgNPs were further assessed through DLS and TEM for size and morphological evaluation. The obtained particles have shown spherical morphology with the size range of 88.8nm. Further, FTIR were performed for compositional and functional group analysis of ...
Journal of the Chemical Society, Dalton Transactions, 2002
J. Chem. Soc., Dalton Trans., 2002, 1631-1634 DOI:10.1039/B109729F (Paper). Molecular structure o... more J. Chem. Soc., Dalton Trans., 2002, 1631-1634 DOI:10.1039/B109729F (Paper). Molecular structure of bis(N-phenylsalicylideneiminato)aluminium-di(μ-isopropoxy) di(isopropoxo)aluminium(III) and its reactions with alkoxyalkanols. ...
Reactions of Me2SiCl2 in a 1:2 molar ratio with internally functionalized oximes in the presence ... more Reactions of Me2SiCl2 in a 1:2 molar ratio with internally functionalized oximes in the presence of Et3N in anhydrous benzene afford compounds of the type [Me2Si{ONC(R)Ar}2] {where R=Me, Ar=2-C5H4N (1), 2-C4H3O (2), 2-C4H3S (3); R=H, Ar=2-C5H4N (4), 2-C4H3O (5), 2-C4H3S (6)}. Molecular weight measurements of all these derivatives in freezing benzene and the FAB mass spectral studies of 1 and
ABSTRACT Modification of [VO(OPri)3] with oximes in different molar ratios, yielded new class of ... more ABSTRACT Modification of [VO(OPri)3] with oximes in different molar ratios, yielded new class of vanadia precursors, [VO{OPri}3−n{L}n] {where, n = 1–3 and LH = C9H16C=NOH (1–3) and (CH3)2C=NOH (4–6)}.All the products are yellow in colour. (1) and (2) are liquid/viscous liquid, while others are solids. Molecular weight measurements of all these derivatives and the ESI-mass spectral studies of (1), (2), (3) and (5) indicate their monomeric nature. 1H and 13C{1H} NMR spectra suggest that the oximato moieties are monodentate in solution which was further confirmed by the 51V NMR signals, appeared in the region expected for tetra-coordinated oxo-vanadium atoms. On ageing, a disproportionation reaction occurs in (1) and some crystals appeared. Single crystal X-ray diffraction analyses of the crystals obtained from (1) as well as from (3) were found to be the same and indicate the presence of side-on {dihapto η 2-(N, O)} binding modes of the oximato ligands, leading to the formation of seven coordination environment around the vanadium atom. Thermogravimetric curve of (1) exhibits multi-step decomposition with the formation of V2O5 as the final product at ~850 °C. Sol–gel transformation of (3) yielded (a) VO2 sintered at 300 °C and (b) V2O5 at 600 °C. Similarly, sol–gel transformations of (1) and (2) yielded V2O5 (c) and (d) at 600 °C, respectively. Formation of monoclinic phase in (a) and orthorhombic phase in (b), (c) and (d) were confirmed by powder XRD patterns.
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