This study examined the effects of multiple subcutaneous glucagon injections with or without co-a... more This study examined the effects of multiple subcutaneous glucagon injections with or without co-administration of oral glycerol on energy status-related blood metabolites and hormones of Holstein dairy cows in the first 2 wk postpartum. Twenty multiparous cows were fed a dry cow ration supplemented with 6 kg of cracked corn during the dry period to increase the likelihood of developing postpartal fatty liver syndrome. Cows with a body condition score of >or=3.5 points (1- to 5-point scale) were assigned randomly to 1 of 4 treatment groups: saline, glucagon, glycerol, or glucagon plus glycerol. Following treatment, serial blood samples were collected over an 8-h period to determine the effects of glucagon and glycerol on blood metabolites and hormones. Treatment effects were determined by comparing the concentrations of metabolites and hormones during the first 4-h period and the entire 8-h period after treatment administration (time 0) with the concentration of the same compounds...
Following the success of our first therapeutic discovery conference in 2017 and the selection of ... more Following the success of our first therapeutic discovery conference in 2017 and the selection of King Abdullah International Medical Research Centre (KAIMRC) as the first Phase 1 clinical site in the Kingdom of Saudi Arabia, we organized our second conference in partnership with leading institutions in academic drug discovery, which included the Structural Genomic Constorium (Oxford, UK), Fraunhofer (Germany) and Institute Material Medica (China); the participation of members of the American Drug Discovery Consterium; European Biotech companies; and local pharma companies, SIPMACO and SudairPharma. In addition, we had European and Northern American venture capital experts attending and presenting at the conference. The purpose of the conference was to bridge the gap between biotech, pharma and academia regarding drug discovery and development. Its aim primarily was to: (a) bring together world experts on academic drug discovery to discuss and propose new approaches to discover and d...
Following the success of our first therapeutic discovery conference in 2017 and the selection of ... more Following the success of our first therapeutic discovery conference in 2017 and the selection of King Abdullah International Medical Research Centre (KAIMRC) as the first Phase 1 clinical site in the Kingdom of Saudi Arabia, we organized our second conference in partnership with leading institutions in academic drug discovery, which included the Structural Genomic Constorium (Oxford, UK), Fraunhofer (Germany) and Institute Material Medica (China); the participation of members of the American Drug Discovery Consterium; European Biotech companies; and local pharma companies, SIPMACO and SudairPharma. In addition, we had European and Northern American venture capital experts attending and presenting at the conference. The purpose of the conference was to bridge the gap between biotech, pharma and academia regarding drug discovery and development. Its aim primarily was to: (a) bring together world experts on academic drug discovery to discuss and propose new approaches to discover and d...
Rare diseases frequently attack and weaken the immune system, increasing the patient’s vulnerabil... more Rare diseases frequently attack and weaken the immune system, increasing the patient’s vulnerability to develop severe conditions after viral infections, such as COVID-19. Many patients with rare diseases also suffer from mental retardation and disability. These rare disease phenotypes do not emerge in older people who are susceptible to COVID-19 infection, but present at a very young age or at birth. These factors must be taken in consideration when caring for this vulnerable patient population during a pandemic, such as COVID-19. Patients with a rare disease have to take their regular medication continuously to control their condition and frequently, the medications, directly or indirectly, affect their immune system. It is important for this patient population, if infected with COVID-19 or another severe form of infection, to adjust the treatment protocol by specialists, in consultation with their own medical team. Special awareness and educational programs, understandable for me...
Investigating the effects of a simulated stress on the tissues involved in lipid metabolism in ra... more Investigating the effects of a simulated stress on the tissues involved in lipid metabolism in rats subjected to varying diets could provide insight into the etiology of liver damage. Twelve adult ...
Recommended Citation Osman, Mohamed; Mehyar, Nimer; Bobe, Gerd; Coetzee, Johann F.; and Beitz, Do... more Recommended Citation Osman, Mohamed; Mehyar, Nimer; Bobe, Gerd; Coetzee, Johann F.; and Beitz, Donald C. (2006) "Acute Effects of Subcutaneous Injection of Glucagon and/or Oral Administration of Glycerol on Blood Metabolites and Hormones of Holstein Dairy Cows Affected with Fatty Liver Disease ," Animal Industry Report: AS 652, ASL R2090. DOI: https://doi.org/10.31274/ans_air-180814-834 Available at: https://lib.dr.iastate.edu/ans_air/vol652/iss1/23
Adenosine 5′-triphosphate (ATP) can release hexokinase I (HKI) from its binding site on the outer... more Adenosine 5′-triphosphate (ATP) can release hexokinase I (HKI) from its binding site on the outer mitochondrial membrane, but the mechanism of ATP release of HKI from mitochondria is unclear. ATP binds to the C-terminal half of HKI as a substrate and to the N-terminal half near the membrane binding element. ATP may also bind to the voltage dependent anion channel (VDAC), the integral membrane component that putatively targets HKI to the mitochondrion. The fluorescent nucleotide analogue 2′,3′-O-(2,4,6-trinitrophenyl) adenosine 5′-diphosphate (TNPADP) binds with high affinity to the C-terminal half of HKI (Kd = 0.79 ± 0.09 μM) 1 This research was supported in part by National Institute of Health Research Grant NS 10546. 2 Graduate student and professor, respectively, Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University. Research conducted and manuscript written by Mehyar with assistance from Muneaki, Shen, Skaff and Honzatko. 3 To whom correspondence sh...
Rare diseases frequently attack and weaken the immune system, increasing the patient's vulner... more Rare diseases frequently attack and weaken the immune system, increasing the patient's vulnerability to develop severe conditions after viral infections, such as COVID-19. Many patients with rare diseases also suffer from mental retardation and disability. These rare disease phenotypes do not emerge in older people who are susceptible to COVID-19 infection, but present at a very young age or at birth. These factors must be taken in consideration when caring for this vulnerable patient population during a pandemic, such as COVID-19. Patients with a rare disease have to take their regular medication continuously to control their condition and frequently, the medications, directly or indirectly, affect their immune system. It is important for this patient population, if infected with COVID-19 or another severe form of infection, to adjust the treatment protocol by specialists, in consultation with their own medical team. Special awareness and educational programs, understandable fo...
Following the success of our first therapeutic discovery conference in 2017 and the selection of ... more Following the success of our first therapeutic discovery conference in 2017 and the selection of King Abdullah International Medical Research Centre (KAIMRC) as the first Phase 1 clinical site in the Kingdom of Saudi Arabia, we organized our second conference in partnership with leading institutions in academic drug discovery, which included the Structural Genomic Constorium (Oxford, UK), Fraunhofer (Germany) and Institute Material Medica (China); the participation of members of the American Drug Discovery Consterium; European Biotech companies; and local pharma companies, SIPMACO and SudairPharma. In addition, we had European and Northern American venture capital experts attending and presenting at the conference. The purpose of the conference was to bridge the gap between biotech, pharma and academia regarding drug discovery and development. Its aim primarily was to: (a) bring together world experts on academic drug discovery to discuss and propose new approaches to discover and d...
Investigating the effects of a simulated stress on the tissues involved in lipid metabolism in ra... more Investigating the effects of a simulated stress on the tissues involved in lipid metabolism in rats subjected to varying diets could provide insight into the etiology of liver damage. Twelve adult ...
This study examined the effects of multiple subcutaneous glucagon injections with or without co-a... more This study examined the effects of multiple subcutaneous glucagon injections with or without co-administration of oral glycerol on energy status-related blood metabolites and hormones of Holstein dairy cows in the first 2 wk postpartum. Twenty multiparous cows were fed a dry cow ration supplemented with 6 kg of cracked corn during the dry period to increase the likelihood of developing postpartal fatty liver syndrome. Cows with a body condition score of >or=3.5 points (1- to 5-point scale) were assigned randomly to 1 of 4 treatment groups: saline, glucagon, glycerol, or glucagon plus glycerol. Following treatment, serial blood samples were collected over an 8-h period to determine the effects of glucagon and glycerol on blood metabolites and hormones. Treatment effects were determined by comparing the concentrations of metabolites and hormones during the first 4-h period and the entire 8-h period after treatment administration (time 0) with the concentration of the same compounds...
This study examined the effects of multiple subcutaneous glucagon injections with or without co-a... more This study examined the effects of multiple subcutaneous glucagon injections with or without co-administration of oral glycerol on energy status-related blood metabolites and hormones of Holstein dairy cows in the first 2 wk postpartum. Twenty multiparous cows were fed a dry cow ration supplemented with 6 kg of cracked corn during the dry period to increase the likelihood of developing postpartal fatty liver syndrome. Cows with a body condition score of >or=3.5 points (1- to 5-point scale) were assigned randomly to 1 of 4 treatment groups: saline, glucagon, glycerol, or glucagon plus glycerol. Following treatment, serial blood samples were collected over an 8-h period to determine the effects of glucagon and glycerol on blood metabolites and hormones. Treatment effects were determined by comparing the concentrations of metabolites and hormones during the first 4-h period and the entire 8-h period after treatment administration (time 0) with the concentration of the same compounds...
Following the success of our first therapeutic discovery conference in 2017 and the selection of ... more Following the success of our first therapeutic discovery conference in 2017 and the selection of King Abdullah International Medical Research Centre (KAIMRC) as the first Phase 1 clinical site in the Kingdom of Saudi Arabia, we organized our second conference in partnership with leading institutions in academic drug discovery, which included the Structural Genomic Constorium (Oxford, UK), Fraunhofer (Germany) and Institute Material Medica (China); the participation of members of the American Drug Discovery Consterium; European Biotech companies; and local pharma companies, SIPMACO and SudairPharma. In addition, we had European and Northern American venture capital experts attending and presenting at the conference. The purpose of the conference was to bridge the gap between biotech, pharma and academia regarding drug discovery and development. Its aim primarily was to: (a) bring together world experts on academic drug discovery to discuss and propose new approaches to discover and d...
Following the success of our first therapeutic discovery conference in 2017 and the selection of ... more Following the success of our first therapeutic discovery conference in 2017 and the selection of King Abdullah International Medical Research Centre (KAIMRC) as the first Phase 1 clinical site in the Kingdom of Saudi Arabia, we organized our second conference in partnership with leading institutions in academic drug discovery, which included the Structural Genomic Constorium (Oxford, UK), Fraunhofer (Germany) and Institute Material Medica (China); the participation of members of the American Drug Discovery Consterium; European Biotech companies; and local pharma companies, SIPMACO and SudairPharma. In addition, we had European and Northern American venture capital experts attending and presenting at the conference. The purpose of the conference was to bridge the gap between biotech, pharma and academia regarding drug discovery and development. Its aim primarily was to: (a) bring together world experts on academic drug discovery to discuss and propose new approaches to discover and d...
Rare diseases frequently attack and weaken the immune system, increasing the patient’s vulnerabil... more Rare diseases frequently attack and weaken the immune system, increasing the patient’s vulnerability to develop severe conditions after viral infections, such as COVID-19. Many patients with rare diseases also suffer from mental retardation and disability. These rare disease phenotypes do not emerge in older people who are susceptible to COVID-19 infection, but present at a very young age or at birth. These factors must be taken in consideration when caring for this vulnerable patient population during a pandemic, such as COVID-19. Patients with a rare disease have to take their regular medication continuously to control their condition and frequently, the medications, directly or indirectly, affect their immune system. It is important for this patient population, if infected with COVID-19 or another severe form of infection, to adjust the treatment protocol by specialists, in consultation with their own medical team. Special awareness and educational programs, understandable for me...
Investigating the effects of a simulated stress on the tissues involved in lipid metabolism in ra... more Investigating the effects of a simulated stress on the tissues involved in lipid metabolism in rats subjected to varying diets could provide insight into the etiology of liver damage. Twelve adult ...
Recommended Citation Osman, Mohamed; Mehyar, Nimer; Bobe, Gerd; Coetzee, Johann F.; and Beitz, Do... more Recommended Citation Osman, Mohamed; Mehyar, Nimer; Bobe, Gerd; Coetzee, Johann F.; and Beitz, Donald C. (2006) "Acute Effects of Subcutaneous Injection of Glucagon and/or Oral Administration of Glycerol on Blood Metabolites and Hormones of Holstein Dairy Cows Affected with Fatty Liver Disease ," Animal Industry Report: AS 652, ASL R2090. DOI: https://doi.org/10.31274/ans_air-180814-834 Available at: https://lib.dr.iastate.edu/ans_air/vol652/iss1/23
Adenosine 5′-triphosphate (ATP) can release hexokinase I (HKI) from its binding site on the outer... more Adenosine 5′-triphosphate (ATP) can release hexokinase I (HKI) from its binding site on the outer mitochondrial membrane, but the mechanism of ATP release of HKI from mitochondria is unclear. ATP binds to the C-terminal half of HKI as a substrate and to the N-terminal half near the membrane binding element. ATP may also bind to the voltage dependent anion channel (VDAC), the integral membrane component that putatively targets HKI to the mitochondrion. The fluorescent nucleotide analogue 2′,3′-O-(2,4,6-trinitrophenyl) adenosine 5′-diphosphate (TNPADP) binds with high affinity to the C-terminal half of HKI (Kd = 0.79 ± 0.09 μM) 1 This research was supported in part by National Institute of Health Research Grant NS 10546. 2 Graduate student and professor, respectively, Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University. Research conducted and manuscript written by Mehyar with assistance from Muneaki, Shen, Skaff and Honzatko. 3 To whom correspondence sh...
Rare diseases frequently attack and weaken the immune system, increasing the patient's vulner... more Rare diseases frequently attack and weaken the immune system, increasing the patient's vulnerability to develop severe conditions after viral infections, such as COVID-19. Many patients with rare diseases also suffer from mental retardation and disability. These rare disease phenotypes do not emerge in older people who are susceptible to COVID-19 infection, but present at a very young age or at birth. These factors must be taken in consideration when caring for this vulnerable patient population during a pandemic, such as COVID-19. Patients with a rare disease have to take their regular medication continuously to control their condition and frequently, the medications, directly or indirectly, affect their immune system. It is important for this patient population, if infected with COVID-19 or another severe form of infection, to adjust the treatment protocol by specialists, in consultation with their own medical team. Special awareness and educational programs, understandable fo...
Following the success of our first therapeutic discovery conference in 2017 and the selection of ... more Following the success of our first therapeutic discovery conference in 2017 and the selection of King Abdullah International Medical Research Centre (KAIMRC) as the first Phase 1 clinical site in the Kingdom of Saudi Arabia, we organized our second conference in partnership with leading institutions in academic drug discovery, which included the Structural Genomic Constorium (Oxford, UK), Fraunhofer (Germany) and Institute Material Medica (China); the participation of members of the American Drug Discovery Consterium; European Biotech companies; and local pharma companies, SIPMACO and SudairPharma. In addition, we had European and Northern American venture capital experts attending and presenting at the conference. The purpose of the conference was to bridge the gap between biotech, pharma and academia regarding drug discovery and development. Its aim primarily was to: (a) bring together world experts on academic drug discovery to discuss and propose new approaches to discover and d...
Investigating the effects of a simulated stress on the tissues involved in lipid metabolism in ra... more Investigating the effects of a simulated stress on the tissues involved in lipid metabolism in rats subjected to varying diets could provide insight into the etiology of liver damage. Twelve adult ...
This study examined the effects of multiple subcutaneous glucagon injections with or without co-a... more This study examined the effects of multiple subcutaneous glucagon injections with or without co-administration of oral glycerol on energy status-related blood metabolites and hormones of Holstein dairy cows in the first 2 wk postpartum. Twenty multiparous cows were fed a dry cow ration supplemented with 6 kg of cracked corn during the dry period to increase the likelihood of developing postpartal fatty liver syndrome. Cows with a body condition score of >or=3.5 points (1- to 5-point scale) were assigned randomly to 1 of 4 treatment groups: saline, glucagon, glycerol, or glucagon plus glycerol. Following treatment, serial blood samples were collected over an 8-h period to determine the effects of glucagon and glycerol on blood metabolites and hormones. Treatment effects were determined by comparing the concentrations of metabolites and hormones during the first 4-h period and the entire 8-h period after treatment administration (time 0) with the concentration of the same compounds...
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