Increasing evidence has been published over recent years on the implication of endocrine-disrupti... more Increasing evidence has been published over recent years on the implication of endocrine-disrupting chemicals (EDCs), including parabens and benzophenones in the pathogenesis and pathophysiology of endometriosis. However, to the best of our knowledge, no study has been published on the ways in which exposure to EDCs might affect cell-signaling pathways related to endometriosis. We aimed to describe the endometriotic tissue expression profile of a panel of 23 genes related to crucial cell-signaling pathways for the development and progression of endometriosis (cell adhesion, invasion/migration, inflammation, angiogenesis, and cell proliferation/hormone stimulation) and explore its relationship with the exposure of patients to parabens (PBs) and benzophenones (BPs). This cross-sectional study included a subsample of 33 women with endometriosis from the EndEA study, measuring their endometriotic tissue expressions of 23 genes, while urinary concentrations of methyl-, ethyl-, propyl-, b...
The number of overweight and obese individuals has increased at an alarming rate in recent decade... more The number of overweight and obese individuals has increased at an alarming rate in recent decades. The imbalance of energy as a result of a high caloric intake and a low energy expenditure does not explain this increase alone, so other behavioral, genetic and environmental factors must be playing an important role. The endocrine disruption hypothesis suggests that human exposure to endocrine disrupting chemicals (EDCs) -which act as obesogens- interferes inappropriately with lipid metabolism and adipogenesis, among other mechanisms, thus promoting obesity and overweightness. Some obesogens have already been identified, but the catalogue of chemical residues that might contribute to this environmental hypothesis has not been completed. The identification of chemicals that are directly related to the development of obesity and its metabolic complications would contribute to establish and/or improve the recommendations and requirements of the public and private sectors on food and con...
La prevalencia de sobrepeso y obesidad se ha incrementado de manera notable en las ultimas decada... more La prevalencia de sobrepeso y obesidad se ha incrementado de manera notable en las ultimas decadas, constituyendo un gran problema de salud publica. El desequilibrio del balance energetico, consecuencia de una alta ingesta calorica y un bajo gasto energetico, es incapaz de explicar por si solo este incremento, de manera que otros factores conductuales, geneticos y ambientales deben estar jugando un papel importante. La hipotesis clinica de disrupcion endocrina sugiere que la exposicion humana a contaminantes ambientales-disruptores endocrinos (DE) con actividad como “obesogenos”, interfiere de forma inapropiada sobre el metabolismo lipidico y la adipogenesis, entre otros mecanismos, promoviendo el sobrepeso y la obesidad. El catalogo completo de residuos quimicos que pueden contribuir a esta hipotesis ambiental no esta aun establecido, aunque ya se conocen algunos compuestos obesogenos. La identificacion de sustancias quimicas directamente relacionadas con el desarrollo de obesidad ...
Increasing evidence has been published over recent years on the implication of endocrine-disrupti... more Increasing evidence has been published over recent years on the implication of endocrine-disrupting chemicals (EDCs), including parabens and benzophenones in the pathogenesis and pathophysiology of endometriosis. However, to the best of our knowledge, no study has been published on the ways in which exposure to EDCs might affect cell-signaling pathways related to endometriosis. We aimed to describe the endometriotic tissue expression profile of a panel of 23 genes related to crucial cell-signaling pathways for the development and progression of endometriosis (cell adhesion, invasion/migration, inflammation, angiogenesis, and cell proliferation/hormone stimulation) and explore its relationship with the exposure of patients to parabens (PBs) and benzophenones (BPs). This cross-sectional study included a subsample of 33 women with endometriosis from the EndEA study, measuring their endometriotic tissue expressions of 23 genes, while urinary concentrations of methyl-, ethyl-, propyl-, b...
The number of overweight and obese individuals has increased at an alarming rate in recent decade... more The number of overweight and obese individuals has increased at an alarming rate in recent decades. The imbalance of energy as a result of a high caloric intake and a low energy expenditure does not explain this increase alone, so other behavioral, genetic and environmental factors must be playing an important role. The endocrine disruption hypothesis suggests that human exposure to endocrine disrupting chemicals (EDCs) -which act as obesogens- interferes inappropriately with lipid metabolism and adipogenesis, among other mechanisms, thus promoting obesity and overweightness. Some obesogens have already been identified, but the catalogue of chemical residues that might contribute to this environmental hypothesis has not been completed. The identification of chemicals that are directly related to the development of obesity and its metabolic complications would contribute to establish and/or improve the recommendations and requirements of the public and private sectors on food and con...
La prevalencia de sobrepeso y obesidad se ha incrementado de manera notable en las ultimas decada... more La prevalencia de sobrepeso y obesidad se ha incrementado de manera notable en las ultimas decadas, constituyendo un gran problema de salud publica. El desequilibrio del balance energetico, consecuencia de una alta ingesta calorica y un bajo gasto energetico, es incapaz de explicar por si solo este incremento, de manera que otros factores conductuales, geneticos y ambientales deben estar jugando un papel importante. La hipotesis clinica de disrupcion endocrina sugiere que la exposicion humana a contaminantes ambientales-disruptores endocrinos (DE) con actividad como “obesogenos”, interfiere de forma inapropiada sobre el metabolismo lipidico y la adipogenesis, entre otros mecanismos, promoviendo el sobrepeso y la obesidad. El catalogo completo de residuos quimicos que pueden contribuir a esta hipotesis ambiental no esta aun establecido, aunque ya se conocen algunos compuestos obesogenos. La identificacion de sustancias quimicas directamente relacionadas con el desarrollo de obesidad ...
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