aim: To evaluate localization of certain zones of craniocerebral trauma and determine their impor... more aim: To evaluate localization of certain zones of craniocerebral trauma and determine their importance for genesis of posttraumatic epilepsy. Patients and Methods: Study encompassed 50 war veterans, with craniocerebral trauma and posttraumatic epilepsy. Control group included 50 war veterans, with war craniocerebral injury who have not experienced epi-leptic seizures. The craniocerebral trauma zone in every patient was registered by computerized tomography (CT) of the brain at the Clinic for Radiology of the University Clinical Centre Tuzla. For statistical analysis it was used x2 test. Results: Average age in examinees ’ group was 29.92 ( ± 8.91); while in control group was 29.98 ( ± 9.97) (p>0.05). Both, injury at several lobes and post-traumatic epilepsy were registered in 22 (44%) patients as well as in 8 (16%) patients in control group, which represents extra statistical significance (p< 0.05). Frontal lobe trauma in examinees ’ group had 7 (14%) patients and 15 (30%) pat...
Aim: To analyze anxiety in patients within 48 hours and 15th day after the ischemic stroke (IS) i... more Aim: To analyze anxiety in patients within 48 hours and 15th day after the ischemic stroke (IS) in relation to gender and location of the lesion.Patients and Methods: We analyzed 40 patients (mean age 65.3±10.3 years) with gender ratio 20:20. Mean age of hospitalized women was 66.35±7.31 years and men 64.2±12.68 years (p=0.5). IS was verified by computerized tomography (CT) of the brain in all patients. Anxiety level was measured with self estimated Zung scale. Score 50 and higher was verification of anxiety. Criteria made by Domasio were used to determine location of the IS.Results: Mean value on anxiety within 48 hours was 44.4 ± 8.8 and 42.2 ± 7.7 15th day after the IS (p=0.237). In 12 (30%) patients anxiety was found during the first and in 10 (25%) during the second evaluation. Women had higher level of anxiety with significant gender differences within first 48 hours (47.75 ± 8.4 : 41.05 ± 7.9) (p=0.013). In 9 (45%) female patients and 3 (15%) male patients anxiety was present...
Post-stroke dementia (PSD) or post-stroke cognitive impairment (PSCI) may affect up to one third ... more Post-stroke dementia (PSD) or post-stroke cognitive impairment (PSCI) may affect up to one third of stroke survivors. Various definitions of PSCI and PSD have been described. We propose PSD as a label for any dementia following stroke in temporal relation. Various tools are available to screen and assess cognition, with few PSD-specific instruments. Choice will depend on purpose of assessment, with differing instruments needed for brief screening (e.g., Montreal Cognitive Assessment) or diagnostic formulation (e.g., NINDS VCI battery). A comprehensive evaluation should include assessment of pre-stroke cognition (e.g., using Informant Questionnaire for Cognitive Decline in the Elderly), mood (e.g., using Hospital Anxiety and Depression Scale), and functional consequences of cognitive impairments (e.g., using modified Rankin Scale). A large number of biomarkers for PSD, including indicators for genetic polymorphisms, biomarkers in the cerebrospinal fluid and in the serum, inflammatory...
The aim of the study was to determine duration of delirium in patients with acute stroke accordin... more The aim of the study was to determine duration of delirium in patients with acute stroke according to sex, age, type and localization of lesion. We assessed delirium prospectively in a sample of 233 consecutive patients with an acute (< or =4 days) stroke using the Delirium Rating Scale (DRS-R-98) and Diagnostic and Statistical Manual of Mental Disorders (DSM IV). The average duration of delirium was 4 days in patients with ischemic stroke and 3 days in patients with hemorrhagic stroke. There was no statistically significant difference in delirium duration between these two patient groups. A longer duration of delirium was recorded in women and in patients older than 65. The period of delirium was longer in patients with right hemispheric lesions. Patients did not differ according to delirium duration, sex, age, type and localization of stroke. In two thirds of patients, the symptoms of delirium completely disappeared on medicamentous treatment, while in the remaining one third o...
The aim of the study was to analyze stroke in young adults in Tuzla Canton, Bosnia and Herzegovin... more The aim of the study was to analyze stroke in young adults in Tuzla Canton, Bosnia and Herzegovina. From January 2001 to December 2005, 3864 patients with first-ever stroke were admitted at the Department of Neurology Tuzla. A retrospective analysis of risk factors, stroke types, severity and one month outcome in all young adults (18-45 years of age) with first-ever stroke was carried out. Out of total, there were 154 (4%) young adults with stroke. Mean age was 38.8 +/- 5.7 years and 47% were women. The leading risk factors were smoking (56%) and hypertension (45%). Subarachnoid hemorrhage (SAH) was more frequent in young adults compared with older patients (> 45 years of age) (22% vs. 3.5%, p < 0.0001), intracerebral hemorrhage (ICH) was similar in both groups (16.9% vs. 15.8%, p = 0.7), but ischemic stroke (IS) was predominant stroke type in the older group (61% vs. 74%, p = 0.0004). Young adults had more frequent lacunar stroke (26.6% vs. 16.1%, p = 0.01) and stroke due to ...
The aim of the study was to analyze the usefulness and side effects of treatment with interferon ... more The aim of the study was to analyze the usefulness and side effects of treatment with interferon beta 1B (Betaferon) in patients with the relapsing-remitting form of multiple sclerosis (RRMS). The study included 32 RRMS patients that had completed two-year therapy with interferon beta 1B or were still receiving this therapy. Every six months, patients were clinically evaluated and scored by the Expanded Disability Status Scale (EDSS). Two-year therapy was completed by 11 (34.3%) of 32 RRMS patients. Relapse was verified in 4 (36.36%) patients. The mean EDSS score was 2.45 +/- 1.03 at the beginning of therapy and 2.54 +/- 0.98 after two-year therapy; the difference was not statistically significant. In 2 (6.25%) patients on therapy for 18 months there was no relapse, and the mean EDSS was 1.75 +/- 0.35 (both at therapy introduction and at 18 months). Five (15.62%) patients were on therapy for one year. The mean EDSS was 1.6 +/- 1.08 at the beginning of therapy and 1.5 +/- 0.70 at one...
The aim of this study was to determine the prevalence of alcohol abuse and alcoholism in the gene... more The aim of this study was to determine the prevalence of alcohol abuse and alcoholism in the general population of Mostar region, Bosnia and Herzegovina. This study was conducted on a stratified sample of 704 participants. The prevalence of alcohol abuse was determined using standardized questionnaire on alcohol consumption--Michigan Alcoholism Screening Test. Prevalence of alcohol abuse with high risk for alcoholism was 9.9% and prevalence of alcohol addiction was 2.1%. In student population, there were 3.9% of alcohol addicts and 11.1% of persons with high risk of alcoholism. In high school population, there were 1.7% of alcohol addicts and 14.4% of persons with high risk of alcoholism. In Mostar region there was a high prevalence of alcoholism and problematic drinking, especially in high school and student population. There is a need for extensive preventive measures that have to include education, early diagnosis and intervention.
For thousands of years it has been known that aggression as a symptom appears in numerous psychia... more For thousands of years it has been known that aggression as a symptom appears in numerous psychiatric disorders and diseases. During the last decade the appearance of the aggressive behavior related to the posttraumatic stress disorder (PTSD) has been frequently investigated, often associated with war trauma. The goal of this study is to analyze the impact of alcoholism on a way war veterans suffering from chronic PTSD express and control aggression. The sample included 240 war veterans with chronic PTSD. The subjects were divided in two groups. PTSD group (n=147) and controlled group composed of those suffering from alcoholism in addition to PTSD (n=93). In this study, the following psychological instruments were used: The Harvard trauma questionnaire for PTSD diagnosis (HTQ); the questionnaire for self-evaluation of aggression (STAXI); The Profile Index Emotion (PIE); questionnaire for auto-diagnosis of alcoholism (CAGE). The obtained results indicate that subjects who have PTSD w...
aim: To evaluate localization of certain zones of craniocerebral trauma and determine their impor... more aim: To evaluate localization of certain zones of craniocerebral trauma and determine their importance for genesis of posttraumatic epilepsy. Patients and Methods: Study encompassed 50 war veterans, with craniocerebral trauma and posttraumatic epilepsy. Control group included 50 war veterans, with war craniocerebral injury who have not experienced epi-leptic seizures. The craniocerebral trauma zone in every patient was registered by computerized tomography (CT) of the brain at the Clinic for Radiology of the University Clinical Centre Tuzla. For statistical analysis it was used x2 test. Results: Average age in examinees ’ group was 29.92 ( ± 8.91); while in control group was 29.98 ( ± 9.97) (p>0.05). Both, injury at several lobes and post-traumatic epilepsy were registered in 22 (44%) patients as well as in 8 (16%) patients in control group, which represents extra statistical significance (p< 0.05). Frontal lobe trauma in examinees ’ group had 7 (14%) patients and 15 (30%) pat...
Aim: To analyze anxiety in patients within 48 hours and 15th day after the ischemic stroke (IS) i... more Aim: To analyze anxiety in patients within 48 hours and 15th day after the ischemic stroke (IS) in relation to gender and location of the lesion.Patients and Methods: We analyzed 40 patients (mean age 65.3±10.3 years) with gender ratio 20:20. Mean age of hospitalized women was 66.35±7.31 years and men 64.2±12.68 years (p=0.5). IS was verified by computerized tomography (CT) of the brain in all patients. Anxiety level was measured with self estimated Zung scale. Score 50 and higher was verification of anxiety. Criteria made by Domasio were used to determine location of the IS.Results: Mean value on anxiety within 48 hours was 44.4 ± 8.8 and 42.2 ± 7.7 15th day after the IS (p=0.237). In 12 (30%) patients anxiety was found during the first and in 10 (25%) during the second evaluation. Women had higher level of anxiety with significant gender differences within first 48 hours (47.75 ± 8.4 : 41.05 ± 7.9) (p=0.013). In 9 (45%) female patients and 3 (15%) male patients anxiety was present...
Post-stroke dementia (PSD) or post-stroke cognitive impairment (PSCI) may affect up to one third ... more Post-stroke dementia (PSD) or post-stroke cognitive impairment (PSCI) may affect up to one third of stroke survivors. Various definitions of PSCI and PSD have been described. We propose PSD as a label for any dementia following stroke in temporal relation. Various tools are available to screen and assess cognition, with few PSD-specific instruments. Choice will depend on purpose of assessment, with differing instruments needed for brief screening (e.g., Montreal Cognitive Assessment) or diagnostic formulation (e.g., NINDS VCI battery). A comprehensive evaluation should include assessment of pre-stroke cognition (e.g., using Informant Questionnaire for Cognitive Decline in the Elderly), mood (e.g., using Hospital Anxiety and Depression Scale), and functional consequences of cognitive impairments (e.g., using modified Rankin Scale). A large number of biomarkers for PSD, including indicators for genetic polymorphisms, biomarkers in the cerebrospinal fluid and in the serum, inflammatory...
The aim of the study was to determine duration of delirium in patients with acute stroke accordin... more The aim of the study was to determine duration of delirium in patients with acute stroke according to sex, age, type and localization of lesion. We assessed delirium prospectively in a sample of 233 consecutive patients with an acute (< or =4 days) stroke using the Delirium Rating Scale (DRS-R-98) and Diagnostic and Statistical Manual of Mental Disorders (DSM IV). The average duration of delirium was 4 days in patients with ischemic stroke and 3 days in patients with hemorrhagic stroke. There was no statistically significant difference in delirium duration between these two patient groups. A longer duration of delirium was recorded in women and in patients older than 65. The period of delirium was longer in patients with right hemispheric lesions. Patients did not differ according to delirium duration, sex, age, type and localization of stroke. In two thirds of patients, the symptoms of delirium completely disappeared on medicamentous treatment, while in the remaining one third o...
The aim of the study was to analyze stroke in young adults in Tuzla Canton, Bosnia and Herzegovin... more The aim of the study was to analyze stroke in young adults in Tuzla Canton, Bosnia and Herzegovina. From January 2001 to December 2005, 3864 patients with first-ever stroke were admitted at the Department of Neurology Tuzla. A retrospective analysis of risk factors, stroke types, severity and one month outcome in all young adults (18-45 years of age) with first-ever stroke was carried out. Out of total, there were 154 (4%) young adults with stroke. Mean age was 38.8 +/- 5.7 years and 47% were women. The leading risk factors were smoking (56%) and hypertension (45%). Subarachnoid hemorrhage (SAH) was more frequent in young adults compared with older patients (> 45 years of age) (22% vs. 3.5%, p < 0.0001), intracerebral hemorrhage (ICH) was similar in both groups (16.9% vs. 15.8%, p = 0.7), but ischemic stroke (IS) was predominant stroke type in the older group (61% vs. 74%, p = 0.0004). Young adults had more frequent lacunar stroke (26.6% vs. 16.1%, p = 0.01) and stroke due to ...
The aim of the study was to analyze the usefulness and side effects of treatment with interferon ... more The aim of the study was to analyze the usefulness and side effects of treatment with interferon beta 1B (Betaferon) in patients with the relapsing-remitting form of multiple sclerosis (RRMS). The study included 32 RRMS patients that had completed two-year therapy with interferon beta 1B or were still receiving this therapy. Every six months, patients were clinically evaluated and scored by the Expanded Disability Status Scale (EDSS). Two-year therapy was completed by 11 (34.3%) of 32 RRMS patients. Relapse was verified in 4 (36.36%) patients. The mean EDSS score was 2.45 +/- 1.03 at the beginning of therapy and 2.54 +/- 0.98 after two-year therapy; the difference was not statistically significant. In 2 (6.25%) patients on therapy for 18 months there was no relapse, and the mean EDSS was 1.75 +/- 0.35 (both at therapy introduction and at 18 months). Five (15.62%) patients were on therapy for one year. The mean EDSS was 1.6 +/- 1.08 at the beginning of therapy and 1.5 +/- 0.70 at one...
The aim of this study was to determine the prevalence of alcohol abuse and alcoholism in the gene... more The aim of this study was to determine the prevalence of alcohol abuse and alcoholism in the general population of Mostar region, Bosnia and Herzegovina. This study was conducted on a stratified sample of 704 participants. The prevalence of alcohol abuse was determined using standardized questionnaire on alcohol consumption--Michigan Alcoholism Screening Test. Prevalence of alcohol abuse with high risk for alcoholism was 9.9% and prevalence of alcohol addiction was 2.1%. In student population, there were 3.9% of alcohol addicts and 11.1% of persons with high risk of alcoholism. In high school population, there were 1.7% of alcohol addicts and 14.4% of persons with high risk of alcoholism. In Mostar region there was a high prevalence of alcoholism and problematic drinking, especially in high school and student population. There is a need for extensive preventive measures that have to include education, early diagnosis and intervention.
For thousands of years it has been known that aggression as a symptom appears in numerous psychia... more For thousands of years it has been known that aggression as a symptom appears in numerous psychiatric disorders and diseases. During the last decade the appearance of the aggressive behavior related to the posttraumatic stress disorder (PTSD) has been frequently investigated, often associated with war trauma. The goal of this study is to analyze the impact of alcoholism on a way war veterans suffering from chronic PTSD express and control aggression. The sample included 240 war veterans with chronic PTSD. The subjects were divided in two groups. PTSD group (n=147) and controlled group composed of those suffering from alcoholism in addition to PTSD (n=93). In this study, the following psychological instruments were used: The Harvard trauma questionnaire for PTSD diagnosis (HTQ); the questionnaire for self-evaluation of aggression (STAXI); The Profile Index Emotion (PIE); questionnaire for auto-diagnosis of alcoholism (CAGE). The obtained results indicate that subjects who have PTSD w...
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