A series of novel 1,3-dioxane-2-carboxylic acid derivatives containing alkyl chain tether and sub... more A series of novel 1,3-dioxane-2-carboxylic acid derivatives containing alkyl chain tether and substituted phenyl group as a lipophilic tail have been prepared as agonists of PPARalpha and gamma. c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid 13c exhibited potent hypoglycemic and lipid lowering activity with high oral bioavailability in animal models.
Two series of 3,6,7-trisubstituted-2-(1H-imidazol-2-ylsulfanyl)-quinoxalines 2a-l and 2-(quinoxal... more Two series of 3,6,7-trisubstituted-2-(1H-imidazol-2-ylsulfanyl)-quinoxalines 2a-l and 2-(quinoxalin-2-yl)-isothioureas 3a-l were prepared. All the test compounds 2a-l and 3a-l were screened in vitro, in a RIN5F cell-based assay for glucose-dependent insulinotropic activity. A significant concentration and glucose-dependent insulin secretion effect was seen with compounds 2a-l and the insulinotropic activity of compound 2l was found to be identical to that of the standard compound (6,7-dichloro-2-trifluromethyl-3-(5-methyl-1,3,4-thiadiazo-2-ylsulfanyl)-quinoxaline (1)).
Clubfoot is the commonest congenital deformity in babies. More than 100,000 babies are born world... more Clubfoot is the commonest congenital deformity in babies. More than 100,000 babies are born worldwide each year with congenital clubfoot. Around 80% of the cases occur in developing nations. We treated 154 feet [mean Pirani score (total) 5.57] in 96 children (78 males, 18 females) by the Ponseti method from January 2003 to December 2005. A prospective follow-up for a mean duration of 19.5 months (range 6–32 months) was undertaken. After six months of treatment the Pirani score was reduced to zero for all patients. The results show that corrective surgery, sometimes multiple, can be avoided in most cases which are usually associated with the development of a stiff, painful foot. Low socio-economic status and illiteracy prevailing in developing nations increases the prevalence of neglected clubfoot that is still harder to correct. Integration into various programs and proper use of available resources can decrease neglected clubfoot and improve chances of successful and timely correction of deformity. Bracing constitutes an important part of treatment and proper motivation and education of the parents mitigates the chances of losing correction. The Ponseti method of correcting clubfoot is especially important in developing countries, where operative facilities are not available in the remote areas and well-trained physicians and personnel can manage the cases effectively with cast treatment only. Le pied bot est parmi les déformations les plus habituelles chez l’enfant. Plus de 100.000 enfants naissent chaque année avec un pied bot congénital. 80% des cas proviennent des pays en voie de développement. Nous avons traité 150 cas de pieds avec un score de Pirani moyen de 5.57 chez 96 enfants. 78 étaient de sexe masculin, 18 de sexe féminin. Nous avons utilisé la méthode de Ponseti de janvier 2003 à décembre 2005. Une étude prospective a été réalisée sur une période de 19,5 mois (6 à 32 mois). Après six mois de traitement, le score de Pirani a été réduit à 0 chez tous les patients. Le résultat montre qu’une correction chirurgicale peut être parfois nécessaire dans les cas présentant un pied raide et très douloureux. L’utilisation de toutes les ressources nécessaires permettent de diminuer le nombre de pieds bots négligés et d’améliorer les chances de succès du traitement de cette déformation. Le traitement orthopédique est une part importante du traitement et la motivation et l’éducation des parents augmentent les chances de succès et diminuent les pertes de correction. La méthode de Ponseti est très importante dans les pays en voie de développement (80%) où les conditions opératoires ne sont pas très faciles et nécessitent un personnel entraîné.
Sulfur-containing fused pyridazinones have drawn much attention due to their potential biological... more Sulfur-containing fused pyridazinones have drawn much attention due to their potential biological activities. 1 Recently, heterocyclic-fused pyridazinones have been synthesized as potential anti-asthmatic and anti-inflammatory agents devoid of CNS and cardiovascular side ...
In the present investigation, two series of 2,5-disubstituted-3-imidazol-2-yl-pyrrolo[2,3-b]pyrid... more In the present investigation, two series of 2,5-disubstituted-3-imidazol-2-yl-pyrrolo[2,3-b]pyridines (2a-l) and thieno[2,3-b]pyridines (3a-l) were designed as analogs of BL 11282 (1). The in vitro glucose dependent insulinotropic activity of all the test compounds was evaluated using RIN5F cell based assay and all the test compounds showed glucose and concentration dependent insulin secretion. The in vivo antidiabetic activities of most potent compounds from each series (2c and 3c) were assessed in C57BL/6J mice. Compounds 2c and 3c showed dose dependent insulin secretion and significant glucose reduction in vivo. In general, compounds 2c and 3c were found to be equipotent at all the three different doses selected and with respect to BL 11282, both the test compounds were found to be more potent, at all the time points.
A series of novel 1,3-dioxane-2-carboxylic acid derivatives containing alkyl chain tether and sub... more A series of novel 1,3-dioxane-2-carboxylic acid derivatives containing alkyl chain tether and substituted phenyl group as a lipophilic tail have been prepared as agonists of PPARalpha and gamma. c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid 13c exhibited potent hypoglycemic and lipid lowering activity with high oral bioavailability in animal models.
Two series of 3,6,7-trisubstituted-2-(1H-imidazol-2-ylsulfanyl)-quinoxalines 2a-l and 2-(quinoxal... more Two series of 3,6,7-trisubstituted-2-(1H-imidazol-2-ylsulfanyl)-quinoxalines 2a-l and 2-(quinoxalin-2-yl)-isothioureas 3a-l were prepared. All the test compounds 2a-l and 3a-l were screened in vitro, in a RIN5F cell-based assay for glucose-dependent insulinotropic activity. A significant concentration and glucose-dependent insulin secretion effect was seen with compounds 2a-l and the insulinotropic activity of compound 2l was found to be identical to that of the standard compound (6,7-dichloro-2-trifluromethyl-3-(5-methyl-1,3,4-thiadiazo-2-ylsulfanyl)-quinoxaline (1)).
Clubfoot is the commonest congenital deformity in babies. More than 100,000 babies are born world... more Clubfoot is the commonest congenital deformity in babies. More than 100,000 babies are born worldwide each year with congenital clubfoot. Around 80% of the cases occur in developing nations. We treated 154 feet [mean Pirani score (total) 5.57] in 96 children (78 males, 18 females) by the Ponseti method from January 2003 to December 2005. A prospective follow-up for a mean duration of 19.5 months (range 6–32 months) was undertaken. After six months of treatment the Pirani score was reduced to zero for all patients. The results show that corrective surgery, sometimes multiple, can be avoided in most cases which are usually associated with the development of a stiff, painful foot. Low socio-economic status and illiteracy prevailing in developing nations increases the prevalence of neglected clubfoot that is still harder to correct. Integration into various programs and proper use of available resources can decrease neglected clubfoot and improve chances of successful and timely correction of deformity. Bracing constitutes an important part of treatment and proper motivation and education of the parents mitigates the chances of losing correction. The Ponseti method of correcting clubfoot is especially important in developing countries, where operative facilities are not available in the remote areas and well-trained physicians and personnel can manage the cases effectively with cast treatment only. Le pied bot est parmi les déformations les plus habituelles chez l’enfant. Plus de 100.000 enfants naissent chaque année avec un pied bot congénital. 80% des cas proviennent des pays en voie de développement. Nous avons traité 150 cas de pieds avec un score de Pirani moyen de 5.57 chez 96 enfants. 78 étaient de sexe masculin, 18 de sexe féminin. Nous avons utilisé la méthode de Ponseti de janvier 2003 à décembre 2005. Une étude prospective a été réalisée sur une période de 19,5 mois (6 à 32 mois). Après six mois de traitement, le score de Pirani a été réduit à 0 chez tous les patients. Le résultat montre qu’une correction chirurgicale peut être parfois nécessaire dans les cas présentant un pied raide et très douloureux. L’utilisation de toutes les ressources nécessaires permettent de diminuer le nombre de pieds bots négligés et d’améliorer les chances de succès du traitement de cette déformation. Le traitement orthopédique est une part importante du traitement et la motivation et l’éducation des parents augmentent les chances de succès et diminuent les pertes de correction. La méthode de Ponseti est très importante dans les pays en voie de développement (80%) où les conditions opératoires ne sont pas très faciles et nécessitent un personnel entraîné.
Sulfur-containing fused pyridazinones have drawn much attention due to their potential biological... more Sulfur-containing fused pyridazinones have drawn much attention due to their potential biological activities. 1 Recently, heterocyclic-fused pyridazinones have been synthesized as potential anti-asthmatic and anti-inflammatory agents devoid of CNS and cardiovascular side ...
In the present investigation, two series of 2,5-disubstituted-3-imidazol-2-yl-pyrrolo[2,3-b]pyrid... more In the present investigation, two series of 2,5-disubstituted-3-imidazol-2-yl-pyrrolo[2,3-b]pyridines (2a-l) and thieno[2,3-b]pyridines (3a-l) were designed as analogs of BL 11282 (1). The in vitro glucose dependent insulinotropic activity of all the test compounds was evaluated using RIN5F cell based assay and all the test compounds showed glucose and concentration dependent insulin secretion. The in vivo antidiabetic activities of most potent compounds from each series (2c and 3c) were assessed in C57BL/6J mice. Compounds 2c and 3c showed dose dependent insulin secretion and significant glucose reduction in vivo. In general, compounds 2c and 3c were found to be equipotent at all the three different doses selected and with respect to BL 11282, both the test compounds were found to be more potent, at all the time points.
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Papers by Pankaj Patel