AimTo test the contribution of programmed cell death 4 (PDCD4) tumour suppressor gene in Barrett&... more AimTo test the contribution of programmed cell death 4 (PDCD4) tumour suppressor gene in Barrett's carcinogenesis.MethodsPDCD4 immunohistochemical expression was assessed in 88 biopsy samples obtained from histologically proven long-segment Barrett's mucosa (BM; 25 non-intestinal columnar metaplasia, 25 intestinal metaplasia (IM), 16 low-grade intraepithelial neoplasia (LG-IEN), 12 high-grade IEN (HG-IEN) and 10 Barrett's adenocarcinoma (BAc)). As controls, 25 additional samples of native oesophageal mucosa (N) were obtained from patients with dyspepsia. To further support the data, the expression levels of miR-21, an important PDCD4 expression regulator, in 14 N, 5 HG-IEN and 11 BAc samples were determined by quantitative real-time PCR analysis.ResultsPDCD4 immunostaining decreased progressively and significantly with the progression of the phenotypic changes occurring during Barrett's carcinogenesis (p<0.001). Normal basal squamous epithelial layers featured str...
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointes... more Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, but they have been rarely reported in the esophagus. The authors present the case of an esophageal GIST and discuss the diagnostic course and therapeutic options, as currently reported in the literature.
Gastroenterology, Volume 138, Issue 5, Pages S-886, May 2010, Authors:Martina Ceolin; Paolo Bocus... more Gastroenterology, Volume 138, Issue 5, Pages S-886, May 2010, Authors:Martina Ceolin; Paolo Bocus; Giorgio Battaglia; Silvia Michieletto; Emanuela Guirroli; Renato Salvador; Alberto Ruol; Giorgio Diamantis; Francesco Cavallin; Ermanno Ancona. ...
Summary Primary Epstein-Barr virus (EBV) infection may present with self-limiting abdominal invol... more Summary Primary Epstein-Barr virus (EBV) infection may present with self-limiting abdominal involvement, characterized by hepatitis with mild elevation of aminotransferases, splenomegaly, and rarely with acute acalculous cholecystitis (AAC). Usually, treatment of EBV related AAC is symptomatic, without the need for surgery. Here, we describe a severe case of AAC occurring as the first manifestation of infectious mononucleosis in a young adult woman, receiving treatment with interleukin 6 receptor (IL-6r) inhibitor for rheumatoid arthritis (RA); moreover, we have performed a review of the literature on EBV-related AAC.
AimTo test the contribution of programmed cell death 4 (PDCD4) tumour suppressor gene in Barrett&... more AimTo test the contribution of programmed cell death 4 (PDCD4) tumour suppressor gene in Barrett's carcinogenesis.MethodsPDCD4 immunohistochemical expression was assessed in 88 biopsy samples obtained from histologically proven long-segment Barrett's mucosa (BM; 25 non-intestinal columnar metaplasia, 25 intestinal metaplasia (IM), 16 low-grade intraepithelial neoplasia (LG-IEN), 12 high-grade IEN (HG-IEN) and 10 Barrett's adenocarcinoma (BAc)). As controls, 25 additional samples of native oesophageal mucosa (N) were obtained from patients with dyspepsia. To further support the data, the expression levels of miR-21, an important PDCD4 expression regulator, in 14 N, 5 HG-IEN and 11 BAc samples were determined by quantitative real-time PCR analysis.ResultsPDCD4 immunostaining decreased progressively and significantly with the progression of the phenotypic changes occurring during Barrett's carcinogenesis (p<0.001). Normal basal squamous epithelial layers featured str...
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointes... more Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, but they have been rarely reported in the esophagus. The authors present the case of an esophageal GIST and discuss the diagnostic course and therapeutic options, as currently reported in the literature.
Gastroenterology, Volume 138, Issue 5, Pages S-886, May 2010, Authors:Martina Ceolin; Paolo Bocus... more Gastroenterology, Volume 138, Issue 5, Pages S-886, May 2010, Authors:Martina Ceolin; Paolo Bocus; Giorgio Battaglia; Silvia Michieletto; Emanuela Guirroli; Renato Salvador; Alberto Ruol; Giorgio Diamantis; Francesco Cavallin; Ermanno Ancona. ...
Summary Primary Epstein-Barr virus (EBV) infection may present with self-limiting abdominal invol... more Summary Primary Epstein-Barr virus (EBV) infection may present with self-limiting abdominal involvement, characterized by hepatitis with mild elevation of aminotransferases, splenomegaly, and rarely with acute acalculous cholecystitis (AAC). Usually, treatment of EBV related AAC is symptomatic, without the need for surgery. Here, we describe a severe case of AAC occurring as the first manifestation of infectious mononucleosis in a young adult woman, receiving treatment with interleukin 6 receptor (IL-6r) inhibitor for rheumatoid arthritis (RA); moreover, we have performed a review of the literature on EBV-related AAC.
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