European journal of medicinal chemistry, Apr 1, 2009
A series of novel 7,8 and 1,8 imidazo fused quinolone carboxamides are synthesized and evaluated ... more A series of novel 7,8 and 1,8 imidazo fused quinolone carboxamides are synthesized and evaluated against antibacterial activity. 1,8 Imidazo fused quinolones exhibit moderate antibacterial activity. Molecular modeling studies were carried out to optimize the pharmacophore.
A microwave assisted green synthetic methodoloy was developed for the synthesis various substitut... more A microwave assisted green synthetic methodoloy was developed for the synthesis various substituted pyrrolidinones derivatives by the one-pot three component reaction of aromatic aldehydes, aniline with dialkylbut-2-ynedioate in the presence of p-TsOH in water medium. The compounds were screened for their in vitro antimicrobial activity against four bacterial organism and two fungal organisms, resulted moderate to good activity with compared to their standard drug.
Journal of chemical and pharmaceutical research, 2012
TETANUS which is more familiarly known as LOCKJAW is a medical condition characterized by a prolo... more TETANUS which is more familiarly known as LOCKJAW is a medical condition characterized by a prolonged contraction of skeletal muscle fibers. The disease is caused by tetanospasmin, a neurotoxin produced by the Grampositive, obligate anaerobic bacterium Clostridium tetani found mainly in free living form in soil. Infection generally occurs through wound contamination and often involves a cut or deep puncture wound. As the infection progresses, muscle spasms develop in the jaw (thus the name "lockjaw") and elsewhere in the body. The main emphasis of this in silico analysis was to find different genes expressed and proteins formed during the diseased condition in humans and to study the evolutionary relationships between the expressed proteins. Single out the group having a common ancestry so as to find out what common domains these proteins share that are functionally active during the disease and then to analyze these domains to find the motif patterns that are altered and ...
The poly (ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear protein involved in DNA repair... more The poly (ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear protein involved in DNA repair and programmed cell death. Substituted 5(H) phenanthradin-6-one analogs were found to be potent PARP-1 inhibitors. Semiempirical methods were used to estimate various physicochemical parameters. The hydration energy (HE), ionization potential (IP), electrophilic index (ω) and partition coefficient ( LogP ) were resulted as independent variables for inhibitory activity of the analogs. The overall increase of HE, IP, and EI and overall decrease of LogP enhance the efficacy of inhibitory nature of these analogs to PARP-1. Docking studies of 5(H) phenanthradin-6-one analogs with PARP-1 were also performed in support of the findings of QSAR studies. Analysis of results of both QSAR and docking studies suggested that remarkable inhibitory activity is exhibited by molecules 9b, 10b1 and 10b2. The hydrogen bond interactions along with hydrophobic and electrostatic interactions are mapped to con...
Environmental Science and Pollution Research, 2020
Herein, cadmium sulfide (CdS) nanoparticles (NPs) and different concentrations (1–5 and 10 wt %) ... more Herein, cadmium sulfide (CdS) nanoparticles (NPs) and different concentrations (1–5 and 10 wt %) of Sn-doped CdS NPs were prepared by a chemical precipitation method using PVP as a capping agent. The synthesized NPs were characterized using various characteristic techniques such as XRD, SEM, TEM, Raman spectroscopy, UV-Vis, and photoluminescence to investigate structural, morphological, and optical properties. Optical band gap of CdS has been tuned by substitution of Sn with different concentrations. Pure CdS and Sn-doped CdS NPs were used for the photocatalytic degradation of methylene blue (MB) dye under direct sunlight irradiation. The photocatalytic activity of the Sn-doped CdS NPs is attributed to the interface actions between Sn and CdS, which significantly decreases the recombination of a photogenerated electron-hole pair. The degradation efficiencies were found to be 91.39% and 97.56% within 180 min for pure CdS and Sn-doped CdS NPs, respectively. Among the catalysts, 4% Sn-doped CdS NPs exhibit best photocatalytic degradation efficiency after 180 min of irradiation.
Journal of Environmental Chemical Engineering, 2021
Abstract Electrochemical sensing of toxic pollutants as well as the degradation of toxic dyes usi... more Abstract Electrochemical sensing of toxic pollutants as well as the degradation of toxic dyes using cost effective nanoparticles-based photocatalyst are one of the most effective ways to reduce environmental contaminants. Herein, ZnO and different percentage (1, 3, 5 & 10%) of Ce and Sn doped ZnO nanoparticles were synthesized by a facile chemical method. The synthesized nanoparticles were used as modified electrode towards electrochemical detection of catechol (CA). It was found that the limit of detection and the sensitivity of the Ce/ZnO (5%) to be 0.21 μM and 0.494 μM μA−1, respectively. The doped ZnO exhibited lower band gap compared to pure ZnO, which facilitates to rapid photocatalytic degradation (~93%) of textile dyes (Crystal Violet & Rhodamine B) and catechol under visible light radiation. The environmental pollutants such as catechol, crystal violet and rhodamine B dye were effectively determined and degraded very successfully using couple of techniques such as cyclic voltametric and photodegradation.
European journal of medicinal chemistry, Apr 1, 2009
A series of novel 7,8 and 1,8 imidazo fused quinolone carboxamides are synthesized and evaluated ... more A series of novel 7,8 and 1,8 imidazo fused quinolone carboxamides are synthesized and evaluated against antibacterial activity. 1,8 Imidazo fused quinolones exhibit moderate antibacterial activity. Molecular modeling studies were carried out to optimize the pharmacophore.
A microwave assisted green synthetic methodoloy was developed for the synthesis various substitut... more A microwave assisted green synthetic methodoloy was developed for the synthesis various substituted pyrrolidinones derivatives by the one-pot three component reaction of aromatic aldehydes, aniline with dialkylbut-2-ynedioate in the presence of p-TsOH in water medium. The compounds were screened for their in vitro antimicrobial activity against four bacterial organism and two fungal organisms, resulted moderate to good activity with compared to their standard drug.
Journal of chemical and pharmaceutical research, 2012
TETANUS which is more familiarly known as LOCKJAW is a medical condition characterized by a prolo... more TETANUS which is more familiarly known as LOCKJAW is a medical condition characterized by a prolonged contraction of skeletal muscle fibers. The disease is caused by tetanospasmin, a neurotoxin produced by the Grampositive, obligate anaerobic bacterium Clostridium tetani found mainly in free living form in soil. Infection generally occurs through wound contamination and often involves a cut or deep puncture wound. As the infection progresses, muscle spasms develop in the jaw (thus the name "lockjaw") and elsewhere in the body. The main emphasis of this in silico analysis was to find different genes expressed and proteins formed during the diseased condition in humans and to study the evolutionary relationships between the expressed proteins. Single out the group having a common ancestry so as to find out what common domains these proteins share that are functionally active during the disease and then to analyze these domains to find the motif patterns that are altered and ...
The poly (ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear protein involved in DNA repair... more The poly (ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear protein involved in DNA repair and programmed cell death. Substituted 5(H) phenanthradin-6-one analogs were found to be potent PARP-1 inhibitors. Semiempirical methods were used to estimate various physicochemical parameters. The hydration energy (HE), ionization potential (IP), electrophilic index (ω) and partition coefficient ( LogP ) were resulted as independent variables for inhibitory activity of the analogs. The overall increase of HE, IP, and EI and overall decrease of LogP enhance the efficacy of inhibitory nature of these analogs to PARP-1. Docking studies of 5(H) phenanthradin-6-one analogs with PARP-1 were also performed in support of the findings of QSAR studies. Analysis of results of both QSAR and docking studies suggested that remarkable inhibitory activity is exhibited by molecules 9b, 10b1 and 10b2. The hydrogen bond interactions along with hydrophobic and electrostatic interactions are mapped to con...
Environmental Science and Pollution Research, 2020
Herein, cadmium sulfide (CdS) nanoparticles (NPs) and different concentrations (1–5 and 10 wt %) ... more Herein, cadmium sulfide (CdS) nanoparticles (NPs) and different concentrations (1–5 and 10 wt %) of Sn-doped CdS NPs were prepared by a chemical precipitation method using PVP as a capping agent. The synthesized NPs were characterized using various characteristic techniques such as XRD, SEM, TEM, Raman spectroscopy, UV-Vis, and photoluminescence to investigate structural, morphological, and optical properties. Optical band gap of CdS has been tuned by substitution of Sn with different concentrations. Pure CdS and Sn-doped CdS NPs were used for the photocatalytic degradation of methylene blue (MB) dye under direct sunlight irradiation. The photocatalytic activity of the Sn-doped CdS NPs is attributed to the interface actions between Sn and CdS, which significantly decreases the recombination of a photogenerated electron-hole pair. The degradation efficiencies were found to be 91.39% and 97.56% within 180 min for pure CdS and Sn-doped CdS NPs, respectively. Among the catalysts, 4% Sn-doped CdS NPs exhibit best photocatalytic degradation efficiency after 180 min of irradiation.
Journal of Environmental Chemical Engineering, 2021
Abstract Electrochemical sensing of toxic pollutants as well as the degradation of toxic dyes usi... more Abstract Electrochemical sensing of toxic pollutants as well as the degradation of toxic dyes using cost effective nanoparticles-based photocatalyst are one of the most effective ways to reduce environmental contaminants. Herein, ZnO and different percentage (1, 3, 5 & 10%) of Ce and Sn doped ZnO nanoparticles were synthesized by a facile chemical method. The synthesized nanoparticles were used as modified electrode towards electrochemical detection of catechol (CA). It was found that the limit of detection and the sensitivity of the Ce/ZnO (5%) to be 0.21 μM and 0.494 μM μA−1, respectively. The doped ZnO exhibited lower band gap compared to pure ZnO, which facilitates to rapid photocatalytic degradation (~93%) of textile dyes (Crystal Violet & Rhodamine B) and catechol under visible light radiation. The environmental pollutants such as catechol, crystal violet and rhodamine B dye were effectively determined and degraded very successfully using couple of techniques such as cyclic voltametric and photodegradation.
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