Alcoholic and chloroform extracts of fruits of Withania coagulans Dunal were screened for anti-in... more Alcoholic and chloroform extracts of fruits of Withania coagulans Dunal were screened for anti-inflammatory activity in carrageenan-induced rat paw edema at the dose level of 100 mg/kg body weight. Both the extracts produced significant (p<0.05 and p<0.01) anti-inflammatory activity when compared to control. The alcoholic extract showed better activity than chloroform extract.
International Journal of Pharmaceutical Research, 2020
New topical pharmaceutical options are critically needed to obviate fungal infections. Luliconazo... more New topical pharmaceutical options are critically needed to obviate fungal infections. Luliconazole is a potent antifungal drug for the treatment of fungal infection. Due to bioavailability barriers of luliconazole, the current study is associated to develop an optimized topical luliconazole solid lipid nanoparticles (SLN) gel formulation against tropical fungal infection with prolonged therapeutic potential. Luliconazole loaded SLN were prepared through the solvent diffusion method using stearic acid &amp; poloxamer 188 and optimized as per their entrapment efficacy. Thereafter, the optimized SLN wes subjected to physicochemical evaluation, followed by the preparation of different gel formulation. The physicochemical parameters of the optimized gel formulation (G3) were evaluated. Further anti-fungal activity of the G3 was determined against the growth of Candida albicans by TLC-Bioautography assay. The results reveal that SLN F6 shows a significant entrapment with 92.13%±0.975 entrapment efficacy. In particle size, size distribution and zeta potential analysis, SLN exhibit a mean particle diameter of ~344.3 nm, PDI of 0.168, intercept value 0.98 and zeta potential ~18.8 mV. The G3 shows a higher entrapment with 91.39%±0.187 entrapment efficacy and in-vitro drug release profile of the G3 with 1.5 % carbopol 934 w/v shown a sustained release profile with 79.57%±0.213 desolvation rate even after 24 hrs. The anti-fungal activity of SLN G3 gel showed a strong zone of inhibition of the growth of C. albicans. Hence, the study concludes that luliconazole loaded SLN G3 gel formulation containing 1.5% w/v carbopol 934 is suitable for topical application and having strong anti-fungal activity.
Polypharmacy can be defined as the use of multiple medications for the treatment of a patient’s m... more Polypharmacy can be defined as the use of multiple medications for the treatment of a patient’s medical conditions. The term polypharmacy suggests that more medication is being used than is clinically indicated. The number of meds taken by a patient that constitutes polypharmacy has not been defined. There are several reasons for poly pharmacy: 1) As the population ages, polypharmacy increases. The elderly often require multiple medications to treat multiple health-related conditions. 2) Patients with multiple co-morbid medical conditions also require numerous medications to treat each condition. It is not unreasonable for patients with multiple comorbid medical conditions to be on 6 to 9 medications to reduce his or her long term risk for those conditions, i.e, diabetes complications and coronary events. 3) A recent hospitalization also puts you at risk of polypharmacy. Medicines are started and stopped quite frequently during your hospital stay. 4) Multiple doctors are prescribing...
A series of quinoxaline derivatives were synthesized by doing molecular modifications at C-3 meth... more A series of quinoxaline derivatives were synthesized by doing molecular modifications at C-3 methyl group of 2-hydroxy-3-methylquinoxaline nucleus. The synthesis was initiated by bromination followed by attachment of p-hydroxy bezaldehydes to 3-methyl group to synthesize 3(4-formyl phenoxymethyl)-quinoxaline-(1 H)-2-one as new intermediate and condense it with substituted aromatic amines to afford the synthesis of Schiff bases of 3-methylquinoxalin-2(1 H)-one. The new compounds (GG1, GG2, GG3, GG4 and GG5) have been synthesized by treating o-phenylene- diamine with ethyl pyruvate to yield 3-methylquinoxaline 2-one, which on bromination afforded the synthesis of 3-bromomethyl quinoxaline-2-one. Finally 3-bromomethyl quinoxaline-2-one was treated with 4-hydroxy benzaldehyde to yield the synthesis of 3-(-4-formyl phenoxy methyl)-quinoxalin 2(1 H)-one (GG1), which was treated with different substituted aromatic amines to yield the synthesis of 3-((4-(substituted-phenylimino)-methyl)-phe...
Alcoholic and chloroform extracts of fruits of Withania coagulans Dunal were screened for anti-in... more Alcoholic and chloroform extracts of fruits of Withania coagulans Dunal were screened for anti-inflammatory activity in carrageenan-induced rat paw edema at the dose level of 100 mg/kg body weight. Both the extracts produced significant (p<0.05 and p<0.01) anti-inflammatory activity when compared to control. The alcoholic extract showed better activity than chloroform extract.
International Journal of Pharmaceutical Research, 2020
New topical pharmaceutical options are critically needed to obviate fungal infections. Luliconazo... more New topical pharmaceutical options are critically needed to obviate fungal infections. Luliconazole is a potent antifungal drug for the treatment of fungal infection. Due to bioavailability barriers of luliconazole, the current study is associated to develop an optimized topical luliconazole solid lipid nanoparticles (SLN) gel formulation against tropical fungal infection with prolonged therapeutic potential. Luliconazole loaded SLN were prepared through the solvent diffusion method using stearic acid &amp; poloxamer 188 and optimized as per their entrapment efficacy. Thereafter, the optimized SLN wes subjected to physicochemical evaluation, followed by the preparation of different gel formulation. The physicochemical parameters of the optimized gel formulation (G3) were evaluated. Further anti-fungal activity of the G3 was determined against the growth of Candida albicans by TLC-Bioautography assay. The results reveal that SLN F6 shows a significant entrapment with 92.13%±0.975 entrapment efficacy. In particle size, size distribution and zeta potential analysis, SLN exhibit a mean particle diameter of ~344.3 nm, PDI of 0.168, intercept value 0.98 and zeta potential ~18.8 mV. The G3 shows a higher entrapment with 91.39%±0.187 entrapment efficacy and in-vitro drug release profile of the G3 with 1.5 % carbopol 934 w/v shown a sustained release profile with 79.57%±0.213 desolvation rate even after 24 hrs. The anti-fungal activity of SLN G3 gel showed a strong zone of inhibition of the growth of C. albicans. Hence, the study concludes that luliconazole loaded SLN G3 gel formulation containing 1.5% w/v carbopol 934 is suitable for topical application and having strong anti-fungal activity.
Polypharmacy can be defined as the use of multiple medications for the treatment of a patient’s m... more Polypharmacy can be defined as the use of multiple medications for the treatment of a patient’s medical conditions. The term polypharmacy suggests that more medication is being used than is clinically indicated. The number of meds taken by a patient that constitutes polypharmacy has not been defined. There are several reasons for poly pharmacy: 1) As the population ages, polypharmacy increases. The elderly often require multiple medications to treat multiple health-related conditions. 2) Patients with multiple co-morbid medical conditions also require numerous medications to treat each condition. It is not unreasonable for patients with multiple comorbid medical conditions to be on 6 to 9 medications to reduce his or her long term risk for those conditions, i.e, diabetes complications and coronary events. 3) A recent hospitalization also puts you at risk of polypharmacy. Medicines are started and stopped quite frequently during your hospital stay. 4) Multiple doctors are prescribing...
A series of quinoxaline derivatives were synthesized by doing molecular modifications at C-3 meth... more A series of quinoxaline derivatives were synthesized by doing molecular modifications at C-3 methyl group of 2-hydroxy-3-methylquinoxaline nucleus. The synthesis was initiated by bromination followed by attachment of p-hydroxy bezaldehydes to 3-methyl group to synthesize 3(4-formyl phenoxymethyl)-quinoxaline-(1 H)-2-one as new intermediate and condense it with substituted aromatic amines to afford the synthesis of Schiff bases of 3-methylquinoxalin-2(1 H)-one. The new compounds (GG1, GG2, GG3, GG4 and GG5) have been synthesized by treating o-phenylene- diamine with ethyl pyruvate to yield 3-methylquinoxaline 2-one, which on bromination afforded the synthesis of 3-bromomethyl quinoxaline-2-one. Finally 3-bromomethyl quinoxaline-2-one was treated with 4-hydroxy benzaldehyde to yield the synthesis of 3-(-4-formyl phenoxy methyl)-quinoxalin 2(1 H)-one (GG1), which was treated with different substituted aromatic amines to yield the synthesis of 3-((4-(substituted-phenylimino)-methyl)-phe...
Uploads
Papers by Director Pharmacy