Reconstitution of healthy endothelial cells in vascular beds offers opportunities for mechanisms ... more Reconstitution of healthy endothelial cells in vascular beds offers opportunities for mechanisms in tissue homeostasis, organ regeneration, and correction of deficient functions. Liver sinusoidal endothelial cells express unique functions and their transplantation is relevant for disease models and for cell therapy. As molecular targets for improving transplanted cell engraftment and proliferation will be highly significant, we determined whether ETA/B receptor antagonism by the drug, bosentan, could overcome cell losses due to cell transplantation-induced cytotoxicity. Cell engraftment and proliferation assays were performed with healthy wild-type liver sinusoidal endothelial cells transplanted into the liver of dipeptidylpeptidase IV knockout mice. Transplanted cells were identified in tissues by enzyme histochemistry. Cells with prospective ETA/B antagonism engrafted significantly better in hepatic sinusoids. Moreover, these cells underwent multiple rounds of division under liver...
The focus of this paper is to investigate whether carbon footprints are reduced due to renewable ... more The focus of this paper is to investigate whether carbon footprints are reduced due to renewable energy use in fuelling the business and commercial interests of the nation’s right from trade, production, consumption in the presence of foreign direct investment (FDI). The quantification of the relationship is carried out for three developed nations and five developing nations. Error Correction Model (ECM) using Autoregressive distributed lag (ARDL) methodology is used to assess short-term and long-term country-wise parameters for the chosen variables in sample countries from 1990 to 2017. The findings demonstrate the persuasive evidence that green energy use is the sustainable path of development. The cointegrated relationship amongst the variables for the long run is validated for all eight individual countries included in the study. High-economic growth and non-renewable energy use are recognized as the major sources of environmental degradation across the country analysis. However...
This essay analyses New York's 2018 proposal to Amazon to locate their second headquarter... more This essay analyses New York's 2018 proposal to Amazon to locate their second headquarters (HQ2) in New York City. In addition to the massive resources and infrastructure offered by the city to Ama...
The objective of this study was to compare the analgesic efficacy of etodolac injection and diclo... more The objective of this study was to compare the analgesic efficacy of etodolac injection and diclofenac injection in patients with postoperative orthopedic pain. This was multicentric, randomized, assessor-blind and parallel-group study. A group of 158 patients with moderate to severe pain following orthopedic surgery were randomly assigned to receive either etodolac 400 mg twice a day (n = 78) or diclofenac 75 mg thrice a day (n = 80). The primary efficacy outcome measures were pain intensity difference, sum of pain intensity differences and pain relief whereas secondary efficacy variables included maximum fall in pain intensity, number of doses of study medication consumed, number of patients who required rescue medication and overall response to therapy. Mean pain intensity differences assessed on 10 cm VAS were significantly better for etodolac arm compared to diclofenac arm at 4, 8, 20 and 24 hours (p < 0.05). Sum of pain intensity differences over the first 8 hours (-21.31 ± 6.26 for etodolac vs. -19.13 ± 6.98 for diclofenac; p = 0.041) and over the 24 hours (-39.83 ± 10.70 for etodolac vs. -35.25 ± 12.00 for diclofenac; p = 0.012) for the etodolac group was significantly superior than diclofenac group. Assessment of pain relief showed that etodolac injection was significantly more effective than diclofenac injection (p < 0.0001) over the 24 hour assessment period. Maximum fall in pain intensity score, number of doses of study medication consumed and patients' and investigators' overall response to the drug at the end of treatment period were also significantly superior in the etodolac arm as compared to the diclofenac arm (p < 0.05). However, the number of patients who were rescued was comparable in both the treatment arms. A change in emotional functioning of the patients was not captured in this study. Both the study medications were well tolerated with no incidence of SAE throughout the study. Etodolac can be considered as an effective alternative to traditional NSAIDS in the treatment of post operative pain.
Optical coherence tomography (OCT), being a noninvasive imaging modality, has begun to find vast ... more Optical coherence tomography (OCT), being a noninvasive imaging modality, has begun to find vast use in the diagnosis and management of ocular diseases such as glaucoma, where the retinal nerve fiber layer (RNFL) has been known to thin. Furthermore, the recent ...
We previously disclosed the discovery of rationally designed N-((1-(4-(propylsulfonyl)piperazin-1... more We previously disclosed the discovery of rationally designed N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1 (GlyT-1), represented by analogues 10 and 11. We describe herein further structure-activity relationship (SAR) exploration of this series via an optimization strategy that primarily focused on the sulfonamide and benzamide appendages of the scaffold. These efforts led to the identification of advanced leads possessing a desirable balance of excellent in vitro GlyT-1 potency and selectivity, favorable ADME and in vitro pharmacological profiles, and suitable pharmacokinetic (PK) and safety characteristics. Representative analogue (+)-67 exhibited robust in vivo activity in the cerebral spinal fluid (CSF) glycine biomarker model in both rodents and non-human primates. Furthermore, rodent microdialysis experiments also demonstrated that oral administration of (+)-67 significantly elevated extracellular glycine levels within ...
Handbook of Research on Advanced Hybrid Intelligent Techniques and Applications
In this chapter, the design and comparative analysis is done in between the most well-known colum... more In this chapter, the design and comparative analysis is done in between the most well-known column compression multipliers by Wallace and Dadda in sub-threshold regime. In order to reduce the hardware which ultimately reduces area, power and overall power delay product, an energy efficient basic modules of the multipliers like AND gates, half adders, full adders and partial product generate units have been analyzed for sub-threshold operation. At the last stage ripple carry adder is used in both multipliers. The performance metrics considered for the analysis of the multipliers are: power, delay and PDP. Simulation studies are carried out for 8x8-bit and 16x16-bit input data width. The proposed circuits show energy efficient results with Spectre simulations for the TSMC 180nm CMOS technology at 0.4V supply voltage. The proposed multipliers so implemented outperform its counterparts exhibiting low power consumption and lesser propagation delay as compared to conventional multipliers.
2014 International Conference on Circuits, Power and Computing Technologies [ICCPCT-2014], 2014
The paper presents the analysis and implementation of ultra low-power, low voltage and low area 4... more The paper presents the analysis and implementation of ultra low-power, low voltage and low area 4-bit carry look ahead adder circuits. Sub-threshold design technique has been used to reduce the power consumption and area while maintaining low complexity of logic design in the proposed circuit. Simulation results illustrate the superiority of the circuits in sub-threshold region against the conventional low power design technique, in terms of power, area and power delay product (PDP). The CLA is implemented on TSMC 0.18μm process models in Cadence Virtuoso Schematic composer with improved driving ability and circuit robustness at 0.4V single ended supply voltage and simulations are carried out on Spectre S. The proposed 4-bit CLA can operate up to 5 MHz and used 0.035 μW of power and occupied an area of 60×92.5 μm2.
Facial expressions are undoubtedly the most effective nonverbal communication. The face has alway... more Facial expressions are undoubtedly the most effective nonverbal communication. The face has always been the equation of a person's identity. The face draws the demarcation line between identity and extinction. Each line on the face adds an attribute to the identity. These lines ...
In continuation of our interest in the solid-phase synthesis of libraries based on peptides,[4 an... more In continuation of our interest in the solid-phase synthesis of libraries based on peptides,[4 and 5] small organic molecules (heterocyclic and acyclic structures) [6, 7, 8, 9 and 10] and natural products [11 and 12] we have now targeted the synthesis of libraries with extensive ...
International Journal of Biological Macromolecules, 2014
ZnO nanoparticle induced exopolysaccharide (EPS) production from Bacillus subtilis strain JCT1 (N... more ZnO nanoparticle induced exopolysaccharide (EPS) production from Bacillus subtilis strain JCT1 (NCBI GenBank Accession No. JN194187) is a novel approach for arid soil applications. In the series of investigations, environmentally benign protocol was followed for the synthesis of ZnO nanoparticles using extracellular enzymes obtained from Aspergillus fumigatus TFR8. Putative characterization techniques were employed for confirmation of size, shape, surface structure, crystalline nature and elemental proportion of ZnO nanoparticles. Results established an average size of ZnO nanoparticles to be 2.9 nm at least at one dimension and oblate spherical in structure. The qualitative composition of the nanoparticles exhibited 97.5% Zn element atom percentage. Biosynthesized ZnO nanoparticles enhanced exopolysaccharide production by 596.1% as compared to control and further EPS amelioration led to enhanced soil aggregation (up to 82%), moisture retention (10.7-14.2%) and soil organic carbon. Soil aggregation stability was further confirmed by Fourier transform infra-red spectroscopy. A possible ZnO nanoparticle mediated biological mechanism for enhancing exopolysaccharide production has been discussed.
Ultracold Neutral Plasmas (UNP's) are created by photoionizing laser-cooled atoms; the resul... more Ultracold Neutral Plasmas (UNP's) are created by photoionizing laser-cooled atoms; the resulting plasma expands due to the thermal pressure of the electrons. Powerful optical diagnostics are available to study these systems where the initial density profiles, energies, and ...
Reconstitution of healthy endothelial cells in vascular beds offers opportunities for mechanisms ... more Reconstitution of healthy endothelial cells in vascular beds offers opportunities for mechanisms in tissue homeostasis, organ regeneration, and correction of deficient functions. Liver sinusoidal endothelial cells express unique functions and their transplantation is relevant for disease models and for cell therapy. As molecular targets for improving transplanted cell engraftment and proliferation will be highly significant, we determined whether ETA/B receptor antagonism by the drug, bosentan, could overcome cell losses due to cell transplantation-induced cytotoxicity. Cell engraftment and proliferation assays were performed with healthy wild-type liver sinusoidal endothelial cells transplanted into the liver of dipeptidylpeptidase IV knockout mice. Transplanted cells were identified in tissues by enzyme histochemistry. Cells with prospective ETA/B antagonism engrafted significantly better in hepatic sinusoids. Moreover, these cells underwent multiple rounds of division under liver...
The focus of this paper is to investigate whether carbon footprints are reduced due to renewable ... more The focus of this paper is to investigate whether carbon footprints are reduced due to renewable energy use in fuelling the business and commercial interests of the nation’s right from trade, production, consumption in the presence of foreign direct investment (FDI). The quantification of the relationship is carried out for three developed nations and five developing nations. Error Correction Model (ECM) using Autoregressive distributed lag (ARDL) methodology is used to assess short-term and long-term country-wise parameters for the chosen variables in sample countries from 1990 to 2017. The findings demonstrate the persuasive evidence that green energy use is the sustainable path of development. The cointegrated relationship amongst the variables for the long run is validated for all eight individual countries included in the study. High-economic growth and non-renewable energy use are recognized as the major sources of environmental degradation across the country analysis. However...
This essay analyses New York's 2018 proposal to Amazon to locate their second headquarter... more This essay analyses New York's 2018 proposal to Amazon to locate their second headquarters (HQ2) in New York City. In addition to the massive resources and infrastructure offered by the city to Ama...
The objective of this study was to compare the analgesic efficacy of etodolac injection and diclo... more The objective of this study was to compare the analgesic efficacy of etodolac injection and diclofenac injection in patients with postoperative orthopedic pain. This was multicentric, randomized, assessor-blind and parallel-group study. A group of 158 patients with moderate to severe pain following orthopedic surgery were randomly assigned to receive either etodolac 400 mg twice a day (n = 78) or diclofenac 75 mg thrice a day (n = 80). The primary efficacy outcome measures were pain intensity difference, sum of pain intensity differences and pain relief whereas secondary efficacy variables included maximum fall in pain intensity, number of doses of study medication consumed, number of patients who required rescue medication and overall response to therapy. Mean pain intensity differences assessed on 10 cm VAS were significantly better for etodolac arm compared to diclofenac arm at 4, 8, 20 and 24 hours (p < 0.05). Sum of pain intensity differences over the first 8 hours (-21.31 ± 6.26 for etodolac vs. -19.13 ± 6.98 for diclofenac; p = 0.041) and over the 24 hours (-39.83 ± 10.70 for etodolac vs. -35.25 ± 12.00 for diclofenac; p = 0.012) for the etodolac group was significantly superior than diclofenac group. Assessment of pain relief showed that etodolac injection was significantly more effective than diclofenac injection (p < 0.0001) over the 24 hour assessment period. Maximum fall in pain intensity score, number of doses of study medication consumed and patients' and investigators' overall response to the drug at the end of treatment period were also significantly superior in the etodolac arm as compared to the diclofenac arm (p < 0.05). However, the number of patients who were rescued was comparable in both the treatment arms. A change in emotional functioning of the patients was not captured in this study. Both the study medications were well tolerated with no incidence of SAE throughout the study. Etodolac can be considered as an effective alternative to traditional NSAIDS in the treatment of post operative pain.
Optical coherence tomography (OCT), being a noninvasive imaging modality, has begun to find vast ... more Optical coherence tomography (OCT), being a noninvasive imaging modality, has begun to find vast use in the diagnosis and management of ocular diseases such as glaucoma, where the retinal nerve fiber layer (RNFL) has been known to thin. Furthermore, the recent ...
We previously disclosed the discovery of rationally designed N-((1-(4-(propylsulfonyl)piperazin-1... more We previously disclosed the discovery of rationally designed N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1 (GlyT-1), represented by analogues 10 and 11. We describe herein further structure-activity relationship (SAR) exploration of this series via an optimization strategy that primarily focused on the sulfonamide and benzamide appendages of the scaffold. These efforts led to the identification of advanced leads possessing a desirable balance of excellent in vitro GlyT-1 potency and selectivity, favorable ADME and in vitro pharmacological profiles, and suitable pharmacokinetic (PK) and safety characteristics. Representative analogue (+)-67 exhibited robust in vivo activity in the cerebral spinal fluid (CSF) glycine biomarker model in both rodents and non-human primates. Furthermore, rodent microdialysis experiments also demonstrated that oral administration of (+)-67 significantly elevated extracellular glycine levels within ...
Handbook of Research on Advanced Hybrid Intelligent Techniques and Applications
In this chapter, the design and comparative analysis is done in between the most well-known colum... more In this chapter, the design and comparative analysis is done in between the most well-known column compression multipliers by Wallace and Dadda in sub-threshold regime. In order to reduce the hardware which ultimately reduces area, power and overall power delay product, an energy efficient basic modules of the multipliers like AND gates, half adders, full adders and partial product generate units have been analyzed for sub-threshold operation. At the last stage ripple carry adder is used in both multipliers. The performance metrics considered for the analysis of the multipliers are: power, delay and PDP. Simulation studies are carried out for 8x8-bit and 16x16-bit input data width. The proposed circuits show energy efficient results with Spectre simulations for the TSMC 180nm CMOS technology at 0.4V supply voltage. The proposed multipliers so implemented outperform its counterparts exhibiting low power consumption and lesser propagation delay as compared to conventional multipliers.
2014 International Conference on Circuits, Power and Computing Technologies [ICCPCT-2014], 2014
The paper presents the analysis and implementation of ultra low-power, low voltage and low area 4... more The paper presents the analysis and implementation of ultra low-power, low voltage and low area 4-bit carry look ahead adder circuits. Sub-threshold design technique has been used to reduce the power consumption and area while maintaining low complexity of logic design in the proposed circuit. Simulation results illustrate the superiority of the circuits in sub-threshold region against the conventional low power design technique, in terms of power, area and power delay product (PDP). The CLA is implemented on TSMC 0.18μm process models in Cadence Virtuoso Schematic composer with improved driving ability and circuit robustness at 0.4V single ended supply voltage and simulations are carried out on Spectre S. The proposed 4-bit CLA can operate up to 5 MHz and used 0.035 μW of power and occupied an area of 60×92.5 μm2.
Facial expressions are undoubtedly the most effective nonverbal communication. The face has alway... more Facial expressions are undoubtedly the most effective nonverbal communication. The face has always been the equation of a person's identity. The face draws the demarcation line between identity and extinction. Each line on the face adds an attribute to the identity. These lines ...
In continuation of our interest in the solid-phase synthesis of libraries based on peptides,[4 an... more In continuation of our interest in the solid-phase synthesis of libraries based on peptides,[4 and 5] small organic molecules (heterocyclic and acyclic structures) [6, 7, 8, 9 and 10] and natural products [11 and 12] we have now targeted the synthesis of libraries with extensive ...
International Journal of Biological Macromolecules, 2014
ZnO nanoparticle induced exopolysaccharide (EPS) production from Bacillus subtilis strain JCT1 (N... more ZnO nanoparticle induced exopolysaccharide (EPS) production from Bacillus subtilis strain JCT1 (NCBI GenBank Accession No. JN194187) is a novel approach for arid soil applications. In the series of investigations, environmentally benign protocol was followed for the synthesis of ZnO nanoparticles using extracellular enzymes obtained from Aspergillus fumigatus TFR8. Putative characterization techniques were employed for confirmation of size, shape, surface structure, crystalline nature and elemental proportion of ZnO nanoparticles. Results established an average size of ZnO nanoparticles to be 2.9 nm at least at one dimension and oblate spherical in structure. The qualitative composition of the nanoparticles exhibited 97.5% Zn element atom percentage. Biosynthesized ZnO nanoparticles enhanced exopolysaccharide production by 596.1% as compared to control and further EPS amelioration led to enhanced soil aggregation (up to 82%), moisture retention (10.7-14.2%) and soil organic carbon. Soil aggregation stability was further confirmed by Fourier transform infra-red spectroscopy. A possible ZnO nanoparticle mediated biological mechanism for enhancing exopolysaccharide production has been discussed.
Ultracold Neutral Plasmas (UNP's) are created by photoionizing laser-cooled atoms; the resul... more Ultracold Neutral Plasmas (UNP's) are created by photoionizing laser-cooled atoms; the resulting plasma expands due to the thermal pressure of the electrons. Powerful optical diagnostics are available to study these systems where the initial density profiles, energies, and ...
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Papers by Priya Gupta