Spiny hyperkeratosis of the palms and soles is a rare dermatosis presenting as multiple tiny kera... more Spiny hyperkeratosis of the palms and soles is a rare dermatosis presenting as multiple tiny keratotic plugs on the palms and soles. There are two different forms of spiny keratoderma of the palms and soles - the hereditary form and the acquired form. The latter is usually associated with internal malignancies or systemic disease. Since spiny hyperkeratosis of the palms and soles has been under-reported and under-diagnosed, it is important for dermatologists not to forget this disease in daily practice. We report this rare disease for the first time in the German literature.
CHILD syndrome (congenital hemidysplasia with ichthyosiform nevus and limb defects) occurs, as a ... more CHILD syndrome (congenital hemidysplasia with ichthyosiform nevus and limb defects) occurs, as a rule, exclusively in girls because the underlying X-linked gene exerts a lethal effect on male embryos. In this report the characteristic manifestations of CHILD syndrome are described in a 2-year-old boy with a normal chromosome constitution 46,XY. This exceptional case is best explained by the assumption of an early somatic mutation and thus compatible with the concept of X-linked dominant male-lethal inheritance of this trait.
ABSTRACT Atypical fibroxanthoma (AFX) is a rare, low-malignant, mesenchymal tumor of the dermis a... more ABSTRACT Atypical fibroxanthoma (AFX) is a rare, low-malignant, mesenchymal tumor of the dermis and is assigned to the group of fibrohistiocytic tumors. The tumor occurs especially in photodamaged skin on the scalp of elderly men. A clinical diagnosis is not possible due to a multitude of possible differential diagnoses (leiomyosarcoma, squamous cell carcinoma, spindle cell malignant melanoma, dermatofibrosarcoma protuberans). Immunohistochemical and histological examinations should be performed to confirm the diagnosis. The tumor shows a very good prognosis after complete excision. Micrographically controlled surgery is considered as the treatment of choice.
Verhandlungen der Deutschen Gesellschaft für Pathologie, 1996
Subepidermal bullous dermatoses are a heterogenous group of disorders characterized by loss of ti... more Subepidermal bullous dermatoses are a heterogenous group of disorders characterized by loss of tissue adhesion in the dermoepidermal junction and formation of a vesicle or bulla in the lamina lucida or under the lamina densa. These diseases can be classified into the following: 1. Subepidermal autoimmune bullous dermatoses. These are characterized by circulating autoantibodies against normal constituents of the basement membrane zone and include the following: Epidermolysis bullosa acquisita, bullous pemphigoid, dermatitis herpetiformis Duhring, linear IgA disease, herpes gestationis, cicatricial pemphigoid and bullous systemic lupus erythematosis (SLE). II. Subepidermal bullous dermatoses, due to mutation of the basement membrane zone proteins. These are epidermolysis bullosa junctionalis and epidermolysis bullosa dystrophicans. III. Subepidermal bullous dermatoses due to metabolic disorders: Porphyria cutanea tarda (PCT). IV. Drug induced Lyell-Syndrome Due to space limitation it ...
Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete, 1993
We describe a 54-year-old man with a polypoid melanoma. The tumour had developed within 1 year. P... more We describe a 54-year-old man with a polypoid melanoma. The tumour had developed within 1 year. Physical examination showed an eroded pedunculated nodule approximately 2.5 x 3 cm in size. Histopathology revealed a pedunculated, sharply demarcated tumour with an eroded surface; it was composed of atypical melanocytes in sheets and nests. Physical examination 11 months after excision of the tumor with 3-cm safety margin disclosed no evidence for enlarged lymph nodes or cutaneous metastases. No metastases were seen on computer tomography. To our knowledge, this patient represents the first case of polypoid melanoma reported in the German literature.
Background: Vertical tumor thickness according to Breslow and histological ulceration are still t... more Background: Vertical tumor thickness according to Breslow and histological ulceration are still the most powerful predictors for the clinical outcome of resectable cutaneous malignant melanoma (MM) without lymph node infiltration. It has been proposed that tumor volume in MM may also be of prognostic relevance. Methods: We retrospectively analyzed the prognostic impact of tumor volume and other established risk factors in 122 MM patients with a median follow-up period of 39.7 months. Results: We found the logarithmic tumor volume to be a better prognostic factor compared to Breslow tumor thickness in multivariate analysis. MM with a tumor volume below a threshold of 140 mm3 had a significantly higher relapse-free survival after 5 years of 98% compared to 47% in larger MMs (p < 0.0001). Conclusion: In some melanomas with a low tumor thickness, a higher tumor volume appeared to be linked to a higher risk of disease recurrence. Inclusion of tumor volume into the risk assessment of r...
Zusammenfassung Das Merkel-Zell-Karzinom (kutanes neuroendokrines Karzinom) ist ein seltener, h... more Zusammenfassung Das Merkel-Zell-Karzinom (kutanes neuroendokrines Karzinom) ist ein seltener, hochgradig maligner, neuroendokriner Hauttumor. Es entwickelt sich im typischen Fall als derber, schnell wachsender, mit der Dermis verbundener Knoten, der histologisch durch monomorphe runde Zellen mit schmalem Zytoplasmasaum und Kernatypien gekennzeichnet ist. Die Tumorzellen exprimieren die Zytokeratine 8, 18, 19, 20, Neurofilament, Synaptophysin, Chromogranin und neuronenspezifische Enolase. Der Erkrankungsverlauf ist durch
Multinucleate cell angiohistiocytoma is a rare, benign, usually asymptomatic fibrohistiocytic and... more Multinucleate cell angiohistiocytoma is a rare, benign, usually asymptomatic fibrohistiocytic and vascular proliferation which occurs predominantly on the extremities of middle-aged women. Histology shows characteristic multinucleate cells and is indispensable for diagnosis. We present a 42-year-old man from Egypt who was diagnosed with multinucleate cell angiohistiocytoma on the left cheek. As no malignant transformation has been reported, with the patient&#39;s agreement, no treatment was performed.
A 69-year-old man presented with multiple recurrent oral ulcerations for about 20 years. After he... more A 69-year-old man presented with multiple recurrent oral ulcerations for about 20 years. After he began having difficulty in breathing and swallowing, esophagogastroscopy was performed and showed ulcerations, erosions and scars on the mucous membrane of the pharynx as well of the esophagus. Linear IgA disease (LAD) was diagnosed based on histopathological and immunofluorescence examinations. In this patient with LAD, the buccal, pharyngeal and esophageal mucosa was affected without involvement of the skin.
Spiny hyperkeratosis of the palms and soles is a rare dermatosis presenting as multiple tiny kera... more Spiny hyperkeratosis of the palms and soles is a rare dermatosis presenting as multiple tiny keratotic plugs on the palms and soles. There are two different forms of spiny keratoderma of the palms and soles - the hereditary form and the acquired form. The latter is usually associated with internal malignancies or systemic disease. Since spiny hyperkeratosis of the palms and soles has been under-reported and under-diagnosed, it is important for dermatologists not to forget this disease in daily practice. We report this rare disease for the first time in the German literature.
CHILD syndrome (congenital hemidysplasia with ichthyosiform nevus and limb defects) occurs, as a ... more CHILD syndrome (congenital hemidysplasia with ichthyosiform nevus and limb defects) occurs, as a rule, exclusively in girls because the underlying X-linked gene exerts a lethal effect on male embryos. In this report the characteristic manifestations of CHILD syndrome are described in a 2-year-old boy with a normal chromosome constitution 46,XY. This exceptional case is best explained by the assumption of an early somatic mutation and thus compatible with the concept of X-linked dominant male-lethal inheritance of this trait.
ABSTRACT Atypical fibroxanthoma (AFX) is a rare, low-malignant, mesenchymal tumor of the dermis a... more ABSTRACT Atypical fibroxanthoma (AFX) is a rare, low-malignant, mesenchymal tumor of the dermis and is assigned to the group of fibrohistiocytic tumors. The tumor occurs especially in photodamaged skin on the scalp of elderly men. A clinical diagnosis is not possible due to a multitude of possible differential diagnoses (leiomyosarcoma, squamous cell carcinoma, spindle cell malignant melanoma, dermatofibrosarcoma protuberans). Immunohistochemical and histological examinations should be performed to confirm the diagnosis. The tumor shows a very good prognosis after complete excision. Micrographically controlled surgery is considered as the treatment of choice.
Verhandlungen der Deutschen Gesellschaft für Pathologie, 1996
Subepidermal bullous dermatoses are a heterogenous group of disorders characterized by loss of ti... more Subepidermal bullous dermatoses are a heterogenous group of disorders characterized by loss of tissue adhesion in the dermoepidermal junction and formation of a vesicle or bulla in the lamina lucida or under the lamina densa. These diseases can be classified into the following: 1. Subepidermal autoimmune bullous dermatoses. These are characterized by circulating autoantibodies against normal constituents of the basement membrane zone and include the following: Epidermolysis bullosa acquisita, bullous pemphigoid, dermatitis herpetiformis Duhring, linear IgA disease, herpes gestationis, cicatricial pemphigoid and bullous systemic lupus erythematosis (SLE). II. Subepidermal bullous dermatoses, due to mutation of the basement membrane zone proteins. These are epidermolysis bullosa junctionalis and epidermolysis bullosa dystrophicans. III. Subepidermal bullous dermatoses due to metabolic disorders: Porphyria cutanea tarda (PCT). IV. Drug induced Lyell-Syndrome Due to space limitation it ...
Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete, 1993
We describe a 54-year-old man with a polypoid melanoma. The tumour had developed within 1 year. P... more We describe a 54-year-old man with a polypoid melanoma. The tumour had developed within 1 year. Physical examination showed an eroded pedunculated nodule approximately 2.5 x 3 cm in size. Histopathology revealed a pedunculated, sharply demarcated tumour with an eroded surface; it was composed of atypical melanocytes in sheets and nests. Physical examination 11 months after excision of the tumor with 3-cm safety margin disclosed no evidence for enlarged lymph nodes or cutaneous metastases. No metastases were seen on computer tomography. To our knowledge, this patient represents the first case of polypoid melanoma reported in the German literature.
Background: Vertical tumor thickness according to Breslow and histological ulceration are still t... more Background: Vertical tumor thickness according to Breslow and histological ulceration are still the most powerful predictors for the clinical outcome of resectable cutaneous malignant melanoma (MM) without lymph node infiltration. It has been proposed that tumor volume in MM may also be of prognostic relevance. Methods: We retrospectively analyzed the prognostic impact of tumor volume and other established risk factors in 122 MM patients with a median follow-up period of 39.7 months. Results: We found the logarithmic tumor volume to be a better prognostic factor compared to Breslow tumor thickness in multivariate analysis. MM with a tumor volume below a threshold of 140 mm3 had a significantly higher relapse-free survival after 5 years of 98% compared to 47% in larger MMs (p < 0.0001). Conclusion: In some melanomas with a low tumor thickness, a higher tumor volume appeared to be linked to a higher risk of disease recurrence. Inclusion of tumor volume into the risk assessment of r...
Zusammenfassung Das Merkel-Zell-Karzinom (kutanes neuroendokrines Karzinom) ist ein seltener, h... more Zusammenfassung Das Merkel-Zell-Karzinom (kutanes neuroendokrines Karzinom) ist ein seltener, hochgradig maligner, neuroendokriner Hauttumor. Es entwickelt sich im typischen Fall als derber, schnell wachsender, mit der Dermis verbundener Knoten, der histologisch durch monomorphe runde Zellen mit schmalem Zytoplasmasaum und Kernatypien gekennzeichnet ist. Die Tumorzellen exprimieren die Zytokeratine 8, 18, 19, 20, Neurofilament, Synaptophysin, Chromogranin und neuronenspezifische Enolase. Der Erkrankungsverlauf ist durch
Multinucleate cell angiohistiocytoma is a rare, benign, usually asymptomatic fibrohistiocytic and... more Multinucleate cell angiohistiocytoma is a rare, benign, usually asymptomatic fibrohistiocytic and vascular proliferation which occurs predominantly on the extremities of middle-aged women. Histology shows characteristic multinucleate cells and is indispensable for diagnosis. We present a 42-year-old man from Egypt who was diagnosed with multinucleate cell angiohistiocytoma on the left cheek. As no malignant transformation has been reported, with the patient&#39;s agreement, no treatment was performed.
A 69-year-old man presented with multiple recurrent oral ulcerations for about 20 years. After he... more A 69-year-old man presented with multiple recurrent oral ulcerations for about 20 years. After he began having difficulty in breathing and swallowing, esophagogastroscopy was performed and showed ulcerations, erosions and scars on the mucous membrane of the pharynx as well of the esophagus. Linear IgA disease (LAD) was diagnosed based on histopathological and immunofluorescence examinations. In this patient with LAD, the buccal, pharyngeal and esophageal mucosa was affected without involvement of the skin.
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Papers by Prof. Dr. med. Mosaad Megahed