IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2021
Low-intensity pulsed ultrasound (LIPUS) accelerates fracture healing by stimulating the productio... more Low-intensity pulsed ultrasound (LIPUS) accelerates fracture healing by stimulating the production of bone callus and the mineralization process. This study compared a novel bimodal acoustic signal (BMAS) device for bone fracture healing to a clinical LIPUS system (EXOGEN; Bioventus, Durham, NC, USA). Thirty rabbits underwent a bilateral fibular osteotomy. Each rabbits’ legs were randomized to receive 20-min treatment daily for 18 days with BMAS or LIPUS. The latter utilizes a longitudinal ultrasonic mode only, while the former employs ultrasound-induced shear stress to promote bone formation. Power Doppler imaging (PDI) was acquired days 0, 2, 4, 7, 11, 14, and 18 post-surgery to monitor treatment response and quantified off-line. X-rays were acquired to evaluate fractures on days 0, 14, 18, and 21. Seventeen rabbits completed the study and were euthanized day 21 post-surgery. The fibulae were analyzed to determine maximum torque, initial torsional stiffness, and angular displacement at failure. ANOVAs and paired t-tests were used to compare pair-wise outcome variables for the two treatment modes on a per rabbit basis. The BMAS system induced better fracture healing with greater stiffness (BMAS 0.21 ± 0.19 versus LIPUS 0.16 ± 0.19 <inline-formula> <tex-math notation="LaTeX">$\text{N}\cdot $ </tex-math></inline-formula>cm/°, <inline-formula> <tex-math notation="LaTeX">${p} =0.050$ </tex-math></inline-formula>) and maximum torque (BMAS 7.84 ± 5.55 versus LIPUS 6.26 ± 3.46 <inline-formula> <tex-math notation="LaTeX">$\text{N}\cdot $ </tex-math></inline-formula>cm, <inline-formula> <tex-math notation="LaTeX">${p} =0.022$ </tex-math></inline-formula>) than the LIPUS system. Quantitative PDI assessments showed a higher amount of vascularity with LIPUS than BMAS on days 4 and 18 (<inline-formula> <tex-math notation="LaTeX">${p} < 0.04$ </tex-math></inline-formula>). In conclusion, the novel BMAS technique achieved better bone fracture healing response than the current Food and Drug Administration (FDA)-approved LIPUS system.
The Journal of Therapeutic Ultrasound has been established to provide an open access, online venu... more The Journal of Therapeutic Ultrasound has been established to provide an open access, online venue for the exponentially growing body of work in biomedical ultrasound therapy.
Ultrasound (US) accelerates healing by stimulating the production of bone callus and the process ... more Ultrasound (US) accelerates healing by stimulating the production of bone callus and the process of mineralization. A US system (EXOGEN; Bioventus, Durham, NC, USA) using low intensity pulsed ultrasound (LIPUS) and this principle is FDA-approved. This study analyzed the effectiveness of a novel bimodal acoustic signal (BMAS) for bone fracture healing compared to the clinically used LIPUS system in an animal model. Seventeen mature white New Zealand female rabbits, underwent a bilateral fibula osteotomy as part of an IACUC-approved protocol. Afterwards, each rabbits’ legs were randomized to receive 20 minutes treatment daily for 18 days with BMAS or EXOGEN. The latter utilizes a longitudinal ultrasonic mode only, while the former employs US-induced shear stress to promote bone formation. Power Doppler imaging (PDI) was acquired days 0, 2, 4, 7, 11, 14 and 18 post-surgery to monitor treatment response and local inflammation. Images were analyzed off-line using ImageJ (NIH, Bethesda, M...
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2021
Low-intensity pulsed ultrasound (LIPUS) accelerates fracture healing by stimulating the productio... more Low-intensity pulsed ultrasound (LIPUS) accelerates fracture healing by stimulating the production of bone callus and the mineralization process. This study compared a novel bimodal acoustic signal (BMAS) device for bone fracture healing to a clinical LIPUS system (EXOGEN; Bioventus, Durham, NC, USA). Thirty rabbits underwent a bilateral fibular osteotomy. Each rabbits’ legs were randomized to receive 20-min treatment daily for 18 days with BMAS or LIPUS. The latter utilizes a longitudinal ultrasonic mode only, while the former employs ultrasound-induced shear stress to promote bone formation. Power Doppler imaging (PDI) was acquired days 0, 2, 4, 7, 11, 14, and 18 post-surgery to monitor treatment response and quantified off-line. X-rays were acquired to evaluate fractures on days 0, 14, 18, and 21. Seventeen rabbits completed the study and were euthanized day 21 post-surgery. The fibulae were analyzed to determine maximum torque, initial torsional stiffness, and angular displacement at failure. ANOVAs and paired t-tests were used to compare pair-wise outcome variables for the two treatment modes on a per rabbit basis. The BMAS system induced better fracture healing with greater stiffness (BMAS 0.21 ± 0.19 versus LIPUS 0.16 ± 0.19 <inline-formula> <tex-math notation="LaTeX">$\text{N}\cdot $ </tex-math></inline-formula>cm/°, <inline-formula> <tex-math notation="LaTeX">${p} =0.050$ </tex-math></inline-formula>) and maximum torque (BMAS 7.84 ± 5.55 versus LIPUS 6.26 ± 3.46 <inline-formula> <tex-math notation="LaTeX">$\text{N}\cdot $ </tex-math></inline-formula>cm, <inline-formula> <tex-math notation="LaTeX">${p} =0.022$ </tex-math></inline-formula>) than the LIPUS system. Quantitative PDI assessments showed a higher amount of vascularity with LIPUS than BMAS on days 4 and 18 (<inline-formula> <tex-math notation="LaTeX">${p} < 0.04$ </tex-math></inline-formula>). In conclusion, the novel BMAS technique achieved better bone fracture healing response than the current Food and Drug Administration (FDA)-approved LIPUS system.
The Journal of Therapeutic Ultrasound has been established to provide an open access, online venu... more The Journal of Therapeutic Ultrasound has been established to provide an open access, online venue for the exponentially growing body of work in biomedical ultrasound therapy.
Ultrasound (US) accelerates healing by stimulating the production of bone callus and the process ... more Ultrasound (US) accelerates healing by stimulating the production of bone callus and the process of mineralization. A US system (EXOGEN; Bioventus, Durham, NC, USA) using low intensity pulsed ultrasound (LIPUS) and this principle is FDA-approved. This study analyzed the effectiveness of a novel bimodal acoustic signal (BMAS) for bone fracture healing compared to the clinically used LIPUS system in an animal model. Seventeen mature white New Zealand female rabbits, underwent a bilateral fibula osteotomy as part of an IACUC-approved protocol. Afterwards, each rabbits’ legs were randomized to receive 20 minutes treatment daily for 18 days with BMAS or EXOGEN. The latter utilizes a longitudinal ultrasonic mode only, while the former employs US-induced shear stress to promote bone formation. Power Doppler imaging (PDI) was acquired days 0, 2, 4, 7, 11, 14 and 18 post-surgery to monitor treatment response and local inflammation. Images were analyzed off-line using ImageJ (NIH, Bethesda, M...
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Papers by Robert Muratore