Journal of Indian Academy of Forensic Medicine, 2015
Holoprosencephaly with Synophthalmia is a rare congenital developmental disorder which was diagno... more Holoprosencephaly with Synophthalmia is a rare congenital developmental disorder which was diagnosed by perinatal autopsy. This case report presents a detailed gross and histologic examination of eyes and brain of a baby with synophthalmia. Incidence of synophthalmia is 1 in 16000 born animal and 1 in 25000 that end in miscarriage. (Tabers cyclopedic medical Dictionary ISBNO-8036-O654-O) A 24 years primi presented with IUD at 29 weeks of her gestation. On internal examination forebrain failed to separate and, had cyclopia (Single Eye) and nose in the form of proboscis (Tubular appendage). Histopathological examination confirmed eye ball structure. Final autopsy diagnosis was Holoprosencephaly with Synophthalmia. Genetic cause and toxin can interfere with embryonic forebrain dividing process. One highly teratogenic substance is Cyclopamine (Teratology Society). Cause of death identified as multiple congenital anomalies. Karyotyping was indicated but not feasible due to delayed autopsy. This case presented here not only of its rarity but also rarity of its diagnosis by perinatal autopsy. Legal and ethical constrains need to be addressed carefully otherwise perinatal autopsy which is gold standard in diagnosing perinatal death will be a dying art.
Introduction: Fine-needle aspiration cytology (FNAC) is a simple, safe, and effective tool for cy... more Introduction: Fine-needle aspiration cytology (FNAC) is a simple, safe, and effective tool for cytological diagnosis of different neoplastic lesions. Computed tomography (CT)-guided core biopsy is also essential for tissue diagnosis. Aims and Objectives: The aim of this study is to assess the diagnostic value and limitations of fine-needle aspiration and core biopsy in diagnosis of intrathoracic lesions; we have done this retrospective study. Materials and Methods: In all 54 cases with mean age of 57.37 years, CT-guided FNAC and core biopsy were performed on same sittings. 20–22 G Chiba needle was used for FNAC, and core biopsy was performed by 18–20 G coaxial automated cutting needle. The cytological and histological evaluations were done in our cytology and histopathology laboratory. Complications were managed by pulmonologists. Results: On the evaluation of FNAC smears, diagnosis was done in 44 cases and 10 cases were inconclusive. In core biopsy, five cases were inconclusive. Most of the tumors were of epithelial origin (43 cases, 87.75%) and 95.59% cases were malignant in our series. Sensitivity and diagnostic accuracy of core biopsy (90.38% and 90.74, respectively) were higher than FNAC (84.62% and 85.18%, respectively). Conclusion: CT-guided core biopsy was more effective and accurate in diagnosis and tumor classification than FNAC in spite of higher complication rate.
Context (Background): Fungal infections also known as mycosis have a worldwide distribution. Thes... more Context (Background): Fungal infections also known as mycosis have a worldwide distribution. These are commonly seen in immunocompromised patients and in immunocompetent patients with history of trauma. Fungal infections are traditionally divided into supercial, subcutaneous, and systemic infection basing on the body part affected. Due to tropical climate Asia has high incidence of fungal infections. The aim of this study was to analyze of the clinicopathological Aims: characteristics of various fungal infections basing on their histomorphological features and their distribution according to age, sex & site of involvement. This was a retrospective study Settings and Design: done over a period of 4 years at a tertiary hospital. In this study we have analyzed spectrum of fun Materials And Methods: gal infections in a tertiary care hospital basing on histomorphological characteristics. All the surgical specimens received were examined grossly, sections taken and histological slides we...
Filariasis is a major health problem in India. Despite the high prevalence, microfilariae are rar... more Filariasis is a major health problem in India. Despite the high prevalence, microfilariae are rarely found in cytology smears. Most of the cases are incidentally found, solely or in association with other pathologies. The study was undertaken to analyze the prevalence and cytology findings of cases of incidentally found microfilariae in cytology smears (fine-needle aspiration cytology [FNAC]/body fluids) from different body parts. This was a retrospective study over 5 years, where the cases of microfilariae in aspirates from swelling of different locations and body fluids were reviewed, and clinic-pathological data were analyzed. Out of 16,738 cases of FNAC and 882 cases of fluid cytology, 22 cases (0.124%) of incidental finding of microfilaria were documented in cytology smears. The cases were diagnosed from lymph nodes (5 cases), skin and soft tissue (4 cases), scrotal (4 cases), breast (3 cases), thyroid (2 cases), and pleural fluid (2 cases). We found eosinophilia in 15 cases (6...
Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology
Rhabdoid meningioma is a rare aggressive variant of meningioma, regarded as WHO Grade III type. H... more Rhabdoid meningioma is a rare aggressive variant of meningioma, regarded as WHO Grade III type. Histologically and cytologically, it is distinctive type having abundant eosinophilic cytoplasm, cytoplasmic inclusion with eccentrically placed vesicular nuclei and prominent nucleoli. High recurrence rate and poor outcome are important features. Here, we are presenting a rare case of rhabdoid meningioma found in a recurrent meningioma of the posterior fossa in a middle-aged female. We emphasized the squash cytology and histology finding of the rare neoplasm.
Indian Journal of Dermatopathology and Diagnostic Dermatology, 2017
Primary mucinous eccrine carcinoma is a rare low-grade malignancy of sweat gland. Axilla is an un... more Primary mucinous eccrine carcinoma is a rare low-grade malignancy of sweat gland. Axilla is an uncommon site of this tumor. Primary mucinous carcinoma mimics metastatic mucinous carcinoma from breast, gastrointestinal tract, lung, and ovary. Histopathology with immunohistochemistry and other ancillary investigations are necessary to confirm the diagnosis and to exclude metastatic mucinous carcinoma. We present a rare case of primary mucinous carcinoma of axillary skin in an elderly male patient, diagnosed by histopathology and immunohistochemistry.
Primary intracranial malignant melanoma is a very rare tumor, and most of the central nervous sys... more Primary intracranial malignant melanoma is a very rare tumor, and most of the central nervous system melanomas are metastatic diseases. Diagnosis needs extensive dermatological, opthalmological, and radiological workup to exclude metastatic melanoma. Histologically, it should be differentiate from benign melanocytic lesions, pigmented choroid plexus carcinoma, and pigmented papillary medulloblastoma. Here, we are reporting a case of primary malignant melanoma of posterior fossa in an adolescent girl diagnosed in squash cytology as well as in histology and confirmed by immunohistochemistry and by excluding metastatic melanoma.
Journal of Indian Academy of Forensic Medicine, 2015
Holoprosencephaly with Synophthalmia is a rare congenital developmental disorder which was diagno... more Holoprosencephaly with Synophthalmia is a rare congenital developmental disorder which was diagnosed by perinatal autopsy. This case report presents a detailed gross and histologic examination of eyes and brain of a baby with synophthalmia. Incidence of synophthalmia is 1 in 16000 born animal and 1 in 25000 that end in miscarriage. (Tabers cyclopedic medical Dictionary ISBNO-8036-O654-O) A 24 years primi presented with IUD at 29 weeks of her gestation. On internal examination forebrain failed to separate and, had cyclopia (Single Eye) and nose in the form of proboscis (Tubular appendage). Histopathological examination confirmed eye ball structure. Final autopsy diagnosis was Holoprosencephaly with Synophthalmia. Genetic cause and toxin can interfere with embryonic forebrain dividing process. One highly teratogenic substance is Cyclopamine (Teratology Society). Cause of death identified as multiple congenital anomalies. Karyotyping was indicated but not feasible due to delayed autopsy. This case presented here not only of its rarity but also rarity of its diagnosis by perinatal autopsy. Legal and ethical constrains need to be addressed carefully otherwise perinatal autopsy which is gold standard in diagnosing perinatal death will be a dying art.
Introduction: Fine-needle aspiration cytology (FNAC) is a simple, safe, and effective tool for cy... more Introduction: Fine-needle aspiration cytology (FNAC) is a simple, safe, and effective tool for cytological diagnosis of different neoplastic lesions. Computed tomography (CT)-guided core biopsy is also essential for tissue diagnosis. Aims and Objectives: The aim of this study is to assess the diagnostic value and limitations of fine-needle aspiration and core biopsy in diagnosis of intrathoracic lesions; we have done this retrospective study. Materials and Methods: In all 54 cases with mean age of 57.37 years, CT-guided FNAC and core biopsy were performed on same sittings. 20–22 G Chiba needle was used for FNAC, and core biopsy was performed by 18–20 G coaxial automated cutting needle. The cytological and histological evaluations were done in our cytology and histopathology laboratory. Complications were managed by pulmonologists. Results: On the evaluation of FNAC smears, diagnosis was done in 44 cases and 10 cases were inconclusive. In core biopsy, five cases were inconclusive. Most of the tumors were of epithelial origin (43 cases, 87.75%) and 95.59% cases were malignant in our series. Sensitivity and diagnostic accuracy of core biopsy (90.38% and 90.74, respectively) were higher than FNAC (84.62% and 85.18%, respectively). Conclusion: CT-guided core biopsy was more effective and accurate in diagnosis and tumor classification than FNAC in spite of higher complication rate.
Context (Background): Fungal infections also known as mycosis have a worldwide distribution. Thes... more Context (Background): Fungal infections also known as mycosis have a worldwide distribution. These are commonly seen in immunocompromised patients and in immunocompetent patients with history of trauma. Fungal infections are traditionally divided into supercial, subcutaneous, and systemic infection basing on the body part affected. Due to tropical climate Asia has high incidence of fungal infections. The aim of this study was to analyze of the clinicopathological Aims: characteristics of various fungal infections basing on their histomorphological features and their distribution according to age, sex & site of involvement. This was a retrospective study Settings and Design: done over a period of 4 years at a tertiary hospital. In this study we have analyzed spectrum of fun Materials And Methods: gal infections in a tertiary care hospital basing on histomorphological characteristics. All the surgical specimens received were examined grossly, sections taken and histological slides we...
Filariasis is a major health problem in India. Despite the high prevalence, microfilariae are rar... more Filariasis is a major health problem in India. Despite the high prevalence, microfilariae are rarely found in cytology smears. Most of the cases are incidentally found, solely or in association with other pathologies. The study was undertaken to analyze the prevalence and cytology findings of cases of incidentally found microfilariae in cytology smears (fine-needle aspiration cytology [FNAC]/body fluids) from different body parts. This was a retrospective study over 5 years, where the cases of microfilariae in aspirates from swelling of different locations and body fluids were reviewed, and clinic-pathological data were analyzed. Out of 16,738 cases of FNAC and 882 cases of fluid cytology, 22 cases (0.124%) of incidental finding of microfilaria were documented in cytology smears. The cases were diagnosed from lymph nodes (5 cases), skin and soft tissue (4 cases), scrotal (4 cases), breast (3 cases), thyroid (2 cases), and pleural fluid (2 cases). We found eosinophilia in 15 cases (6...
Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology
Rhabdoid meningioma is a rare aggressive variant of meningioma, regarded as WHO Grade III type. H... more Rhabdoid meningioma is a rare aggressive variant of meningioma, regarded as WHO Grade III type. Histologically and cytologically, it is distinctive type having abundant eosinophilic cytoplasm, cytoplasmic inclusion with eccentrically placed vesicular nuclei and prominent nucleoli. High recurrence rate and poor outcome are important features. Here, we are presenting a rare case of rhabdoid meningioma found in a recurrent meningioma of the posterior fossa in a middle-aged female. We emphasized the squash cytology and histology finding of the rare neoplasm.
Indian Journal of Dermatopathology and Diagnostic Dermatology, 2017
Primary mucinous eccrine carcinoma is a rare low-grade malignancy of sweat gland. Axilla is an un... more Primary mucinous eccrine carcinoma is a rare low-grade malignancy of sweat gland. Axilla is an uncommon site of this tumor. Primary mucinous carcinoma mimics metastatic mucinous carcinoma from breast, gastrointestinal tract, lung, and ovary. Histopathology with immunohistochemistry and other ancillary investigations are necessary to confirm the diagnosis and to exclude metastatic mucinous carcinoma. We present a rare case of primary mucinous carcinoma of axillary skin in an elderly male patient, diagnosed by histopathology and immunohistochemistry.
Primary intracranial malignant melanoma is a very rare tumor, and most of the central nervous sys... more Primary intracranial malignant melanoma is a very rare tumor, and most of the central nervous system melanomas are metastatic diseases. Diagnosis needs extensive dermatological, opthalmological, and radiological workup to exclude metastatic melanoma. Histologically, it should be differentiate from benign melanocytic lesions, pigmented choroid plexus carcinoma, and pigmented papillary medulloblastoma. Here, we are reporting a case of primary malignant melanoma of posterior fossa in an adolescent girl diagnosed in squash cytology as well as in histology and confirmed by immunohistochemistry and by excluding metastatic melanoma.
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