Tropical gastroenterology: official journal of the Digestive Diseases Foundation
Introduction of 'silent' exocrine atrophy (and endocrine &amp... more Introduction of 'silent' exocrine atrophy (and endocrine 'enrichment') in pancreatic grafts following ductular blockade may have a role in human diabetes by circumventing currently elusive islet isolation/purification protocols. To explore this potential, pancreatic isografts were performed in 12 pairs of inbred Wistar NIN rats. Donor pancreatectomy was performed after distal clamping and canulation of common bile duct and injection of 0.5 ml. polyacrylamide gel (blocked n = 7) or normal saline (un-blocked n = 5) respectively. One to 2 m.m. fragments of the resulting mildly distended pancreases were transplanted in to 2 sites (renal capsule and iliac fossa subcutaneously) of cach recipient. Post-operative biopsies of the transplanted grafts (unilateral nephrectomy and iliac fossa biopsies) revealed macroscopic and microscopic evidence of necrotizing pancreatitis in both the groups at both the sites (histiocytic and giant cell infiltration, fat necrosis and focal calcification with destruction of exocrine and endocrine cells) as early as 1 and 3 weeks. Possible detrimental factors include: volume and pressure of ductal injection, graft sites (confined spaces), post-operative wound infection and bio-compatibility of the material used for ductular blockade.
Page 1. MJA Volume 185 Number 8 16 October 2006 417 edged and appreciated. (Received 9 Mar 20... more Page 1. MJA Volume 185 Number 8 16 October 2006 417 edged and appreciated. (Received 9 Mar 2006, accepted 13 Sep 2006) ❏ Locally acquired infection with Entamoeba histolytica in men who have sex with men in Australia ...
One hundred and thirty two cockroaches of species Blattella germanica--96 from hospital ward (tes... more One hundred and thirty two cockroaches of species Blattella germanica--96 from hospital ward (test group) and 36 from residential areas (control group) were caught during Nov. 1985 to Nov. 1986. A variety of pathogenic and non-pathogenic bacteria were isolated from test and control group of insects. Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus faecalis, and Micrococci were isolated only from the test group of cockroaches. A high percentage (98.95 per cent) of test cockroaches were found to be carriers of various microorganisms as compared to the control group (80.55 per cent), the difference being statistically significant (p less than 0.001). Quantitative analysis in this study revealed that higher number of microorganisms are carried by test group of insects in the hospital environment. This, thereby suggests that these insects can play an important role in the etiology of hospital acquired infections.
The American journal of tropical medicine and hygiene, 2007
A prospective, comparative study of the prevalence of enteric protozoa was determined among human... more A prospective, comparative study of the prevalence of enteric protozoa was determined among human immunodeficiency virus (HIV)- positive and HIV-negative men who have sex with men (MSM) in Sydney, Australia. A total of 1,868 patients submitted stool specimens; 1,246 were from MSM (628 HIV positive and 618 HIV positive) and 622 from non-MSM were examined over a 36-month period. A total of 651 (52.2%) stool specimens from MSM were positive for protozoa compared with 85 (13%) from non-MSM. There was a significant difference in the prevalence of Blastocystis hominis, Endolimax nana, Entamoeba histolytica/dispar complex, Entamoeba hartmanni, Iodamoeba butschlii, and Enteromonas hominis detected between MSM and non-MSM (P<0.001). The only notable difference between HIV-negative and HIV-positive MSM was that HIV-infected MSM were found to more likely have a Cryptosporidium parvum infection. Entamoeba histolytica was found in 3 patients, E. dispar in 25, and E. moshkovskii in 17, all of ...
Page 1. MJA Volume 185 Number 8 16 October 2006 417 edged and appreciated. (Received 9 Mar 20... more Page 1. MJA Volume 185 Number 8 16 October 2006 417 edged and appreciated. (Received 9 Mar 2006, accepted 13 Sep 2006) ❏ Locally acquired infection with Entamoeba histolytica in men who have sex with men in Australia ...
Orthovanadate-resistant mutants of diploid yeast Candida albicans were isolated by using two step... more Orthovanadate-resistant mutants of diploid yeast Candida albicans were isolated by using two step mutational process. Such mutants had altered plasma membrane H(+)-ATPase activity. Based on the levels of PM-ATPase activity, these mutants could be grouped into two categories; one group included those mutants which did not exhibit reduction in PM-ATPase activity while the other displayed a reduction of upto 40% in enzyme activity. These mutants exhibited a number of distinct phenotypic characteristics and altered abilities with regard to phenotypic divergence. Results demonstrate the importance of PM-ATPase in overall physiology of this pathogenic yeast.
The vector potential of houseflies (Musca domestica) for Klebsiella spp. was investigated. Klebsi... more The vector potential of houseflies (Musca domestica) for Klebsiella spp. was investigated. Klebsiella spp. (mostly Klebsiella pneumoniae) were isolated from 36.7% of hospital flies and 28.1% of infected wounds of patients. Antibiograms of Klebsiella spp. showed that 82.0% of isolates from hospital flies and 96.3% from infected wounds were resistant to four or more commonly used antimicrobials. In contrast, from the control group, only 8.7% klebsiella isolates showed similar antimicrobial resistance pattern (P less than 0.001). Similar strains of Klebsiella spp. were encountered among patients and hospital houseflies. The results indicate that flies in the hospital environs are potential vectors of hospital resistant strains of Klebsiella spp.
Annals of tropical medicine and parasitology, 1991
Soft tissue infestation by maggots of flies (myiasis) is a well-recognized complication of neglec... more Soft tissue infestation by maggots of flies (myiasis) is a well-recognized complication of neglected wounds. Mixed infestation by larvae of more than one species of fly is a rarity. We report, for the first time in India, one such case of cutaneous myiasis due to mixed infestation--in this instance by Chrysomya bezziana and Sarcophaga sp. in a drug addict.
A report on a patient with multiple myeloma, undergoing bone marrow transplant, who developed sys... more A report on a patient with multiple myeloma, undergoing bone marrow transplant, who developed systemic fungal infection due to Candida krusei after bone marrow transplantation. The subsequent appearance of Ketoconazole resistant C. krusei is probably the first report of its kind from India. The significance of the findings is discussed.
The possibility that hospital cockroaches may act as vectors of drug-resistant Klebsiella spp. wa... more The possibility that hospital cockroaches may act as vectors of drug-resistant Klebsiella spp. was investigated during Nov 1985 to April 1989, at the All India Institute of Medical Sciences (AIIMS) hospital. Klebsiella spp. (majority Klebsiella pneumoniae) were isolated from 28.3% of hospital cockroaches and 28.1% of infected wounds of patients. Most of Klebsiella isolates from patients (96.3%), and hospital cockroaches (85.9%) showed multiple drug resistance to four or more antimicrobials. Similar strains of Klebsiella spp. were encountered among patients and hospital cockroaches. These findings suggest that hospital cockroaches may act as vectors of drug-resistant Klebsiella spp. and may contribute to the epidemiology of nosocomial infections.
Survival time studies of Pseudomonas aeruginosa in cockroaches (Blattella germanica) were carried... more Survival time studies of Pseudomonas aeruginosa in cockroaches (Blattella germanica) were carried out under standard laboratory conditions. Cockroaches were fed with graded doses (10(2), 10(5) or 10(7) per insect) of P. aeruginosa. Depending on the excretion of P. aeruginosa the cockroaches were categorized as non-excretors, intermittent excretors or continuous excretors. When a dose of 10(2) P. aeruginosa was used all the insects were non-excretors but with doses of 10(5) or 10(7) per insect, P. aeruginosa multiplied in the gut of the cockroaches and was excreted for up to 114 days. The significance of these findings is discussed.
Tropical gastroenterology: official journal of the Digestive Diseases Foundation
Introduction of &amp;amp;#39;silent&amp;amp;#39; exocrine atrophy (and endocrine &amp... more Introduction of &amp;amp;#39;silent&amp;amp;#39; exocrine atrophy (and endocrine &amp;amp;#39;enrichment&amp;amp;#39;) in pancreatic grafts following ductular blockade may have a role in human diabetes by circumventing currently elusive islet isolation/purification protocols. To explore this potential, pancreatic isografts were performed in 12 pairs of inbred Wistar NIN rats. Donor pancreatectomy was performed after distal clamping and canulation of common bile duct and injection of 0.5 ml. polyacrylamide gel (blocked n = 7) or normal saline (un-blocked n = 5) respectively. One to 2 m.m. fragments of the resulting mildly distended pancreases were transplanted in to 2 sites (renal capsule and iliac fossa subcutaneously) of cach recipient. Post-operative biopsies of the transplanted grafts (unilateral nephrectomy and iliac fossa biopsies) revealed macroscopic and microscopic evidence of necrotizing pancreatitis in both the groups at both the sites (histiocytic and giant cell infiltration, fat necrosis and focal calcification with destruction of exocrine and endocrine cells) as early as 1 and 3 weeks. Possible detrimental factors include: volume and pressure of ductal injection, graft sites (confined spaces), post-operative wound infection and bio-compatibility of the material used for ductular blockade.
Page 1. MJA Volume 185 Number 8 16 October 2006 417 edged and appreciated. (Received 9 Mar 20... more Page 1. MJA Volume 185 Number 8 16 October 2006 417 edged and appreciated. (Received 9 Mar 2006, accepted 13 Sep 2006) ❏ Locally acquired infection with Entamoeba histolytica in men who have sex with men in Australia ...
One hundred and thirty two cockroaches of species Blattella germanica--96 from hospital ward (tes... more One hundred and thirty two cockroaches of species Blattella germanica--96 from hospital ward (test group) and 36 from residential areas (control group) were caught during Nov. 1985 to Nov. 1986. A variety of pathogenic and non-pathogenic bacteria were isolated from test and control group of insects. Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus faecalis, and Micrococci were isolated only from the test group of cockroaches. A high percentage (98.95 per cent) of test cockroaches were found to be carriers of various microorganisms as compared to the control group (80.55 per cent), the difference being statistically significant (p less than 0.001). Quantitative analysis in this study revealed that higher number of microorganisms are carried by test group of insects in the hospital environment. This, thereby suggests that these insects can play an important role in the etiology of hospital acquired infections.
The American journal of tropical medicine and hygiene, 2007
A prospective, comparative study of the prevalence of enteric protozoa was determined among human... more A prospective, comparative study of the prevalence of enteric protozoa was determined among human immunodeficiency virus (HIV)- positive and HIV-negative men who have sex with men (MSM) in Sydney, Australia. A total of 1,868 patients submitted stool specimens; 1,246 were from MSM (628 HIV positive and 618 HIV positive) and 622 from non-MSM were examined over a 36-month period. A total of 651 (52.2%) stool specimens from MSM were positive for protozoa compared with 85 (13%) from non-MSM. There was a significant difference in the prevalence of Blastocystis hominis, Endolimax nana, Entamoeba histolytica/dispar complex, Entamoeba hartmanni, Iodamoeba butschlii, and Enteromonas hominis detected between MSM and non-MSM (P<0.001). The only notable difference between HIV-negative and HIV-positive MSM was that HIV-infected MSM were found to more likely have a Cryptosporidium parvum infection. Entamoeba histolytica was found in 3 patients, E. dispar in 25, and E. moshkovskii in 17, all of ...
Page 1. MJA Volume 185 Number 8 16 October 2006 417 edged and appreciated. (Received 9 Mar 20... more Page 1. MJA Volume 185 Number 8 16 October 2006 417 edged and appreciated. (Received 9 Mar 2006, accepted 13 Sep 2006) ❏ Locally acquired infection with Entamoeba histolytica in men who have sex with men in Australia ...
Orthovanadate-resistant mutants of diploid yeast Candida albicans were isolated by using two step... more Orthovanadate-resistant mutants of diploid yeast Candida albicans were isolated by using two step mutational process. Such mutants had altered plasma membrane H(+)-ATPase activity. Based on the levels of PM-ATPase activity, these mutants could be grouped into two categories; one group included those mutants which did not exhibit reduction in PM-ATPase activity while the other displayed a reduction of upto 40% in enzyme activity. These mutants exhibited a number of distinct phenotypic characteristics and altered abilities with regard to phenotypic divergence. Results demonstrate the importance of PM-ATPase in overall physiology of this pathogenic yeast.
The vector potential of houseflies (Musca domestica) for Klebsiella spp. was investigated. Klebsi... more The vector potential of houseflies (Musca domestica) for Klebsiella spp. was investigated. Klebsiella spp. (mostly Klebsiella pneumoniae) were isolated from 36.7% of hospital flies and 28.1% of infected wounds of patients. Antibiograms of Klebsiella spp. showed that 82.0% of isolates from hospital flies and 96.3% from infected wounds were resistant to four or more commonly used antimicrobials. In contrast, from the control group, only 8.7% klebsiella isolates showed similar antimicrobial resistance pattern (P less than 0.001). Similar strains of Klebsiella spp. were encountered among patients and hospital houseflies. The results indicate that flies in the hospital environs are potential vectors of hospital resistant strains of Klebsiella spp.
Annals of tropical medicine and parasitology, 1991
Soft tissue infestation by maggots of flies (myiasis) is a well-recognized complication of neglec... more Soft tissue infestation by maggots of flies (myiasis) is a well-recognized complication of neglected wounds. Mixed infestation by larvae of more than one species of fly is a rarity. We report, for the first time in India, one such case of cutaneous myiasis due to mixed infestation--in this instance by Chrysomya bezziana and Sarcophaga sp. in a drug addict.
A report on a patient with multiple myeloma, undergoing bone marrow transplant, who developed sys... more A report on a patient with multiple myeloma, undergoing bone marrow transplant, who developed systemic fungal infection due to Candida krusei after bone marrow transplantation. The subsequent appearance of Ketoconazole resistant C. krusei is probably the first report of its kind from India. The significance of the findings is discussed.
The possibility that hospital cockroaches may act as vectors of drug-resistant Klebsiella spp. wa... more The possibility that hospital cockroaches may act as vectors of drug-resistant Klebsiella spp. was investigated during Nov 1985 to April 1989, at the All India Institute of Medical Sciences (AIIMS) hospital. Klebsiella spp. (majority Klebsiella pneumoniae) were isolated from 28.3% of hospital cockroaches and 28.1% of infected wounds of patients. Most of Klebsiella isolates from patients (96.3%), and hospital cockroaches (85.9%) showed multiple drug resistance to four or more antimicrobials. Similar strains of Klebsiella spp. were encountered among patients and hospital cockroaches. These findings suggest that hospital cockroaches may act as vectors of drug-resistant Klebsiella spp. and may contribute to the epidemiology of nosocomial infections.
Survival time studies of Pseudomonas aeruginosa in cockroaches (Blattella germanica) were carried... more Survival time studies of Pseudomonas aeruginosa in cockroaches (Blattella germanica) were carried out under standard laboratory conditions. Cockroaches were fed with graded doses (10(2), 10(5) or 10(7) per insect) of P. aeruginosa. Depending on the excretion of P. aeruginosa the cockroaches were categorized as non-excretors, intermittent excretors or continuous excretors. When a dose of 10(2) P. aeruginosa was used all the insects were non-excretors but with doses of 10(5) or 10(7) per insect, P. aeruginosa multiplied in the gut of the cockroaches and was excreted for up to 114 days. The significance of these findings is discussed.
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