Although regulatory improvements for air quality in the European Union have been made, air pollut... more Although regulatory improvements for air quality in the European Union have been made, air pollution is still a pressing problem and, its impact on health, both mortality and morbidity, is a topic of intense research nowadays. The main goal of this work is to assess the impact of the exposure to air pollutants on the number of daily hospital admissions due to respiratory causes in 58 spatial locations of Portugal mainland, during the period 2005-2017. To this end, INteger Generalised AutoRegressive Conditional Heteroskedastic (INGARCH)-based models are extensively used. This family of models has proven to be very useful in the analysis of serially dependent count data. Such models include information on the past history of the time series, as well as the effect of external covariates. In particular, daily hospitalisation counts, air quality and temperature data are endowed within INGARCH models of optimal orders, where the automatic inclusion of the most significant covariates is ca...
The use of sprinkler irrigation for rice (Oryza sativa L.) crop is a relatively recent practice i... more The use of sprinkler irrigation for rice (Oryza sativa L.) crop is a relatively recent practice in Brazil. Therefore, crop soil and fertilization management are still not very well defined. Another problem is the inexistence of specific cultivars adapted to this cropping system. This study aimed to evaluate sprinkler-irrigated upland rice cultivars under different soil management practices and nitrogen sidedressing rates in relation to yield and grain quality. A randomized block design was used, arranged as a 3 x 3 x 5 factorial scheme, totaling 45 treatments consisting of the combination of three rice cultivars (Primavera, Confiança and Maravilha), three soil management systems (disk harrow + levelling harrow, moldboard plow + levelling harrow and no-till) and five nitrogen rates, applied as sidedressing (0, 25, 50, 75 and 100 kg ha-1), with four replicates. The experiment was set up during the 1999/2000 and 2000/2001 cropping seasons, in Selvíria, MS, Brazil, on a Typic Haplustox ...
In the last decades, the initial phase of the design process has been discussed from the point of... more In the last decades, the initial phase of the design process has been discussed from the point of view of the construction process economy contribution. In this sense, several authors highlight the decisions made at this stage as an impacting point of influence on the direct cost of the building. This concern is repeated in the cases investigated by the ZEMCH (Zero Energy Mass Custom Homes) group in Brazil, which is focused on social housing, consequently, cost becomes a fundamental factor that must be considered on these buildings’ life cycle. Furthermore, ZEMCH’s workshops in Brazil have characterized the initial phase of the design process as a process that requires speed and simultaneous control of a large amount of data by the designers. Over these perspectives, the objective of this work in progress is to verify the potential of a diagrammatic artifact as an intuitive tool of visualizing information and supporting decision making in the initial phase of the urban land subdivis...
A extensa variedade de medicamentos, a falta de conhecimento das suas propriedades, fácil acesso ... more A extensa variedade de medicamentos, a falta de conhecimento das suas propriedades, fácil acesso e seu uso excessivo podem causar danos à saúde, inclusive óbitos, representando um desafio para os serviços de saúde. O presente trabalho teve como objetivo analisar de forma retrospectiva o perfil epidemiológico das notificações de intoxicações agudas causadas por medicamentos ocorridas no Piauí, no período de 2007 até 2019. Trata-se de um estudo epidemiológico, descritivo, do tipo quantitativo, analisando o perfil epidemiológico das intoxicações medicamentosas notificadas no Piauí, no período de 2007 a 2019. Foram notificados 6.210 casos durante o período analisado, revelando-se 2019 como o ano de maior número de intoxicações por medicações em valores absolutos (17,74%). Com relação ao número de notificações na zona urbana (n=5.189) em que o gênero feminino é predominante (n= 4.433), prevalecendo às faixas etárias de 20-39 anos (n=2.510) e 15-19 anos (n=1.012). A tentativa de suicídio...
A procura de alternativas viáveis para reduzir o uso de fertilizantes tem crescido e a inoculação... more A procura de alternativas viáveis para reduzir o uso de fertilizantes tem crescido e a inoculação de sementes com Azospirillum brasilense pode suprir tal necessidade. Dessa forma o objetivo do trabalho foi avaliar o desempenho agronômico do milho, em função da inoculação das sementes com A. brasilense e das doses de nitrogênio em cobertura, em sistema plantio direto, nos anos agrícolas de 2010/11 e 2011/12 (primeira safra). Os experimentos foram conduzidos na área experimental da Faculdade de Engenharia de Ilha Solteira, localizada no município de Selvíria – MS, em LATOSSOLO VERMELHO Distrófico típico argiloso e com irrigação por aspersão. O delineamento experimental foi o de blocos casualizados dispostos em um esquema fatorial 5x2, com quatro repetições. Os tratamentos foram constituídos por cinco doses de nitrogênio em cobertura (0, 30, 60, 90 e 120 kg ha-1 de N), com ou sem inoculação de sementes com Azospirillum brasilense. Foram avaliados: população final de plantas, teor de N ...
Tree planting and natural regeneration are the main approaches to achieve global forest restorati... more Tree planting and natural regeneration are the main approaches to achieve global forest restoration targets, affecting multiple hydrological processes, such as infiltration of rainfall. Our understanding of the effect of land use history and vegetation on the recovery of water infiltration and soil attributes in both restoration strategies is limited. Therefore, we investigated the recovery of top-soil saturated soil hydraulic conductivity (Ks), soil physical and hydraulic properties in five land use types: (i) a secondary old-growth forest; (ii) a forest established through assisted passive restoration 11 years ago; (iii) an actively restored forest, with a more intensive land use history and 11 years of age; (iv) a pasture with low-intensity use; and (v) a pasture with high-intensity use, in the Brazilian Atlantic Forest. For these land use types, we determined the historical land use patterns and conducted soil sampling, using the Beerkan method to determine Ks values in the fiel...
Revista da Sociedade Brasileira de Medicina Tropical
Currently, there are no laboratory tests or sensitive and specific molecular markers for the earl... more Currently, there are no laboratory tests or sensitive and specific molecular markers for the early diagnosis of leprosy. The aim of this study was to analyze the clinical characteristics of patients with leprosy and investigate their immunological profile, comparing this with the type of lesion and the presence or absence of a Bacillus Calmette-Guérin (BCG) vaccination scar. Statistical analyzes were performed by employing comparative tests (Pearson´s chi-square) to evaluate the variables in different clinical forms, considering significance at the 5% level. The study identified a predominance of lepromatous leprosy (26.9%) in patients aged between 34-53 years. Caucasians predominantly had borderline tuberculoid (BT) clinical forms (42%); a predominance of males with borderline lepromatous (19%) and lepromatous leprosy (26.9%) forms was observed; and the presence of BCG vaccination scars (27.5%) and lower limb nerves were more affected (38%) predominantly in the BT clinical form. Si...
Mimetic seeds simulate the appearance of fleshy fruits and arilled seeds without producing nutrit... more Mimetic seeds simulate the appearance of fleshy fruits and arilled seeds without producing nutritive tissues as a reward for seed dispersers. In this strategy of seed dispersal, seeds may remain attached to the mother plant for long periods after maturity, increasing their availability to naïve seed dispersers. The hypothesis that seed coat impermeability in many tropical Fabaceae with mimetic seeds serves as an exaptation to protect the seeds from deterioration and rotting while awaiting dispersal was investigated. Seed coat impermeability was evaluated in five mimetic-seeded species of tropical Fabaceae in south-eastern Brazil (Abarema langsdorffii, Abrus precatorius, Adenanthera pavonina, Erythrina velutina and Ormosia arborea) and in Erythrina speciosa, a 'basal' species in its genus, which has monochromatic brown seeds and no mimetic displays. Seed hardness was evaluated as a defence against accelerated ageing (humid chamber at 41 degrees C for 144 h). Seed development ...
O conhecimento das plantas de uma região, sua época de florescimento e as características do póle... more O conhecimento das plantas de uma região, sua época de florescimento e as características do pólen, auxiliam na determinação das espécies vegetais que contribuem para a composição do mel. Durante o período de 1994 a 1997 foram inventariadas, semanalmente, em diferentes horários e num raio de aproximadamente 300m dos apiários da USP/ESALQ, em Piracicaba,SP (22°43'S, 47°27'W e 580 m) e do Instituto de Zootecnia, em Pindamonhangaba, SP (22°57'S, 45°27'W e 560 m), as plantas que estavam sendo visitadas por abelhas. Foram anotados o mês e o período de florescimento das plantas inventariadas. Em Piracicaba foram identificadas 94 espécies de plantas pertencentes a 41 famílias (maior número de espécies nas famílias Asteraceae e Myrtaceae) e em Pindamonhangaba, 76 espécies, pertencentes a 26 famílias (maior número de espécies nas famílias Asteraceae e Verbenaceae). Os resultados indicam que 21 famílias, 22 gêneros e 15 espécies de plantas visitadas pelas abelhas africanizadas...
Os fatores prognósticos histológicos podem colaborar para determinar a evolução desta neoplasia. ... more Os fatores prognósticos histológicos podem colaborar para determinar a evolução desta neoplasia. OBJETIVO: Correlacionar a expressão imunoistoquímica do p53 e Ki-67 com idade, grau histológico, comprometimento de linfonodos e estadiamento patológico de pacientes com carcinomas epidermóides de laringe. MÉTODO: Foram avaliados trinta casos consecutivos de carcinomas epidermóides de laringe, submetidos à técnica de imunoistoquímica para verificar a expressão dos anticorpos p53 e Ki-67. RESULTADO: A idade média foi de 56,2 anos e a imunoexpressão dos marcadores foi mais observada no grupo com mais de 50 anos de idade, especialmente a do anticorpo Ki-67 (p=0,032). Não houve relação do p53 e Ki-67 com o comprometimento de linfonodos. O Ki-67 se expressou em 70% nos casos de alto grau histológico e 80% nos de baixo, enquanto o p53 em 70% apenas nos de alto grau. O estadiamento patológico mostrou que no grupo dos carcinomas avançados a expressão do p53 foi de 61,5%, enquanto o Ki-67 mostrou...
International Journal of Entrepreneurship and Small Business, 2012
ABSTRACT The purpose of this paper is to provide an insight into entrepreneurial orientation, mar... more ABSTRACT The purpose of this paper is to provide an insight into entrepreneurial orientation, market orientation and internationalisation in born global small and micro-businesses in Ireland, when owner-manager perceptions are taken into account. Following an exploration of the major theoretical approaches of SME internationalisation and performance, and entrepreneurial/market orientations, a qualitative study is undertaken on owner-managers of four born global firms to present a conceptual model. Although there are a number of studies on born global firms and extensive research on entrepreneurial and market orientations, this study proposes to combine internationalisation and orientation approaches in studying small and micro-businesses. Future studies could empirically test the proposed new conceptual model within a large sample.
In Vitro Cellular & Developmental Biology - Animal, 2008
We are attempting to recreate a stretch reflex circuit on a patterned Bio-MEMS (bio-microelectrom... more We are attempting to recreate a stretch reflex circuit on a patterned Bio-MEMS (bio-microelectromechanical systems) chip with deflecting micro-cantilevers. The first steps to recreate this system is to be able to grow individual components of the circuit (sensory neuron, motoneuron, skeletal muscle, and muscle spindle) on a patternable, synthetic substrate coating the MEMS device. Sensory neurons represent the afferent portion of the stretch reflex arc and also play a significant role in transmitting the signal from the muscle spindle to the spinal cord motoneurons. We have utilized a synthetic silane substrate N-1[3-(trimethoxysilyl) propyl) diethylenetriamine (DETA) on which to grow and pattern the cells. DETA forms a self-assembled monolayer on a variety of silicon substrates, including glass, and can be patterned using photolithography. In this paper, we have evaluated the growth of sensory neurons on this synthetic silane substrate. We have investigated the immunocytochemical and electrophysiological properties of the sensory neurons on DETA and compared the resultant properties with a biological control substrate (ornithine/laminin). Immunocytochemical studies revealed the survival and growth of all three subtypes of sensory neurons: trkA, trkB, and trkC on both surfaces. Furthermore, whole-cell patch clamp recordings were used to study the electrophysiological properties of the sensory neurons on the two surfaces. There were no significant differences in the electrical properties of the neurons grown on either surface. This is the first study analyzing the immunocytochemical and electrophysiological properties of sensory neurons grown long-term in a completely defined environment and on a nonbiological substrate.
Although regulatory improvements for air quality in the European Union have been made, air pollut... more Although regulatory improvements for air quality in the European Union have been made, air pollution is still a pressing problem and, its impact on health, both mortality and morbidity, is a topic of intense research nowadays. The main goal of this work is to assess the impact of the exposure to air pollutants on the number of daily hospital admissions due to respiratory causes in 58 spatial locations of Portugal mainland, during the period 2005-2017. To this end, INteger Generalised AutoRegressive Conditional Heteroskedastic (INGARCH)-based models are extensively used. This family of models has proven to be very useful in the analysis of serially dependent count data. Such models include information on the past history of the time series, as well as the effect of external covariates. In particular, daily hospitalisation counts, air quality and temperature data are endowed within INGARCH models of optimal orders, where the automatic inclusion of the most significant covariates is ca...
The use of sprinkler irrigation for rice (Oryza sativa L.) crop is a relatively recent practice i... more The use of sprinkler irrigation for rice (Oryza sativa L.) crop is a relatively recent practice in Brazil. Therefore, crop soil and fertilization management are still not very well defined. Another problem is the inexistence of specific cultivars adapted to this cropping system. This study aimed to evaluate sprinkler-irrigated upland rice cultivars under different soil management practices and nitrogen sidedressing rates in relation to yield and grain quality. A randomized block design was used, arranged as a 3 x 3 x 5 factorial scheme, totaling 45 treatments consisting of the combination of three rice cultivars (Primavera, Confiança and Maravilha), three soil management systems (disk harrow + levelling harrow, moldboard plow + levelling harrow and no-till) and five nitrogen rates, applied as sidedressing (0, 25, 50, 75 and 100 kg ha-1), with four replicates. The experiment was set up during the 1999/2000 and 2000/2001 cropping seasons, in Selvíria, MS, Brazil, on a Typic Haplustox ...
In the last decades, the initial phase of the design process has been discussed from the point of... more In the last decades, the initial phase of the design process has been discussed from the point of view of the construction process economy contribution. In this sense, several authors highlight the decisions made at this stage as an impacting point of influence on the direct cost of the building. This concern is repeated in the cases investigated by the ZEMCH (Zero Energy Mass Custom Homes) group in Brazil, which is focused on social housing, consequently, cost becomes a fundamental factor that must be considered on these buildings’ life cycle. Furthermore, ZEMCH’s workshops in Brazil have characterized the initial phase of the design process as a process that requires speed and simultaneous control of a large amount of data by the designers. Over these perspectives, the objective of this work in progress is to verify the potential of a diagrammatic artifact as an intuitive tool of visualizing information and supporting decision making in the initial phase of the urban land subdivis...
A extensa variedade de medicamentos, a falta de conhecimento das suas propriedades, fácil acesso ... more A extensa variedade de medicamentos, a falta de conhecimento das suas propriedades, fácil acesso e seu uso excessivo podem causar danos à saúde, inclusive óbitos, representando um desafio para os serviços de saúde. O presente trabalho teve como objetivo analisar de forma retrospectiva o perfil epidemiológico das notificações de intoxicações agudas causadas por medicamentos ocorridas no Piauí, no período de 2007 até 2019. Trata-se de um estudo epidemiológico, descritivo, do tipo quantitativo, analisando o perfil epidemiológico das intoxicações medicamentosas notificadas no Piauí, no período de 2007 a 2019. Foram notificados 6.210 casos durante o período analisado, revelando-se 2019 como o ano de maior número de intoxicações por medicações em valores absolutos (17,74%). Com relação ao número de notificações na zona urbana (n=5.189) em que o gênero feminino é predominante (n= 4.433), prevalecendo às faixas etárias de 20-39 anos (n=2.510) e 15-19 anos (n=1.012). A tentativa de suicídio...
A procura de alternativas viáveis para reduzir o uso de fertilizantes tem crescido e a inoculação... more A procura de alternativas viáveis para reduzir o uso de fertilizantes tem crescido e a inoculação de sementes com Azospirillum brasilense pode suprir tal necessidade. Dessa forma o objetivo do trabalho foi avaliar o desempenho agronômico do milho, em função da inoculação das sementes com A. brasilense e das doses de nitrogênio em cobertura, em sistema plantio direto, nos anos agrícolas de 2010/11 e 2011/12 (primeira safra). Os experimentos foram conduzidos na área experimental da Faculdade de Engenharia de Ilha Solteira, localizada no município de Selvíria – MS, em LATOSSOLO VERMELHO Distrófico típico argiloso e com irrigação por aspersão. O delineamento experimental foi o de blocos casualizados dispostos em um esquema fatorial 5x2, com quatro repetições. Os tratamentos foram constituídos por cinco doses de nitrogênio em cobertura (0, 30, 60, 90 e 120 kg ha-1 de N), com ou sem inoculação de sementes com Azospirillum brasilense. Foram avaliados: população final de plantas, teor de N ...
Tree planting and natural regeneration are the main approaches to achieve global forest restorati... more Tree planting and natural regeneration are the main approaches to achieve global forest restoration targets, affecting multiple hydrological processes, such as infiltration of rainfall. Our understanding of the effect of land use history and vegetation on the recovery of water infiltration and soil attributes in both restoration strategies is limited. Therefore, we investigated the recovery of top-soil saturated soil hydraulic conductivity (Ks), soil physical and hydraulic properties in five land use types: (i) a secondary old-growth forest; (ii) a forest established through assisted passive restoration 11 years ago; (iii) an actively restored forest, with a more intensive land use history and 11 years of age; (iv) a pasture with low-intensity use; and (v) a pasture with high-intensity use, in the Brazilian Atlantic Forest. For these land use types, we determined the historical land use patterns and conducted soil sampling, using the Beerkan method to determine Ks values in the fiel...
Revista da Sociedade Brasileira de Medicina Tropical
Currently, there are no laboratory tests or sensitive and specific molecular markers for the earl... more Currently, there are no laboratory tests or sensitive and specific molecular markers for the early diagnosis of leprosy. The aim of this study was to analyze the clinical characteristics of patients with leprosy and investigate their immunological profile, comparing this with the type of lesion and the presence or absence of a Bacillus Calmette-Guérin (BCG) vaccination scar. Statistical analyzes were performed by employing comparative tests (Pearson´s chi-square) to evaluate the variables in different clinical forms, considering significance at the 5% level. The study identified a predominance of lepromatous leprosy (26.9%) in patients aged between 34-53 years. Caucasians predominantly had borderline tuberculoid (BT) clinical forms (42%); a predominance of males with borderline lepromatous (19%) and lepromatous leprosy (26.9%) forms was observed; and the presence of BCG vaccination scars (27.5%) and lower limb nerves were more affected (38%) predominantly in the BT clinical form. Si...
Mimetic seeds simulate the appearance of fleshy fruits and arilled seeds without producing nutrit... more Mimetic seeds simulate the appearance of fleshy fruits and arilled seeds without producing nutritive tissues as a reward for seed dispersers. In this strategy of seed dispersal, seeds may remain attached to the mother plant for long periods after maturity, increasing their availability to naïve seed dispersers. The hypothesis that seed coat impermeability in many tropical Fabaceae with mimetic seeds serves as an exaptation to protect the seeds from deterioration and rotting while awaiting dispersal was investigated. Seed coat impermeability was evaluated in five mimetic-seeded species of tropical Fabaceae in south-eastern Brazil (Abarema langsdorffii, Abrus precatorius, Adenanthera pavonina, Erythrina velutina and Ormosia arborea) and in Erythrina speciosa, a 'basal' species in its genus, which has monochromatic brown seeds and no mimetic displays. Seed hardness was evaluated as a defence against accelerated ageing (humid chamber at 41 degrees C for 144 h). Seed development ...
O conhecimento das plantas de uma região, sua época de florescimento e as características do póle... more O conhecimento das plantas de uma região, sua época de florescimento e as características do pólen, auxiliam na determinação das espécies vegetais que contribuem para a composição do mel. Durante o período de 1994 a 1997 foram inventariadas, semanalmente, em diferentes horários e num raio de aproximadamente 300m dos apiários da USP/ESALQ, em Piracicaba,SP (22°43'S, 47°27'W e 580 m) e do Instituto de Zootecnia, em Pindamonhangaba, SP (22°57'S, 45°27'W e 560 m), as plantas que estavam sendo visitadas por abelhas. Foram anotados o mês e o período de florescimento das plantas inventariadas. Em Piracicaba foram identificadas 94 espécies de plantas pertencentes a 41 famílias (maior número de espécies nas famílias Asteraceae e Myrtaceae) e em Pindamonhangaba, 76 espécies, pertencentes a 26 famílias (maior número de espécies nas famílias Asteraceae e Verbenaceae). Os resultados indicam que 21 famílias, 22 gêneros e 15 espécies de plantas visitadas pelas abelhas africanizadas...
Os fatores prognósticos histológicos podem colaborar para determinar a evolução desta neoplasia. ... more Os fatores prognósticos histológicos podem colaborar para determinar a evolução desta neoplasia. OBJETIVO: Correlacionar a expressão imunoistoquímica do p53 e Ki-67 com idade, grau histológico, comprometimento de linfonodos e estadiamento patológico de pacientes com carcinomas epidermóides de laringe. MÉTODO: Foram avaliados trinta casos consecutivos de carcinomas epidermóides de laringe, submetidos à técnica de imunoistoquímica para verificar a expressão dos anticorpos p53 e Ki-67. RESULTADO: A idade média foi de 56,2 anos e a imunoexpressão dos marcadores foi mais observada no grupo com mais de 50 anos de idade, especialmente a do anticorpo Ki-67 (p=0,032). Não houve relação do p53 e Ki-67 com o comprometimento de linfonodos. O Ki-67 se expressou em 70% nos casos de alto grau histológico e 80% nos de baixo, enquanto o p53 em 70% apenas nos de alto grau. O estadiamento patológico mostrou que no grupo dos carcinomas avançados a expressão do p53 foi de 61,5%, enquanto o Ki-67 mostrou...
International Journal of Entrepreneurship and Small Business, 2012
ABSTRACT The purpose of this paper is to provide an insight into entrepreneurial orientation, mar... more ABSTRACT The purpose of this paper is to provide an insight into entrepreneurial orientation, market orientation and internationalisation in born global small and micro-businesses in Ireland, when owner-manager perceptions are taken into account. Following an exploration of the major theoretical approaches of SME internationalisation and performance, and entrepreneurial/market orientations, a qualitative study is undertaken on owner-managers of four born global firms to present a conceptual model. Although there are a number of studies on born global firms and extensive research on entrepreneurial and market orientations, this study proposes to combine internationalisation and orientation approaches in studying small and micro-businesses. Future studies could empirically test the proposed new conceptual model within a large sample.
In Vitro Cellular & Developmental Biology - Animal, 2008
We are attempting to recreate a stretch reflex circuit on a patterned Bio-MEMS (bio-microelectrom... more We are attempting to recreate a stretch reflex circuit on a patterned Bio-MEMS (bio-microelectromechanical systems) chip with deflecting micro-cantilevers. The first steps to recreate this system is to be able to grow individual components of the circuit (sensory neuron, motoneuron, skeletal muscle, and muscle spindle) on a patternable, synthetic substrate coating the MEMS device. Sensory neurons represent the afferent portion of the stretch reflex arc and also play a significant role in transmitting the signal from the muscle spindle to the spinal cord motoneurons. We have utilized a synthetic silane substrate N-1[3-(trimethoxysilyl) propyl) diethylenetriamine (DETA) on which to grow and pattern the cells. DETA forms a self-assembled monolayer on a variety of silicon substrates, including glass, and can be patterned using photolithography. In this paper, we have evaluated the growth of sensory neurons on this synthetic silane substrate. We have investigated the immunocytochemical and electrophysiological properties of the sensory neurons on DETA and compared the resultant properties with a biological control substrate (ornithine/laminin). Immunocytochemical studies revealed the survival and growth of all three subtypes of sensory neurons: trkA, trkB, and trkC on both surfaces. Furthermore, whole-cell patch clamp recordings were used to study the electrophysiological properties of the sensory neurons on the two surfaces. There were no significant differences in the electrical properties of the neurons grown on either surface. This is the first study analyzing the immunocytochemical and electrophysiological properties of sensory neurons grown long-term in a completely defined environment and on a nonbiological substrate.
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