Muon spin rotation (muSR) has been used to investigate the mixed state of the recently discovered... more Muon spin rotation (muSR) has been used to investigate the mixed state of the recently discovered superconductor YNi2B2C. The width of the muSR-lineshape at low temperature gives a measure of the superconducting penetration depth lambda(T = 0), while the field dependence of the linewidth allows an estimate of the superconducting coherence length xi(T = 0).
Small-angle neutron scattering is used in combination with transport measurements to investigate ... more Small-angle neutron scattering is used in combination with transport measurements to investigate the current-induced effects on the morphology of the intermediate mixed state (IMS) domains in the intertype superconductor niobium. We report the robust self-organisation of the vortex lattice domains to elongated parallel stripes perpendicular to the applied current in a steady-state. The experimental results for the formation of the superstructure are supported by theoretical calculations, which highlight important details of the vortex matter evolution. The investigation demonstrates a mechanism of a spontaneous pattern formation that is closely related to the universal physics governing the IMS in low-κ superconductors.
Monomeric alpha-synuclein (aSyn) is a well characterised as a lipid binding protein. aSyn is know... more Monomeric alpha-synuclein (aSyn) is a well characterised as a lipid binding protein. aSyn is known to form amyloid fibrils which are also localised with lipids and organelles in so called Lewy bodies, insoluble structures found in Parkinson’s disease patient’s brains. It is still unclear under which conditions the aSyn-lipid interaction can start to become pathological. Previous work to address pathological interactions has focused on using synthetic lipid membranes, which lack the complexity of physiological lipid membranes which not only have a more complex lipid composition, but also contain lipid interacting proteins. Here, we investigate how either monomeric or fibrillar aSyn interact with physiological synaptic vesicles (SV) isolated from rodent brain. Using small angle neutron scattering and high-resolution imaging we observe that aSyn fibrils disintegrate SV, whereas aSyn monomers cause clustering of SV. Furthermore, SV enhance the aggregation rate of aSyn, however increasin...
ABSTRACTSmall-angle neutron studies have been performed on samples of continuous inhomogeneous ma... more ABSTRACTSmall-angle neutron studies have been performed on samples of continuous inhomogeneous magnetic recording media. This has allowed the local magnetic structure to be probed at a sub-nanometre resolution, revealing some interesting information about the size and shape of the magnetic grains and their relation to the physical grains.
Small-angle scattering of X-rays and neutrons is a routine method for the determination of nanopa... more Small-angle scattering of X-rays and neutrons is a routine method for the determination of nanoparticle sizes. The so-called Guinier law represents the low-q approximation for the small-angle scattering curve from an assembly of particles. The Guinier law has originally been derived for nonmagnetic particle-matrix-type systems and it is successfully employed for the estimation of particle sizes in various scientific domains (e.g. soft-matter physics, biology, colloidal chemistry, materials science). An important prerequisite for it to apply is the presence of a discontinuous interface separating particles and matrix. Here, the Guinier law is introduced for the case of magnetic small-angle neutron scattering and its applicability is experimentally demonstrated for the example of nanocrystalline cobalt. It is well known that the magnetic microstructure of nanocrystalline ferromagnets is highly nonuniform on the nanometre length scale and characterized by a spectrum of continuously var...
Muon spin rotation (muSR) has been used to investigate the mixed state of the recently discovered... more Muon spin rotation (muSR) has been used to investigate the mixed state of the recently discovered superconductor YNi2B2C. The width of the muSR-lineshape at low temperature gives a measure of the superconducting penetration depth lambda(T = 0), while the field dependence of the linewidth allows an estimate of the superconducting coherence length xi(T = 0).
Small-angle neutron scattering is used in combination with transport measurements to investigate ... more Small-angle neutron scattering is used in combination with transport measurements to investigate the current-induced effects on the morphology of the intermediate mixed state (IMS) domains in the intertype superconductor niobium. We report the robust self-organisation of the vortex lattice domains to elongated parallel stripes perpendicular to the applied current in a steady-state. The experimental results for the formation of the superstructure are supported by theoretical calculations, which highlight important details of the vortex matter evolution. The investigation demonstrates a mechanism of a spontaneous pattern formation that is closely related to the universal physics governing the IMS in low-κ superconductors.
Monomeric alpha-synuclein (aSyn) is a well characterised as a lipid binding protein. aSyn is know... more Monomeric alpha-synuclein (aSyn) is a well characterised as a lipid binding protein. aSyn is known to form amyloid fibrils which are also localised with lipids and organelles in so called Lewy bodies, insoluble structures found in Parkinson’s disease patient’s brains. It is still unclear under which conditions the aSyn-lipid interaction can start to become pathological. Previous work to address pathological interactions has focused on using synthetic lipid membranes, which lack the complexity of physiological lipid membranes which not only have a more complex lipid composition, but also contain lipid interacting proteins. Here, we investigate how either monomeric or fibrillar aSyn interact with physiological synaptic vesicles (SV) isolated from rodent brain. Using small angle neutron scattering and high-resolution imaging we observe that aSyn fibrils disintegrate SV, whereas aSyn monomers cause clustering of SV. Furthermore, SV enhance the aggregation rate of aSyn, however increasin...
ABSTRACTSmall-angle neutron studies have been performed on samples of continuous inhomogeneous ma... more ABSTRACTSmall-angle neutron studies have been performed on samples of continuous inhomogeneous magnetic recording media. This has allowed the local magnetic structure to be probed at a sub-nanometre resolution, revealing some interesting information about the size and shape of the magnetic grains and their relation to the physical grains.
Small-angle scattering of X-rays and neutrons is a routine method for the determination of nanopa... more Small-angle scattering of X-rays and neutrons is a routine method for the determination of nanoparticle sizes. The so-called Guinier law represents the low-q approximation for the small-angle scattering curve from an assembly of particles. The Guinier law has originally been derived for nonmagnetic particle-matrix-type systems and it is successfully employed for the estimation of particle sizes in various scientific domains (e.g. soft-matter physics, biology, colloidal chemistry, materials science). An important prerequisite for it to apply is the presence of a discontinuous interface separating particles and matrix. Here, the Guinier law is introduced for the case of magnetic small-angle neutron scattering and its applicability is experimentally demonstrated for the example of nanocrystalline cobalt. It is well known that the magnetic microstructure of nanocrystalline ferromagnets is highly nonuniform on the nanometre length scale and characterized by a spectrum of continuously var...
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Papers by Robert Cubitt