PURPOSE Pediatric neuro-oncology resources are mostly unknown in Chile. We report the human and m... more PURPOSE Pediatric neuro-oncology resources are mostly unknown in Chile. We report the human and material resources available in Chilean hospitals providing pediatric neuro-oncology services. METHODS A cross-sectional survey was distributed to 17 hospitals providing pediatric neuro-oncology services (Programa Infantil Nacional de Drogas Antineoplásicas [PINDA] hospitals, 11; private, 6). RESULTS Response rate was 71% (PINDA, 8; private, 4). Pediatric neuro-oncology services were mainly provided within general hospitals (67%). Registries for pediatric CNS tumors and chemotherapy-related toxicities were available in 100% and 67% of hospitals, respectively. CNS tumors were treated by pediatric oncologists in 92% of hospitals; none were formally trained in neuro-oncology. The most used treatment protocols were the national PINDA protocols. All WHO essential medicines for childhood cancer were available in more than 80% of the hospitals except for gemcitabine, oxaliplatin, paclitaxel, and...
Background: Patients with acute lymphoblastic leukemia (ALL) have high risk of severe influenza i... more Background: Patients with acute lymphoblastic leukemia (ALL) have high risk of severe influenza infection and vaccination is highly recommended. The immunogenicity and effectiveness of vaccination are lower than in healthy people. Aim: To evaluate the immune response induced by influenza vaccine in children with ALL and observe effectiveness. Method : Children with ALL in maintenance phase and healthy children were recruited. Blood samples were taken at vaccination day (D0) and at day 28 (D28). Humoral response was evaluated by hemaglutination inhibition test (HAI) against H1N1. Patients were followed up for one year, clinical data and influenza episodes were recorded. Results : 34 children with ALL and 9 healthy children were included. Concerning HAI on D28, 12/34 patients and 5/8 healthy children had titers ≥ 1/40, with seroprotection rates of 35 and 63% respectively. Seroprotected children were older than non-seroprotected ones. During follow-up, only 3 patients non seroprotected...
Introducción Los niños con cáncer pueden presentar múltiples dermatosis derivadas del cáncer mism... more Introducción Los niños con cáncer pueden presentar múltiples dermatosis derivadas del cáncer mismo o secundarias a su terapéutica. El objetivo es conocer las manifestaciones cutáneas de niños con cáncer en quimioterapia, y compararlas con niños controles sanos. Este es el primer estudio chileno que las describe. Pacientes y método Se realizó un estudio analítico descriptivo transversal. Mediante examen físico y registro en ficha se estudiaron 82 niños. Los casos fueron 41 niños con cáncer en quimioterapia del Servicio de Oncología Infantil del Hospital Sótero del Río. Los controles, 41 pacientes sanos hospitalizados por patología quirúrgica en el mismo hospital. Ambos grupos fueron pareados por sexo, edad, estado nutricional, fenotipo y tipo de exposición solar en relación 1:1. Los datos se analizaron con software SPSS. Resultados: La xerosis se encontró en el 73,2% (n=60). El 54,9% (n=45) presentó dermatosis inflamatoria, pigmentaria o infecciosa. En niños con cáncer, el 56,1% (n=...
PURPOSE Pediatric neuro-oncology resources are mostly unknown in Chile. We report the human and m... more PURPOSE Pediatric neuro-oncology resources are mostly unknown in Chile. We report the human and material resources available in Chilean hospitals providing pediatric neuro-oncology services. METHODS A cross-sectional survey was distributed to 17 hospitals providing pediatric neuro-oncology services (Programa Infantil Nacional de Drogas Antineoplásicas [PINDA] hospitals, 11; private, 6). RESULTS Response rate was 71% (PINDA, 8; private, 4). Pediatric neuro-oncology services were mainly provided within general hospitals (67%). Registries for pediatric CNS tumors and chemotherapy-related toxicities were available in 100% and 67% of hospitals, respectively. CNS tumors were treated by pediatric oncologists in 92% of hospitals; none were formally trained in neuro-oncology. The most used treatment protocols were the national PINDA protocols. All WHO essential medicines for childhood cancer were available in more than 80% of the hospitals except for gemcitabine, oxaliplatin, paclitaxel, and...
Background: Patients with acute lymphoblastic leukemia (ALL) have high risk of severe influenza i... more Background: Patients with acute lymphoblastic leukemia (ALL) have high risk of severe influenza infection and vaccination is highly recommended. The immunogenicity and effectiveness of vaccination are lower than in healthy people. Aim: To evaluate the immune response induced by influenza vaccine in children with ALL and observe effectiveness. Method : Children with ALL in maintenance phase and healthy children were recruited. Blood samples were taken at vaccination day (D0) and at day 28 (D28). Humoral response was evaluated by hemaglutination inhibition test (HAI) against H1N1. Patients were followed up for one year, clinical data and influenza episodes were recorded. Results : 34 children with ALL and 9 healthy children were included. Concerning HAI on D28, 12/34 patients and 5/8 healthy children had titers ≥ 1/40, with seroprotection rates of 35 and 63% respectively. Seroprotected children were older than non-seroprotected ones. During follow-up, only 3 patients non seroprotected...
Introducción Los niños con cáncer pueden presentar múltiples dermatosis derivadas del cáncer mism... more Introducción Los niños con cáncer pueden presentar múltiples dermatosis derivadas del cáncer mismo o secundarias a su terapéutica. El objetivo es conocer las manifestaciones cutáneas de niños con cáncer en quimioterapia, y compararlas con niños controles sanos. Este es el primer estudio chileno que las describe. Pacientes y método Se realizó un estudio analítico descriptivo transversal. Mediante examen físico y registro en ficha se estudiaron 82 niños. Los casos fueron 41 niños con cáncer en quimioterapia del Servicio de Oncología Infantil del Hospital Sótero del Río. Los controles, 41 pacientes sanos hospitalizados por patología quirúrgica en el mismo hospital. Ambos grupos fueron pareados por sexo, edad, estado nutricional, fenotipo y tipo de exposición solar en relación 1:1. Los datos se analizaron con software SPSS. Resultados: La xerosis se encontró en el 73,2% (n=60). El 54,9% (n=45) presentó dermatosis inflamatoria, pigmentaria o infecciosa. En niños con cáncer, el 56,1% (n=...
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