Objective: There are few studies of esophageal function subsequent to the ingestion of lye. We in... more Objective: There are few studies of esophageal function subsequent to the ingestion of lye. We investigated the esophageal motility of patients who had ingested liquid sodium hydroxide. Methods: Esophageal manometry was performed on 21 patients who [1-53 yr before the manometric examination (median: 13 yr)] had drunk 10-30 g of sodium hydroxide diluted in water. The results were compared with those obtained for a control group of 22 healthy volunteers. Results: The lower esophageal sphincter (LES) pressure of the caustic group (14.9 +/- 1.7 mm Hg, mean +/- SE) did not differ (p > 0.05) from that of the control group (17.4 +/- 1.1 mm Hg). LES pressure in eight patients was below 10 mm Hg. The amplitude of contraction was lower (p < 0.01) in the caustic group than in the control group. In the proximal part of the esophageal body, the duration of contraction was longer (p < 0.01) in the caustic group (2.3 +/- 0.1 s) than in controls (1.8 +/- 0.1 s). Nonperistaltic contraction was a finding in 14 patients, repetitive in five of them. The velocity of peristaltic contractions was higher (p < 0.05) in the caustic group (distal: 3.2 +/- 0.2 cm/s) than in the control group (2.2 +/- 0.2 cm/s). Although there was some impairment of esophageal motor function in 71% of the patients, they were asymptomatic when we performed esophageal manometry. Conclusions: Esophageal motility impairment was present in most of the patients who ingested sodium hydroxide. Nonperistaltic contractions of low amplitude were found most frequently.
O carcinoma epidermóide sarcomatóide da laringe é neoplasia rara que continua a estimular controv... more O carcinoma epidermóide sarcomatóide da laringe é neoplasia rara que continua a estimular controvérsias entre os patologistas. Vários termos têm sido usados para descrever tal lesão, incluindo carcinossarcom.a, carcinoma de células fusiformes, carcinoma sarcomatóide, pseudossarcoma, carcinoma epidermóide com estroma "sarcoma like" carcinoma pleomórfico, carcinoma polipóide e carcinoma metaplásico. O achado histopatológico característico é a presença de carcinoma epidermóide associado a componente de células fusiformes. Apresenta-se caso de paciente masculino, 59 anos, branco, com queixa de disfonia há 1 ano, acompanhada de disfagia e dispnéia. Ao exame laringoscóplco indireto notou-se extensa lesão tumoral localizada na Iaringe com destruição parcial da glote. O exame histopatológico demonstrou tratar-se de carcinoma epidermóide bem diferenciado com extensas áreas anaplásicas,. de componente fusocelular. Acompanhava massa tumoral metastática peritraqueal com componente fus...
INTRODUCTIONThe reimplantation of a complete tracheal segment (CTS) as an autograft or homograft ... more INTRODUCTIONThe reimplantation of a complete tracheal segment (CTS) as an autograft or homograft often results in total or partial necrosis of the CTS. However, previous experiments suggested that when the CTS is first vascularized by the sternohyoid muscle (SM) 21 days before the reimplantation, the CTS can be reimplanted without ischemia or stenosis. However, it is not clear if the CTS requires 21 days to attain full revascularization.GOALThis study aims to ascertain the minimum time necessary for revascularization of the 6 rings CTS by the SM allowing reimplantation free of ischemia.METHODSFifteen mongrel dogs, divided into 3 groups were submitted to 2 sequential surgical procedures. In the first procedure, a SM flap was used to envelop 6 rings CTS in all dogs. After periods of 21 days (group 1, n = 5), 14 days (group 2, n = 5) and 7 days (group 3, n = 5), the compound flaps (CTS and SM) were neovascularized. Each CTS was transected and mobilized from the trachea and then replace...
Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
The authors report on their findings after analysing the results of an intermittent combination c... more The authors report on their findings after analysing the results of an intermittent combination chemotherapy with Bleomycin (B.L.M.), Methotrexate (M.T.X.), Cyclophosphamide and corticoid (B.M.E.M.), in 117 cases of tumors of the Head and Neck. There were 30,0% of complete remission and 77,8% of responsiveness mors. Significant response rates were achieved with this B.M.E.M. combination therapy in: both advanced and not advanced tumors, both well and poor differentiated carcinomas; both exophitic and endophytic tumors.
OBJECTIVESThe development of techniques causing fewer sequelae without compromising oncologic con... more OBJECTIVESThe development of techniques causing fewer sequelae without compromising oncologic control has led to better phonation, breathing, and postoperative swallowing in patients submitted to cordectomy. The objective of the present study was to describe post‐cordectomy laryngeal reconstruction with a vestibular fold flap and to analyze the resulting laryngeal functions.STUDY DESIGNProspective study.METHODSTen patients, 9 males and 1 female, aged 45 to 75 years (mean, 64.5 years), were evaluated. The patients had squamous cell carcinomas in the glottic region and were treated surgically by laryngofissure and cordectomy with the use of a vestibular fold flap for laryngeal reconstruction. The patients were followed up for functional laryngeal analysis that consisted of videolaryngostrobos‐copy, endoscopic evaluation of swallowing, and voice recording for perceptive auditory analysis, and for computing purposes.RESULTSNo patients depended on tracheostomy during the late postoperati...
Resumo: Os autores analisam os dados epidemiológicos do câncer de Cabeça e Pescoço entre os pacie... more Resumo: Os autores analisam os dados epidemiológicos do câncer de Cabeça e Pescoço entre os pacientes atendidos no Hospital das Clínicas-FMRPUSP, verificam a procedência dos mesmos e analisam alguns fatores de risco envolvidos nesta populaçäo. Foram ...
Objective: There are few studies of esophageal function subsequent to the ingestion of lye. We in... more Objective: There are few studies of esophageal function subsequent to the ingestion of lye. We investigated the esophageal motility of patients who had ingested liquid sodium hydroxide. Methods: Esophageal manometry was performed on 21 patients who [1-53 yr before the manometric examination (median: 13 yr)] had drunk 10-30 g of sodium hydroxide diluted in water. The results were compared with those obtained for a control group of 22 healthy volunteers. Results: The lower esophageal sphincter (LES) pressure of the caustic group (14.9 +/- 1.7 mm Hg, mean +/- SE) did not differ (p > 0.05) from that of the control group (17.4 +/- 1.1 mm Hg). LES pressure in eight patients was below 10 mm Hg. The amplitude of contraction was lower (p < 0.01) in the caustic group than in the control group. In the proximal part of the esophageal body, the duration of contraction was longer (p < 0.01) in the caustic group (2.3 +/- 0.1 s) than in controls (1.8 +/- 0.1 s). Nonperistaltic contraction was a finding in 14 patients, repetitive in five of them. The velocity of peristaltic contractions was higher (p < 0.05) in the caustic group (distal: 3.2 +/- 0.2 cm/s) than in the control group (2.2 +/- 0.2 cm/s). Although there was some impairment of esophageal motor function in 71% of the patients, they were asymptomatic when we performed esophageal manometry. Conclusions: Esophageal motility impairment was present in most of the patients who ingested sodium hydroxide. Nonperistaltic contractions of low amplitude were found most frequently.
O carcinoma epidermóide sarcomatóide da laringe é neoplasia rara que continua a estimular controv... more O carcinoma epidermóide sarcomatóide da laringe é neoplasia rara que continua a estimular controvérsias entre os patologistas. Vários termos têm sido usados para descrever tal lesão, incluindo carcinossarcom.a, carcinoma de células fusiformes, carcinoma sarcomatóide, pseudossarcoma, carcinoma epidermóide com estroma "sarcoma like" carcinoma pleomórfico, carcinoma polipóide e carcinoma metaplásico. O achado histopatológico característico é a presença de carcinoma epidermóide associado a componente de células fusiformes. Apresenta-se caso de paciente masculino, 59 anos, branco, com queixa de disfonia há 1 ano, acompanhada de disfagia e dispnéia. Ao exame laringoscóplco indireto notou-se extensa lesão tumoral localizada na Iaringe com destruição parcial da glote. O exame histopatológico demonstrou tratar-se de carcinoma epidermóide bem diferenciado com extensas áreas anaplásicas,. de componente fusocelular. Acompanhava massa tumoral metastática peritraqueal com componente fus...
INTRODUCTIONThe reimplantation of a complete tracheal segment (CTS) as an autograft or homograft ... more INTRODUCTIONThe reimplantation of a complete tracheal segment (CTS) as an autograft or homograft often results in total or partial necrosis of the CTS. However, previous experiments suggested that when the CTS is first vascularized by the sternohyoid muscle (SM) 21 days before the reimplantation, the CTS can be reimplanted without ischemia or stenosis. However, it is not clear if the CTS requires 21 days to attain full revascularization.GOALThis study aims to ascertain the minimum time necessary for revascularization of the 6 rings CTS by the SM allowing reimplantation free of ischemia.METHODSFifteen mongrel dogs, divided into 3 groups were submitted to 2 sequential surgical procedures. In the first procedure, a SM flap was used to envelop 6 rings CTS in all dogs. After periods of 21 days (group 1, n = 5), 14 days (group 2, n = 5) and 7 days (group 3, n = 5), the compound flaps (CTS and SM) were neovascularized. Each CTS was transected and mobilized from the trachea and then replace...
Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
The authors report on their findings after analysing the results of an intermittent combination c... more The authors report on their findings after analysing the results of an intermittent combination chemotherapy with Bleomycin (B.L.M.), Methotrexate (M.T.X.), Cyclophosphamide and corticoid (B.M.E.M.), in 117 cases of tumors of the Head and Neck. There were 30,0% of complete remission and 77,8% of responsiveness mors. Significant response rates were achieved with this B.M.E.M. combination therapy in: both advanced and not advanced tumors, both well and poor differentiated carcinomas; both exophitic and endophytic tumors.
OBJECTIVESThe development of techniques causing fewer sequelae without compromising oncologic con... more OBJECTIVESThe development of techniques causing fewer sequelae without compromising oncologic control has led to better phonation, breathing, and postoperative swallowing in patients submitted to cordectomy. The objective of the present study was to describe post‐cordectomy laryngeal reconstruction with a vestibular fold flap and to analyze the resulting laryngeal functions.STUDY DESIGNProspective study.METHODSTen patients, 9 males and 1 female, aged 45 to 75 years (mean, 64.5 years), were evaluated. The patients had squamous cell carcinomas in the glottic region and were treated surgically by laryngofissure and cordectomy with the use of a vestibular fold flap for laryngeal reconstruction. The patients were followed up for functional laryngeal analysis that consisted of videolaryngostrobos‐copy, endoscopic evaluation of swallowing, and voice recording for perceptive auditory analysis, and for computing purposes.RESULTSNo patients depended on tracheostomy during the late postoperati...
Resumo: Os autores analisam os dados epidemiológicos do câncer de Cabeça e Pescoço entre os pacie... more Resumo: Os autores analisam os dados epidemiológicos do câncer de Cabeça e Pescoço entre os pacientes atendidos no Hospital das Clínicas-FMRPUSP, verificam a procedência dos mesmos e analisam alguns fatores de risco envolvidos nesta populaçäo. Foram ...
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